JP2016531546A5 - - Google Patents
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- JP2016531546A5 JP2016531546A5 JP2016515415A JP2016515415A JP2016531546A5 JP 2016531546 A5 JP2016531546 A5 JP 2016531546A5 JP 2016515415 A JP2016515415 A JP 2016515415A JP 2016515415 A JP2016515415 A JP 2016515415A JP 2016531546 A5 JP2016531546 A5 JP 2016531546A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- amino acid
- sample
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 15
- 238000000034 method Methods 0.000 claims 12
- 150000001413 amino acids Chemical group 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 8
- 102000005927 Cysteine Proteases Human genes 0.000 claims 5
- 108010005843 Cysteine Proteases Proteins 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 2
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 101710112752 Cytotoxin Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 229940122803 Vinca alkaloid Drugs 0.000 claims 1
- 108010044540 auristatin Proteins 0.000 claims 1
- 229930195731 calicheamicin Natural products 0.000 claims 1
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000002619 cytotoxin Substances 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 230000004481 post-translational protein modification Effects 0.000 claims 1
- UOWVMDUEMSNCAV-WYENRQIDSA-N rachelmycin Chemical compound C1([C@]23C[C@@H]2CN1C(=O)C=1NC=2C(OC)=C(O)C4=C(C=2C=1)CCN4C(=O)C1=CC=2C=4CCN(C=4C(O)=C(C=2N1)OC)C(N)=O)=CC(=O)C1=C3C(C)=CN1 UOWVMDUEMSNCAV-WYENRQIDSA-N 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1316744.0 | 2013-09-20 | ||
| GBGB1316744.0A GB201316744D0 (en) | 2013-09-20 | 2013-09-20 | Method |
| PCT/EP2014/069920 WO2015040125A1 (en) | 2013-09-20 | 2014-09-18 | A method for analysing a sample of immunoglobulin molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016531546A JP2016531546A (ja) | 2016-10-13 |
| JP2016531546A5 true JP2016531546A5 (https=) | 2017-10-26 |
Family
ID=49553168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016515415A Withdrawn JP2016531546A (ja) | 2013-09-20 | 2014-09-18 | 免疫グロブリン分子試料を分析する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20160231329A1 (https=) |
| EP (1) | EP3047280A1 (https=) |
| JP (1) | JP2016531546A (https=) |
| KR (1) | KR20160079784A (https=) |
| AU (1) | AU2014323081A1 (https=) |
| CA (1) | CA2923704A1 (https=) |
| GB (1) | GB201316744D0 (https=) |
| SG (1) | SG11201602138VA (https=) |
| WO (1) | WO2015040125A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1343895B1 (en) * | 2000-12-21 | 2008-06-18 | ID Biomedical Corporation | Streptococcus pyogenes antigens and corresponding dna fragments |
| ES2702183T3 (es) | 2013-03-15 | 2019-02-27 | Mayo Found Medical Education & Res | Identificación y monitorización de inmunoglobulinas monoclonales por masa molecular |
| WO2015154052A1 (en) | 2014-04-04 | 2015-10-08 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
| GB201502306D0 (en) | 2015-02-12 | 2015-04-01 | Hansa Medical Ab | Protein |
| GB201502305D0 (en) | 2015-02-12 | 2015-04-01 | Hansa Medical Ab | Protein |
| CN108026164A (zh) | 2015-09-24 | 2018-05-11 | 梅约医学教育与研究基金会 | 通过质谱鉴定免疫球蛋白游离轻链 |
| WO2017097918A1 (en) | 2015-12-09 | 2017-06-15 | F. Hoffmann-La Roche Ag | Method for determining the in vivo interaction mode |
| EP3387439B1 (en) | 2015-12-09 | 2020-02-26 | H. Hoffnabb-La Roche Ag | Direct affinity measurement of human igg1 binding multimeric antigens |
| ES2877754T3 (es) * | 2016-02-04 | 2021-11-17 | Genovis Ab | Nuevas proteasas estreptocócicas |
| EP3465221B1 (en) * | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Bioanalytical method for the characterization of site-specific antibody-drug conjugates |
| AU2017325022B2 (en) | 2016-09-07 | 2022-10-13 | Mayo Foundation For Medical Education And Research | Identification and monitoring of cleaved immunoglobulins by molecular mass |
| WO2018093868A1 (en) * | 2016-11-16 | 2018-05-24 | University Of Florida Research Foundation, Inc. | Immunoglobulin proteases, compositions, and uses thereof |
| DK3630968T3 (da) | 2017-05-26 | 2024-07-29 | Genovis Ab | Enzymer til glycananalyse |
| EP3681907A4 (en) | 2017-09-13 | 2021-07-07 | Mayo Foundation for Medical Education and Research | IDENTIFICATION AND MONITORING OF IMMUNOGLOBULIN J-CHAINS |
| WO2019055634A1 (en) | 2017-09-13 | 2019-03-21 | Mayo Foundation For Medical Education And Research | IDENTIFICATION AND MONITORING OF A MACROPHAGE APOPTOSIS INHIBITOR |
| EP4079848A1 (en) * | 2021-04-22 | 2022-10-26 | Genovis Ab | Immunoglobulin cleaving enzyme |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965709A (en) * | 1991-08-14 | 1999-10-12 | Genentech, Inc. | IgE antagonists |
| GB0130228D0 (en) * | 2001-12-18 | 2002-02-06 | Hansa Medica Ab | Protein |
| EP2748197A2 (en) * | 2011-08-26 | 2014-07-02 | Merrimack Pharmaceuticals, Inc. | Tandem fc bispecific antibodies |
-
2013
- 2013-09-20 GB GBGB1316744.0A patent/GB201316744D0/en not_active Ceased
-
2014
- 2014-09-18 US US15/023,042 patent/US20160231329A1/en not_active Abandoned
- 2014-09-18 AU AU2014323081A patent/AU2014323081A1/en not_active Abandoned
- 2014-09-18 CA CA2923704A patent/CA2923704A1/en not_active Abandoned
- 2014-09-18 SG SG11201602138VA patent/SG11201602138VA/en unknown
- 2014-09-18 WO PCT/EP2014/069920 patent/WO2015040125A1/en not_active Ceased
- 2014-09-18 EP EP14772310.0A patent/EP3047280A1/en not_active Withdrawn
- 2014-09-18 JP JP2016515415A patent/JP2016531546A/ja not_active Withdrawn
- 2014-09-18 KR KR1020167010252A patent/KR20160079784A/ko not_active Withdrawn
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