JP2009528284A - Ｐｌｋ１阻害剤としての４−フェニル−チアゾール−５−カルボン酸及び４−フェニル−チアゾール−５−カルボン酸アミド - Google Patents

Ｐｌｋ１阻害剤としての４−フェニル−チアゾール−５−カルボン酸及び４−フェニル−チアゾール−５−カルボン酸アミド Download PDF

Info

Publication number
JP2009528284A
JP2009528284A JP2008555763A JP2008555763A JP2009528284A JP 2009528284 A JP2009528284 A JP 2009528284A JP 2008555763 A JP2008555763 A JP 2008555763A JP 2008555763 A JP2008555763 A JP 2008555763A JP 2009528284 A JP2009528284 A JP 2009528284A
Authority
JP
Japan
Prior art keywords
carboxylic acid
thiazole
benzimidazol
phenyl
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008555763A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009528284A5 (enExample
Inventor
フレデリック ボーイラン，ジョン
カイ，ジャンピン
フォトゥイ，ナデール
ギレスピー，ポール
アラン，ジュニア グッドナウ，ロバート
ロー，カン
ミシュ，クリストフ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2009528284A publication Critical patent/JP2009528284A/ja
Publication of JP2009528284A5 publication Critical patent/JP2009528284A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2008555763A 2006-02-27 2007-02-19 Ｐｌｋ１阻害剤としての４−フェニル−チアゾール−５−カルボン酸及び４−フェニル−チアゾール−５−カルボン酸アミド Pending JP2009528284A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77696406P 2006-02-27 2006-02-27
PCT/EP2007/051541 WO2007096315A1 (en) 2006-02-27 2007-02-19 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as plk1 inhibitors

Publications (2)

Publication Number Publication Date
JP2009528284A true JP2009528284A (ja) 2009-08-06
JP2009528284A5 JP2009528284A5 (enExample) 2012-06-07

Family

ID=38051896

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008555763A Pending JP2009528284A (ja) 2006-02-27 2007-02-19 Ｐｌｋ１阻害剤としての４−フェニル−チアゾール−５−カルボン酸及び４−フェニル−チアゾール−５−カルボン酸アミド

Country Status (19)

Country Link
US (1) US7504513B2 (enExample)
EP (1) EP1991543A1 (enExample)
JP (1) JP2009528284A (enExample)
KR (1) KR101060539B1 (enExample)
CN (1) CN101415704A (enExample)
AR (1) AR059621A1 (enExample)
AU (1) AU2007217575A1 (enExample)
BR (1) BRPI0710473A2 (enExample)
CA (1) CA2642921A1 (enExample)
CR (1) CR10206A (enExample)
EC (1) ECSP088700A (enExample)
IL (1) IL193481A0 (enExample)
MA (1) MA30260B1 (enExample)
MX (1) MX2008010884A (enExample)
NO (1) NO20083708L (enExample)
RU (1) RU2008138163A (enExample)
TW (1) TW200745097A (enExample)
WO (1) WO2007096315A1 (enExample)
ZA (1) ZA200807074B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008149784A1 (ja) * 2007-06-08 2008-12-11 Nec Corporation 半導体集積回路及びフィルタ制御方法
WO2009094224A1 (en) 2008-01-25 2009-07-30 Millennium Pharmaceuticals, Inc. Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors
AU2008354754B2 (en) * 2008-04-17 2014-09-11 The Johns Hopkins University On01910. Na enhances chemotherapeutic agent activity in drug-resistant tumors
JP2012502404A (ja) * 2008-09-10 2012-01-26 データレース リミテッド データ保存媒体
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
JP2012512223A (ja) 2008-12-18 2012-05-31 エフ．ホフマン−ラ ロシュ アーゲー チアゾリル−ベンズイミダゾール類
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
JP2012516329A (ja) * 2009-01-30 2012-07-19 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｐｉ３ｋ阻害剤としてのヘテロアリールおよびその使用
US9090601B2 (en) * 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
US9062038B2 (en) 2010-08-11 2015-06-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
EP2603214A4 (en) 2010-08-11 2013-12-18 Millennium Pharm Inc HETEROARYLE AND USES THEREOF
US8859768B2 (en) 2010-08-11 2014-10-14 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
MX2013004003A (es) 2010-10-13 2013-10-01 Millenium Pharmaceuticals Inc Heteroarilos y usos de los mismos.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
WO2005075470A1 (en) * 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds
JP2006505522A (ja) * 2002-08-08 2006-02-16 スミスクライン ビーチャム コーポレーション チオフェン化合物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
US4818270A (en) * 1986-08-28 1989-04-04 Monsanto Company 2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds as herbicide antidotes, compositions and use
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
CA2416527C (en) 2000-08-10 2009-12-22 Pharmacia Italia S.P.A. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
WO2003070283A2 (en) 2002-02-22 2003-08-28 Klaus Strebhardt Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
NZ535232A (en) 2002-02-28 2007-05-31 Univ Temple Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
US7183276B2 (en) * 2002-02-28 2007-02-27 Takeda Pharmaceutical Company Limited Azole compounds
RS95404A (sr) 2002-05-03 2006-10-27 Schering Aktiengesellschaft Tiazolidinoni i njihova primena kao inhibitora polo like kinaze
US6906186B1 (en) 2002-07-30 2005-06-14 Isis Pharmaceuticals, Inc. Antisense modulation of polo-like kinase expression
WO2004046317A2 (en) 2002-11-14 2004-06-03 Massachusetts Institue Of Technology Products and processes for modulating peptide-peptide binding domain interactions
WO2004043936A1 (ja) 2002-11-14 2004-05-27 Kyowa Hakko Kogyo Co., Ltd. Ｐｌｋ阻害剤
JP3837670B2 (ja) 2002-12-12 2006-10-25 富士通株式会社 データ中継装置、連想メモリデバイス、および連想メモリデバイス利用情報検索方法
GB0302220D0 (en) 2003-01-30 2003-03-05 Cyclacel Ltd Use
ES2325440T3 (es) 2003-02-20 2009-09-04 Smithkline Beecham Corporation Compuestos de pirimidina.
US7462614B2 (en) 2003-04-01 2008-12-09 Smithkline Beecham Corporation Imidazotriazine compounds
DK1641780T3 (da) 2003-06-24 2009-02-02 Pfizer Prod Inc Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivater
WO2005019193A2 (en) 2003-08-20 2005-03-03 Smithkline Beecham Corporation Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk)
BRPI0415759A (pt) 2003-10-21 2006-12-19 Cyclacel Ltd compostos de pirimidin-4-il-3,4-tiona e uso dos mesmos na terapia
DE10351744A1 (de) 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
JP2006505522A (ja) * 2002-08-08 2006-02-16 スミスクライン ビーチャム コーポレーション チオフェン化合物
WO2005075470A1 (en) * 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds

Also Published As

Publication number Publication date
ZA200807074B (en) 2009-10-28
US7504513B2 (en) 2009-03-17
MX2008010884A (es) 2008-09-03
AR059621A1 (es) 2008-04-16
NO20083708L (no) 2008-09-23
BRPI0710473A2 (pt) 2011-08-16
IL193481A0 (en) 2009-05-04
WO2007096315A1 (en) 2007-08-30
RU2008138163A (ru) 2010-04-10
TW200745097A (en) 2007-12-16
US20070203210A1 (en) 2007-08-30
KR101060539B1 (ko) 2011-08-30
MA30260B1 (fr) 2009-03-02
AU2007217575A1 (en) 2007-08-30
CR10206A (es) 2008-09-22
ECSP088700A (es) 2008-09-29
KR20080090550A (ko) 2008-10-08
CA2642921A1 (en) 2007-08-30
CN101415704A (zh) 2009-04-22
EP1991543A1 (en) 2008-11-19

Similar Documents

Publication Publication Date Title
KR101060539B1 (ko) Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드
EP2493862B1 (en) Imidazole derivatives as ido inhibitors
JP4805916B2 (ja) 化合物、組成物、および方法
JP2021508722A (ja) 芳香族ビニルまたは芳香族エチル系誘導体、その製造方法、中間体、薬物組成物および使用
CN104003940B (zh) 2,4‑二氟‑5‑(酞嗪酮‑1‑甲基)‑苯甲酰哌嗪类化合物及其用途
AU2005244736A1 (en) Raf modulators and methods of use
JP2003532730A (ja) 細胞増殖抑制剤として有用な１，１−ジオキソイソチアゾリジンを持つインダゾール
KR102214225B1 (ko) 5원 헤테로시클릭 아미드계 wnt 경로 억제제
CA2407370A1 (en) Heterocycles that are inhibitors of impdh enzyme
Jin et al. 4-([1, 2, 4] Triazolo [1, 5-a] pyridin-6-yl)-5 (3)-(6-methylpyridin-2-yl) imidazole and-pyrazole derivatives as potent and selective inhibitors of transforming growth factor-β type I receptor kinase
CN103058949A (zh) 做为dhodh抑制剂的噻唑衍生物及其应用
KR19990076788A (ko) 티아졸릴벤조푸란 유도체 및 그를 함유하는 약제학적 조성물
CA2983040A1 (en) Heterocyclic-imidazole compounds, pharmaceutical compositions thereof, preparation method therefor and use thereof
WO2012131501A1 (en) Substituted benzimidazole compounds as cot kinase inhibitors
JP7266901B2 (ja) 複素環式化合物、調製方法及びその医薬的な応用
WO2004013132A1 (en) Furanthiazole derivatives as heparanase inhibitors
EP2855470A1 (en) Novel bicyclic thiazole compounds
WO2004099190A1 (en) Novel substituted benzimidazole derivatives
AU2020264679B2 (en) Selective ligands of human constitutive androstane receptor
JP2009514865A (ja) 有糸分裂キネシン阻害剤
US20240217969A1 (en) Substituted pyrrole carboxamides, process for their preparation and their use as kinase inhibitors
CZ34975U1 (cs) Ligandy lidského konstitutivního adrostanového receptoru
HK1168106B (en) Imidazole derivatives as ido inhibitors

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111101

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120131

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120207

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20120416

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120515

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120725

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120801

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130423