KR101060539B1 - Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드 - Google Patents

Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드 Download PDF

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Publication number
KR101060539B1
KR101060539B1 KR1020087021067A KR20087021067A KR101060539B1 KR 101060539 B1 KR101060539 B1 KR 101060539B1 KR 1020087021067 A KR1020087021067 A KR 1020087021067A KR 20087021067 A KR20087021067 A KR 20087021067A KR 101060539 B1 KR101060539 B1 KR 101060539B1
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KR
South Korea
Prior art keywords
carboxylic acid
thiazole
formula
phenyl
dimethoxy
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Expired - Fee Related
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KR1020087021067A
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English (en)
Korean (ko)
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KR20080090550A (ko
Inventor
존 프레데릭 보일랜
?컸? 차이
나데 포뚜이
폴 길레스피
주니어 로버트 앨런 굿나우
캉 르
크리스토프 미슈
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에프. 호프만-라 로슈 아게
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Publication of KR20080090550A publication Critical patent/KR20080090550A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR1020087021067A 2006-02-27 2007-02-19 Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드 Expired - Fee Related KR101060539B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77696406P 2006-02-27 2006-02-27
US60/776,964 2006-02-27
PCT/EP2007/051541 WO2007096315A1 (en) 2006-02-27 2007-02-19 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as plk1 inhibitors

Publications (2)

Publication Number Publication Date
KR20080090550A KR20080090550A (ko) 2008-10-08
KR101060539B1 true KR101060539B1 (ko) 2011-08-30

Family

ID=38051896

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087021067A Expired - Fee Related KR101060539B1 (ko) 2006-02-27 2007-02-19 Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드

Country Status (19)

Country Link
US (1) US7504513B2 (enExample)
EP (1) EP1991543A1 (enExample)
JP (1) JP2009528284A (enExample)
KR (1) KR101060539B1 (enExample)
CN (1) CN101415704A (enExample)
AR (1) AR059621A1 (enExample)
AU (1) AU2007217575A1 (enExample)
BR (1) BRPI0710473A2 (enExample)
CA (1) CA2642921A1 (enExample)
CR (1) CR10206A (enExample)
EC (1) ECSP088700A (enExample)
IL (1) IL193481A0 (enExample)
MA (1) MA30260B1 (enExample)
MX (1) MX2008010884A (enExample)
NO (1) NO20083708L (enExample)
RU (1) RU2008138163A (enExample)
TW (1) TW200745097A (enExample)
WO (1) WO2007096315A1 (enExample)
ZA (1) ZA200807074B (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008149784A1 (ja) * 2007-06-08 2008-12-11 Nec Corporation 半導体集積回路及びフィルタ制御方法
WO2009094224A1 (en) 2008-01-25 2009-07-30 Millennium Pharmaceuticals, Inc. Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors
AU2008354754B2 (en) * 2008-04-17 2014-09-11 The Johns Hopkins University On01910. Na enhances chemotherapeutic agent activity in drug-resistant tumors
JP2012502404A (ja) * 2008-09-10 2012-01-26 データレース リミテッド データ保存媒体
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
JP2012512223A (ja) 2008-12-18 2012-05-31 エフ．ホフマン−ラ ロシュ アーゲー チアゾリル−ベンズイミダゾール類
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
JP2012516329A (ja) * 2009-01-30 2012-07-19 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｐｉ３ｋ阻害剤としてのヘテロアリールおよびその使用
US9090601B2 (en) * 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
US9062038B2 (en) 2010-08-11 2015-06-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
EP2603214A4 (en) 2010-08-11 2013-12-18 Millennium Pharm Inc HETEROARYLE AND USES THEREOF
US8859768B2 (en) 2010-08-11 2014-10-14 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
MX2013004003A (es) 2010-10-13 2013-10-01 Millenium Pharmaceuticals Inc Heteroarilos y usos de los mismos.

Citations (1)

* Cited by examiner, † Cited by third party
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WO2005075470A1 (en) * 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds

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US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
US4818270A (en) * 1986-08-28 1989-04-04 Monsanto Company 2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds as herbicide antidotes, compositions and use
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
CA2416527C (en) 2000-08-10 2009-12-22 Pharmacia Italia S.P.A. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
WO2003070283A2 (en) 2002-02-22 2003-08-28 Klaus Strebhardt Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
NZ535232A (en) 2002-02-28 2007-05-31 Univ Temple Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
US7183276B2 (en) * 2002-02-28 2007-02-27 Takeda Pharmaceutical Company Limited Azole compounds
RS95404A (sr) 2002-05-03 2006-10-27 Schering Aktiengesellschaft Tiazolidinoni i njihova primena kao inhibitora polo like kinaze
US6906186B1 (en) 2002-07-30 2005-06-14 Isis Pharmaceuticals, Inc. Antisense modulation of polo-like kinase expression
MXPA05001544A (es) 2002-08-08 2005-04-19 Smithkline Beecham Corp Compuestos de tiofeno.
WO2004046317A2 (en) 2002-11-14 2004-06-03 Massachusetts Institue Of Technology Products and processes for modulating peptide-peptide binding domain interactions
WO2004043936A1 (ja) 2002-11-14 2004-05-27 Kyowa Hakko Kogyo Co., Ltd. Ｐｌｋ阻害剤
JP3837670B2 (ja) 2002-12-12 2006-10-25 富士通株式会社 データ中継装置、連想メモリデバイス、および連想メモリデバイス利用情報検索方法
GB0302220D0 (en) 2003-01-30 2003-03-05 Cyclacel Ltd Use
ES2325440T3 (es) 2003-02-20 2009-09-04 Smithkline Beecham Corporation Compuestos de pirimidina.
US7462614B2 (en) 2003-04-01 2008-12-09 Smithkline Beecham Corporation Imidazotriazine compounds
DK1641780T3 (da) 2003-06-24 2009-02-02 Pfizer Prod Inc Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivater
WO2005019193A2 (en) 2003-08-20 2005-03-03 Smithkline Beecham Corporation Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk)
BRPI0415759A (pt) 2003-10-21 2006-12-19 Cyclacel Ltd compostos de pirimidin-4-il-3,4-tiona e uso dos mesmos na terapia
DE10351744A1 (de) 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2005075470A1 (en) * 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds

Also Published As

Publication number Publication date
ZA200807074B (en) 2009-10-28
US7504513B2 (en) 2009-03-17
MX2008010884A (es) 2008-09-03
AR059621A1 (es) 2008-04-16
NO20083708L (no) 2008-09-23
BRPI0710473A2 (pt) 2011-08-16
IL193481A0 (en) 2009-05-04
WO2007096315A1 (en) 2007-08-30
RU2008138163A (ru) 2010-04-10
TW200745097A (en) 2007-12-16
JP2009528284A (ja) 2009-08-06
US20070203210A1 (en) 2007-08-30
MA30260B1 (fr) 2009-03-02
AU2007217575A1 (en) 2007-08-30
CR10206A (es) 2008-09-22
ECSP088700A (es) 2008-09-29
KR20080090550A (ko) 2008-10-08
CA2642921A1 (en) 2007-08-30
CN101415704A (zh) 2009-04-22
EP1991543A1 (en) 2008-11-19

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