DE69927251T2 - Verfahren zur herstellung von purinderivaten und dessen zwischenprodukte - Google Patents

Verfahren zur herstellung von purinderivaten und dessen zwischenprodukte Download PDF

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Publication number
DE69927251T2
DE69927251T2 DE69927251T DE69927251T DE69927251T2 DE 69927251 T2 DE69927251 T2 DE 69927251T2 DE 69927251 T DE69927251 T DE 69927251T DE 69927251 T DE69927251 T DE 69927251T DE 69927251 T2 DE69927251 T2 DE 69927251T2
Authority
DE
Germany
Prior art keywords
formula
compound
alkyl
palladium
catalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69927251T
Other languages
German (de)
English (en)
Other versions
DE69927251D1 (de
Inventor
Richard Harlow FREER
Graham Richard Harlow GEEN
Thomas Weir Harlow RAMSAY
Andrew Colin Tonbridge SHARE
Neil Michael Harlow SMITH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis International Pharmaceutical Ltd
Original Assignee
Novartis International Pharmaceutical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis International Pharmaceutical Ltd filed Critical Novartis International Pharmaceutical Ltd
Publication of DE69927251D1 publication Critical patent/DE69927251D1/de
Application granted granted Critical
Publication of DE69927251T2 publication Critical patent/DE69927251T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DE69927251T 1998-04-02 1999-03-30 Verfahren zur herstellung von purinderivaten und dessen zwischenprodukte Expired - Fee Related DE69927251T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9807114.5A GB9807114D0 (en) 1998-04-02 1998-04-02 Novel process
GB9807114 1998-04-02
PCT/EP1999/002308 WO1999051603A1 (en) 1998-04-02 1999-03-30 Process for the production of purine derivatives and intermediates therefor

Publications (2)

Publication Number Publication Date
DE69927251D1 DE69927251D1 (de) 2005-10-20
DE69927251T2 true DE69927251T2 (de) 2006-06-29

Family

ID=10829763

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69927251T Expired - Fee Related DE69927251T2 (de) 1998-04-02 1999-03-30 Verfahren zur herstellung von purinderivaten und dessen zwischenprodukte

Country Status (15)

Country Link
US (2) US6555685B1 (https=)
EP (1) EP1068209B1 (https=)
JP (1) JP4524040B2 (https=)
KR (1) KR100701114B1 (https=)
CN (1) CN1153769C (https=)
AT (1) ATE304541T1 (https=)
AU (1) AU3420099A (https=)
BR (1) BR9908964A (https=)
CA (1) CA2322583A1 (https=)
DE (1) DE69927251T2 (https=)
DK (1) DK1068209T3 (https=)
ES (1) ES2247793T3 (https=)
GB (1) GB9807114D0 (https=)
IL (1) IL138288A (https=)
WO (1) WO1999051603A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60202245T2 (de) 2001-08-30 2005-09-01 Ajinomoto Co., Inc. Herstellungsmethode von Famciclovir und Herstellungs- bzw. Kristallisationsmethode eines entsprechenden Intermediates
AU2003268213A1 (en) * 2002-08-26 2004-03-11 Teva Pharmaceutical Industries Ltd. Crystalline solid famciclovir forms i, ii, iii and preparation thereof
CA2522573A1 (en) * 2003-04-30 2004-11-18 Teva Pharmaceutical Industries Ltd. Process for the preparation of famciclovir
EP1556383A1 (en) * 2003-09-04 2005-07-27 Teva Pharmaceutical Industries Ltd. Process for preparing famciclovir
WO2005103025A1 (en) * 2004-04-21 2005-11-03 Novogen Research Pty Ltd Isoflavene synthetic method and catalyst
GB2426247A (en) * 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
DK2609083T3 (da) 2010-08-27 2015-03-30 Gruenenthal Gmbh Substituerede 2-oxy-quinolin-3-carboxamider som KCNQ2/3 modulatorer
SI2609086T1 (sl) 2010-08-27 2015-04-30 Gruenenthal Gmbh Substituirani 2-okso in 2-tiokso-dihidrokinolin-3-karboksamidi kot KCNQ2/3 modulatorji
TW201211007A (en) 2010-08-27 2012-03-16 Gruenenthal Gmbh Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
MX2013002295A (es) 2010-09-01 2013-05-09 Gruenenthal Gmbh 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
CN102070636B (zh) * 2011-01-17 2012-05-23 浙江大学 喷昔洛韦的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73682A (en) 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
JPH06279443A (ja) * 1993-01-27 1994-10-04 Asahi Chem Ind Co Ltd ６’−ホモネプラノシンａ誘導体およびその製造法
GB9407698D0 (en) * 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals

Also Published As

Publication number Publication date
JP2002510691A (ja) 2002-04-09
IL138288A (en) 2005-07-25
CN1153769C (zh) 2004-06-16
US20030130512A1 (en) 2003-07-10
DE69927251D1 (de) 2005-10-20
GB9807114D0 (en) 1998-06-03
ATE304541T1 (de) 2005-09-15
US6555685B1 (en) 2003-04-29
US6806375B2 (en) 2004-10-19
CN1294589A (zh) 2001-05-09
WO1999051603A1 (en) 1999-10-14
ES2247793T3 (es) 2006-03-01
EP1068209B1 (en) 2005-09-14
DK1068209T3 (da) 2005-11-14
BR9908964A (pt) 2000-12-05
KR100701114B1 (ko) 2007-03-29
IL138288A0 (en) 2001-10-31
CA2322583A1 (en) 1999-10-14
AU3420099A (en) 1999-10-25
EP1068209A1 (en) 2001-01-17
JP4524040B2 (ja) 2010-08-11
KR20010034702A (ko) 2001-04-25
HK1034512A1 (en) 2001-10-26

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