KR101244609B1 - 트리펩티드 및 테트라펩티드 티오에테르 - Google Patents

트리펩티드 및 테트라펩티드 티오에테르 Download PDF

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Publication number
KR101244609B1
KR101244609B1 KR1020077018022A KR20077018022A KR101244609B1 KR 101244609 B1 KR101244609 B1 KR 101244609B1 KR 1020077018022 A KR1020077018022 A KR 1020077018022A KR 20077018022 A KR20077018022 A KR 20077018022A KR 101244609 B1 KR101244609 B1 KR 101244609B1
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KR
South Korea
Prior art keywords
compound
substituted
unsubstituted
halo
glutamyl
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Expired - Fee Related
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KR1020077018022A
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English (en)
Korean (ko)
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KR20070104391A (ko
Inventor
나탈리아 아우레코에체아
앤드류 비 켈슨
로버트 더블유 맥사타
루이스 로빈슨
안소니 제이 산체스
니콜라스 엠 산티아고
스티븐 알 쇼우
레이나 제이 시몬
Original Assignee
텔리크 인코포레이티드
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Publication of KR20070104391A publication Critical patent/KR20070104391A/ko
Application granted granted Critical
Publication of KR101244609B1 publication Critical patent/KR101244609B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077018022A 2005-01-06 2006-01-04 트리펩티드 및 테트라펩티드 티오에테르 Expired - Fee Related KR101244609B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64193205P 2005-01-06 2005-01-06
US60/641,932 2005-01-06
PCT/US2006/000219 WO2006074249A1 (en) 2005-01-06 2006-01-04 Tripeptide and tetrapeptide thioethers

Publications (2)

Publication Number Publication Date
KR20070104391A KR20070104391A (ko) 2007-10-25
KR101244609B1 true KR101244609B1 (ko) 2013-03-25

Family

ID=36123437

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077018022A Expired - Fee Related KR101244609B1 (ko) 2005-01-06 2006-01-04 트리펩티드 및 테트라펩티드 티오에테르
KR1020077012531A Ceased KR20070091611A (ko) 2005-01-06 2006-01-05 트리펩티드 및 테트라펩티드 술폰

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020077012531A Ceased KR20070091611A (ko) 2005-01-06 2006-01-05 트리펩티드 및 테트라펩티드 술폰

Country Status (24)

Country Link
US (2) US7129215B2 (https=)
EP (2) EP1833978B1 (https=)
JP (2) JP4903716B2 (https=)
KR (2) KR101244609B1 (https=)
CN (2) CN101090977B (https=)
AR (2) AR051889A1 (https=)
AT (2) ATE410520T1 (https=)
AU (2) AU2006204022B2 (https=)
BR (2) BRPI0606520A2 (https=)
CA (2) CA2587284C (https=)
DE (2) DE602006003064D1 (https=)
DK (2) DK1833978T3 (https=)
EA (2) EA200701398A1 (https=)
ES (2) ES2314890T3 (https=)
HR (2) HRP20090128T3 (https=)
IL (2) IL182836A (https=)
MX (2) MX2007008255A (https=)
NZ (2) NZ555362A (https=)
PL (2) PL1833978T3 (https=)
PT (2) PT1833978E (https=)
SI (2) SI1833978T1 (https=)
TW (2) TWI317739B (https=)
WO (2) WO2006074249A1 (https=)
ZA (2) ZA200704487B (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
BRPI0606520A2 (pt) * 2005-01-06 2009-06-30 Telik Inc tripeptìdeo e tetrapeptìdeo tioéteres
US20070154963A1 (en) * 2005-12-30 2007-07-05 Danying Cai Method to determine whether a compound is a cellular GSTpi inhibitor
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
WO2008056207A1 (en) * 2006-11-08 2008-05-15 Chongxi Yu Transdermal delivery systems of peptides and related compounds
AU2016213759B2 (en) * 2006-11-08 2018-03-29 Chongxi Yu Transdermal delivery systems of peptides and related compounds
WO2008149181A1 (en) 2007-06-04 2008-12-11 Techfields Inc Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses
WO2010065936A1 (en) 2008-12-04 2010-06-10 Chongxi Yu High penetration compositions and their applications
DE102008060888A1 (de) 2008-12-09 2010-06-10 Evonik Stockhausen Gmbh Verfahren zur Herstellung von Acrolein umfassend die Aufarbeitung einer Rohglycerin-Phase
EP2427475B1 (en) 2009-05-08 2020-11-04 Techfields Biochem Co., Ltd. High penetration prodrug compositions of peptides and peptide-related compounds
CA2797458A1 (en) * 2010-06-07 2011-12-15 Telik, Inc. Tablet formulation of ezatiostat
JP2013528214A (ja) 2010-06-07 2013-07-08 テリック，インコーポレイテッド 結晶性エザチオスタット塩酸塩非溶媒和物ｄ型の調製
US20130035389A1 (en) * 2011-08-05 2013-02-07 Telik, Inc. Methods for treating myelodysplastic syndrome with ezatiostat
JP5970439B2 (ja) * 2013-09-20 2016-08-17 チョンシー ユー ペプチド及び関連化合物の経皮送達システム
CN106146616A (zh) * 2015-04-03 2016-11-23 浙江海正药业股份有限公司 环肽类化合物及其制备和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008563A1 (en) 1993-09-24 1995-03-30 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
WO1998009986A1 (en) 1996-09-02 1998-03-12 The Manchester Metropolitan University S-blocked glutathiones

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599903A (en) 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5556942A (en) 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds
US5955432A (en) 1992-04-03 1999-09-21 Terrapin Technologies, Inc. Metabolic effects of certain glutathione analogs
US5767086A (en) 1992-04-03 1998-06-16 Terrapin Technologies, Inc. Bone marrow stimulation by certain glutathione analogs
CA2105492C (en) * 1993-09-03 2000-02-01 Lawrence M. Kauvar Glutathione analogs and paralog panels comprising glutathione mimics
US5908919A (en) * 1993-10-01 1999-06-01 Terrapin Technologies Urethane mediated, GST specific molecular release systems
JPH11507056A (ja) * 1995-06-07 1999-06-22 テラピン テクノロジーズ、インク． グルタチオンアナログの代謝的効果
TW576838B (en) * 1998-04-16 2004-02-21 Teijin Ltd Glutathione derivatives and application form thereof
ATE286741T1 (de) 1999-01-27 2005-01-15 Telik Inc Glutathioneanaloge enthaltende therapeutische zusammensetzungen
US7029695B2 (en) 2001-07-10 2006-04-18 Telik, Inc. Therapeutic compositions containing glutathione analogs
TWI323662B (en) * 2002-11-15 2010-04-21 Telik Inc Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy
BRPI0606520A2 (pt) * 2005-01-06 2009-06-30 Telik Inc tripeptìdeo e tetrapeptìdeo tioéteres

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008563A1 (en) 1993-09-24 1995-03-30 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
WO1998009986A1 (en) 1996-09-02 1998-03-12 The Manchester Metropolitan University S-blocked glutathiones

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Medicinal Chemistry, Vol.14, pp.402-404 (1971.) *
Pesticide Biochemistry and Physiology, Vol.37, pp.121-129 (1990.) *

Also Published As

Publication number Publication date
SI1833842T1 (sl) 2009-04-30
DE602006003064D1 (en) 2008-11-20
EP1833978A1 (en) 2007-09-19
EA200701398A1 (ru) 2007-12-28
US20060148719A1 (en) 2006-07-06
TW200635949A (en) 2006-10-16
PL1833842T3 (pl) 2009-04-30
JP4903717B2 (ja) 2012-03-28
PL1833978T3 (pl) 2009-04-30
KR20070104391A (ko) 2007-10-25
BRPI0606396A2 (pt) 2009-06-23
EA200701399A1 (ru) 2008-02-28
CA2587284C (en) 2014-03-25
CN101080418A (zh) 2007-11-28
US20060160749A1 (en) 2006-07-20
AR051890A1 (es) 2007-02-14
KR20070091611A (ko) 2007-09-11
AU2006203901B2 (en) 2011-06-02
AU2006203901A1 (en) 2006-07-13
JP2008526880A (ja) 2008-07-24
PT1833842E (pt) 2008-12-11
NZ555361A (en) 2009-05-31
DK1833978T3 (da) 2009-02-09
TW200635948A (en) 2006-10-16
CA2587284A1 (en) 2006-07-13
AU2006204022B2 (en) 2011-01-20
MX2007008254A (es) 2007-09-11
IL183107A0 (en) 2007-09-20
SI1833978T1 (sl) 2009-04-30
MX2007008255A (es) 2007-09-11
NZ555362A (en) 2009-05-31
EP1833978B1 (en) 2008-10-08
JP2008526859A (ja) 2008-07-24
CA2587310A1 (en) 2006-07-13
US7129215B2 (en) 2006-10-31
WO2006074249A1 (en) 2006-07-13
HRP20090134T3 (hr) 2009-04-30
IL183107A (en) 2010-11-30
HK1106778A1 (en) 2008-03-20
JP4903716B2 (ja) 2012-03-28
EP1833842A1 (en) 2007-09-19
TWI317738B (en) 2009-12-01
PT1833978E (pt) 2008-12-02
HK1106796A1 (en) 2008-03-20
ATE410440T1 (de) 2008-10-15
CN101090977B (zh) 2013-04-10
ZA200704488B (en) 2008-09-25
ES2314891T3 (es) 2009-03-16
AR051889A1 (es) 2007-02-14
DK1833842T3 (da) 2009-02-09
ZA200704487B (en) 2008-09-25
US7192918B2 (en) 2007-03-20
ATE410520T1 (de) 2008-10-15
EP1833842B1 (en) 2008-10-08
DE602006003063D1 (de) 2008-11-20
ES2314890T3 (es) 2009-03-16
CN101090977A (zh) 2007-12-19
WO2006074409A9 (en) 2006-12-14
TWI317739B (en) 2009-12-01
AU2006204022A1 (en) 2006-07-13
CA2587310C (en) 2013-11-12
WO2006074409A1 (en) 2006-07-13
BRPI0606520A2 (pt) 2009-06-30
HRP20090128T3 (hr) 2009-04-30
IL182836A (en) 2010-11-30
IL182836A0 (en) 2007-08-19

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