EE200300328A - IL-18 inhibiitorite kasutamine südamehaiguse raviks ja/või ennetamiseks - Google Patents

IL-18 inhibiitorite kasutamine südamehaiguse raviks ja/või ennetamiseks

Info

Publication number
EE200300328A
EE200300328A EEP200300328A EEP200300328A EE200300328A EE 200300328 A EE200300328 A EE 200300328A EE P200300328 A EEP200300328 A EE P200300328A EE P200300328 A EEP200300328 A EE P200300328A EE 200300328 A EE200300328 A EE 200300328A
Authority
EE
Estonia
Prior art keywords
inhibitors
prevention
treatment
heart disease
heart
Prior art date
Application number
EEP200300328A
Other languages
English (en)
Inventor
Dinarello Charles
Pomerantz Benjamin
Reznikov Leonid
Harken Alden
Chvatchko Yolande
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200300328A publication Critical patent/EE200300328A/et
Publication of EE05534B1 publication Critical patent/EE05534B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
EEP200300328A 2001-01-29 2002-01-28 IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks EE05534B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01101959 2001-01-29
PCT/EP2002/000844 WO2002060479A1 (en) 2001-01-29 2002-01-28 Use of il-18 inhibitors for the treatment and/or prevention of heart disease

Publications (2)

Publication Number Publication Date
EE200300328A true EE200300328A (et) 2003-10-15
EE05534B1 EE05534B1 (et) 2012-04-16

Family

ID=8176323

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300328A EE05534B1 (et) 2001-01-29 2002-01-28 IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks

Country Status (32)

Country Link
US (1) US20040234523A1 (et)
EP (1) EP1355668B1 (et)
JP (2) JP4860897B2 (et)
KR (1) KR100857376B1 (et)
CN (1) CN1326562C (et)
AR (1) AR032422A1 (et)
AT (1) ATE380558T1 (et)
BG (1) BG66483B1 (et)
BR (1) BR0206819A (et)
CA (1) CA2435466C (et)
CY (1) CY1107203T1 (et)
CZ (1) CZ305653B6 (et)
DE (1) DE60224004T2 (et)
DK (1) DK1355668T3 (et)
EA (2) EA006767B1 (et)
EE (1) EE05534B1 (et)
ES (1) ES2295332T3 (et)
HK (1) HK1062810A1 (et)
HR (1) HRP20030609A2 (et)
HU (1) HU229164B1 (et)
IL (2) IL157024A0 (et)
ME (1) ME00549B (et)
MX (1) MXPA03006776A (et)
NO (1) NO331083B1 (et)
PL (1) PL213568B1 (et)
PT (1) PT1355668E (et)
RS (1) RS51125B (et)
SI (1) SI1355668T1 (et)
SK (1) SK287620B6 (et)
UA (1) UA80676C2 (et)
WO (1) WO2002060479A1 (et)
ZA (1) ZA200305439B (et)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102504024A (zh) 2000-02-10 2012-06-20 雅培制药有限公司 结合人白介素-18的抗体及制备和使用方法
JP2004528010A (ja) 2000-10-11 2004-09-16 バイロン・セラピューティックス・インコーポレーテッド 免疫モジュレーションのための核酸およびポリペプチド
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
WO2004101617A1 (en) 2003-05-13 2004-11-25 Applied Research Systems Ars Holding N.V. Active variants of the il-18 binding protein and medical uses thereof
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
JP4961559B2 (ja) * 2004-03-11 2012-06-27 友昭 星野 インターロイキン１８阻害剤を有効成分とする疾患の予防又は治療剤
DK1885753T3 (da) 2005-06-03 2011-10-03 Ares Trading Sa Fremstilling af rekombinant II-18-proteiner
EP1891088B1 (en) 2005-06-10 2011-10-19 Ares Trading S.A. Process for the purification of il-18 binding protein
EP2207475A4 (en) * 2007-11-05 2010-12-22 Kci Licensing Inc IDENTIFICATION OF TISSUE FOR DEBRIDEMENT
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
KR102321172B1 (ko) * 2013-09-05 2021-11-05 에이비2 바이오 에스에이 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ)
KR102511343B1 (ko) * 2015-03-05 2023-03-17 에이비2 바이오 에스에이 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) 및 항체
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) * 1995-11-21 1999-02-25 Yamanouchi Pharma Co Ltd Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
IL125190A (en) * 1996-09-12 2003-01-12 Idun Pharmaceuticals Inc Tricyclic compounds for the inhibition of the ice/ced-3 protease family of enzymes and pharmaceutical compositions containing the same
AU7624798A (en) * 1996-12-06 1998-06-29 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1 beta converting enzyme
CA2282845A1 (en) * 1997-03-18 1998-09-24 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
DE19743687C1 (de) * 1997-10-06 1998-11-26 Henkel Kgaa Detergensgemische und deren Verwendung
WO2000000490A2 (en) * 1998-06-26 2000-01-06 Eli Lilly And Company 5-ht1f agonists
KR100537558B1 (ko) * 1998-09-01 2005-12-19 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 인터류킨-18 결합 단백질
EP1022027A1 (en) * 1999-01-22 2000-07-26 Applied Research Systems ARS Holding N.V. Tumor necrosis factor antagonists and their use in endometriosis
WO2000055114A1 (en) * 1999-03-16 2000-09-21 Cytovia, Inc. Substituted 2-aminobenzamide caspase inhibitors and the use thereof
EP1177168B1 (en) * 1999-04-09 2007-05-30 Cytovia, Inc. Caspase inhibitors and the use thereof
AU6078500A (en) * 1999-07-09 2001-01-30 Amgen, Inc. Combination therapy for conditions leading to bone loss
CN102504024A (zh) * 2000-02-10 2012-06-20 雅培制药有限公司 结合人白介素-18的抗体及制备和使用方法
ES2305082T3 (es) * 2000-05-05 2008-11-01 Laboratoires Serono Sa Uso de inhibidores de il-18 para el tratamiento y/o la prevencion de la aterosclerosis.
WO2002032374A2 (en) * 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders

Also Published As

Publication number Publication date
ATE380558T1 (de) 2007-12-15
BR0206819A (pt) 2004-02-03
SK10892003A3 (sk) 2004-02-03
JP2004522748A (ja) 2004-07-29
ES2295332T3 (es) 2008-04-16
CN1499982A (zh) 2004-05-26
IL157024A0 (en) 2004-02-08
JP4860897B2 (ja) 2012-01-25
EA200501549A1 (ru) 2006-04-28
UA80676C2 (en) 2007-10-25
JP2009102354A (ja) 2009-05-14
CA2435466A1 (en) 2002-08-08
EA200300844A1 (ru) 2003-12-25
BG66483B1 (bg) 2015-03-31
HUP0303306A3 (en) 2005-12-28
NO20033228L (no) 2003-09-26
CN1326562C (zh) 2007-07-18
CY1107203T1 (el) 2012-11-21
CZ20032335A3 (en) 2004-07-14
DE60224004D1 (de) 2008-01-24
US20040234523A1 (en) 2004-11-25
WO2002060479A1 (en) 2002-08-08
NO331083B1 (no) 2011-10-03
HK1062810A1 (en) 2004-11-26
SI1355668T1 (sl) 2008-06-30
KR100857376B1 (ko) 2008-09-05
IL157024A (en) 2014-02-27
YU57803A (sh) 2006-05-25
EA010180B1 (ru) 2008-06-30
MXPA03006776A (es) 2003-10-24
HU229164B1 (en) 2013-09-30
PT1355668E (pt) 2008-01-04
EP1355668B1 (en) 2007-12-12
ME00549B (me) 2011-10-10
HRP20030609A2 (en) 2005-06-30
KR20030070143A (ko) 2003-08-27
SK287620B6 (sk) 2011-04-05
PL213568B1 (pl) 2013-03-29
HUP0303306A2 (hu) 2004-01-28
RS51125B (sr) 2010-10-31
DK1355668T3 (da) 2008-05-05
EE05534B1 (et) 2012-04-16
AR032422A1 (es) 2003-11-05
NO20033228D0 (no) 2003-07-16
CA2435466C (en) 2012-04-03
PL366802A1 (en) 2005-02-07
DE60224004T2 (de) 2009-07-23
ZA200305439B (en) 2004-07-15
BG108128A (bg) 2004-11-30
CZ305653B6 (cs) 2016-01-27
EP1355668A1 (en) 2003-10-29
EA006767B1 (ru) 2006-04-28

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Legal Events

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GB1A Change in the ownership or in the address of the owner
HC1A Change of owner name