DE60224004D1 - Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten - Google Patents

Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten

Info

Publication number
DE60224004D1
DE60224004D1 DE60224004T DE60224004T DE60224004D1 DE 60224004 D1 DE60224004 D1 DE 60224004D1 DE 60224004 T DE60224004 T DE 60224004T DE 60224004 T DE60224004 T DE 60224004T DE 60224004 D1 DE60224004 D1 DE 60224004D1
Authority
DE
Germany
Prior art keywords
inhibitors
prevention
treatment
heart diseases
heart
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60224004T
Other languages
English (en)
Other versions
DE60224004T2 (de
Inventor
Charles Dinarello
Benjamin Pomerantz
Leonid Reznikov
Alden Harken
Yolande Chvatchko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Laboratoires Serono SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono SA filed Critical Laboratoires Serono SA
Publication of DE60224004D1 publication Critical patent/DE60224004D1/de
Application granted granted Critical
Publication of DE60224004T2 publication Critical patent/DE60224004T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE60224004T 2001-01-29 2002-01-28 Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten Expired - Lifetime DE60224004T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01101959 2001-01-29
EP01101959 2001-01-29
PCT/EP2002/000844 WO2002060479A1 (en) 2001-01-29 2002-01-28 Use of il-18 inhibitors for the treatment and/or prevention of heart disease

Publications (2)

Publication Number Publication Date
DE60224004D1 true DE60224004D1 (de) 2008-01-24
DE60224004T2 DE60224004T2 (de) 2009-07-23

Family

ID=8176323

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60224004T Expired - Lifetime DE60224004T2 (de) 2001-01-29 2002-01-28 Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten

Country Status (32)

Country Link
US (1) US20040234523A1 (de)
EP (1) EP1355668B1 (de)
JP (2) JP4860897B2 (de)
KR (1) KR100857376B1 (de)
CN (1) CN1326562C (de)
AR (1) AR032422A1 (de)
AT (1) ATE380558T1 (de)
BG (1) BG66483B1 (de)
BR (1) BR0206819A (de)
CA (1) CA2435466C (de)
CY (1) CY1107203T1 (de)
CZ (1) CZ305653B6 (de)
DE (1) DE60224004T2 (de)
DK (1) DK1355668T3 (de)
EA (2) EA006767B1 (de)
EE (1) EE05534B1 (de)
ES (1) ES2295332T3 (de)
HK (1) HK1062810A1 (de)
HR (1) HRP20030609A2 (de)
HU (1) HU229164B1 (de)
IL (2) IL157024A0 (de)
ME (1) ME00549B (de)
MX (1) MXPA03006776A (de)
NO (1) NO331083B1 (de)
PL (1) PL213568B1 (de)
PT (1) PT1355668E (de)
RS (1) RS51125B (de)
SI (1) SI1355668T1 (de)
SK (1) SK287620B6 (de)
UA (1) UA80676C2 (de)
WO (1) WO2002060479A1 (de)
ZA (1) ZA200305439B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI373343B (en) 2000-02-10 2012-10-01 Abbott Gmbh & Co Kg Antibodies that bind human interleukin-18 and methods of making and using
AU1174402A (en) 2000-10-11 2002-04-22 Viron Therapeutics Inc Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
ATE549353T1 (de) 2003-05-13 2012-03-15 Merck Serono Sa Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
JP4961559B2 (ja) * 2004-03-11 2012-06-27 友昭 星野 インターロイキン１８阻害剤を有効成分とする疾患の予防又は治療剤
PT1885753E (pt) 2005-06-03 2011-10-06 Ares Trading Sa Produção de proteína recombinante de ligação a il-18
SI1891088T1 (sl) 2005-06-10 2012-02-29 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina
EP2207475A4 (de) 2007-11-05 2010-12-22 Kci Licensing Inc Identifikation von zur ausschneidung bestimmtem gewebe
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
DK3041864T3 (da) 2013-09-05 2021-09-27 Ab2 Bio Sa Il-18-bindende protein (il-18bp) ved inflammatoriske sygdomme
MY194040A (en) * 2015-03-05 2022-11-09 Ab2 Bio Sa Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases
WO2018013509A1 (en) * 2016-07-11 2018-01-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) * 1995-11-21 1999-02-25 Yamanouchi Pharma Co Ltd Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
DE69734718T2 (de) * 1996-09-12 2006-08-24 Idun Pharmaceuticals, Inc., San Diego Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie
JP4094066B2 (ja) * 1996-12-06 2008-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド インターロイキン−１β変換酵素のインヒビター
PL336464A1 (en) * 1997-03-18 2000-06-19 Basf Ag Method of and compositions for modulating reactivity in respect to corticosteroids i
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
DE19743687C1 (de) * 1997-10-06 1998-11-26 Henkel Kgaa Detergensgemische und deren Verwendung
AU4961499A (en) * 1998-06-26 2000-01-17 Eli Lilly And Company 5-HT1f agonists
CA2340579A1 (en) * 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin 18-binding protein
EP1022027A1 (de) * 1999-01-22 2000-07-26 Applied Research Systems ARS Holding N.V. Antagonisten von Tumornecrosefaktor und ihre Verwendungen gegen Endometriose
CA2367340A1 (en) * 1999-03-16 2000-09-21 Cytovia, Inc. Substituted 2-aminobenzamide caspase inhibitors and the use thereof
CN1176941C (zh) * 1999-04-09 2004-11-24 西托维亚公司 Caspase抑制剂及其应用
WO2001003719A2 (en) * 1999-07-09 2001-01-18 Amgen Inc. Combination therapy for conditions leading to bone loss
TWI373343B (en) * 2000-02-10 2012-10-01 Abbott Gmbh & Co Kg Antibodies that bind human interleukin-18 and methods of making and using
HU229375B1 (en) * 2000-05-05 2013-11-28 Inst Nat Sante Rech Med Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis
WO2002032374A2 (en) * 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders

Also Published As

Publication number Publication date
CZ305653B6 (cs) 2016-01-27
HUP0303306A2 (hu) 2004-01-28
HU229164B1 (en) 2013-09-30
IL157024A (en) 2014-02-27
EE05534B1 (et) 2012-04-16
CN1326562C (zh) 2007-07-18
NO331083B1 (no) 2011-10-03
PL213568B1 (pl) 2013-03-29
SK10892003A3 (sk) 2004-02-03
UA80676C2 (en) 2007-10-25
AR032422A1 (es) 2003-11-05
WO2002060479A1 (en) 2002-08-08
CY1107203T1 (el) 2012-11-21
JP2009102354A (ja) 2009-05-14
ATE380558T1 (de) 2007-12-15
SI1355668T1 (sl) 2008-06-30
JP4860897B2 (ja) 2012-01-25
DK1355668T3 (da) 2008-05-05
CZ20032335A3 (en) 2004-07-14
PT1355668E (pt) 2008-01-04
EA010180B1 (ru) 2008-06-30
ES2295332T3 (es) 2008-04-16
MXPA03006776A (es) 2003-10-24
YU57803A (sh) 2006-05-25
RS51125B (sr) 2010-10-31
NO20033228D0 (no) 2003-07-16
ZA200305439B (en) 2004-07-15
DE60224004T2 (de) 2009-07-23
PL366802A1 (en) 2005-02-07
JP2004522748A (ja) 2004-07-29
BR0206819A (pt) 2004-02-03
CA2435466A1 (en) 2002-08-08
EA006767B1 (ru) 2006-04-28
EA200501549A1 (ru) 2006-04-28
CA2435466C (en) 2012-04-03
NO20033228L (no) 2003-09-26
US20040234523A1 (en) 2004-11-25
HRP20030609A2 (en) 2005-06-30
HUP0303306A3 (en) 2005-12-28
BG108128A (bg) 2004-11-30
KR100857376B1 (ko) 2008-09-05
IL157024A0 (en) 2004-02-08
EP1355668A1 (de) 2003-10-29
EA200300844A1 (ru) 2003-12-25
HK1062810A1 (en) 2004-11-26
EP1355668B1 (de) 2007-12-12
ME00549B (me) 2011-10-10
BG66483B1 (bg) 2015-03-31
EE200300328A (et) 2003-10-15
KR20030070143A (ko) 2003-08-27
SK287620B6 (sk) 2011-04-05
CN1499982A (zh) 2004-05-26

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