KR101335055B1 - 신규한 5-치환된 7-아미노[1,3]티아졸로[4,5-ｄ]피리미딘유도체 - Google Patents

신규한 5-치환된 7-아미노[1,3]티아졸로[4,5-ｄ]피리미딘유도체 Download PDF

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KR101335055B1
KR101335055B1 KR1020077022813A KR20077022813A KR101335055B1 KR 101335055 B1 KR101335055 B1 KR 101335055B1 KR 1020077022813 A KR1020077022813 A KR 1020077022813A KR 20077022813 A KR20077022813 A KR 20077022813A KR 101335055 B1 KR101335055 B1 KR 101335055B1
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amino
thiazolo
thio
compound
formula
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KR20080004483A (ko
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군나르 노르드발
콜린 레이
토비아스 라인
다니엘 손
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아스트라제네카 아베
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020077022813A 2005-04-06 2006-04-03 신규한 5-치환된 7-아미노[1,3]티아졸로[4,5-ｄ]피리미딘유도체 Expired - Fee Related KR101335055B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0500767 2005-04-06
SE0500767-9 2005-04-06
PCT/SE2006/000399 WO2006107258A1 (en) 2005-04-06 2006-04-03 Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives

Publications (2)

Publication Number Publication Date
KR20080004483A KR20080004483A (ko) 2008-01-09
KR101335055B1 true KR101335055B1 (ko) 2013-12-02

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Country Status (30)

Country Link
US (2) US7947693B2 (https=)
EP (1) EP1869056B1 (https=)
JP (1) JP5165553B2 (https=)
KR (1) KR101335055B1 (https=)
CN (1) CN101193897B (https=)
AR (1) AR055890A1 (https=)
AT (1) ATE487727T1 (https=)
AU (1) AU2006231836B2 (https=)
BR (1) BRPI0609738A2 (https=)
CA (1) CA2604017C (https=)
CY (1) CY1111316T1 (https=)
DE (1) DE602006018124D1 (https=)
DK (1) DK1869056T3 (https=)
ES (1) ES2354450T3 (https=)
HR (1) HRP20110047T1 (https=)
IL (1) IL185912A0 (https=)
MX (1) MX2007012060A (https=)
NO (1) NO20075603L (https=)
NZ (1) NZ561460A (https=)
PL (1) PL1869056T3 (https=)
PT (1) PT1869056E (https=)
RS (1) RS51581B (https=)
RU (1) RU2419623C2 (https=)
SA (1) SA06270072B1 (https=)
SI (1) SI1869056T1 (https=)
TW (1) TW200714605A (https=)
UA (1) UA90707C2 (https=)
UY (1) UY29454A1 (https=)
WO (1) WO2006107258A1 (https=)
ZA (1) ZA200708187B (https=)

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AR053347A1 (es) 2005-04-06 2007-05-02 Astrazeneca Ab Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
TW200820973A (en) 2006-09-29 2008-05-16 Astrazeneca Ab Novel compounds 480
RU2437889C2 (ru) * 2006-09-29 2011-12-27 Астразенека Аб НОВЫЕ 5,7-ДИЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ [1,3]ТИАЗОЛО[4,5-d]ПИРИМИДИН-2-(3Н)-АМИНА И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ
AU2009221063B2 (en) 2008-03-07 2013-03-21 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1
JP5509100B2 (ja) 2008-03-07 2014-06-04 アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニ 新規な１−ベンジル−３−ヒドロキシメチルインダゾール誘導体及びそのＭＣＰ−１，ＣＸ３ＣＲ１及びｐ４０の発現に基づく疾病の治療への使用
EA019711B1 (ru) 2008-03-07 2014-05-30 Ацьенде Кимике Рьюните Анджелини Франческо A.K.P.A.Ф. С.П.А. ПРОИЗВОДНЫЕ 1-БЕНЗИЛ-3-ГИДРОКСИМЕТИЛИНДАЗОЛА, СОДЕРЖАЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ИХ ПРИМЕНЕНИЕ ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ, ОБУСЛОВЛЕННЫХ ЭКСПРЕССИЕЙ МСР-1, СХ3CR1 ИЛИ р40
AR076601A1 (es) 2009-05-21 2011-06-22 Chlorion Pharma Inc Pirimidinas como agentes terapeuticos
JO3437B1 (ar) 2009-10-30 2019-10-20 Esai R & D Man Co Ltd أجسام مضادة محسنة مضادة للفراكتالكين البشري واستخداماتها
JP6076913B2 (ja) 2010-12-07 2017-02-08 ドレクセル ユニバーシティ 癌からの転移を阻害する方法
US8476301B2 (en) 2011-09-13 2013-07-02 Eisai R&D Management Co., Ltd. Pyrrolidin-3-ylacetic acid derivative
TWI543975B (zh) 2011-09-13 2016-08-01 Eisai R&D Man Co Ltd Pyrrolidin-3-yl acetic acid derivatives
ES2642805T3 (es) 2013-03-12 2017-11-20 Eisai R&D Management Co., Ltd. Sal de un derivado del ácido pirrolidín-3-ilacético y cristales de esta
BR112016006319A2 (pt) 2013-09-27 2017-08-01 Nimbus Iris Inc inibidores de irak e usos dos mesmos
WO2016200939A1 (en) * 2015-06-08 2016-12-15 The Johns Hopkins University Radiofluorinated 7-amino-5-thio-thiazolo[4,5-d]pyrimidines for imaging fractalkine receptor (cx3cr1)
US11267817B2 (en) 2017-05-02 2022-03-08 Drexel University Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists
GB201807898D0 (en) 2018-05-15 2018-06-27 Kancera Ab New processes and products with increased chiral purity
GB201811169D0 (en) * 2018-07-06 2018-08-29 Kancera Ab New compounds
GB202006849D0 (en) 2020-05-08 2020-06-24 Kancera Ab New use
PE20251587A1 (es) 2022-10-19 2025-06-16 Astrazeneca Ab 1,3,5-triazinas 2,4,6-trisustituidas como modulares de cx3cr1
WO2025219939A1 (en) 2024-04-17 2025-10-23 Astrazeneca Ab Salts and polymorphs of cx3cr1 modulators
WO2025219950A1 (en) 2024-04-18 2025-10-23 Astrazeneca Ab Small molecule cx3cr1 modulators
WO2025219947A1 (en) 2024-04-18 2025-10-23 Astrazeneca Ab Thio-substituted 1,3,5-triazine cx3cr1 modulators

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WO2001058906A1 (en) 2000-02-11 2001-08-16 Astrazeneca Ab Pyrimidine compounds and their use as modulators of chemokine receptor activity
WO2002076990A1 (en) 2001-03-27 2002-10-03 Astrazeneca Ab Thiazolopyrimidine derivatives and use thereof as antagonists of the cx3 cr1 receptor

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WO2000009511A1 (en) 1998-08-13 2000-02-24 Astrazeneca Ab Novel thiazolopyrimidine compounds
WO2001058906A1 (en) 2000-02-11 2001-08-16 Astrazeneca Ab Pyrimidine compounds and their use as modulators of chemokine receptor activity
WO2002076990A1 (en) 2001-03-27 2002-10-03 Astrazeneca Ab Thiazolopyrimidine derivatives and use thereof as antagonists of the cx3 cr1 receptor

Also Published As

Publication number Publication date
IL185912A0 (en) 2008-01-06
SI1869056T1 (sl) 2011-02-28
ES2354450T3 (es) 2011-03-15
PT1869056E (pt) 2011-01-13
EP1869056B1 (en) 2010-11-10
EP1869056A4 (en) 2010-02-17
MX2007012060A (es) 2007-12-13
WO2006107258A1 (en) 2006-10-12
HRP20110047T1 (hr) 2011-03-31
CN101193897B (zh) 2010-12-01
JP2008535835A (ja) 2008-09-04
AU2006231836A1 (en) 2006-10-12
DE602006018124D1 (de) 2010-12-23
CA2604017C (en) 2012-03-06
US20110092519A1 (en) 2011-04-21
UA90707C2 (en) 2010-05-25
CY1111316T1 (el) 2015-08-05
KR20080004483A (ko) 2008-01-09
RU2007140551A (ru) 2009-05-20
BRPI0609738A2 (pt) 2011-10-18
DK1869056T3 (da) 2011-02-07
US7947693B2 (en) 2011-05-24
RS51581B (sr) 2011-08-31
TW200714605A (en) 2007-04-16
ZA200708187B (en) 2008-11-26
CN101193897A (zh) 2008-06-04
EP1869056A1 (en) 2007-12-26
JP5165553B2 (ja) 2013-03-21
AR055890A1 (es) 2007-09-12
US20080214578A1 (en) 2008-09-04
NZ561460A (en) 2010-12-24
AU2006231836B2 (en) 2010-07-15
US9440992B2 (en) 2016-09-13
NO20075603L (no) 2008-01-04
SA06270072B1 (ar) 2009-02-07
RU2419623C2 (ru) 2011-05-27
HK1118556A1 (en) 2009-02-13
CA2604017A1 (en) 2006-10-12
ATE487727T1 (de) 2010-11-15
UY29454A1 (es) 2006-11-30
PL1869056T3 (pl) 2011-04-29

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