KR100631874B1 - 펩타이드의 합성 방법 및 조성물 - Google Patents

펩타이드의 합성 방법 및 조성물 Download PDF

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Publication number
KR100631874B1
KR100631874B1 KR1020027000199A KR20027000199A KR100631874B1 KR 100631874 B1 KR100631874 B1 KR 100631874B1 KR 1020027000199 A KR1020027000199 A KR 1020027000199A KR 20027000199 A KR20027000199 A KR 20027000199A KR 100631874 B1 KR100631874 B1 KR 100631874B1
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South Korea
Prior art keywords
seq
peptide
group
side chain
wqeweqkitall
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KR1020027000199A
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English (en)
Korean (ko)
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KR20020038676A (ko
Inventor
브레이브라이언
앤더슨마크
프레드릭폴
강명철
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트라이머리스 인코퍼레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020027000199A 1999-07-07 2000-07-05 펩타이드의 합성 방법 및 조성물 Expired - Fee Related KR100631874B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/349,205 US6469136B1 (en) 1999-07-07 1999-07-07 Methods and composition for peptide synthesis
US09/349,205 1999-07-07
PCT/US2000/035725 WO2001034635A2 (en) 1999-07-07 2000-07-05 Methods and compositions for peptide synthesis

Publications (2)

Publication Number Publication Date
KR20020038676A KR20020038676A (ko) 2002-05-23
KR100631874B1 true KR100631874B1 (ko) 2006-10-09

Family

ID=23371340

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027000199A Expired - Fee Related KR100631874B1 (ko) 1999-07-07 2000-07-05 펩타이드의 합성 방법 및 조성물

Country Status (17)

Country Link
US (2) US6469136B1 (https=)
EP (1) EP1372686B1 (https=)
JP (1) JP2003530311A (https=)
KR (1) KR100631874B1 (https=)
CN (1) CN1267449C (https=)
AR (1) AR024686A1 (https=)
AT (1) ATE288278T1 (https=)
AU (1) AU4133701A (https=)
BR (1) BR0012249A (https=)
CA (1) CA2378086A1 (https=)
DE (1) DE60017955T2 (https=)
DK (1) DK1372686T3 (https=)
ES (1) ES2236043T3 (https=)
MX (1) MXPA02000021A (https=)
PT (1) PT1372686E (https=)
TW (1) TWI237640B (https=)
WO (1) WO2001034635A2 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6656906B1 (en) * 1998-05-20 2003-12-02 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
SK782002A3 (en) * 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
WO2004013165A1 (en) * 2002-07-24 2004-02-12 F. Hoffmann-La Roche Ag Pegylated t1249 polypeptide
US20040158037A1 (en) * 2003-02-12 2004-08-12 Bohling James Charles Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith
AU2004200485A1 (en) * 2003-02-25 2004-09-09 Rohm And Haas Company Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto
PL2298347T3 (pl) * 2003-05-06 2016-03-31 Bioverativ Therapeutics Inc Białka chimeryczne czynnika krzepnięcia do leczenia zaburzenia hemostazy
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US7348004B2 (en) 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
WO2005063792A2 (en) * 2003-12-31 2005-07-14 F. Hoffmann-La Roche Ag Methods for recovering cleaved peptide from a support
EP1701976A2 (en) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptide synthesis and deprotection with co-solvent
WO2005063800A2 (en) * 2003-12-31 2005-07-14 F. Hoffmann-La Roche Ag Peptide synthesis using decanting filter
ATE376556T1 (de) * 2003-12-31 2007-11-15 Hoffmann La Roche Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel
ATE410437T1 (de) * 2003-12-31 2008-10-15 Hoffmann La Roche Verfahren und systeme zur rückgewinnung von peptiden
KR101276422B1 (ko) * 2004-03-15 2013-06-19 넥타르 테라퓨틱스 Ｈｉｖ 유입 억제제의 중합체-기재 조성물 및 콘쥬게이트
ES2329270T3 (es) * 2004-12-30 2009-11-24 F. Hoffmann-La Roche Ag Sintesis del peptido t-1249 utilizando fragmentos intermediarios del ipeptido.
JP4886702B2 (ja) * 2004-12-30 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー ペプチド中間体断片を使用するペプチドｔ−２０の合成
WO2006069779A1 (en) * 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Preparing of peptides with excellent solubility
WO2006069697A1 (en) * 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Colorimetrically assessing peptide characteristics
WO2006105199A2 (en) * 2005-03-30 2006-10-05 Trimeris, Inc. Compositions and methods for synthesis of peptide and related conjugate
TW200745163A (en) 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
CA2651070A1 (en) 2006-05-03 2007-11-15 Mallinckrodt Inc. Composition and method for the release of protected peptides from a resin
CN101195653B (zh) * 2006-12-08 2010-05-12 吉尔生化（上海）有限公司 亮丙瑞林的固液合成法
TW200911289A (en) * 2007-08-09 2009-03-16 Syntonix Pharmaceuticals Inc Immunomodulatory peptides
CN101874038A (zh) * 2007-09-25 2010-10-27 特里梅里斯公司 治疗性抗-hiv肽的合成方法
CN101835794A (zh) * 2007-10-27 2010-09-15 霍夫曼-拉罗奇有限公司 使用固相和溶液相组合技术的促胰岛素肽合成法
EP2222695A2 (en) * 2007-12-11 2010-09-01 F. Hoffmann-La Roche AG Insulinotropic peptide synthesis using solid and solution phase combination techniques
WO2010014909A1 (en) * 2008-08-01 2010-02-04 Syntonix Pharmaceuticals, Inc. Immunomodulatory peptides
TW201217527A (en) 2010-07-09 2012-05-01 Biogen Idec Hemophilia Inc Processable single chain molecules and polypeptides made using same
CN102268065A (zh) * 2011-06-23 2011-12-07 成都圣诺科技发展有限公司 氨基保护丝氨酸寡肽及其制备方法和用途
CN102603869B (zh) * 2012-03-27 2013-03-27 西安华澳丽康生物工程有限公司 六胜肽的合成方法
WO2014144549A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Factor ix polypeptide formulations
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
CN108572171A (zh) * 2017-03-10 2018-09-25 江苏金斯瑞生物科技有限公司 一种检测哌啶残留的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100358209B1 (ko) 1992-07-20 2003-01-24 듀크 유니버시티 Hiv복제를저해하는조성물
JP3401005B2 (ja) 1992-12-11 2003-04-28 ユニバーシティ オブ フロリダ 有害生物の防除のための材料および方法
WO1994028929A1 (en) 1993-06-07 1994-12-22 Genentech, Inc. Hiv envelope polypeptides
US6479055B1 (en) 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US5464933A (en) 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
WO1999048513A1 (en) * 1998-03-23 1999-09-30 Trimeris, Inc. Methods and compositions for peptide synthesis
US6258782B1 (en) * 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
US6217666B1 (en) 1998-08-31 2001-04-17 Danieli Technology, Inc. Countercurrent reduction of oxides on moving metal

Also Published As

Publication number Publication date
AU4133701A (en) 2001-06-06
ES2236043T3 (es) 2005-07-16
CN1267449C (zh) 2006-08-02
EP1372686B1 (en) 2005-02-02
CN1450906A (zh) 2003-10-22
JP2003530311A (ja) 2003-10-14
TWI237640B (en) 2005-08-11
EP1372686A4 (en) 2004-01-02
US6767993B2 (en) 2004-07-27
KR20020038676A (ko) 2002-05-23
US6469136B1 (en) 2002-10-22
DK1372686T3 (da) 2005-05-30
PT1372686E (pt) 2005-05-31
WO2001034635A3 (en) 2003-10-16
DE60017955T2 (de) 2006-01-12
BR0012249A (pt) 2003-11-11
WO2001034635A9 (en) 2002-08-01
US20030125516A1 (en) 2003-07-03
CA2378086A1 (en) 2001-05-17
WO2001034635A2 (en) 2001-05-17
DE60017955D1 (de) 2005-03-10
MXPA02000021A (es) 2002-07-02
AR024686A1 (es) 2002-10-23
EP1372686A2 (en) 2004-01-02
ATE288278T1 (de) 2005-02-15

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