KR100689943B1 - 당뇨병 치료용 ＦＢＰａｓｅ 억제제 및 인슐린 증감제의조합물 - Google Patents

당뇨병 치료용 ＦＢＰａｓｅ 억제제 및 인슐린 증감제의조합물 Download PDF

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Publication number
KR100689943B1
KR100689943B1 KR1020017008102A KR20017008102A KR100689943B1 KR 100689943 B1 KR100689943 B1 KR 100689943B1 KR 1020017008102 A KR1020017008102 A KR 1020017008102A KR 20017008102 A KR20017008102 A KR 20017008102A KR 100689943 B1 KR100689943 B1 KR 100689943B1
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South Korea
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group
alkyl
substituted
aryl
pharmaceutical composition
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English (en)
Korean (ko)
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KR20010099942A (ko
Inventor
마크 디. 에리온
폴 반포엘제
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메타베이시스 테라퓨틱스, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020017008102A 1998-12-24 1999-12-22 당뇨병 치료용 ＦＢＰａｓｅ 억제제 및 인슐린 증감제의조합물 Expired - Fee Related KR100689943B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11471898P 1998-12-24 1998-12-24
US60/114,718 1998-12-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020067022095A Division KR20060114724A (ko) 1998-12-24 1999-12-22 당뇨병 치료용 ＦＢＰａｓｅ 억제제 및 인슐린 증감제의조합물

Publications (2)

Publication Number Publication Date
KR20010099942A KR20010099942A (ko) 2001-11-09
KR100689943B1 true KR100689943B1 (ko) 2007-03-08

Family

ID=22357016

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020017008102A Expired - Fee Related KR100689943B1 (ko) 1998-12-24 1999-12-22 당뇨병 치료용 ＦＢＰａｓｅ 억제제 및 인슐린 증감제의조합물
KR1020077008649A Ceased KR20070046210A (ko) 1998-12-24 1999-12-22 당뇨병 치료용 ＦＢＰａｓｅ 억제제 및 인슐린 증감제의조합물
KR1020067022095A Ceased KR20060114724A (ko) 1998-12-24 1999-12-22 당뇨병 치료용 ＦＢＰａｓｅ 억제제 및 인슐린 증감제의조합물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020077008649A Ceased KR20070046210A (ko) 1998-12-24 1999-12-22 당뇨병 치료용 ＦＢＰａｓｅ 억제제 및 인슐린 증감제의조합물
KR1020067022095A Ceased KR20060114724A (ko) 1998-12-24 1999-12-22 당뇨병 치료용 ＦＢＰａｓｅ 억제제 및 인슐린 증감제의조합물

Country Status (25)

Country Link
EP (1) EP1143955B1 (enExample)
JP (1) JP2003515523A (enExample)
KR (3) KR100689943B1 (enExample)
CN (3) CN100352505C (enExample)
AT (1) ATE300288T1 (enExample)
AU (1) AU771039B2 (enExample)
BR (1) BR9917005A (enExample)
CA (1) CA2354053A1 (enExample)
CZ (1) CZ20012353A3 (enExample)
DE (1) DE69926400T2 (enExample)
DK (1) DK1143955T3 (enExample)
ES (1) ES2246586T3 (enExample)
HK (1) HK1046863B (enExample)
HU (1) HUP0402506A3 (enExample)
ID (1) ID30237A (enExample)
IL (2) IL143569A0 (enExample)
MX (1) MXPA01006511A (enExample)
NO (1) NO20013115L (enExample)
NZ (1) NZ512219A (enExample)
PL (1) PL352756A1 (enExample)
PT (1) PT1143955E (enExample)
RU (2) RU2227749C2 (enExample)
SK (1) SK9172001A3 (enExample)
WO (1) WO2000038666A2 (enExample)
ZA (1) ZA200105016B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014099804A1 (en) 2012-12-18 2014-06-26 Huntair, Inc. Air filter assembly

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039344A1 (en) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
CZ297264B6 (cs) 1998-09-09 2006-10-11 Metabasis Therapeutics, Inc. Nové heteroaromatické inhibitory fruktóza-1,6-bisfosfatázy
CN1740182A (zh) * 1999-12-22 2006-03-01 症变治疗公司 新的双氨基化膦酸酯前药
EP1607401A1 (en) * 2000-03-08 2005-12-21 Metabasis Therapeutics, Inc. Novel aryl fructose-1,6-Bisphosphatase inhibitors
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
CN101301294A (zh) * 2000-07-06 2008-11-12 症变治疗公司 Fbp酶抑制剂与抗糖尿病药联合用于治疗糖尿病
US7022725B2 (en) 2000-11-17 2006-04-04 Takeda Pharmaceutical Company Limited Isoxazole derivatives
AU2003235501A1 (en) 2002-05-13 2003-11-11 Metabasis Therapeutics, Inc. PMEA and PMPA cyclic producing synthesis
IL164809A0 (en) 2002-05-13 2005-12-18 Metabasis Therapeutics Inc Novel phosphonic acid basdrugs of pmea and its analogues
WO2004022083A1 (en) * 2002-09-04 2004-03-18 Dsm Ip Assets B.V. A nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction
UA80991C2 (en) 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
KR101166749B1 (ko) * 2003-02-11 2012-07-27 베르날리스(캠브리지)리미티드 열쇼크 단백질 저해제로서의 이소옥사졸 화합물
TWI349550B (en) 2003-12-26 2011-10-01 A thiazole derivative and adenosine a2a receptor antagonist containing the same
EP1778250A2 (en) * 2004-08-18 2007-05-02 Metabasis Therapeutics, Inc. Novel thiazole inhibitors of fructose 1,6-bisphosphatase
BRPI0519006A2 (pt) * 2004-12-13 2008-12-23 Daiichi Sankyo Co Ltd uso de um inibidor de fbpase, kit de uma composiÇço farmacÊutica, uso de uma preparaÇço de biguanida e um inibidor de fbpase, agente terapÊutico para diabetes melito, e, combinaÇço de agentes terapÊuticos
CN101115483A (zh) * 2004-12-15 2008-01-30 第一三共株式会社 含有FBPase抑制剂的药物组合物
WO2006126673A1 (ja) * 2005-05-27 2006-11-30 Daiichi Sankyo Company, Limited 組み合わせによる糖尿病治療薬
EP1894930A4 (en) 2005-06-23 2010-06-23 Kyowa Hakko Kirin Co Ltd THIAZOLE DERIVATIVE
WO2008057930A2 (en) 2006-11-02 2008-05-15 Aestus Therapeutics, Inc. Methods of treating neuropathic pain with retinoic acid receptor agonists
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
EP3623364A1 (en) 2014-02-13 2020-03-18 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CN105481896A (zh) * 2015-12-03 2016-04-13 浙江大学 一种地马格列的制备方法
CN113416739B (zh) * 2021-06-24 2022-04-19 黑龙江八一农垦大学 鲁氏酵母菌基因在提高微生物产hdmf的产量中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968790A (en) * 1988-08-12 1990-11-06 American Cyanamid Company Antidiabetic phosphates
JPH03157377A (ja) * 1988-11-18 1991-07-05 Takeda Chem Ind Ltd チオ尿素誘導体及びａｇｅ生成阻害剤
JPH03504728A (ja) * 1989-01-24 1991-10-17 ジェンシア・ファーマシュウティカルズ，インコーポレイテッド Ａｉｃａリボシドの放出および血液グルコースの低減のための化合物および方法
TW438587B (en) * 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US5859037A (en) * 1997-02-19 1999-01-12 Warner-Lambert Company Sulfonylurea-glitazone combinations for diabetes
AU6691798A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
DE69819311T2 (de) * 1997-03-07 2004-07-29 Metabasis Therapeutics Inc., San Diego Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase
WO1998039344A1 (en) * 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014099804A1 (en) 2012-12-18 2014-06-26 Huntair, Inc. Air filter assembly

Also Published As

Publication number Publication date
HK1046863A1 (zh) 2003-01-30
CN1714866A (zh) 2006-01-04
HUP0402506A2 (hu) 2005-04-28
PL352756A1 (en) 2003-09-08
NO20013115D0 (no) 2001-06-21
KR20070046210A (ko) 2007-05-02
IL143569A0 (en) 2002-04-21
CN101164618A (zh) 2008-04-23
EP1143955A3 (en) 2002-08-28
MXPA01006511A (es) 2004-03-19
KR20060114724A (ko) 2006-11-07
SK9172001A3 (en) 2002-04-04
JP2003515523A (ja) 2003-05-07
CZ20012353A3 (cs) 2001-12-12
HK1046863B (zh) 2008-07-25
ID30237A (id) 2001-11-15
IL143569A (en) 2006-06-11
BR9917005A (pt) 2002-04-02
PT1143955E (pt) 2005-11-30
ES2246586T3 (es) 2006-02-16
WO2000038666A2 (en) 2000-07-06
DK1143955T3 (da) 2005-11-14
HUP0402506A3 (en) 2007-05-29
NZ512219A (en) 2004-12-24
RU2227749C2 (ru) 2004-04-27
NO20013115L (no) 2001-08-24
EP1143955A2 (en) 2001-10-17
WO2000038666A3 (en) 2001-11-29
CA2354053A1 (en) 2000-07-06
ATE300288T1 (de) 2005-08-15
CN1350466A (zh) 2002-05-22
DE69926400T2 (de) 2006-05-24
AU771039B2 (en) 2004-03-11
DE69926400D1 (de) 2005-09-01
KR20010099942A (ko) 2001-11-09
CN100352505C (zh) 2007-12-05
RU2003132054A (ru) 2005-04-20
ZA200105016B (en) 2002-09-19
AU2058300A (en) 2000-07-31
EP1143955B1 (en) 2005-07-27

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