KR100683374B1 - 백신의 제조 - Google Patents

백신의 제조 Download PDF

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KR100683374B1
KR100683374B1 KR1020027006678A KR20027006678A KR100683374B1 KR 100683374 B1 KR100683374 B1 KR 100683374B1 KR 1020027006678 A KR1020027006678 A KR 1020027006678A KR 20027006678 A KR20027006678 A KR 20027006678A KR 100683374 B1 KR100683374 B1 KR 100683374B1
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virus
cells
cell
per
human
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KR20020064910A (ko
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마리아 그라지아 파우
알폰수스 게라르두스 코넬리스 마리아 우이트덴하그
고베르트 요한 스코우텐
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크루셀 홀란드 비.브이.
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    • C12N2760/16011Orthomyxoviridae
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020027006678A 1999-11-26 2000-11-24 백신의 제조 Expired - Lifetime KR100683374B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99203983.4 1999-11-26
EP99203983A EP1103610A1 (en) 1999-11-26 1999-11-26 Production of vaccines from immortalised mammalian cell lines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020067020200A Division KR20060107868A (ko) 1999-11-26 2000-11-24 인플루엔자 바이러스 농축방법

Publications (2)

Publication Number Publication Date
KR20020064910A KR20020064910A (ko) 2002-08-10
KR100683374B1 true KR100683374B1 (ko) 2007-02-15

Family

ID=8240914

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020027006678A Expired - Lifetime KR100683374B1 (ko) 1999-11-26 2000-11-24 백신의 제조
KR1020067020200A Abandoned KR20060107868A (ko) 1999-11-26 2000-11-24 인플루엔자 바이러스 농축방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020067020200A Abandoned KR20060107868A (ko) 1999-11-26 2000-11-24 인플루엔자 바이러스 농축방법

Country Status (20)

Country Link
EP (3) EP1103610A1 (https=)
JP (1) JP4331432B2 (https=)
KR (2) KR100683374B1 (https=)
CN (1) CN1306033C (https=)
AT (1) ATE286537T1 (https=)
AU (2) AU775966B2 (https=)
BR (1) BR0015846A (https=)
CA (1) CA2392653C (https=)
DE (1) DE60017234T3 (https=)
DK (1) DK1108787T4 (https=)
EA (1) EA006136B1 (https=)
ES (1) ES2235770T5 (https=)
IL (2) IL149788A0 (https=)
MX (1) MXPA02005237A (https=)
NO (1) NO333527B1 (https=)
NZ (1) NZ527942A (https=)
PT (1) PT1108787E (https=)
SI (1) SI1108787T2 (https=)
WO (1) WO2001038362A2 (https=)
ZA (1) ZA200204078B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200015323A (ko) 2018-08-03 2020-02-12 에릭스바이오(주) 바이러스 치료 장치 또는 백신 제조 장치

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL160406A0 (en) 1995-06-15 2004-07-25 Crucell Holland Bv A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products
US7297680B2 (en) 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
US6855544B1 (en) 1999-04-15 2005-02-15 Crucell Holland B.V. Recombinant protein production in a human cell
US7604960B2 (en) 1999-04-15 2009-10-20 Crucell Holland B.V. Transient protein expression methods
US8236561B2 (en) 1999-04-15 2012-08-07 Crucell Holland B.V. Efficient production of IgA in recombinant mammalian cells
US7192759B1 (en) 1999-11-26 2007-03-20 Crucell Holland B.V. Production of vaccines
US7425437B2 (en) 1999-11-26 2008-09-16 Crucell Holland B.V. Vaccines against West Nile Virus
US7527961B2 (en) 1999-11-26 2009-05-05 Crucell Holland B.V. Production of vaccines
US7521220B2 (en) * 1999-11-26 2009-04-21 Crucell Holland B.V. Production of vaccines
US8715922B2 (en) 2001-01-19 2014-05-06 ViroNovative Virus causing respiratory tract illness in susceptible mammals
KR20040002853A (ko) 2001-01-19 2004-01-07 비로노바티브 비.브이. 감응성 포유류에서 호흡계 질환을 유발하는 바이러스
EP1256803A1 (en) 2001-05-07 2002-11-13 Crucell Holland B.V. Methods for the identification of antiviral compounds
PT1465987E (pt) 2001-12-07 2008-04-15 Crucell Holland Bv Produção de vírus, isolados virais e vacinas
AU2002225509A1 (en) * 2001-12-07 2003-06-17 Crucell Holland B.V. Production and of viruses, viral isolates and vaccines
DK1456238T3 (da) 2001-12-17 2008-08-18 Crucell Holland Bv Produktion af F(ab')2-fragmenter i pattedyrceller
EP1485468A4 (en) 2002-02-21 2007-01-03 Medimmune Vaccines Inc RECOMBINANT PARAIN FLUENZAVIRUS EXPRESSION SYSTEMS AND VACCINES WITH ANTIGENS FROM METAPNEUMOVIRUS STEM-RELATED HETEROLOGISTS
EP1497440B1 (en) 2002-04-25 2008-08-20 Crucell Holland B.V. Stable adenoviral vectors and methods for propagation thereof
DE60330795D1 (de) * 2002-11-08 2010-02-11 Crucell Holland Bv Impfstoff gegen west nile virus
CA2501975A1 (en) * 2002-12-20 2004-07-08 Crucell Holland B.V. Recombinant virus production for the manufacturing of vaccines
EP1622574A4 (en) * 2003-04-25 2006-10-18 Medimmune Vaccines Inc EXPRESSION SYSTEMS OF RECOMBINANT PARAINFLUENZA VIRUSES AND VACCINES COMPRISING HETEROLOGOUS ANTIGENS DERIVED FROM METAPNEUMOVIRUS
WO2004099396A1 (en) 2003-05-09 2004-11-18 Crucell Holland B.V. Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom
CN1863918B (zh) 2003-10-02 2011-03-30 克鲁塞尔荷兰公司 用于重组腺病毒的包装细胞
US20070207461A1 (en) 2004-02-23 2007-09-06 Crucell Holland B.V. Virus Purification Methods
CA2557046A1 (en) * 2004-03-05 2005-10-13 John Crowley Process for cell culturing by continuous perfusion and alternating tangential flow
JP5600375B2 (ja) 2004-03-09 2014-10-01 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド インフルエンザウイルスワクチン
EP2848692B1 (en) 2004-05-21 2017-08-16 Novartis Vaccines and Diagnostics, Inc. Alphavirus vectors for influenza virus vaccines
ATE489965T1 (de) 2004-09-09 2010-12-15 Novartis Vaccines & Diagnostic Verminderung von potentiellen iatrogenen risiken in verbindung mit influenza impfstoffen
JP2006090864A (ja) * 2004-09-24 2006-04-06 Denka Seiken Co Ltd ワクチン中の特定成分の含量を求める方法
US7510719B2 (en) 2004-12-08 2009-03-31 Medimmune, Llc Methods of producing influenza vaccine compositions
CA2591665C (en) 2004-12-20 2015-05-05 Crucell Holland B.V. Binding molecules capable of neutralizing west nile virus and uses thereof
CA2602944C (en) 2005-04-11 2015-08-11 Crucell Holland B.V. Virus purification using ultrafiltration
WO2006120230A2 (en) 2005-05-12 2006-11-16 Crucell Holland B.V. Host cell specific binding molecules capable of neutralizing viruses and uses thereof
EP1907536B1 (en) 2005-07-22 2010-04-07 Crucell Holland B.V. Cell line for producing coronaviruses
ES2525518T3 (es) 2005-11-01 2014-12-26 Novartis Vaccines And Diagnostics Gmbh Vacunas virales derivadas de células con niveles reducidos de ADN celular residual
KR101685246B1 (ko) 2006-07-14 2016-12-09 디피엑스 홀딩스 비.브이. 개선된 세포 배양 방법
JP5421250B2 (ja) * 2007-07-03 2014-02-19 トランスジーン ソシエテ アノニム トリ不死化細胞株
ES2450998T3 (es) * 2007-12-13 2014-03-26 F. Hoffmann-La Roche Ag Nuevas variantes de proteína de cubierta E1 de rubéola y su utilización en la detección de anticuerpos anti-rubéola
JP5518041B2 (ja) 2008-03-18 2014-06-11 ノバルティス アーゲー インフルエンザウイルスワクチン抗原の調製における改良
EP2296701A1 (en) 2008-06-11 2011-03-23 Flugen, Inc. Cell-based systems for producing influenza vaccines
DK2307538T3 (da) * 2008-07-15 2016-01-18 Crucell Holland Bv Skalérbar fremgangsmåde til dyrkning af per.c6-celler og fremstilling af produkter derfra
EP2168987A1 (en) * 2008-09-22 2010-03-31 Mucosis B.V. Multifunctional linker protein containing an antibody against hemagglutinin, a conserved influenza antigen and an immunostimulating carrier binding domain
WO2010046335A1 (en) * 2008-10-21 2010-04-29 Crucell Holland B.V. Production of influenza virus by reverse genetics in per.c6 cells under serum free conditions
CA2741961A1 (en) 2008-11-05 2010-05-14 Glaxosmithkline Biologicals S.A. Novel method
SI2454364T1 (sl) 2009-07-16 2014-08-29 Crucell Holland B.V. Izdelava polio virusa v visokih titrih za izdelavo cepiva
US20130203151A1 (en) 2010-04-26 2013-08-08 Scott Balsitis Production of alphavirus replicon particles in packaging cells
WO2012051211A2 (en) 2010-10-11 2012-04-19 Novartis Ag Antigen delivery platforms
WO2012103361A1 (en) 2011-01-26 2012-08-02 Novartis Ag Rsv immunization regimen
RU2014118727A (ru) 2011-10-11 2015-11-20 Новартис Аг Рекомбинантные самореплицирующиеся полицистронные молекулы рнк
US20140348863A1 (en) 2011-10-12 2014-11-27 Alessia Bianchi Cmv antigens and uses thereof
CN102526720B (zh) * 2012-01-11 2013-12-11 中国人民解放军军事医学科学院微生物流行病研究所 一种流感病毒疫苗的制备方法
EP2822585B1 (en) 2012-03-06 2017-05-17 Janssen Vaccines & Prevention B.V. Improved vaccination against influenza
CN102631673A (zh) * 2012-04-17 2012-08-15 金宇保灵生物药品有限公司 口蹄疫疫苗浓缩纯化方法
HUE056073T2 (hu) 2013-03-15 2022-01-28 Genzyme Corp Magas denzitású sejtbanki tárolási eljárások
US20160100570A1 (en) 2014-09-18 2016-04-14 Genzyme Corporation Ultra-high density cell banking methods
AU2015252119A1 (en) 2014-11-07 2016-05-26 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
US11118238B2 (en) 2014-12-17 2021-09-14 Fundación Para La Investigación Mèdica Aplicada Nucleic acid constructs and gene therapy vectors for use in the treatment of Wilson's disease and other conditions
US11147887B2 (en) 2014-12-17 2021-10-19 Fundación Para La Investigación Mèdica Aplicada Nucleic acid constructs and gene therapy vectors for use in the treatment of Wilson disease
KR102790570B1 (ko) * 2015-07-07 2025-04-04 세퀴러스 유케이 리미티드 인플루엔자 효능 검정
ES2642723B1 (es) 2016-05-12 2018-10-22 Servizo Galego De Saúde (Sergas) Uso de los niveles de anticuerpos anti-CD26 como biomarcadores de enfermedades autoinmunes y/o inflamatorias.
KR20200117981A (ko) 2017-11-03 2020-10-14 다케다 백신즈 인코포레이티드 지카 백신 및 면역원성 조성물, 그리고 이를 이용하는 방법들
EP3717505A4 (en) 2017-12-01 2021-12-01 Encoded Therapeutics, Inc. GENENICALLY MODIFIED DNA-BINDING PROTEINS
US20210292791A1 (en) 2018-10-12 2021-09-23 Vivet Therapeutics Codon-optimized transgene for the treatment of progressive familiar intrahepatic cholestasis type 3 (pfic3)
EP3880809A4 (en) 2018-11-16 2023-01-11 Encoded Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF WILSON'S DISEASE
BR112021019845A2 (pt) 2019-05-08 2022-02-15 Takeda Vaccines Inc Composições de vírus inativado e formulações de vacina contra zika
PL3976798T3 (pl) 2019-05-29 2026-04-07 Encoded Therapeutics, Inc. Kompozycje i sposoby selektywnej regulacji genów
CN116390773A (zh) 2020-08-06 2023-07-04 应用医学研究基金会 用于通过基因疗法治疗诸如阿尔茨海默病的Tau蛋白病的病毒颗粒
US20230265456A1 (en) 2020-08-10 2023-08-24 Fundacion Para La Investigacion Medica Aplicada Gene therapy vector expressing cyp27a1 for the treatment of cerebrotendinous xanthomatosis
IL301255A (en) 2020-10-09 2023-05-01 UCB Biopharma SRL Nucleic acid structures, viral vectors and viral particles
EP4423286A1 (en) 2021-10-28 2024-09-04 UCB Biopharma SRL Nucleic acid constructs, viral vectors and viral particles
EP4476329A1 (en) 2022-02-09 2024-12-18 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
JP2025531878A (ja) 2022-09-12 2025-09-25 アケロ セラピューティクス,インコーポレイティド Fgf21変異体ポリペプチド
WO2026037841A1 (en) 2024-08-12 2026-02-19 ONA Therapeutics S.L. Anti-fgfr4 molecules and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024068A1 (en) * 1997-11-10 1999-05-20 Michigan State University Immortal avian cell line to grow avian and animal viruses to produce vaccines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3547779A (en) * 1968-12-18 1970-12-15 Merck & Co Inc Process for producing purified concentrated influenza virus
US5192539A (en) * 1988-07-21 1993-03-09 Akzo N.V. Infectious bursal disease virus production in continuous cell lines
FR2723740B1 (fr) * 1994-08-16 1996-11-08 Pasteur Merieux Serums Vacc Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024068A1 (en) * 1997-11-10 1999-05-20 Michigan State University Immortal avian cell line to grow avian and animal viruses to produce vaccines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Human Gene Therapy, vol. 9(13), pp. 1909-1917
US-A-5,192,539

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200015323A (ko) 2018-08-03 2020-02-12 에릭스바이오(주) 바이러스 치료 장치 또는 백신 제조 장치

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