KR101391461B1 - Ｍｅｋ 억제제로서의 피리돈 설폰아미드 및 피리돈 설파미드 - Google Patents
Ｍｅｋ 억제제로서의 피리돈 설폰아미드 및 피리돈 설파미드 Download PDFInfo
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- KR101391461B1 KR101391461B1 KR1020087028158A KR20087028158A KR101391461B1 KR 101391461 B1 KR101391461 B1 KR 101391461B1 KR 1020087028158 A KR1020087028158 A KR 1020087028158A KR 20087028158 A KR20087028158 A KR 20087028158A KR 101391461 B1 KR101391461 B1 KR 101391461B1
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- 0 *c(cc1*)ccc1NC(C(N)=CN1*)=C(*)C1=O Chemical compound *c(cc1*)ccc1NC(C(N)=CN1*)=C(*)C1=O 0.000 description 3
- KTRYYJAURAOPHE-UHFFFAOYSA-N CC(C(N(C)C=C1CNS(C2(CCO)CC2)(=O)=O)=O)=C1Nc(ccc(I)c1)c1Cl Chemical compound CC(C(N(C)C=C1CNS(C2(CCO)CC2)(=O)=O)=O)=C1Nc(ccc(I)c1)c1Cl KTRYYJAURAOPHE-UHFFFAOYSA-N 0.000 description 1
- UFBISYFSBRCQRI-UHFFFAOYSA-N CC(C(N(C)C=C1NS(C2(CC(O)=O)CC2)(=O)=O)=O)=C1Nc(c(Cl)c1)ccc1I Chemical compound CC(C(N(C)C=C1NS(C2(CC(O)=O)CC2)(=O)=O)=O)=C1Nc(c(Cl)c1)ccc1I UFBISYFSBRCQRI-UHFFFAOYSA-N 0.000 description 1
- ULVKMPFSFXUZBH-UHFFFAOYSA-N CC(C)N(C(C)C)S(NC(C(Nc(c(F)c1)ccc1I)=C1)=CN(C)C1=O)(=O)=O Chemical compound CC(C)N(C(C)C)S(NC(C(Nc(c(F)c1)ccc1I)=C1)=CN(C)C1=O)(=O)=O ULVKMPFSFXUZBH-UHFFFAOYSA-N 0.000 description 1
- VYISQDHCOBAYOV-UHFFFAOYSA-N CC(C)N(C=C(C(Nc(ccc(Br)c1)c1F)=C1C#CC)NS(N(CC(CO)O)C2CC2)(=O)=O)C1=O Chemical compound CC(C)N(C=C(C(Nc(ccc(Br)c1)c1F)=C1C#CC)NS(N(CC(CO)O)C2CC2)(=O)=O)C1=O VYISQDHCOBAYOV-UHFFFAOYSA-N 0.000 description 1
- DOBMCRMAPUFBPQ-UHFFFAOYSA-N CC(N(C=C(C(Nc(c(F)c1)ccc1Br)=C1)NS(N(CC(CO)O)C2CC2)(=O)=O)C1=O)=C Chemical compound CC(N(C=C(C(Nc(c(F)c1)ccc1Br)=C1)NS(N(CC(CO)O)C2CC2)(=O)=O)C1=O)=C DOBMCRMAPUFBPQ-UHFFFAOYSA-N 0.000 description 1
- HXOYWCSTHVTLOW-UHFFFAOYSA-N CC1(C)OC(CN)CO1 Chemical compound CC1(C)OC(CN)CO1 HXOYWCSTHVTLOW-UHFFFAOYSA-N 0.000 description 1
- FEDHEMZAPDEJLA-UHFFFAOYSA-N CC1(C)OC(CNS(Cl)(=O)=O)CO1 Chemical compound CC1(C)OC(CNS(Cl)(=O)=O)CO1 FEDHEMZAPDEJLA-UHFFFAOYSA-N 0.000 description 1
- YFWIVAUPRJHWLU-UHFFFAOYSA-N CN(C)S(NC(C(Nc(c(F)c1)ccc1Br)=C1)=CN(C)C1=O)(=O)=O Chemical compound CN(C)S(NC(C(Nc(c(F)c1)ccc1Br)=C1)=CN(C)C1=O)(=O)=O YFWIVAUPRJHWLU-UHFFFAOYSA-N 0.000 description 1
- KKIACBRNMRWEGE-UHFFFAOYSA-N CN(C=C(C(Nc(c(F)c1)ccc1Br)=C1Cl)NS(C2CC2)(=O)=O)C1=O Chemical compound CN(C=C(C(Nc(c(F)c1)ccc1Br)=C1Cl)NS(C2CC2)(=O)=O)C1=O KKIACBRNMRWEGE-UHFFFAOYSA-N 0.000 description 1
- PRUIAZSFUWEGTG-UHFFFAOYSA-N CN(C=C(C(Nc(ccc(I)c1)c1F)=C1)NS(C2(CC(CO)O)CC2)(=O)=O)C1=O Chemical compound CN(C=C(C(Nc(ccc(I)c1)c1F)=C1)NS(C2(CC(CO)O)CC2)(=O)=O)C1=O PRUIAZSFUWEGTG-UHFFFAOYSA-N 0.000 description 1
- VFMZAENHYDEXQU-UHFFFAOYSA-N CN(C=C(C(Nc(ccc(I)c1)c1F)=C1)NS(C2CC2)(=O)=O)C1=O Chemical compound CN(C=C(C(Nc(ccc(I)c1)c1F)=C1)NS(C2CC2)(=O)=O)C1=O VFMZAENHYDEXQU-UHFFFAOYSA-N 0.000 description 1
- PWHRAEWVBJVUAR-UHFFFAOYSA-N Cc1cc(I)ccc1NC(C(NS(N(C)C)(=O)=O)=CN(c1ccc[nH]1)C1=O)=C1F Chemical compound Cc1cc(I)ccc1NC(C(NS(N(C)C)(=O)=O)=CN(c1ccc[nH]1)C1=O)=C1F PWHRAEWVBJVUAR-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79312906P | 2006-04-18 | 2006-04-18 | |
| US60/793,129 | 2006-04-18 | ||
| PCT/US2007/066894 WO2007121481A2 (en) | 2006-04-18 | 2007-04-18 | Pyridone sulfonamides and pyridone sulfamides as mek inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20090005193A KR20090005193A (ko) | 2009-01-12 |
| KR101391461B1 true KR101391461B1 (ko) | 2014-05-07 |
Family
ID=38610466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087028158A Expired - Fee Related KR101391461B1 (ko) | 2006-04-18 | 2008-11-18 | Ｍｅｋ 억제제로서의 피리돈 설폰아미드 및 피리돈 설파미드 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7897624B2 (https=) |
| EP (1) | EP2012786B1 (https=) |
| JP (1) | JP5269762B2 (https=) |
| KR (1) | KR101391461B1 (https=) |
| CN (1) | CN101454004B (https=) |
| AT (1) | ATE483463T1 (https=) |
| AU (1) | AU2007237901B2 (https=) |
| BR (1) | BRPI0710817A2 (https=) |
| CA (1) | CA2649122C (https=) |
| DE (1) | DE602007009663D1 (https=) |
| EA (1) | EA016674B1 (https=) |
| ES (1) | ES2354182T3 (https=) |
| IL (1) | IL194595A (https=) |
| MX (1) | MX2008013097A (https=) |
| WO (1) | WO2007121481A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004030611A2 (en) * | 2002-08-23 | 2004-04-15 | Ribapharm Inc. | Non-nucleoside reverse transcriptase inhibitors |
| US7429667B2 (en) * | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
| US9095581B2 (en) | 2005-07-21 | 2015-08-04 | Ardea Biosciences, Inc. | Combinations of MEK inhibitors and Raf kinase inhibitors and uses thereof |
| US7842836B2 (en) | 2006-04-11 | 2010-11-30 | Ardea Biosciences | N-aryl-N'alkyl sulfamides as MEK inhibitors |
| JP5269762B2 (ja) | 2006-04-18 | 2013-08-21 | アーディア・バイオサイエンシーズ・インコーポレイテッド | Ｍｅｋ阻害剤としてのピリドンスルホンアミドおよびピリドンスルファミド |
| US8509487B2 (en) * | 2007-04-19 | 2013-08-13 | Avago Technologies General Ip (Singapore) Pte. Ltd. | System and method for optically measuring a parameter of an object |
| CA2924436A1 (en) * | 2007-07-30 | 2009-02-05 | Ardea Biosciences, Inc. | Pharmaceutical combinations of n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide as inhibitors of mek and methods of use |
| AR071587A1 (es) * | 2008-04-21 | 2010-06-30 | Novartis Ag | Compuestos heterociclicos como inhibidores de mek |
| HRP20160044T1 (hr) | 2008-08-04 | 2016-02-26 | Merck Patent Gmbh | Novi spojevi fenilamino izonikotinamida |
| WO2010068738A1 (en) | 2008-12-10 | 2010-06-17 | Dana-Farber Cancer Institute, Inc. | Mek mutations conferring resistance to mek inhibitors |
| UY32486A (es) * | 2009-03-11 | 2010-10-29 | Ardea Biosciences Inc | Tratamiento del cáncer de páncreas |
| CN102448938A (zh) * | 2009-03-27 | 2012-05-09 | 阿迪生物科学公司 | 作为mek抑制剂的二氢吡啶磺酰胺和二氢吡啶硫酰胺 |
| CN102459188A (zh) * | 2009-06-15 | 2012-05-16 | 凯美隆(北京)药业技术有限公司 | 新型6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
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| US20070244164A1 (en) | 2007-10-18 |
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| JP2009534408A (ja) | 2009-09-24 |
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| US7897624B2 (en) | 2011-03-01 |
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| US8716318B2 (en) | 2014-05-06 |
| DE602007009663D1 (de) | 2010-11-18 |
| EP2012786A4 (en) | 2010-02-24 |
| JP5269762B2 (ja) | 2013-08-21 |
| WO2007121481A2 (en) | 2007-10-25 |
| BRPI0710817A2 (pt) | 2011-08-23 |
| EP2012786A2 (en) | 2009-01-14 |
| EA016674B1 (ru) | 2012-06-29 |
| CN101454004B (zh) | 2013-12-04 |
| KR20090005193A (ko) | 2009-01-12 |
| CN101454004A (zh) | 2009-06-10 |
| WO2007121481A8 (en) | 2008-10-16 |
| IL194595A (en) | 2015-04-30 |
| EP2012786B1 (en) | 2010-10-06 |
| MX2008013097A (es) | 2008-10-27 |
| CA2649122A1 (en) | 2007-10-25 |
| HK1128617A1 (en) | 2009-11-06 |
| AU2007237901A1 (en) | 2007-10-25 |
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