KR100769050B1 - 오리나무 추출물을 함유하는 항바이러스 조성물 - Google Patents
오리나무 추출물을 함유하는 항바이러스 조성물 Download PDFInfo
- Publication number
- KR100769050B1 KR100769050B1 KR1020070012216A KR20070012216A KR100769050B1 KR 100769050 B1 KR100769050 B1 KR 100769050B1 KR 1020070012216 A KR1020070012216 A KR 1020070012216A KR 20070012216 A KR20070012216 A KR 20070012216A KR 100769050 B1 KR100769050 B1 KR 100769050B1
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- South Korea
- Prior art keywords
- influenza virus
- extract
- virus
- alder
- japonic
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- 239000000284 extract Substances 0.000 title claims abstract description 31
- 239000000203 mixture Substances 0.000 title claims abstract description 10
- 241000219496 Alnus Species 0.000 title claims abstract description 9
- 230000000840 anti-viral effect Effects 0.000 title abstract description 11
- 241000712461 unidentified influenza virus Species 0.000 claims abstract description 43
- 201000010099 disease Diseases 0.000 claims abstract description 9
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- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 description 1
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- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
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- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 description 1
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- PGZUMBJQJWIWGJ-ONAKXNSWSA-N oseltamivir phosphate Chemical compound OP(O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 PGZUMBJQJWIWGJ-ONAKXNSWSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
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- 230000002062 proliferating effect Effects 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
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- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 229960000329 ribavirin Drugs 0.000 description 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
Abstract
Description
대조군 | 부위 (응집괴수/샘플수) | 오리나무 추출액(㎍/㎖) | ||||
400 | 300 | 200 | 100 | |||
바이러스 | 무바이러스 | 잎 (응집괴수/샘플수) | 0/3 | 1/3 | 1/3 | 2/3 |
6/6 | 0/6 | 줄기(심재) (응집괴수/샘플수) | 0/3 | 1/3 | 3/3 | 2/3 |
줄기(수피) (응집괴수/샘플수) | 0/6 | 0/6 | 2/6 | 3/3 | ||
꽃 (응집괴수/샘플수) | 0/3 | 0/3 | 0/3 | 1/3 |
대조군 | 부위 (MTT OD값±표준편차) | 오리나무 추출액(㎍/㎖) | ||||
400 | 300 | 200 | 100 | |||
바이러스 | 무바이러스 | 잎 (MTT OD값±표준편차) | 0.406±0.037 | 0.409±0.050 | 0.942±0.203 | 1.156±0.023 |
6/6 | 0/6 | 줄기(심재) (MTT OD값±표준편차) | 0.309±0.045 | 0.392±0.108 | 0.409±0.005 | 0.390±0.088 |
줄기(수피) (MTT OD값±표준편차) | 0.844±0.113 | 0.690±0.123 | 0.521±0.074 | 0.570±0.078 | ||
꽃 (MTT OD값±표준편차) | 0.288±0.053 | 0.290±0.029 | 0.239±0.024 | 0.226±0.047 |
Claims (6)
- 오리나무(Alnus japonic)의 잎, 줄기의 심재 및 줄기의 수피 중 어느 하나에서 추출된 추출물 및 약학적으로 허용 가능한 첨가제를 함유하는 인플루엔자 바이러스(influenza virus) 질환의 예방 또는 치료용 약학 조성물.
- 제1항에 있어서, 상기 인플루엔자 바이러스는 인간 인플루엔자 바이러스, 돼지 인플루엔자 바이러스, 말 인플루엔자 바이러스 및 조류 인플루엔자 바이러스로 구성된 군에서 선택되는 것을 특징으로 하는 조성물.
- 제2항에 있어서, 상기 조류 인플루엔자 바이러스는 KBNP-0028(기탁번호 KCTC 10866BP)인 것을 특징으로 하는 조성물.
- 오리나무 추출물을 유효성분으로 함유하는 인플루엔자 바이러스(influenza virus) 사멸제.
- 제4항에 있어서, 상기 인플루엔자 바이러스는 인간 인플루엔자 바이러스, 돼지 인플루엔자 바이러스, 말 인플루엔자 바이러스 및 조류 인플루엔자 바이러스로 구성된 군에서 선택되는 것을 특징으로 하는 사멸제.
- 제5항에 있어서, 상기 조류 인플루엔자 바이러스는 KBNP-0028(기탁번호 KCTC 10866BP)인 것을 특징으로 하는 사멸제.
Priority Applications (1)
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KR1020070012216A KR100769050B1 (ko) | 2007-02-06 | 2007-02-06 | 오리나무 추출물을 함유하는 항바이러스 조성물 |
Applications Claiming Priority (1)
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---|---|---|---|
KR1020070012216A KR100769050B1 (ko) | 2007-02-06 | 2007-02-06 | 오리나무 추출물을 함유하는 항바이러스 조성물 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020060059188A Division KR100721703B1 (ko) | 2006-06-29 | 2006-06-29 | 오리나무 추출물을 함유하는 항바이러스 조성물 |
Publications (1)
Publication Number | Publication Date |
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KR100769050B1 true KR100769050B1 (ko) | 2007-10-22 |
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Family Applications (1)
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KR1020070012216A KR100769050B1 (ko) | 2007-02-06 | 2007-02-06 | 오리나무 추출물을 함유하는 항바이러스 조성물 |
Country Status (1)
Country | Link |
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KR (1) | KR100769050B1 (ko) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009075488A3 (en) * | 2007-12-11 | 2009-08-06 | Rnl Bio Co Ltd | Anti-influenza viral composition containing bark or stem extract of alnus japonica |
WO2009148280A2 (ko) * | 2008-06-05 | 2009-12-10 | 주식회사 알앤엘바이오 | 바이러스 억제제로서 유용한 디아릴 헤파토노이드계 화합물 |
CN102112427A (zh) * | 2008-06-05 | 2011-06-29 | Rnl生物技术株式会社 | 新型二芳基庚酸类化合物及其使用 |
JP2011522038A (ja) * | 2008-06-05 | 2011-07-28 | アールエヌエル バイオ カンパニー リミテッド | ウイルス抑制剤として有用なトリテルペノイド系化合物 |
US8426370B2 (en) | 2008-06-05 | 2013-04-23 | Rnl Bio Co., Ltd. | Diaryl hepatonoid-based compounds and use thereof |
KR20220071570A (ko) * | 2020-11-24 | 2022-05-31 | 동의과학대학교산학협력단 | 소독제 겸용 해충 기피제 조성물, 이의 제작 방법 및 이에 의해 제작된 소독제 겸용 해충 기피제 |
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2007
- 2007-02-06 KR KR1020070012216A patent/KR100769050B1/ko active IP Right Grant
Non-Patent Citations (1)
Title |
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해당 상항 없음. |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009075488A3 (en) * | 2007-12-11 | 2009-08-06 | Rnl Bio Co Ltd | Anti-influenza viral composition containing bark or stem extract of alnus japonica |
KR100923884B1 (ko) * | 2007-12-11 | 2009-10-28 | 주식회사 알앤엘바이오 | 항인플루엔자 바이러스 활성이 높은 오리나무 수피 또는줄기 추출물의 제조방법 |
US8470378B2 (en) | 2007-12-11 | 2013-06-25 | Rnl Bio Co., Ltd | Anti-influenza viral composition containing bark or stem extract of Alnus japonica |
JP2011522038A (ja) * | 2008-06-05 | 2011-07-28 | アールエヌエル バイオ カンパニー リミテッド | ウイルス抑制剤として有用なトリテルペノイド系化合物 |
KR100950428B1 (ko) * | 2008-06-05 | 2010-04-02 | 주식회사 알앤엘바이오 | 바이러스 억제제로서 유용한 디아릴헵타노이드계 화합물 |
CN102112427A (zh) * | 2008-06-05 | 2011-06-29 | Rnl生物技术株式会社 | 新型二芳基庚酸类化合物及其使用 |
WO2009148280A3 (ko) * | 2008-06-05 | 2010-03-04 | 주식회사 알앤엘바이오 | 바이러스 억제제로서 유용한 디아릴 헤파토노이드계 화합물 |
JP2011522039A (ja) * | 2008-06-05 | 2011-07-28 | アールエヌエル バイオ カンパニー リミテッド | ウイルス抑制剤として有用なジアリールヘパトノイド系化合物 |
JP2011523660A (ja) * | 2008-06-05 | 2011-08-18 | アールエヌエル バイオ カンパニー リミテッド | 新規ジアリールヘパトノイド系化合物及びその用途 |
US8426370B2 (en) | 2008-06-05 | 2013-04-23 | Rnl Bio Co., Ltd. | Diaryl hepatonoid-based compounds and use thereof |
WO2009148280A2 (ko) * | 2008-06-05 | 2009-12-10 | 주식회사 알앤엘바이오 | 바이러스 억제제로서 유용한 디아릴 헤파토노이드계 화합물 |
KR20220071570A (ko) * | 2020-11-24 | 2022-05-31 | 동의과학대학교산학협력단 | 소독제 겸용 해충 기피제 조성물, 이의 제작 방법 및 이에 의해 제작된 소독제 겸용 해충 기피제 |
KR102511332B1 (ko) | 2020-11-24 | 2023-03-16 | 동의과학대학교산학협력단 | 소독제 겸용 해충 기피제 조성물, 이의 제작 방법 및 이에 의해 제작된 소독제 겸용 해충 기피제 |
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