WO2012019430A8 - 酞嗪酮类衍生物、其制备方法及其在医药上的应用 - Google Patents

酞嗪酮类衍生物、其制备方法及其在医药上的应用 Download PDF

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Publication number
WO2012019430A8
WO2012019430A8 PCT/CN2011/001268 CN2011001268W WO2012019430A8 WO 2012019430 A8 WO2012019430 A8 WO 2012019430A8 CN 2011001268 W CN2011001268 W CN 2011001268W WO 2012019430 A8 WO2012019430 A8 WO 2012019430A8
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WO
WIPO (PCT)
Prior art keywords
preparation
pharmaceutical use
phthalazinone derivative
derivative
phthalazinone
Prior art date
Application number
PCT/CN2011/001268
Other languages
English (en)
French (fr)
Other versions
WO2012019430A1 (zh
Inventor
邓炳初
张学军
李晓涛
朱耀平
杨斌斌
Original Assignee
上海恒瑞医药有限公司
江苏恒瑞医药股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 上海恒瑞医药有限公司, 江苏恒瑞医药股份有限公司 filed Critical 上海恒瑞医药有限公司
Priority to CN201180004612.2A priority Critical patent/CN102762549B/zh
Priority to TW100141560A priority patent/TW201307349A/zh
Publication of WO2012019430A1 publication Critical patent/WO2012019430A1/zh
Publication of WO2012019430A8 publication Critical patent/WO2012019430A8/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/CN2011/001268 2010-08-10 2011-08-02 酞嗪酮类衍生物、其制备方法及其在医药上的应用 WO2012019430A1 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201180004612.2A CN102762549B (zh) 2010-08-10 2011-08-02 酞嗪酮类衍生物、其制备方法及其在医药上的应用
TW100141560A TW201307349A (zh) 2011-08-02 2011-11-15 酞嗪酮類衍生物、其製備方法及其在醫藥上的應用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2010102496361A CN102372698A (zh) 2010-08-10 2010-08-10 酞嗪酮类衍生物、其制备方法及其在医药上的应用
CN201010249636.1 2010-08-10

Publications (2)

Publication Number Publication Date
WO2012019430A1 WO2012019430A1 (zh) 2012-02-16
WO2012019430A8 true WO2012019430A8 (zh) 2012-05-10

Family

ID=45567317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2011/001268 WO2012019430A1 (zh) 2010-08-10 2011-08-02 酞嗪酮类衍生物、其制备方法及其在医药上的应用

Country Status (2)

Country Link
CN (2) CN102372698A (zh)
WO (1) WO2012019430A1 (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102766135B (zh) * 2012-07-09 2017-05-03 云南大学 二氢呋喃并茚烷‑咪唑盐类化合物及其制备方法
CN103724352B (zh) * 2012-10-16 2017-11-28 江苏盛迪医药有限公司 一种dpp‑iv抑制剂的中间体、其制备方法和通过其制备dpp‑iv抑制剂的方法
MA38080A1 (fr) * 2012-12-31 2018-02-28 Cadila Healthcare Ltd Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1
CA2905751A1 (en) 2013-03-13 2014-10-09 Forma Therapeutics, Inc. Novel compounds and compositions for inhibition of fasn
KR101670126B1 (ko) 2013-09-13 2016-10-27 일동제약(주) 신규 프탈라지논 유도체 및 그 제조방법
US10487123B2 (en) 2014-10-16 2019-11-26 Monsanto Technology Llc Chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests
MA45918A (fr) 2016-08-15 2019-06-19 Bayer Ag Dérivés hétérocycliques bicycliques condensés utilisés comme pesticides
CN110087730B (zh) * 2016-09-27 2023-03-28 百济神州(苏州)生物科技有限公司 使用包含parp抑制剂的组合产品治疗癌症
CN108727391A (zh) * 2017-04-21 2018-11-02 上海迪诺医药科技有限公司 Parp抑制剂化合物非晶形及其制备方法和应用
WO2018192576A1 (zh) * 2017-04-21 2018-10-25 上海迪诺医药科技有限公司 Parp抑制化合物的制备方法、其中间体、非晶形、溶剂合物、药物组合物及应用
WO2019002344A1 (en) 2017-06-29 2019-01-03 Lonza Guangzhou Nansha Ltd. PROCESS FOR THE PREPARATION OF ALPHA-METHYL-L-PROLINE
CN108341792B (zh) * 2018-04-28 2021-09-17 苏州莱克施德药业有限公司 一种Volasertib中间体1-环丙基甲基哌嗪的制备方法
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
WO2020092395A1 (en) 2018-10-29 2020-05-07 Forma Therapeutics, Inc. SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE
MX2021005764A (es) 2018-11-16 2021-10-01 Jiangsu Hengrui Medicine Co Composición farmacéutica que comprende inhibidores de poli (adenosina difosfato (adp)-ribosa) polimerasas (parp).
CN111138335B (zh) * 2020-01-14 2021-10-01 山东四环药业股份有限公司 一种光学活性2-甲基脯氨酸的制备方法
CN115702151A (zh) 2020-04-21 2023-02-14 伊迪恩斯股份有限公司 酞嗪酮化合物的结晶形式
CN111606842A (zh) * 2020-05-27 2020-09-01 安徽中羰碳一工业技术有限责任公司 一种2-（4-哌啶基）-2-丙醇及其盐酸盐的制备方法
CN114685374B (zh) * 2020-12-28 2024-04-12 山东道合药业有限公司 一种合成奥拉帕尼的新工艺
CN112679411B (zh) * 2020-12-31 2022-04-01 上海再启生物技术有限公司 一种手性5-(甲胺基)六氢环戊并[c]吡咯-2(1H)-Boc甲磺酸盐的制备方法
CN112624981B (zh) * 2021-03-09 2021-05-25 南京桦冠生物技术有限公司 一种2-氟-5-[(4-氧代-3h-2,3-二氮杂萘基)甲基]苯甲酸的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
EP1953147A1 (en) * 2005-11-21 2008-08-06 Japan Tobacco, Inc. Heterocyclic compound and medicinal application thereof
TW200900396A (en) * 2007-04-10 2009-01-01 Kudos Pharm Ltd Phthalazinone derivatives
US20090023727A1 (en) * 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives

Also Published As

Publication number Publication date
CN102762549B (zh) 2015-05-27
CN102372698A (zh) 2012-03-14
CN102762549A (zh) 2012-10-31
WO2012019430A1 (zh) 2012-02-16

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