AR024686A1 - Un metodo para sintetizar un peptido - Google Patents
Un metodo para sintetizar un peptidoInfo
- Publication number
- AR024686A1 AR024686A1 ARP000103508A ARP000103508A AR024686A1 AR 024686 A1 AR024686 A1 AR 024686A1 AR P000103508 A ARP000103508 A AR P000103508A AR P000103508 A ARP000103508 A AR P000103508A AR 024686 A1 AR024686 A1 AR 024686A1
- Authority
- AR
- Argentina
- Prior art keywords
- peptide
- peptides
- seq
- group
- protected side
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 5
- 230000002194 synthesizing effect Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108010033276 Peptide Fragments Proteins 0.000 abstract 2
- 102000007079 Peptide Fragments Human genes 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 108010037251 peptide T1249 Proteins 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/349,205 US6469136B1 (en) | 1999-07-07 | 1999-07-07 | Methods and composition for peptide synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR024686A1 true AR024686A1 (es) | 2002-10-23 |
Family
ID=23371340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000103508A AR024686A1 (es) | 1999-07-07 | 2000-07-07 | Un metodo para sintetizar un peptido |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6469136B1 (https=) |
| EP (1) | EP1372686B1 (https=) |
| JP (1) | JP2003530311A (https=) |
| KR (1) | KR100631874B1 (https=) |
| CN (1) | CN1267449C (https=) |
| AR (1) | AR024686A1 (https=) |
| AT (1) | ATE288278T1 (https=) |
| AU (1) | AU4133701A (https=) |
| BR (1) | BR0012249A (https=) |
| CA (1) | CA2378086A1 (https=) |
| DE (1) | DE60017955T2 (https=) |
| DK (1) | DK1372686T3 (https=) |
| ES (1) | ES2236043T3 (https=) |
| MX (1) | MXPA02000021A (https=) |
| PT (1) | PT1372686E (https=) |
| TW (1) | TWI237640B (https=) |
| WO (1) | WO2001034635A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6656906B1 (en) * | 1998-05-20 | 2003-12-02 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| WO2004013165A1 (en) * | 2002-07-24 | 2004-02-12 | F. Hoffmann-La Roche Ag | Pegylated t1249 polypeptide |
| US20040158037A1 (en) * | 2003-02-12 | 2004-08-12 | Bohling James Charles | Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith |
| AU2004200485A1 (en) * | 2003-02-25 | 2004-09-09 | Rohm And Haas Company | Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto |
| PL2298347T3 (pl) * | 2003-05-06 | 2016-03-31 | Bioverativ Therapeutics Inc | Białka chimeryczne czynnika krzepnięcia do leczenia zaburzenia hemostazy |
| TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| WO2005063792A2 (en) * | 2003-12-31 | 2005-07-14 | F. Hoffmann-La Roche Ag | Methods for recovering cleaved peptide from a support |
| EP1701976A2 (en) * | 2003-12-31 | 2006-09-20 | F.Hoffmann-La Roche Ag | Peptide synthesis and deprotection with co-solvent |
| WO2005063800A2 (en) * | 2003-12-31 | 2005-07-14 | F. Hoffmann-La Roche Ag | Peptide synthesis using decanting filter |
| ATE376556T1 (de) * | 2003-12-31 | 2007-11-15 | Hoffmann La Roche | Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel |
| ATE410437T1 (de) * | 2003-12-31 | 2008-10-15 | Hoffmann La Roche | Verfahren und systeme zur rückgewinnung von peptiden |
| KR101276422B1 (ko) * | 2004-03-15 | 2013-06-19 | 넥타르 테라퓨틱스 | Ｈｉｖ 유입 억제제의 중합체-기재 조성물 및 콘쥬게이트 |
| ES2329270T3 (es) * | 2004-12-30 | 2009-11-24 | F. Hoffmann-La Roche Ag | Sintesis del peptido t-1249 utilizando fragmentos intermediarios del ipeptido. |
| JP4886702B2 (ja) * | 2004-12-30 | 2012-02-29 | エフ．ホフマン−ラ ロシュ アーゲー | ペプチド中間体断片を使用するペプチドｔ−２０の合成 |
| WO2006069779A1 (en) * | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Preparing of peptides with excellent solubility |
| WO2006069697A1 (en) * | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Colorimetrically assessing peptide characteristics |
| WO2006105199A2 (en) * | 2005-03-30 | 2006-10-05 | Trimeris, Inc. | Compositions and methods for synthesis of peptide and related conjugate |
| TW200745163A (en) | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
| CA2651070A1 (en) | 2006-05-03 | 2007-11-15 | Mallinckrodt Inc. | Composition and method for the release of protected peptides from a resin |
| CN101195653B (zh) * | 2006-12-08 | 2010-05-12 | 吉尔生化（上海）有限公司 | 亮丙瑞林的固液合成法 |
| TW200911289A (en) * | 2007-08-09 | 2009-03-16 | Syntonix Pharmaceuticals Inc | Immunomodulatory peptides |
| CN101874038A (zh) * | 2007-09-25 | 2010-10-27 | 特里梅里斯公司 | 治疗性抗-hiv肽的合成方法 |
| CN101835794A (zh) * | 2007-10-27 | 2010-09-15 | 霍夫曼-拉罗奇有限公司 | 使用固相和溶液相组合技术的促胰岛素肽合成法 |
| EP2222695A2 (en) * | 2007-12-11 | 2010-09-01 | F. Hoffmann-La Roche AG | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| WO2010014909A1 (en) * | 2008-08-01 | 2010-02-04 | Syntonix Pharmaceuticals, Inc. | Immunomodulatory peptides |
| TW201217527A (en) | 2010-07-09 | 2012-05-01 | Biogen Idec Hemophilia Inc | Processable single chain molecules and polypeptides made using same |
| CN102268065A (zh) * | 2011-06-23 | 2011-12-07 | 成都圣诺科技发展有限公司 | 氨基保护丝氨酸寡肽及其制备方法和用途 |
| CN102603869B (zh) * | 2012-03-27 | 2013-03-27 | 西安华澳丽康生物工程有限公司 | 六胜肽的合成方法 |
| WO2014144549A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Factor ix polypeptide formulations |
| US10450343B2 (en) | 2013-03-21 | 2019-10-22 | Sanofi-Aventis Deutschland Gmbh | Synthesis of cyclic imide containing peptide products |
| CA2907454C (en) | 2013-03-21 | 2021-05-04 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
| CN108572171A (zh) * | 2017-03-10 | 2018-09-25 | 江苏金斯瑞生物科技有限公司 | 一种检测哌啶残留的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100358209B1 (ko) | 1992-07-20 | 2003-01-24 | 듀크 유니버시티 | Hiv복제를저해하는조성물 |
| JP3401005B2 (ja) | 1992-12-11 | 2003-04-28 | ユニバーシティ オブ フロリダ | 有害生物の防除のための材料および方法 |
| WO1994028929A1 (en) | 1993-06-07 | 1994-12-22 | Genentech, Inc. | Hiv envelope polypeptides |
| US6479055B1 (en) | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
| US5464933A (en) | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| WO1999048513A1 (en) * | 1998-03-23 | 1999-09-30 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| US6258782B1 (en) * | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| US6217666B1 (en) | 1998-08-31 | 2001-04-17 | Danieli Technology, Inc. | Countercurrent reduction of oxides on moving metal |
-
1999
- 1999-07-07 US US09/349,205 patent/US6469136B1/en not_active Expired - Fee Related
-
2000
- 2000-07-05 AU AU41337/01A patent/AU4133701A/en not_active Abandoned
- 2000-07-05 DE DE60017955T patent/DE60017955T2/de not_active Expired - Fee Related
- 2000-07-05 CA CA002378086A patent/CA2378086A1/en not_active Abandoned
- 2000-07-05 PT PT00992116T patent/PT1372686E/pt unknown
- 2000-07-05 BR BR0012249-1A patent/BR0012249A/pt not_active IP Right Cessation
- 2000-07-05 AT AT00992116T patent/ATE288278T1/de not_active IP Right Cessation
- 2000-07-05 WO PCT/US2000/035725 patent/WO2001034635A2/en not_active Ceased
- 2000-07-05 KR KR1020027000199A patent/KR100631874B1/ko not_active Expired - Fee Related
- 2000-07-05 ES ES00992116T patent/ES2236043T3/es not_active Expired - Lifetime
- 2000-07-05 DK DK00992116T patent/DK1372686T3/da active
- 2000-07-05 MX MXPA02000021A patent/MXPA02000021A/es active IP Right Grant
- 2000-07-05 CN CNB008125309A patent/CN1267449C/zh not_active Expired - Fee Related
- 2000-07-05 EP EP00992116A patent/EP1372686B1/en not_active Expired - Lifetime
- 2000-07-05 JP JP2001537346A patent/JP2003530311A/ja not_active Ceased
- 2000-07-07 AR ARP000103508A patent/AR024686A1/es active IP Right Grant
- 2000-08-05 TW TW089113543A patent/TWI237640B/zh active
-
2002
- 2002-03-29 US US10/109,748 patent/US6767993B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU4133701A (en) | 2001-06-06 |
| ES2236043T3 (es) | 2005-07-16 |
| CN1267449C (zh) | 2006-08-02 |
| EP1372686B1 (en) | 2005-02-02 |
| CN1450906A (zh) | 2003-10-22 |
| JP2003530311A (ja) | 2003-10-14 |
| TWI237640B (en) | 2005-08-11 |
| EP1372686A4 (en) | 2004-01-02 |
| US6767993B2 (en) | 2004-07-27 |
| KR100631874B1 (ko) | 2006-10-09 |
| KR20020038676A (ko) | 2002-05-23 |
| US6469136B1 (en) | 2002-10-22 |
| DK1372686T3 (da) | 2005-05-30 |
| PT1372686E (pt) | 2005-05-31 |
| WO2001034635A3 (en) | 2003-10-16 |
| DE60017955T2 (de) | 2006-01-12 |
| BR0012249A (pt) | 2003-11-11 |
| WO2001034635A9 (en) | 2002-08-01 |
| US20030125516A1 (en) | 2003-07-03 |
| CA2378086A1 (en) | 2001-05-17 |
| WO2001034635A2 (en) | 2001-05-17 |
| DE60017955D1 (de) | 2005-03-10 |
| MXPA02000021A (es) | 2002-07-02 |
| EP1372686A2 (en) | 2004-01-02 |
| ATE288278T1 (de) | 2005-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |