BR0015846A - Método para a produção de um vìrus e/ou proteìnas virais diferentes de adenovìrus ou proteìnas adenovirais, uso de uma célula humana, vìrus ou proteìna viral para uso em uma vacina obtenìvel por meio dos citados métodos e uso, célula humana kit para determinar a atividade de uma protease em uma amostra, uso de uma proteìna viral ou um vìrus, método para concentrar vìrus influenza em condições capazes de, pelo menos em parte,preservar a capacidade de infecção do vìrus, e, vìrus influenza infeccioso ou seus derivados. - Google Patents
Método para a produção de um vìrus e/ou proteìnas virais diferentes de adenovìrus ou proteìnas adenovirais, uso de uma célula humana, vìrus ou proteìna viral para uso em uma vacina obtenìvel por meio dos citados métodos e uso, célula humana kit para determinar a atividade de uma protease em uma amostra, uso de uma proteìna viral ou um vìrus, método para concentrar vìrus influenza em condições capazes de, pelo menos em parte,preservar a capacidade de infecção do vìrus, e, vìrus influenza infeccioso ou seus derivados.Info
- Publication number
- BR0015846A BR0015846A BR0015846-1A BR0015846A BR0015846A BR 0015846 A BR0015846 A BR 0015846A BR 0015846 A BR0015846 A BR 0015846A BR 0015846 A BR0015846 A BR 0015846A
- Authority
- BR
- Brazil
- Prior art keywords
- virus
- viral protein
- human cell
- production
- influenza viruses
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 19
- 238000000034 method Methods 0.000 title abstract 9
- 210000005260 human cell Anatomy 0.000 title abstract 6
- 108010067390 Viral Proteins Proteins 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 241000712461 unidentified influenza virus Species 0.000 title abstract 3
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 title abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 230000002458 infectious effect Effects 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 title 1
- 239000002609 medium Substances 0.000 abstract 2
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000010924 continuous production Methods 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 229960003971 influenza vaccine Drugs 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16651—Methods of production or purification of viral material
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- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
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- C12N2770/36011—Togaviridae
- C12N2770/36211—Rubivirus, e.g. rubella virus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Genetics & Genomics (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
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- Biotechnology (AREA)
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- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
"MéTODO PARA A PRODUçãO DE UM VìRUS E/OU PROTEìNAS VIRAIS DIFERENTES DE ADENOVìRUS OU PROTEìNAS ADENOVIRAIS, USO DE UMA CéLULA HUMANA, VìRUS OU PROTEìNA VIRAL PARA USO EM UMA VACINA OBTENìVEL POR MEIO DOS CITADOS MéTODO E USO, CéLULA HUMANA KIT PARA DETERMINAR A ATIVIDADE DE UMA PROTEASE EM UMA AMOSTRA, USO DE UMA PROTEìNA VIRAL OU UM VìRUS, MéTODO PARA CONCENTRAR VìRUS INFLUENZA EM CONDIçõES CAPAZES DE, PELO MENOS EM PARTE, PRESERVAR A CAPACIDADE DE INFECçãO DO VIRUS, E, VIRUS INFLUENZA INFECCIOSO OU SEUS DERIVADOS". Proporciona-se meios e métodos inéditos para a produção de vírus mamíferos, compreendendo infectar uma cultura de células humana imortalizadas com o vírus, incubar a cultura infectada com vírus para propagar o vírus em condições que permitem o desenvolvimento do vírus, e formar um meio contendo virus e remover o meio contendo vírus. Os vírus podem ser coletados e usados para a produção de vacinas. Vantagens células humanas da presente invenção podem ser cultivadas em condições definidas isentas de soro, e as células apresentam capacidade aperfeiçoada para propagar vírus. Em particular, proporciona-se métodos para produzir, em células humanas cultivadas, vírus Influenza e vacinas derivadas dos mesmos. Este método elimina a necessidade de se usar embriões inteiros de galinhas para a produção de vacinas de Influenza. O método proporciona também a remoção contínua ou em bateladas de meios de cultura. Assim, a presente invenção permite a produção contínua e em grande escala de vírus com alta concentração.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99203983.4 | 1999-11-26 | ||
EP99203983A EP1103610A1 (en) | 1999-11-26 | 1999-11-26 | Production of vaccines from immortalised mammalian cell lines |
PCT/NL2000/000862 WO2001038362A2 (en) | 1999-11-26 | 2000-11-24 | Production of vaccines |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0015846B1 BRPI0015846B1 (pt) | 2001-05-31 |
BR0015846A true BR0015846A (pt) | 2002-07-16 |
BRPI0015846B8 BRPI0015846B8 (pt) | 2021-05-25 |
Family
ID=8240914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0015846-1A BR0015846A (pt) | 1999-11-26 | 2000-11-24 | Método para a produção de um vìrus e/ou proteìnas virais diferentes de adenovìrus ou proteìnas adenovirais, uso de uma célula humana, vìrus ou proteìna viral para uso em uma vacina obtenìvel por meio dos citados métodos e uso, célula humana kit para determinar a atividade de uma protease em uma amostra, uso de uma proteìna viral ou um vìrus, método para concentrar vìrus influenza em condições capazes de, pelo menos em parte,preservar a capacidade de infecção do vìrus, e, vìrus influenza infeccioso ou seus derivados. |
Country Status (21)
Country | Link |
---|---|
EP (3) | EP1103610A1 (pt) |
JP (1) | JP4331432B2 (pt) |
KR (2) | KR20060107868A (pt) |
CN (1) | CN1306033C (pt) |
AT (1) | ATE286537T1 (pt) |
AU (2) | AU775966B2 (pt) |
BR (1) | BR0015846A (pt) |
CA (1) | CA2392653C (pt) |
DE (1) | DE60017234T3 (pt) |
DK (1) | DK1108787T4 (pt) |
EA (1) | EA006136B1 (pt) |
ES (1) | ES2235770T5 (pt) |
HK (1) | HK1057236A1 (pt) |
IL (2) | IL149788A0 (pt) |
MX (1) | MXPA02005237A (pt) |
NO (1) | NO333527B1 (pt) |
NZ (1) | NZ527942A (pt) |
PT (1) | PT1108787E (pt) |
SI (1) | SI1108787T2 (pt) |
WO (1) | WO2001038362A2 (pt) |
ZA (1) | ZA200204078B (pt) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI0833934T2 (sl) | 1995-06-15 | 2013-04-30 | Crucell Holland B.V. | Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji |
US7604960B2 (en) | 1999-04-15 | 2009-10-20 | Crucell Holland B.V. | Transient protein expression methods |
WO2003048197A1 (en) * | 2001-12-07 | 2003-06-12 | Crucell Holland B.V. | Production and of viruses, viral isolates and vaccines |
US8236561B2 (en) | 1999-04-15 | 2012-08-07 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
US6855544B1 (en) | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
US7192759B1 (en) | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
US7425437B2 (en) | 1999-11-26 | 2008-09-16 | Crucell Holland B.V. | Vaccines against West Nile Virus |
US7527961B2 (en) | 1999-11-26 | 2009-05-05 | Crucell Holland B.V. | Production of vaccines |
US7521220B2 (en) * | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
US8715922B2 (en) | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
IL157003A0 (en) | 2001-01-19 | 2004-02-08 | Vironovative Bv | A virus causing respiratory tract illness in susceptible mammals |
EP1256803A1 (en) | 2001-05-07 | 2002-11-13 | Crucell Holland B.V. | Methods for the identification of antiviral compounds |
ATE384785T1 (de) | 2001-12-07 | 2008-02-15 | Crucell Holland Bv | Herstellung von viren, virusisolaten, und impfstoffen |
DE60226896D1 (de) * | 2001-12-17 | 2008-07-10 | Crucell Holland Bv | Herstellung von f(ab')2 fragmenten in saügetierzelle |
CN1646684B (zh) | 2002-02-21 | 2010-10-06 | 免疫医疗疫苗公司 | 重组副流感病毒表达系统以及包含源自间质肺病毒的异种抗原的疫苗 |
CA2478508C (en) | 2002-04-25 | 2013-07-02 | Crucell Holland B.V. | Stable adenoviral vectors and methods for propagation thereof |
ATE453708T1 (de) * | 2002-11-08 | 2010-01-15 | Crucell Holland Bv | Impfstoff gegen west nile virus |
EP1590450A2 (en) * | 2002-12-20 | 2005-11-02 | Crucell Holland B.V. | Recombinant virus production for the manufacturing of vaccines |
CA2523657A1 (en) * | 2003-04-25 | 2005-03-31 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
CN101328473B (zh) * | 2003-05-09 | 2012-05-02 | 克鲁塞尔荷兰公司 | E1-永生化的细胞培养物及培养所述细胞以提高从中获取的产物产量的方法 |
DK1670925T3 (da) | 2003-10-02 | 2013-07-08 | Crucell Holland Bv | Pakningsceller til rekombinat adenovirus |
DK1780269T3 (da) | 2004-02-23 | 2009-10-12 | Crucell Holland Bv | Virusrensningsmetoder |
EP2540815A1 (en) * | 2004-03-05 | 2013-01-02 | DSM IP Assets B.V. | Perfusion cell culture |
DE202005022108U1 (de) | 2004-03-09 | 2013-11-12 | Novartis Vaccines And Diagnostics, Inc. | Influenza-Virus-Impfstoffe |
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