KR101054247B1 - 정제된 요산산화효소 제제 및 이를 포함한 조성물, 그리고 그 정제법 - Google Patents

정제된 요산산화효소 제제 및 이를 포함한 조성물, 그리고 그 정제법 Download PDF

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KR101054247B1
KR101054247B1 KR1020087024272A KR20087024272A KR101054247B1 KR 101054247 B1 KR101054247 B1 KR 101054247B1 KR 1020087024272 A KR1020087024272 A KR 1020087024272A KR 20087024272 A KR20087024272 A KR 20087024272A KR 101054247 B1 KR101054247 B1 KR 101054247B1
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uricase
aggregates
peg
octamer
uricases
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KR20080098686A (ko
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메리 알. 셔먼
마아크 지. 피. 사이퍼
엘. 데이비드 윌리엄스
마이클 에스. 허쉬필드
수잔 제이. 켈리
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듀크 유니버서티
마운틴 뷰 파마슈티컬즈 인크.
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020087024272A 2000-02-10 2001-02-07 정제된 요산산화효소 제제 및 이를 포함한 조성물, 그리고 그 정제법 Expired - Lifetime KR101054247B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/501,730 2000-02-10
US09/501,730 US6783965B1 (en) 2000-02-10 2000-02-10 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
PCT/US2001/040069 WO2001059078A2 (en) 2000-02-10 2001-02-07 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates

Related Parent Applications (1)

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KR1020027010189A Division KR100884724B1 (ko) 2000-02-10 2001-02-07 비면역원성 중합체 컨쥬게이트의 제조를 위한 응집체 없는 요산산화효소

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KR20080098686A KR20080098686A (ko) 2008-11-11
KR101054247B1 true KR101054247B1 (ko) 2011-08-08

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KR1020087024272A Expired - Lifetime KR101054247B1 (ko) 2000-02-10 2001-02-07 정제된 요산산화효소 제제 및 이를 포함한 조성물, 그리고 그 정제법
KR1020077018682A Ceased KR20070092329A (ko) 2000-02-10 2001-02-07 비면역원성 중합체 컨쥬게이트의 제조를 위한 응집체 없는요산산화효소
KR1020027010189A Expired - Lifetime KR100884724B1 (ko) 2000-02-10 2001-02-07 비면역원성 중합체 컨쥬게이트의 제조를 위한 응집체 없는 요산산화효소

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KR1020077018682A Ceased KR20070092329A (ko) 2000-02-10 2001-02-07 비면역원성 중합체 컨쥬게이트의 제조를 위한 응집체 없는요산산화효소
KR1020027010189A Expired - Lifetime KR100884724B1 (ko) 2000-02-10 2001-02-07 비면역원성 중합체 컨쥬게이트의 제조를 위한 응집체 없는 요산산화효소

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US (3) US6783965B1 (https=)
EP (3) EP2196538B1 (https=)
JP (2) JP5165826B2 (https=)
KR (3) KR101054247B1 (https=)
CN (2) CN100491532C (https=)
AT (1) ATE463576T1 (https=)
AU (3) AU4997501A (https=)
BE (1) BE2013C045I2 (https=)
BR (1) BRPI0108386B8 (https=)
CA (1) CA2398679C (https=)
CY (3) CY1110142T1 (https=)
CZ (1) CZ304864B6 (https=)
DE (1) DE60141742D1 (https=)
DK (3) DK1254237T3 (https=)
ES (2) ES2524153T3 (https=)
FR (1) FR13C0036I2 (https=)
HU (1) HU227127B1 (https=)
IL (3) IL151065A0 (https=)
LU (1) LU92237I2 (https=)
MX (1) MXPA02007545A (https=)
NZ (1) NZ520434A (https=)
PL (1) PL208064B1 (https=)
PT (2) PT1254237E (https=)
RU (3) RU2281954C2 (https=)
TW (2) TWI322184B (https=)
WO (1) WO2001059078A2 (https=)
ZA (1) ZA200207206B (https=)

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