KR100776623B1 - 디펩티딜 펩티데이즈-ⅳ(ｄｐｐ-ⅳ) 저해용 신규 화합물,그것의 제조방법 및 그것을 활성성분으로서 함유하는 약제조성물 - Google Patents

디펩티딜 펩티데이즈-ⅳ(ｄｐｐ-ⅳ) 저해용 신규 화합물,그것의 제조방법 및 그것을 활성성분으로서 함유하는 약제조성물 Download PDF

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Publication number
KR100776623B1
KR100776623B1 KR1020060029138A KR20060029138A KR100776623B1 KR 100776623 B1 KR100776623 B1 KR 100776623B1 KR 1020060029138 A KR1020060029138 A KR 1020060029138A KR 20060029138 A KR20060029138 A KR 20060029138A KR 100776623 B1 KR100776623 B1 KR 100776623B1
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South Korea
Prior art keywords
trifluoromethyl
amino
dihydropyrido
oxobutyl
oxo
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Expired - Lifetime
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KR1020060029138A
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Korean (ko)
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KR20060105609A (ko
Inventor
이창석
고종성
구기동
김근태
김경희
홍상용
김성섭
김민정
임현주
임동철
김혜진
한희운
부성철
권오환
김성호
허광청
김지영
염지호
여동준
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주식회사 엘지생명과학
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Assigned to 주식회사 엘지화학 reassignment 주식회사 엘지화학 권리의 전부이전등록 Assignors: 주식회사 엘지생명과학
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
KR1020060029138A 2005-04-01 2006-03-30 디펩티딜 펩티데이즈-ⅳ(ｄｐｐ-ⅳ) 저해용 신규 화합물,그것의 제조방법 및 그것을 활성성분으로서 함유하는 약제조성물 Expired - Lifetime KR100776623B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
KR20050027756 2005-04-01
KR1020050027756 2005-04-01
KR1020050053761 2005-06-22
KR20050053761 2005-06-22
KR1020050085980 2005-09-15
KR20050085980 2005-09-15
KR20050122361 2005-12-13
KR1020050122361 2005-12-13

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020070086444A Division KR100830902B1 (ko) 2005-04-01 2007-08-28 디펩티딜 펩티데이즈-ｉｖ(ｄｐｐ-ｉｖ) 저해용 신규화합물, 그것의 제조방법 및 그것을 활성성분으로서함유하는 약제 조성물
KR1020070086486A Division KR100794184B1 (ko) 2005-04-01 2007-08-28 디펩티딜 펩티데이즈-ｉｖ(ｄｐｐ-ｉｖ) 저해용 신규화합물, 그것의 제조방법 및 그것을 활성성분으로서함유하는 약제 조성물

Publications (2)

Publication Number Publication Date
KR20060105609A KR20060105609A (ko) 2006-10-11
KR100776623B1 true KR100776623B1 (ko) 2007-11-15

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KR1020060029138A Expired - Lifetime KR100776623B1 (ko) 2005-04-01 2006-03-30 디펩티딜 펩티데이즈-ⅳ(ｄｐｐ-ⅳ) 저해용 신규 화합물,그것의 제조방법 및 그것을 활성성분으로서 함유하는 약제조성물
KR1020070086486A Expired - Lifetime KR100794184B1 (ko) 2005-04-01 2007-08-28 디펩티딜 펩티데이즈-ｉｖ(ｄｐｐ-ｉｖ) 저해용 신규화합물, 그것의 제조방법 및 그것을 활성성분으로서함유하는 약제 조성물
KR1020070086444A Expired - Lifetime KR100830902B1 (ko) 2005-04-01 2007-08-28 디펩티딜 펩티데이즈-ｉｖ(ｄｐｐ-ｉｖ) 저해용 신규화합물, 그것의 제조방법 및 그것을 활성성분으로서함유하는 약제 조성물

Family Applications After (2)

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KR1020070086486A Expired - Lifetime KR100794184B1 (ko) 2005-04-01 2007-08-28 디펩티딜 펩티데이즈-ｉｖ(ｄｐｐ-ｉｖ) 저해용 신규화합물, 그것의 제조방법 및 그것을 활성성분으로서함유하는 약제 조성물
KR1020070086444A Expired - Lifetime KR100830902B1 (ko) 2005-04-01 2007-08-28 디펩티딜 펩티데이즈-ｉｖ(ｄｐｐ-ｉｖ) 저해용 신규화합물, 그것의 제조방법 및 그것을 활성성분으로서함유하는 약제 조성물

Country Status (28)

Country Link
US (1) US7879848B2 (https=)
EP (1) EP1863812B1 (https=)
JP (1) JP4977685B2 (https=)
KR (3) KR100776623B1 (https=)
CN (1) CN101151265B (https=)
AR (1) AR053195A1 (https=)
AT (1) ATE473976T1 (https=)
AU (1) AU2006229520B2 (https=)
BR (1) BRPI0609424B8 (https=)
CA (1) CA2602248C (https=)
DE (1) DE602006015443D1 (https=)
DK (1) DK1863812T3 (https=)
EA (1) EA012591B1 (https=)
ES (1) ES2349178T3 (https=)
IL (1) IL185479A (https=)
MA (1) MA29586B1 (https=)
MX (1) MX2007012175A (https=)
MY (1) MY150102A (https=)
NZ (1) NZ560789A (https=)
PE (1) PE20061354A1 (https=)
PL (1) PL1863812T3 (https=)
PT (1) PT1863812E (https=)
SI (1) SI1863812T1 (https=)
TW (1) TWI357902B (https=)
UA (1) UA89396C2 (https=)
UY (1) UY29448A1 (https=)
WO (1) WO2006104356A1 (https=)
ZA (1) ZA200708304B (https=)

Cited By (4)

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WO2012060590A3 (en) * 2010-11-01 2012-06-28 Lg Life Sciences Ltd. Hydrate of 1-{(2s)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-di- hydropyrido[3,4-d]pyrimidin-7(6h)-yl]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate
KR20250137744A (ko) 2024-03-11 2025-09-19 엠에프씨 주식회사 제미글립틴의 신규 결정형 및 이의 제조방법
KR20250147756A (ko) 2024-03-27 2025-10-14 엠에프씨 주식회사 신규한 형태의 제미글립틴 말산염 결정형 및 이의 제조방법
KR20260008397A (ko) 2024-07-09 2026-01-16 주식회사 경보제약 제미글립틴 옥살레이트 1 수화물 염 및 이의 제조방법

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007148185A2 (en) 2006-06-21 2007-12-27 Pfizer Products Inc. Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors
JP2010500300A (ja) 2006-08-08 2010-01-07 サノフィ−アベンティス アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
KR20120030570A (ko) 2007-04-03 2012-03-28 미쓰비시 타나베 파마 코퍼레이션 디펩티딜 펩티다아제 4 저해 화합물과 감미료와의 병용
CN101357922B (zh) * 2007-08-02 2011-05-18 山东轩竹医药科技有限公司 新的dpp-iv抑制剂
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP2011506297A (ja) * 2007-12-05 2011-03-03 アストラゼネカ アクチボラグ 新規な化合物ｉｉｉ
EP2220086A4 (en) * 2007-12-21 2010-12-22 Lg Life Sciences Ltd DIPEPTIDYLPEPTIDASE IV-INHIBITABLE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREFOR AS ACTIVE AGENT
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
CN101486689B (zh) * 2008-01-18 2011-08-10 山东轩竹医药科技有限公司 具有磺酰胺基甲酰胺哌嗪结构的dpp-iv抑制剂
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
JO2870B1 (en) * 2008-11-13 2015-03-15 ميرك شارب اند دوهم كورب Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US9428471B2 (en) 2009-03-13 2016-08-30 Sun Chemical B.V. Cyclic carbamate compounds useful in energy-curable compositions
MX2012001729A (es) 2009-08-26 2012-06-13 Sanofi Sa Nuevos hidratos cristalinos de fluoroglicosido heteroaromatico, productos farmaceuticos que comprenden estos compuestos, y su empleo.
US8871760B2 (en) * 2009-09-21 2014-10-28 Roche Palo Alto Llc [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
CN102260265B (zh) * 2010-05-24 2015-09-02 上海阳帆医药科技有限公司 六氢吡咯[3,4-b]吡咯衍生物、其制备方法及其用途
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
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EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
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US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
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CN105085528A (zh) * 2014-05-15 2015-11-25 成都贝斯凯瑞生物科技有限公司 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物
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CN117682981A (zh) * 2022-09-02 2024-03-12 中国科学院大连化学物理研究所 一种吉格列汀药物前体的制备方法
KR20250097733A (ko) 2023-12-21 2025-06-30 이니스트에스티 주식회사 디펩티딜 펩티데이즈-iv (dpp-iv) 억제제의 신규한 염, 이의 제조 방법 및 이를 포함하는 약제학적 조성물
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004498A1 (en) 2001-07-06 2003-01-16 Merck & Co., Inc. Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004007468A1 (en) 2002-07-15 2004-01-22 Merck & Co., Inc. Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
WO2004064778A2 (en) 2003-01-17 2004-08-05 Merck & Co. Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004069162A2 (en) 2003-01-31 2004-08-19 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5150173A1 (es) 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
US6861440B2 (en) * 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
AU2002360732A1 (en) * 2001-12-26 2003-07-24 Guilford Pharmaceuticals Change inhibitors of dipeptidyl peptidase iv
ATE373660T1 (de) * 2002-03-25 2007-10-15 Merck & Co Inc Heterocyclische beta-aminoverbindungen als inhibitoren der dipeptidylpeptidase zur behandlung bzw. prävention von diabetes
JP4459807B2 (ja) * 2002-04-29 2010-04-28 メルク エンド カムパニー インコーポレーテッド テトラヒドロピラニルシクロペンチルテトラヒドロイソキノリン系のケモカイン受容体活性調節剤
JP2004285325A (ja) * 2002-12-17 2004-10-14 Fuji Photo Film Co Ltd パターン形成方法及び物質付着パターン材料
WO2004058266A1 (en) * 2002-12-20 2004-07-15 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
CN101090885A (zh) * 2004-02-23 2007-12-19 塔夫茨大学信托人 作为构象限定的肽模拟物抑制剂的内酰胺类化合物
US7291427B2 (en) * 2004-03-19 2007-11-06 Fujifilm Corporation Surface graft material, conductive pattern material, and production method thereof
DE102004020908A1 (de) * 2004-04-28 2005-11-17 Grünenthal GmbH Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen
DE102005016170A1 (de) * 2005-04-07 2006-10-12 Grünenthal GmbH 4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
KR20080015102A (ko) * 2005-05-10 2008-02-18 버텍스 파마슈티칼스 인코포레이티드 이온 채널 조절인자로서의 바이사이클릭 유도체
WO2007136990A2 (en) * 2006-05-16 2007-11-29 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
EP2229395A1 (en) * 2008-01-17 2010-09-22 Grünenthal GmbH Substituted sulfonamide derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004498A1 (en) 2001-07-06 2003-01-16 Merck & Co., Inc. Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004007468A1 (en) 2002-07-15 2004-01-22 Merck & Co., Inc. Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
WO2004064778A2 (en) 2003-01-17 2004-08-05 Merck & Co. Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004069162A2 (en) 2003-01-31 2004-08-19 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012060590A3 (en) * 2010-11-01 2012-06-28 Lg Life Sciences Ltd. Hydrate of 1-{(2s)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-di- hydropyrido[3,4-d]pyrimidin-7(6h)-yl]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate
US8859567B2 (en) 2010-11-01 2014-10-14 Lg Life Sciences Ltd. Hydrate of 1-{(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-di-hydropyrido[3,4-D]pyrimidin-7(6H)-yl]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate
AP3287A (en) * 2010-11-01 2015-05-31 Lg Life Sciences Ltd Hydrate of 1-{(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-DI-hydropyrido[3,4-D]pyrimidin-7(6H)-YL]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate
EA024679B1 (ru) * 2010-11-01 2016-10-31 ЭлДжи ЛАЙФ САЙЕНСИЗ ЛТД. ГИДРАТ ТАРТРАТА 1-{(2S)-2-АМИНО-4-[2,4-БИС-(ТРИФТОРМЕТИЛ)-5,8-ДИГИДРОПИРИДО[3,4-d]ПИРИМИДИН-7(6H)-ИЛ]-4-ОКСОБУТИЛ}-5,5-ДИФТОРПИПЕРИДИН-2-ОНА
KR20250137744A (ko) 2024-03-11 2025-09-19 엠에프씨 주식회사 제미글립틴의 신규 결정형 및 이의 제조방법
KR20250147756A (ko) 2024-03-27 2025-10-14 엠에프씨 주식회사 신규한 형태의 제미글립틴 말산염 결정형 및 이의 제조방법
KR20260008397A (ko) 2024-07-09 2026-01-16 주식회사 경보제약 제미글립틴 옥살레이트 1 수화물 염 및 이의 제조방법

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UY29448A1 (es) 2006-10-31
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CA2602248C (en) 2011-06-28
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KR100794184B1 (ko) 2008-01-11
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