EE05534B1 - IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks - Google Patents

IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks

Info

Publication number
EE05534B1
EE05534B1 EEP200300328A EEP200300328A EE05534B1 EE 05534 B1 EE05534 B1 EE 05534B1 EE P200300328 A EEP200300328 A EE P200300328A EE P200300328 A EEP200300328 A EE P200300328A EE 05534 B1 EE05534 B1 EE 05534B1
Authority
EE
Estonia
Prior art keywords
cardiomyopathy
medicament
inhibitors
prevention
manufacture
Prior art date
Application number
EEP200300328A
Other languages
English (en)
Estonian (et)
Inventor
Dinarello Charles
Pomerantz Benjamin
Reznikov Leonid
Harken Alden
Chvatchko Yolande
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200300328A publication Critical patent/EE200300328A/xx
Publication of EE05534B1 publication Critical patent/EE05534B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EEP200300328A 2001-01-29 2002-01-28 IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks EE05534B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01101959 2001-01-29
PCT/EP2002/000844 WO2002060479A1 (en) 2001-01-29 2002-01-28 Use of il-18 inhibitors for the treatment and/or prevention of heart disease

Publications (2)

Publication Number Publication Date
EE200300328A EE200300328A (et) 2003-10-15
EE05534B1 true EE05534B1 (et) 2012-04-16

Family

ID=8176323

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300328A EE05534B1 (et) 2001-01-29 2002-01-28 IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks

Country Status (32)

Country Link
US (1) US20040234523A1 (de)
EP (1) EP1355668B1 (de)
JP (2) JP4860897B2 (de)
KR (1) KR100857376B1 (de)
CN (1) CN1326562C (de)
AR (1) AR032422A1 (de)
AT (1) ATE380558T1 (de)
BG (1) BG66483B1 (de)
BR (1) BR0206819A (de)
CA (1) CA2435466C (de)
CY (1) CY1107203T1 (de)
CZ (1) CZ305653B6 (de)
DE (1) DE60224004T2 (de)
DK (1) DK1355668T3 (de)
EA (2) EA010180B1 (de)
EE (1) EE05534B1 (de)
ES (1) ES2295332T3 (de)
HK (1) HK1062810A1 (de)
HR (1) HRP20030609A2 (de)
HU (1) HU229164B1 (de)
IL (2) IL157024A0 (de)
ME (1) ME00549B (de)
MX (1) MXPA03006776A (de)
NO (1) NO331083B1 (de)
PL (1) PL213568B1 (de)
PT (1) PT1355668E (de)
RS (1) RS51125B (de)
SI (1) SI1355668T1 (de)
SK (1) SK287620B6 (de)
UA (1) UA80676C2 (de)
WO (1) WO2002060479A1 (de)
ZA (1) ZA200305439B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ520392A (en) 2000-02-10 2005-04-29 Abbott Lab Antibodies that bind human interleukin-18 and methods of making and using
US6894155B2 (en) 2000-10-11 2005-05-17 Viron Therapeutics Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
DK1622939T3 (da) 2003-05-13 2012-04-10 Merck Serono Sa Aktive varianter af det IL-18-bindende protein og medicinske anvendelser deraf
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
JP4961559B2 (ja) * 2004-03-11 2012-06-27 友昭 星野 インターロイキン１８阻害剤を有効成分とする疾患の予防又は治療剤
EP1885753B1 (de) 2005-06-03 2011-07-27 Ares Trading S.A. Herstellung eines rekombinanten Il-18-bindenden Proteins
SI1891088T1 (sl) 2005-06-10 2012-02-29 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina
AU2008324814B2 (en) * 2007-11-05 2013-05-16 Solventum Intellectual Properties Company Identification of tissue for debridement
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
PL3041864T3 (pl) 2013-09-05 2021-12-20 Ab2 Bio Sa Białko wiążące il-18 (il-18bp) w chorobach zapalnych
RU2755691C2 (ru) 2015-03-05 2021-09-20 Аб2 Био Са Il-18-связывающие белок (il-18bp) и антитела при воспалительных заболеваниях
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) * 1995-11-21 1999-02-25 Yamanouchi Pharma Co Ltd Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
DE69734718T2 (de) * 1996-09-12 2006-08-24 Idun Pharmaceuticals, Inc., San Diego Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie
JP4094066B2 (ja) * 1996-12-06 2008-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド インターロイキン−１β変換酵素のインヒビター
EP0998300A1 (de) * 1997-03-18 2000-05-10 Basf Aktiengesellschaft Zusammensetzungen zur modulation der empfänglichkeit für corticosteroiden
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
DE19743687C1 (de) * 1997-10-06 1998-11-26 Henkel Kgaa Detergensgemische und deren Verwendung
AU4961499A (en) * 1998-06-26 2000-01-17 Eli Lilly And Company 5-HT1f agonists
KR100537558B1 (ko) * 1998-09-01 2005-12-19 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 인터류킨-18 결합 단백질
EP1022027A1 (de) * 1999-01-22 2000-07-26 Applied Research Systems ARS Holding N.V. Antagonisten von Tumornecrosefaktor und ihre Verwendungen gegen Endometriose
DE60030097T2 (de) * 1999-03-16 2007-03-08 Cytovia, Inc., San Diego Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung
MXPA01010127A (es) * 1999-04-09 2002-08-20 Cytovia Inc Inhibidores de la caspasa y el uso de los mismos.
WO2001003719A2 (en) * 1999-07-09 2001-01-18 Amgen Inc. Combination therapy for conditions leading to bone loss
NZ520392A (en) * 2000-02-10 2005-04-29 Abbott Lab Antibodies that bind human interleukin-18 and methods of making and using
MXPA02010895A (es) * 2000-05-05 2003-03-27 Applied Research Systems Uso de inhibidores de interleucina 18 para el tratamiento y/o prevencion de aterosclerosis.
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders

Also Published As

Publication number Publication date
EA200300844A1 (ru) 2003-12-25
CA2435466C (en) 2012-04-03
CN1326562C (zh) 2007-07-18
ATE380558T1 (de) 2007-12-15
EA010180B1 (ru) 2008-06-30
BG108128A (bg) 2004-11-30
JP2004522748A (ja) 2004-07-29
CZ305653B6 (cs) 2016-01-27
EP1355668A1 (de) 2003-10-29
CZ20032335A3 (en) 2004-07-14
IL157024A (en) 2014-02-27
EE200300328A (et) 2003-10-15
BG66483B1 (bg) 2015-03-31
DE60224004T2 (de) 2009-07-23
PL366802A1 (en) 2005-02-07
JP4860897B2 (ja) 2012-01-25
UA80676C2 (en) 2007-10-25
PT1355668E (pt) 2008-01-04
EA006767B1 (ru) 2006-04-28
MXPA03006776A (es) 2003-10-24
KR100857376B1 (ko) 2008-09-05
NO20033228L (no) 2003-09-26
SK287620B6 (sk) 2011-04-05
NO331083B1 (no) 2011-10-03
ZA200305439B (en) 2004-07-15
DE60224004D1 (de) 2008-01-24
SI1355668T1 (sl) 2008-06-30
CY1107203T1 (el) 2012-11-21
HUP0303306A2 (hu) 2004-01-28
RS51125B (sr) 2010-10-31
NO20033228D0 (no) 2003-07-16
EP1355668B1 (de) 2007-12-12
ES2295332T3 (es) 2008-04-16
JP2009102354A (ja) 2009-05-14
DK1355668T3 (da) 2008-05-05
WO2002060479A1 (en) 2002-08-08
HRP20030609A2 (en) 2005-06-30
HK1062810A1 (en) 2004-11-26
AR032422A1 (es) 2003-11-05
IL157024A0 (en) 2004-02-08
HU229164B1 (en) 2013-09-30
KR20030070143A (ko) 2003-08-27
HUP0303306A3 (en) 2005-12-28
SK10892003A3 (sk) 2004-02-03
EA200501549A1 (ru) 2006-04-28
PL213568B1 (pl) 2013-03-29
ME00549B (me) 2011-10-10
BR0206819A (pt) 2004-02-03
CA2435466A1 (en) 2002-08-08
CN1499982A (zh) 2004-05-26
YU57803A (sh) 2006-05-25
US20040234523A1 (en) 2004-11-25

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Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
HC1A Change of owner name