WO2009148280A3 - 바이러스 억제제로서 유용한 디아릴 헤파토노이드계 화합물 - Google Patents

바이러스 억제제로서 유용한 디아릴 헤파토노이드계 화합물 Download PDF

Info

Publication number
WO2009148280A3
WO2009148280A3 PCT/KR2009/002995 KR2009002995W WO2009148280A3 WO 2009148280 A3 WO2009148280 A3 WO 2009148280A3 KR 2009002995 W KR2009002995 W KR 2009002995W WO 2009148280 A3 WO2009148280 A3 WO 2009148280A3
Authority
WO
WIPO (PCT)
Prior art keywords
based compound
compound useful
virus inhibitor
diaryl hepatonoid
hepatonoid
Prior art date
Application number
PCT/KR2009/002995
Other languages
English (en)
French (fr)
Other versions
WO2009148280A2 (ko
Inventor
라정찬
김영호
권혁준
윈후퉁
Original Assignee
주식회사 알앤엘바이오
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 알앤엘바이오 filed Critical 주식회사 알앤엘바이오
Priority to JP2011512384A priority Critical patent/JP2011522039A/ja
Priority to US12/996,302 priority patent/US20110105738A1/en
Priority to CN200980130299XA priority patent/CN102112119B/zh
Publication of WO2009148280A2 publication Critical patent/WO2009148280A2/ko
Publication of WO2009148280A3 publication Critical patent/WO2009148280A3/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

본 발명은 바이러스 활성 억제를 위한, 하기 화학식(1)의 디아릴 헤파토노이드계(diaryl hepatonoid) 화합물의 용도에 관한 것이다. 본 발명에 따른 디아릴 헤파토노이드계(diaryl hepatonoid) 화합물은 바이러스 활성 억제 효능이 우수하므로 바이러스와 관련된 질환에 대한 치료제로서 유용하게 사용될 수 있다.
PCT/KR2009/002995 2008-06-05 2009-06-04 바이러스 억제제로서 유용한 디아릴 헤파토노이드계 화합물 WO2009148280A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2011512384A JP2011522039A (ja) 2008-06-05 2009-06-04 ウイルス抑制剤として有用なジアリールヘパトノイド系化合物
US12/996,302 US20110105738A1 (en) 2008-06-05 2009-06-04 Diaryl hepatonoid-based compounds useful as virus inhibitors
CN200980130299XA CN102112119B (zh) 2008-06-05 2009-06-04 用作病毒抑制剂的二芳基庚酮类化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0052842 2008-06-05
KR20080052842 2008-06-05

Publications (2)

Publication Number Publication Date
WO2009148280A2 WO2009148280A2 (ko) 2009-12-10
WO2009148280A3 true WO2009148280A3 (ko) 2010-03-04

Family

ID=41398686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/002995 WO2009148280A2 (ko) 2008-06-05 2009-06-04 바이러스 억제제로서 유용한 디아릴 헤파토노이드계 화합물

Country Status (5)

Country Link
US (1) US20110105738A1 (ko)
JP (1) JP2011522039A (ko)
KR (1) KR100950428B1 (ko)
CN (1) CN102112119B (ko)
WO (1) WO2009148280A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100987303B1 (ko) * 2009-12-14 2010-10-12 주식회사 알앤엘바이오 오리나무 유래 디아릴헵타노이드계 화합물을 포함하는 항산화 및 간보호용 조성물
ES2392938T3 (es) 2010-03-26 2012-12-17 Cesa Alliance S.A. Composiciones antivirales que comprenden geraniol y carvona
KR102068612B1 (ko) * 2018-04-23 2020-01-21 경북대학교 산학협력단 플라티필론을 포함하는 아토피 피부염의 예방 또는 치료용 조성물
KR102424758B1 (ko) * 2020-08-11 2022-07-26 숙명여자대학교산학협력단 오리나무 추출물을 함유하는 골격근 근육관련 질환의 예방 및 치료용 조성물
CN112480191A (zh) * 2020-11-30 2021-03-12 广西师范大学 一种米杨噎苷a和b单体的分离纯化方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050215635A1 (en) * 2004-03-08 2005-09-29 Rafi M Mohamed Diarylheptanoid compounds and uses thereof
KR100629314B1 (ko) * 2004-03-03 2006-09-29 한국생명공학연구원 오리나무 추출물 또는 그로부터 분리된 디아릴헵타노이드계 화합물을 유효성분으로 하는 심장순환계질환의 예방 및 치료용 조성물
KR100721703B1 (ko) * 2006-06-29 2007-05-25 주식회사 알앤엘바이오 오리나무 추출물을 함유하는 항바이러스 조성물
KR100769050B1 (ko) * 2007-02-06 2007-10-22 주식회사 알앤엘바이오 오리나무 추출물을 함유하는 항바이러스 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100629314B1 (ko) * 2004-03-03 2006-09-29 한국생명공학연구원 오리나무 추출물 또는 그로부터 분리된 디아릴헵타노이드계 화합물을 유효성분으로 하는 심장순환계질환의 예방 및 치료용 조성물
US20050215635A1 (en) * 2004-03-08 2005-09-29 Rafi M Mohamed Diarylheptanoid compounds and uses thereof
KR100721703B1 (ko) * 2006-06-29 2007-05-25 주식회사 알앤엘바이오 오리나무 추출물을 함유하는 항바이러스 조성물
KR100769050B1 (ko) * 2007-02-06 2007-10-22 주식회사 알앤엘바이오 오리나무 추출물을 함유하는 항바이러스 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HYUN WOO LIM ET AL., KOREAN JOURNAL OF PHARMACOGNOSY, vol. 35, no. 4, 2004, pages 384 - 387 *
JAE-HEE LEE ET AL., KOREAN JOURNAL OF PHARMACOGNOSY, vol. 34, no. 2, 2003, pages 190 - 192 *

Also Published As

Publication number Publication date
WO2009148280A2 (ko) 2009-12-10
US20110105738A1 (en) 2011-05-05
KR100950428B1 (ko) 2010-04-02
JP2011522039A (ja) 2011-07-28
KR20090127071A (ko) 2009-12-09
CN102112119A (zh) 2011-06-29
CN102112119B (zh) 2013-05-29

Similar Documents

Publication Publication Date Title
WO2009126863A3 (en) Pyridyl inhibitors of hedgehog signalling
WO2007085895A3 (en) Fap inhibitors
WO2009051670A3 (en) Oxylipin compounds for the treatment of ophthalmic conditions
WO2009156462A3 (en) Organic compounds
WO2007139992A3 (en) ALDOSTERONE SYNTHASE AND/OR 11β-HYDROXYLASE INHIBITORS
WO2006113942A3 (en) Method of inhibiting cathepsin activity
WO2009152356A3 (en) Compounds and compositions useful for the treatment of malaria
WO2012019426A8 (zh) 酞嗪酮类衍生物、其制备方法及其在医药上的应用
WO2008011131A3 (en) Amide compounds
WO2010042163A3 (en) Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and sirt1, and methods of treating disorders
WO2009026179A3 (en) Antiinfective proanthocyanidin compounds and methods of use thereof
WO2010057101A3 (en) Compounds useful as hiv blockers
WO2008013838A3 (en) Pyridizinone derivatives
WO2006127379A3 (en) Par2-modulating compounds and their use
WO2012019430A8 (zh) 酞嗪酮类衍生物、其制备方法及其在医药上的应用
WO2010144378A3 (en) Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds
WO2008022024A3 (en) Imidazole amines as inhibitors of beta-secretase
MX2009006481A (es) Derivados de imidazol 1-sustituidos, y su uso como inhibidores de la sintasa de aldosterona.
MX2009003834A (es) Derivados de pirrolidina como inhibidores de iap.
WO2008084223A3 (en) Chemical compounds 637: pyridopyrimidinediones as pde4 inhibitors
WO2009135179A3 (en) The use of solid carrier particles to improve the processability of a pharmaceutical agent
WO2007133865A3 (en) Hcv/hiv inhibitors an their uses
WO2009148279A3 (ko) 바이러스 억제제로서 유용한 트리테르페노이드계 화합물
WO2012046030A3 (en) Phosphodiesterase inhibitors
WO2005085236A3 (en) Caspase inhibitors and uses thereof

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200980130299.X

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09758533

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2011512384

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 12996302

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 09758533

Country of ref document: EP

Kind code of ref document: A2