KR100857376B1 - 심장 질환의 치료 및/또는 예방에 사용되는 il-18저해물질 - Google Patents

심장 질환의 치료 및/또는 예방에 사용되는 il-18저해물질 Download PDF

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KR100857376B1
KR100857376B1 KR1020037009941A KR20037009941A KR100857376B1 KR 100857376 B1 KR100857376 B1 KR 100857376B1 KR 1020037009941 A KR1020037009941 A KR 1020037009941A KR 20037009941 A KR20037009941 A KR 20037009941A KR 100857376 B1 KR100857376 B1 KR 100857376B1
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heart disease
pharmaceutical composition
tnf
myocardial
ischemic heart
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Korean (ko)
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KR20030070143A (ko
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차알스 디나렐로
벤자민 포메란츠
레오니드 레즈니코브
알덴 하르켄
올란드 츠바트츠코
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라보라토리스 세로노 에스.에이.
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020037009941A 2001-01-29 2002-01-28 심장 질환의 치료 및/또는 예방에 사용되는 il-18저해물질 Expired - Lifetime KR100857376B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01101959 2001-01-29
EP01101959.3 2001-01-29
PCT/EP2002/000844 WO2002060479A1 (en) 2001-01-29 2002-01-28 Use of il-18 inhibitors for the treatment and/or prevention of heart disease

Publications (2)

Publication Number Publication Date
KR20030070143A KR20030070143A (ko) 2003-08-27
KR100857376B1 true KR100857376B1 (ko) 2008-09-05

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ID=8176323

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KR1020037009941A Expired - Lifetime KR100857376B1 (ko) 2001-01-29 2002-01-28 심장 질환의 치료 및/또는 예방에 사용되는 il-18저해물질

Country Status (31)

Country Link
US (1) US20040234523A1 (https=)
EP (1) EP1355668B1 (https=)
JP (2) JP4860897B2 (https=)
KR (1) KR100857376B1 (https=)
CN (1) CN1326562C (https=)
AR (1) AR032422A1 (https=)
AT (1) ATE380558T1 (https=)
BG (1) BG66483B1 (https=)
BR (1) BR0206819A (https=)
CA (1) CA2435466C (https=)
CY (1) CY1107203T1 (https=)
CZ (1) CZ305653B6 (https=)
DE (1) DE60224004T2 (https=)
DK (1) DK1355668T3 (https=)
EA (2) EA006767B1 (https=)
EE (1) EE05534B1 (https=)
ES (1) ES2295332T3 (https=)
HR (1) HRP20030609A2 (https=)
HU (1) HU229164B1 (https=)
IL (2) IL157024A0 (https=)
ME (1) ME00549B (https=)
MX (1) MXPA03006776A (https=)
NO (1) NO331083B1 (https=)
PL (1) PL213568B1 (https=)
PT (1) PT1355668E (https=)
RS (1) RS51125B (https=)
SI (1) SI1355668T1 (https=)
SK (1) SK287620B6 (https=)
UA (1) UA80676C2 (https=)
WO (1) WO2002060479A1 (https=)
ZA (1) ZA200305439B (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI335336B (https=) 2000-02-10 2011-01-01 Abbott Gmbh & Co Kg
CA2424983A1 (en) 2000-10-11 2002-04-18 Viron Therapeutics, Inc. Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
US20080076708A1 (en) 2003-05-13 2008-03-27 Valter Altarocca Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
JP4961559B2 (ja) * 2004-03-11 2012-06-27 友昭 星野 インターロイキン18阻害剤を有効成分とする疾患の予防又は治療剤
EP2267024B1 (en) 2005-06-03 2012-05-09 Ares Trading S.A. Production of recombinant Il-18 binding protein
PT1891088E (pt) 2005-06-10 2011-12-19 Ares Trading Sa Processo para a purificação da proteína de ligação il-18
JP5968590B2 (ja) * 2007-11-05 2016-08-10 ケーシーアイ ライセンシング インコーポレイテッド 創面切除のための組織の同定
US9376489B2 (en) 2012-09-07 2016-06-28 Novartis Ag IL-18 binding molecules
CN115925928A (zh) * 2013-09-05 2023-04-07 Ab2生物股份有限公司 炎性疾病中的il-18结合蛋白(il-18bp)
US10882905B2 (en) * 2015-03-05 2021-01-05 Ab2 Bio Sa IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases
WO2018013509A1 (en) * 2016-07-11 2018-01-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO1998024804A2 (en) * 1996-12-06 1998-06-11 Vertex Pharmaceuticals Incorporated INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
WO1999009063A1 (en) * 1997-08-14 1999-02-25 Yeda Research And Development Co. Ltd. Interleukin-18 binding proteins, their preparation and use
WO2001058956A2 (en) * 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using

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US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) * 1995-11-21 1999-02-25 Yamanouchi Pharma Co Ltd Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
EP0929311B8 (en) * 1996-09-12 2006-02-01 Idun Pharmaceuticals, Inc. INHIBITION OF APOPTOSIS USING INTERLEUKIN-1 beta-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS
SK122199A3 (en) * 1997-03-18 2000-12-11 Basf Ag Methods and compositions for modulating responsiveness to corticosteroids
DE19743687C1 (de) * 1997-10-06 1998-11-26 Henkel Kgaa Detergensgemische und deren Verwendung
AU4961499A (en) * 1998-06-26 2000-01-17 Eli Lilly And Company 5-HT1f agonists
CA2340579A1 (en) * 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin 18-binding protein
EP1022027A1 (en) * 1999-01-22 2000-07-26 Applied Research Systems ARS Holding N.V. Tumor necrosis factor antagonists and their use in endometriosis
JP2002539183A (ja) * 1999-03-16 2002-11-19 サイトビア インコーポレイテッド 置換2−アミノベンズアミドカスパーゼインヒビターおよびその使用
CN1176941C (zh) * 1999-04-09 2004-11-24 西托维亚公司 Caspase抑制剂及其应用
WO2001003719A2 (en) * 1999-07-09 2001-01-18 Amgen Inc. Combination therapy for conditions leading to bone loss
EE05056B1 (et) * 2000-05-05 2008-08-15 Applied Research Systems Ars Holding N.V. IL-18 inhibiitorite kasutamine ravimi valmistamiseks, mis on ette n„htud ateroskleroosi ravimiseks ja/v?i ennetamiseks
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024804A2 (en) * 1996-12-06 1998-06-11 Vertex Pharmaceuticals Incorporated INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
WO1999009063A1 (en) * 1997-08-14 1999-02-25 Yeda Research And Development Co. Ltd. Interleukin-18 binding proteins, their preparation and use
WO2001058956A2 (en) * 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using

Also Published As

Publication number Publication date
DE60224004D1 (de) 2008-01-24
BG108128A (bg) 2004-11-30
CZ305653B6 (cs) 2016-01-27
EA200300844A1 (ru) 2003-12-25
HU229164B1 (en) 2013-09-30
UA80676C2 (en) 2007-10-25
YU57803A (sh) 2006-05-25
CN1326562C (zh) 2007-07-18
EA200501549A1 (ru) 2006-04-28
SK10892003A3 (sk) 2004-02-03
EA006767B1 (ru) 2006-04-28
HUP0303306A3 (en) 2005-12-28
CY1107203T1 (el) 2012-11-21
EP1355668B1 (en) 2007-12-12
EE200300328A (et) 2003-10-15
BR0206819A (pt) 2004-02-03
EE05534B1 (et) 2012-04-16
NO331083B1 (no) 2011-10-03
JP2004522748A (ja) 2004-07-29
HK1062810A1 (en) 2004-11-26
BG66483B1 (bg) 2015-03-31
IL157024A0 (en) 2004-02-08
CZ20032335A3 (en) 2004-07-14
ME00549B (me) 2011-10-10
ES2295332T3 (es) 2008-04-16
JP2009102354A (ja) 2009-05-14
JP4860897B2 (ja) 2012-01-25
PL366802A1 (en) 2005-02-07
SI1355668T1 (sl) 2008-06-30
NO20033228D0 (no) 2003-07-16
HRP20030609A2 (en) 2005-06-30
EA010180B1 (ru) 2008-06-30
NO20033228L (no) 2003-09-26
CA2435466C (en) 2012-04-03
KR20030070143A (ko) 2003-08-27
PL213568B1 (pl) 2013-03-29
RS51125B (sr) 2010-10-31
PT1355668E (pt) 2008-01-04
CN1499982A (zh) 2004-05-26
ATE380558T1 (de) 2007-12-15
EP1355668A1 (en) 2003-10-29
IL157024A (en) 2014-02-27
SK287620B6 (sk) 2011-04-05
ZA200305439B (en) 2004-07-15
DE60224004T2 (de) 2009-07-23
MXPA03006776A (es) 2003-10-24
CA2435466A1 (en) 2002-08-08
WO2002060479A1 (en) 2002-08-08
DK1355668T3 (da) 2008-05-05
HUP0303306A2 (hu) 2004-01-28
AR032422A1 (es) 2003-11-05
US20040234523A1 (en) 2004-11-25

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