KR100701114B1 - 푸린 유도체 및 이를 위한 중간체를 제조하는 방법 - Google Patents

푸린 유도체 및 이를 위한 중간체를 제조하는 방법 Download PDF

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Publication number
KR100701114B1
KR100701114B1 KR1020007010707A KR20007010707A KR100701114B1 KR 100701114 B1 KR100701114 B1 KR 100701114B1 KR 1020007010707 A KR1020007010707 A KR 1020007010707A KR 20007010707 A KR20007010707 A KR 20007010707A KR 100701114 B1 KR100701114 B1 KR 100701114B1
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KR
South Korea
Prior art keywords
formula
compound
alkyl
iii
palladium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020007010707A
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English (en)
Korean (ko)
Other versions
KR20010034702A (ko
Inventor
리차드 프리어
그레이암 리차드 기인
토마스 웨어 람세이
앤드류 콜린 쉐어
네일 마이클 스미쓰
Original Assignee
노파르티스 인터내셔널 파마슈티칼 리미티드
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Application filed by 노파르티스 인터내셔널 파마슈티칼 리미티드 filed Critical 노파르티스 인터내셔널 파마슈티칼 리미티드
Publication of KR20010034702A publication Critical patent/KR20010034702A/ko
Application granted granted Critical
Publication of KR100701114B1 publication Critical patent/KR100701114B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
KR1020007010707A 1998-04-02 1999-03-30 푸린 유도체 및 이를 위한 중간체를 제조하는 방법 Expired - Fee Related KR100701114B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9807114.5A GB9807114D0 (en) 1998-04-02 1998-04-02 Novel process
GB9807114.5 1998-04-02

Publications (2)

Publication Number Publication Date
KR20010034702A KR20010034702A (ko) 2001-04-25
KR100701114B1 true KR100701114B1 (ko) 2007-03-29

Family

ID=10829763

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007010707A Expired - Fee Related KR100701114B1 (ko) 1998-04-02 1999-03-30 푸린 유도체 및 이를 위한 중간체를 제조하는 방법

Country Status (15)

Country Link
US (2) US6555685B1 (https=)
EP (1) EP1068209B1 (https=)
JP (1) JP4524040B2 (https=)
KR (1) KR100701114B1 (https=)
CN (1) CN1153769C (https=)
AT (1) ATE304541T1 (https=)
AU (1) AU3420099A (https=)
BR (1) BR9908964A (https=)
CA (1) CA2322583A1 (https=)
DE (1) DE69927251T2 (https=)
DK (1) DK1068209T3 (https=)
ES (1) ES2247793T3 (https=)
GB (1) GB9807114D0 (https=)
IL (1) IL138288A (https=)
WO (1) WO1999051603A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60202245T2 (de) 2001-08-30 2005-09-01 Ajinomoto Co., Inc. Herstellungsmethode von Famciclovir und Herstellungs- bzw. Kristallisationsmethode eines entsprechenden Intermediates
AU2003268213A1 (en) * 2002-08-26 2004-03-11 Teva Pharmaceutical Industries Ltd. Crystalline solid famciclovir forms i, ii, iii and preparation thereof
CA2522573A1 (en) * 2003-04-30 2004-11-18 Teva Pharmaceutical Industries Ltd. Process for the preparation of famciclovir
EP1556383A1 (en) * 2003-09-04 2005-07-27 Teva Pharmaceutical Industries Ltd. Process for preparing famciclovir
WO2005103025A1 (en) * 2004-04-21 2005-11-03 Novogen Research Pty Ltd Isoflavene synthetic method and catalyst
GB2426247A (en) * 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
DK2609083T3 (da) 2010-08-27 2015-03-30 Gruenenthal Gmbh Substituerede 2-oxy-quinolin-3-carboxamider som KCNQ2/3 modulatorer
SI2609086T1 (sl) 2010-08-27 2015-04-30 Gruenenthal Gmbh Substituirani 2-okso in 2-tiokso-dihidrokinolin-3-karboksamidi kot KCNQ2/3 modulatorji
TW201211007A (en) 2010-08-27 2012-03-16 Gruenenthal Gmbh Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
MX2013002295A (es) 2010-09-01 2013-05-09 Gruenenthal Gmbh 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
CN102070636B (zh) * 2011-01-17 2012-05-23 浙江大学 喷昔洛韦的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73682A (en) 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
JPH06279443A (ja) * 1993-01-27 1994-10-04 Asahi Chem Ind Co Ltd ６’−ホモネプラノシンａ誘導体およびその製造法
GB9407698D0 (en) * 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals

Also Published As

Publication number Publication date
JP2002510691A (ja) 2002-04-09
IL138288A (en) 2005-07-25
CN1153769C (zh) 2004-06-16
US20030130512A1 (en) 2003-07-10
DE69927251D1 (de) 2005-10-20
GB9807114D0 (en) 1998-06-03
ATE304541T1 (de) 2005-09-15
US6555685B1 (en) 2003-04-29
US6806375B2 (en) 2004-10-19
CN1294589A (zh) 2001-05-09
WO1999051603A1 (en) 1999-10-14
ES2247793T3 (es) 2006-03-01
EP1068209B1 (en) 2005-09-14
DK1068209T3 (da) 2005-11-14
BR9908964A (pt) 2000-12-05
IL138288A0 (en) 2001-10-31
CA2322583A1 (en) 1999-10-14
AU3420099A (en) 1999-10-25
EP1068209A1 (en) 2001-01-17
JP4524040B2 (ja) 2010-08-11
KR20010034702A (ko) 2001-04-25
DE69927251T2 (de) 2006-06-29
HK1034512A1 (en) 2001-10-26

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