KR101345008B1 - 항바이러스 화합물 - Google Patents

항바이러스 화합물 Download PDF

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Publication number
KR101345008B1
KR101345008B1 KR1020087003628A KR20087003628A KR101345008B1 KR 101345008 B1 KR101345008 B1 KR 101345008B1 KR 1020087003628 A KR1020087003628 A KR 1020087003628A KR 20087003628 A KR20087003628 A KR 20087003628A KR 101345008 B1 KR101345008 B1 KR 101345008B1
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KR
South Korea
Prior art keywords
alkyl
reaction
acid
groups
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020087003628A
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English (en)
Korean (ko)
Other versions
KR20080027947A (ko
Inventor
에어솝 조
정 우. 김
샤오닝 씨. 생
Original Assignee
길리애드 사이언시즈, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 길리애드 사이언시즈, 인코포레이티드 filed Critical 길리애드 사이언시즈, 인코포레이티드
Publication of KR20080027947A publication Critical patent/KR20080027947A/ko
Application granted granted Critical
Publication of KR101345008B1 publication Critical patent/KR101345008B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020087003628A 2005-07-14 2006-07-14 항바이러스 화합물 Expired - Fee Related KR101345008B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69909605P 2005-07-14 2005-07-14
US60/699,096 2005-07-14
US70055905P 2005-07-18 2005-07-18
US60/700,559 2005-07-18
PCT/US2006/027605 WO2007009109A2 (en) 2005-07-14 2006-07-14 Antiviral compounds

Publications (2)

Publication Number Publication Date
KR20080027947A KR20080027947A (ko) 2008-03-28
KR101345008B1 true KR101345008B1 (ko) 2013-12-31

Family

ID=37387254

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087003628A Expired - Fee Related KR101345008B1 (ko) 2005-07-14 2006-07-14 항바이러스 화합물

Country Status (13)

Country Link
US (1) US20070072809A1 (cg-RX-API-DMAC7.html)
EP (1) EP1907403B1 (cg-RX-API-DMAC7.html)
JP (1) JP2009501724A (cg-RX-API-DMAC7.html)
KR (1) KR101345008B1 (cg-RX-API-DMAC7.html)
CN (1) CN101243096B (cg-RX-API-DMAC7.html)
AR (1) AR054838A1 (cg-RX-API-DMAC7.html)
AU (1) AU2006267066A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0613056A2 (cg-RX-API-DMAC7.html)
CA (1) CA2614276A1 (cg-RX-API-DMAC7.html)
MX (1) MX2008000609A (cg-RX-API-DMAC7.html)
NZ (1) NZ564830A (cg-RX-API-DMAC7.html)
TW (1) TWI389908B (cg-RX-API-DMAC7.html)
WO (1) WO2007009109A2 (cg-RX-API-DMAC7.html)

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Publication number Publication date
AU2006267066A1 (en) 2007-01-18
WO2007009109A2 (en) 2007-01-18
US20070072809A1 (en) 2007-03-29
NZ564830A (en) 2010-12-24
KR20080027947A (ko) 2008-03-28
JP2009501724A (ja) 2009-01-22
TW200738741A (en) 2007-10-16
EP1907403A2 (en) 2008-04-09
CA2614276A1 (en) 2007-01-18
BRPI0613056A2 (pt) 2010-12-14
CN101243096B (zh) 2013-02-06
WO2007009109A3 (en) 2007-06-07
CN101243096A (zh) 2008-08-13
MX2008000609A (es) 2008-03-19
EP1907403B1 (en) 2013-12-25
AR054838A1 (es) 2007-07-18
TWI389908B (zh) 2013-03-21

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