KR100668400B1 - 테트라히드로피리도에테르 - Google Patents

테트라히드로피리도에테르 Download PDF

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Publication number
KR100668400B1
KR100668400B1 KR1020017003553A KR20017003553A KR100668400B1 KR 100668400 B1 KR100668400 B1 KR 100668400B1 KR 1020017003553 A KR1020017003553 A KR 1020017003553A KR 20017003553 A KR20017003553 A KR 20017003553A KR 100668400 B1 KR100668400 B1 KR 100668400B1
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KR
South Korea
Prior art keywords
hydroxy
dimethyl
formula
phenyl
naphthyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020017003553A
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English (en)
Korean (ko)
Other versions
KR20010075223A (ko
Inventor
포스티우스스테판
시몬볼프강-알렉산더
그룬틀러게르하르트
하나우어귀도
허버라인하르트
크로메르볼프강
스투름에른스트
센-빌핑거요르그
Original Assignee
알타나 파마 아게
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Application filed by 알타나 파마 아게 filed Critical 알타나 파마 아게
Publication of KR20010075223A publication Critical patent/KR20010075223A/ko
Application granted granted Critical
Publication of KR100668400B1 publication Critical patent/KR100668400B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
KR1020017003553A 1998-09-23 1999-09-17 테트라히드로피리도에테르 Expired - Fee Related KR100668400B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98117988.0 1998-09-23
DE19843504 1998-09-23
DE19843504.5 1998-09-23
EP98117988 1998-09-23

Publications (2)

Publication Number Publication Date
KR20010075223A KR20010075223A (ko) 2001-08-09
KR100668400B1 true KR100668400B1 (ko) 2007-01-17

Family

ID=26049024

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017003553A Expired - Fee Related KR100668400B1 (ko) 1998-09-23 1999-09-17 테트라히드로피리도에테르

Country Status (31)

Country Link
US (4) US6436953B1 (enExample)
EP (1) EP1115725B1 (enExample)
JP (1) JP4145492B2 (enExample)
KR (1) KR100668400B1 (enExample)
CN (2) CN100506821C (enExample)
AT (1) ATE231862T1 (enExample)
AU (1) AU763463B2 (enExample)
BG (1) BG65195B1 (enExample)
BR (1) BR9914044A (enExample)
CA (1) CA2344251A1 (enExample)
CZ (1) CZ292335B6 (enExample)
DE (1) DE69905178T2 (enExample)
DK (1) DK1115725T3 (enExample)
EA (1) EA005377B1 (enExample)
EE (1) EE04677B1 (enExample)
ES (1) ES2191464T3 (enExample)
GE (1) GEP20032926B (enExample)
HK (1) HK1038360B (enExample)
HR (1) HRP20010224A2 (enExample)
HU (1) HUP0102990A3 (enExample)
ID (1) ID28896A (enExample)
IL (2) IL142063A0 (enExample)
NO (1) NO317304B1 (enExample)
NZ (1) NZ510610A (enExample)
PL (1) PL193616B1 (enExample)
PT (1) PT1115725E (enExample)
RS (1) RS50145B (enExample)
SI (1) SI1115725T1 (enExample)
SK (1) SK285165B6 (enExample)
TR (1) TR200100805T2 (enExample)
WO (1) WO2000017200A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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US6436953B1 (en) * 1998-09-23 2002-08-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahydropyridoethers
AU3966600A (en) 1999-04-17 2000-11-02 Byk Gulden Lomberg Chemische Fabrik Gmbh Haloalkoxy imidazonaphthyridines
CA2285516C (en) * 1999-05-12 2010-12-07 President And Fellows Of Harvard College Dopamine transporter imaging agents
PL365165A1 (en) * 2000-03-29 2004-12-27 Altana Pharma Ag Tricyclic imidazopyridines
CZ20023194A3 (cs) * 2000-03-29 2003-01-15 Altana Pharma Ag Prekursory imidazopyridinových derivátů
AU1056302A (en) * 2000-10-25 2002-05-06 Byk Gulden Lomberg Chem Fab Polysubstituted imidazopyridines as gastric secretion inhibitors
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
US20040082605A1 (en) * 2001-03-08 2004-04-29 Arne Eek Use
CA2452802A1 (en) 2001-08-02 2003-02-20 Altana Pharma Ag Tricyclic epoxides
MXPA04001048A (es) * 2001-08-03 2004-05-20 Altana Pharma Ag Imidazopiridinas sustituidas con alquilo, para el tratamiento de trastornos gastrointestinales.
WO2003014120A1 (en) * 2001-08-03 2003-02-20 Altana Pharma Ag Amino-substituted imidazopyridines for the treatment of gastrointestinal diseases
JP2005519933A (ja) 2002-02-15 2005-07-07 アルタナ　ファルマ　アクチエンゲゼルシャフト 三環式ｎ−アシル化合物
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
HRP20041160A2 (en) * 2002-05-07 2005-08-31 Altana Pharma Ag Novel combination for the treatment of airway disorders
EA008304B1 (ru) 2002-11-19 2007-04-27 Алтана Фарма Аг 8-замещённые имидазопиридины
WO2004052374A1 (en) 2002-12-12 2004-06-24 Altana Pharma Ag Combination medicament
EA010107B1 (ru) * 2002-12-20 2008-06-30 Алтана Фарма Аг Силиловые простые эфиры
RS20050603A (sr) * 2003-02-17 2007-09-21 Altana Pharma Ag., NOVE KOMBINACIJE I NOVA PRIMENA FARMACEUTSKIH AKTIVNIH JEDINjENjA
ES2335498T3 (es) 2003-03-10 2010-03-29 Nycomed Gmbh Nuevo proceso para la preparacion de reflumilast.
TW200503783A (en) * 2003-04-11 2005-02-01 Altana Pharma Ag Oral pharmaceutical preparation for proton pump antagonists
SA04250092B1 (ar) * 2003-05-14 2008-05-04 التانا فاروا ايه جي مركب وسيط جديد لتحضير مركبات إيميدازوبيريدين imidazopyridines فعالة علاجياً
MXPA05012463A (es) * 2003-05-27 2006-01-30 Altana Pharma Ag Combinaciones farmaceuticas de un inhibidor de bomba protonica y un compuesto que modifica la motilidad gastrointestinal.
JP2007507425A (ja) * 2003-08-29 2007-03-29 ダイノゲン ファーマシューティカルズ，インコーポレイテッド 胃腸管運動障害を処置するために有用な組成物
PL1670482T5 (pl) 2003-09-16 2022-10-03 Covis Pharma Gmbh Zastosowanie cyklezonidu w leczeniu chorób układu oddechowego
CA2544325A1 (en) * 2003-11-03 2005-05-12 Astrazeneca Ab Imidazo [1,2-a] pyridine derivatives for the treatment of silent gastro-esophageal reflux
EP1697358A1 (en) 2003-12-19 2006-09-06 Altana Pharma AG Intermediates for the preparation of tricyclic dihydropyrano -imidazo -pyridines derivatives
AR047605A1 (es) * 2004-02-17 2006-01-25 Altana Pharma Ag Imidazopiridinas triciclicas e intermediarios en la sintesis de las mismas,sus procesos de preparacion,composiciones farmaceuticas que los contienen y usos.
KR100958829B1 (ko) 2004-09-03 2010-05-25 주식회사유한양행 피롤로[2,3-ｃ]피리딘 유도체 및 그의 제조방법
MX2007002219A (es) 2004-09-03 2007-05-04 Yuhan Corp Derivados de pirrolo [3,2-b ] piridina y procesos para su preparacion.
EP1784402B1 (en) 2004-09-03 2011-08-03 Yuhan Corporation PYRROLO[3,2-c]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
EP2258350B1 (en) * 2005-03-16 2014-12-24 Takeda GmbH Taste masked dosage form containing roflumilast
EP2080513A1 (en) 2008-01-16 2009-07-22 Schraermeyer, Ulrich, Prof. Dr. rer. nat Tetrahydropyridoethers for treatment of AMD
MX2012000275A (es) 2009-07-09 2012-02-08 Raqualia Pharma Inc Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal.
WO2012027240A1 (en) * 2010-08-23 2012-03-01 Schering Corporation Fused tricyclic inhibitors of mammalian target of rapamycin
EP2861571B1 (en) * 2012-06-15 2017-05-03 Bio-Pharm Solutions Co., Ltd. Phenylalkyl sulfamate compound and muscle relaxant composition comprising the same
WO2015052256A1 (en) 2013-10-08 2015-04-16 Katairo Gmbh Tetrahydropyridoethers for the treatment of stargardt's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468400A (en) * 1982-12-20 1984-08-28 Schering Corporation Antiulcer tricyclic imidazo [1,2-a]pyridines
HU204828B (en) 1987-07-16 1992-02-28 Byk Gulden Lomberg Chem Fab Process for producing new diazole derivatives and pharmaceutical compositions comprising such compounds
SE9401197D0 (sv) * 1994-04-11 1994-04-11 Astra Ab Active compounds
CA2196076A1 (en) * 1994-07-28 1996-02-08 Gerhard Grundler Acyl imidazopyridines
SK283288B6 (sk) * 1997-03-24 2003-05-02 Altana Pharma Ag Tetrahydropyridínové zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
WO1998042707A1 (en) * 1997-03-24 1998-10-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahydropyrido compounds
US6436953B1 (en) 1998-09-23 2002-08-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahydropyridoethers

Also Published As

Publication number Publication date
PL193616B1 (pl) 2007-02-28
ES2191464T3 (es) 2003-09-01
DE69905178D1 (de) 2003-03-06
YU21401A (sh) 2004-03-12
CN1560055A (zh) 2005-01-05
BG105270A (en) 2001-11-30
HK1038360B (en) 2003-05-16
CN1155598C (zh) 2004-06-30
RS50145B (sr) 2009-03-25
US6436953B1 (en) 2002-08-20
EE04677B1 (et) 2006-08-15
TR200100805T2 (tr) 2001-08-21
HUP0102990A2 (hu) 2002-01-28
US20020169320A1 (en) 2002-11-14
US7393860B1 (en) 2008-07-01
US6696460B2 (en) 2004-02-24
EA005377B1 (ru) 2005-02-24
WO2000017200A1 (en) 2000-03-30
CN100506821C (zh) 2009-07-01
IL142063A (en) 2007-10-31
US7105676B2 (en) 2006-09-12
NZ510610A (en) 2003-07-25
NO20011243D0 (no) 2001-03-12
SI1115725T1 (en) 2003-06-30
HUP0102990A3 (en) 2002-09-30
BR9914044A (pt) 2001-12-04
SK285165B6 (sk) 2006-07-07
JP4145492B2 (ja) 2008-09-03
ID28896A (id) 2001-07-12
CN1319101A (zh) 2001-10-24
CZ20011082A3 (cs) 2001-09-12
BG65195B1 (bg) 2007-06-29
HRP20010224A2 (en) 2002-04-30
PL346617A1 (en) 2002-02-25
GEP20032926B (en) 2003-03-25
PT1115725E (pt) 2003-06-30
EE200100172A (et) 2002-06-17
EP1115725B1 (en) 2003-01-29
DK1115725T3 (da) 2003-06-23
US20040162310A1 (en) 2004-08-19
ATE231862T1 (de) 2003-02-15
NO317304B1 (no) 2004-10-04
EP1115725A1 (en) 2001-07-18
SK3992001A3 (en) 2001-12-03
CZ292335B6 (cs) 2003-09-17
EA200100315A1 (ru) 2001-10-22
KR20010075223A (ko) 2001-08-09
IL142063A0 (en) 2002-03-10
AU763463B2 (en) 2003-07-24
JP2002526499A (ja) 2002-08-20
NO20011243L (no) 2001-03-12
CA2344251A1 (en) 2000-03-30
DE69905178T2 (de) 2003-07-17
HK1038360A1 (en) 2002-03-15
AU6192099A (en) 2000-04-10

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