JP2009528284A - Ｐｌｋ１阻害剤としての４−フェニル−チアゾール−５−カルボン酸及び４−フェニル−チアゾール−５−カルボン酸アミド - Google Patents

Ｐｌｋ１阻害剤としての４−フェニル−チアゾール−５−カルボン酸及び４−フェニル−チアゾール−５−カルボン酸アミド Download PDF

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Publication number
JP2009528284A
JP2009528284A JP2008555763A JP2008555763A JP2009528284A JP 2009528284 A JP2009528284 A JP 2009528284A JP 2008555763 A JP2008555763 A JP 2008555763A JP 2008555763 A JP2008555763 A JP 2008555763A JP 2009528284 A JP2009528284 A JP 2009528284A
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JP
Japan
Prior art keywords
carboxylic acid
thiazole
benzimidazol
phenyl
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008555763A
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English (en)
Japanese (ja)
Other versions
JP2009528284A5 (enExample
Inventor
フレデリック ボーイラン，ジョン
カイ，ジャンピン
フォトゥイ，ナデール
ギレスピー，ポール
アラン，ジュニア グッドナウ，ロバート
ロー，カン
ミシュ，クリストフ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2009528284A publication Critical patent/JP2009528284A/ja
Publication of JP2009528284A5 publication Critical patent/JP2009528284A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2008555763A 2006-02-27 2007-02-19 Ｐｌｋ１阻害剤としての４−フェニル−チアゾール−５−カルボン酸及び４−フェニル−チアゾール−５−カルボン酸アミド Pending JP2009528284A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77696406P 2006-02-27 2006-02-27
PCT/EP2007/051541 WO2007096315A1 (en) 2006-02-27 2007-02-19 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as plk1 inhibitors

Publications (2)

Publication Number Publication Date
JP2009528284A true JP2009528284A (ja) 2009-08-06
JP2009528284A5 JP2009528284A5 (enExample) 2012-06-07

Family

ID=38051896

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008555763A Pending JP2009528284A (ja) 2006-02-27 2007-02-19 Ｐｌｋ１阻害剤としての４−フェニル−チアゾール−５−カルボン酸及び４−フェニル−チアゾール−５−カルボン酸アミド

Country Status (19)

Country Link
US (1) US7504513B2 (enExample)
EP (1) EP1991543A1 (enExample)
JP (1) JP2009528284A (enExample)
KR (1) KR101060539B1 (enExample)
CN (1) CN101415704A (enExample)
AR (1) AR059621A1 (enExample)
AU (1) AU2007217575A1 (enExample)
BR (1) BRPI0710473A2 (enExample)
CA (1) CA2642921A1 (enExample)
CR (1) CR10206A (enExample)
EC (1) ECSP088700A (enExample)
IL (1) IL193481A0 (enExample)
MA (1) MA30260B1 (enExample)
MX (1) MX2008010884A (enExample)
NO (1) NO20083708L (enExample)
RU (1) RU2008138163A (enExample)
TW (1) TW200745097A (enExample)
WO (1) WO2007096315A1 (enExample)
ZA (1) ZA200807074B (enExample)

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US8412867B2 (en) * 2007-06-08 2013-04-02 Nec Corporation Semiconductor integrated circuit and filter and informational delivery method using same
WO2009094224A1 (en) 2008-01-25 2009-07-30 Millennium Pharmaceuticals, Inc. Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors
CN102056607B (zh) * 2008-04-17 2014-07-30 约翰·霍普金斯大学 On01910.na促进在抗药性肿瘤中化学治疗剂的活性
ES2388570T3 (es) * 2008-09-10 2012-10-16 Datalase Ltd Medio de almacenamiento de datos
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
CA2745596A1 (en) * 2008-12-18 2010-10-28 F. Hoffmann-La Roche Ag Thiazolyl-benzimidazoles
US9139589B2 (en) 2009-01-30 2015-09-22 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9090601B2 (en) * 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
WO2012021611A1 (en) 2010-08-11 2012-02-16 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
EP2603216A4 (en) 2010-08-11 2013-12-18 Millennium Pharm Inc HETEROARYLE AND USES THEREOF
TW201217365A (en) 2010-08-11 2012-05-01 Millennium Pharm Inc Heteroaryls and uses thereof
UY33671A (es) 2010-10-13 2012-04-30 Millenium Pharmaceuticals Inc Heteroarilos y sus usos

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
WO2005075470A1 (en) * 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds
JP2006505522A (ja) * 2002-08-08 2006-02-16 スミスクライン ビーチャム コーポレーション チオフェン化合物

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US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
US4818270A (en) * 1986-08-28 1989-04-04 Monsanto Company 2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds as herbicide antidotes, compositions and use
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
DE60143041D1 (de) 2000-08-10 2010-10-21 Pfizer Italia Srl Bizyklische pyrazole wirksam als kinase inhibitoren, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
AU2003206946A1 (en) 2002-02-22 2003-09-09 Klaus Strebhardt Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
WO2003072554A1 (fr) * 2002-02-28 2003-09-04 Takeda Chemical Industries, Ltd. Composes d'azole
ES2373945T3 (es) 2002-02-28 2012-02-10 Temple University - Of The Commonwealth System Of Higher Education Bencilsulfonas de (e)-2,6-dialcoxiestirilo amino sustituido sustituidas en 4 para tratar trastornos proliferativos.
KR20040106451A (ko) 2002-05-03 2004-12-17 쉐링 악티엔게젤샤프트 폴로-유사 키나제 억제제로서의 티아졸리디논 및 그의 용도
US6906186B1 (en) 2002-07-30 2005-06-14 Isis Pharmaceuticals, Inc. Antisense modulation of polo-like kinase expression
WO2004043936A1 (ja) 2002-11-14 2004-05-27 Kyowa Hakko Kogyo Co., Ltd. Ｐｌｋ阻害剤
WO2004046317A2 (en) 2002-11-14 2004-06-03 Massachusetts Institue Of Technology Products and processes for modulating peptide-peptide binding domain interactions
JP3837670B2 (ja) 2002-12-12 2006-10-25 富士通株式会社 データ中継装置、連想メモリデバイス、および連想メモリデバイス利用情報検索方法
GB0302220D0 (en) 2003-01-30 2003-03-05 Cyclacel Ltd Use
EP1597251B1 (en) 2003-02-20 2009-06-10 SmithKline Beecham Corporation Pyrimidine compounds
JP2006522127A (ja) 2003-04-01 2006-09-28 スミスクライン ビーチャム コーポレーション イミダゾトリアジン化合物
KR20070092333A (ko) 2003-06-24 2007-09-12 화이자 프로덕츠 인크. 1-[(벤조이미다졸-1-일)퀴놀린-8-일]피페리딘-4-일아민유도체의 제조 방법
WO2005019193A2 (en) 2003-08-20 2005-03-03 Smithkline Beecham Corporation Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk)
JP5164380B2 (ja) 2003-10-21 2013-03-21 サイクラセル リミテッド ピリミジン−４−イル−３，４−チオン化合物及び治療におけるその使用
DE10351744A1 (de) 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel

Patent Citations (3)

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JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
JP2006505522A (ja) * 2002-08-08 2006-02-16 スミスクライン ビーチャム コーポレーション チオフェン化合物
WO2005075470A1 (en) * 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds

Also Published As

Publication number Publication date
ZA200807074B (en) 2009-10-28
AU2007217575A1 (en) 2007-08-30
MA30260B1 (fr) 2009-03-02
MX2008010884A (es) 2008-09-03
NO20083708L (no) 2008-09-23
IL193481A0 (en) 2009-05-04
CN101415704A (zh) 2009-04-22
TW200745097A (en) 2007-12-16
KR20080090550A (ko) 2008-10-08
ECSP088700A (es) 2008-09-29
KR101060539B1 (ko) 2011-08-30
AR059621A1 (es) 2008-04-16
US7504513B2 (en) 2009-03-17
BRPI0710473A2 (pt) 2011-08-16
US20070203210A1 (en) 2007-08-30
RU2008138163A (ru) 2010-04-10
EP1991543A1 (en) 2008-11-19
WO2007096315A1 (en) 2007-08-30
CR10206A (es) 2008-09-22
CA2642921A1 (en) 2007-08-30

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