CN1267449C - 用于肽合成的方法和组合物 - Google Patents

用于肽合成的方法和组合物 Download PDF

Info

Publication number
CN1267449C
CN1267449C CNB008125309A CN00812530A CN1267449C CN 1267449 C CN1267449 C CN 1267449C CN B008125309 A CNB008125309 A CN B008125309A CN 00812530 A CN00812530 A CN 00812530A CN 1267449 C CN1267449 C CN 1267449C
Authority
CN
China
Prior art keywords
seq
peptide
group
side chain
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008125309A
Other languages
English (en)
Chinese (zh)
Other versions
CN1450906A (zh
Inventor
B·布雷
M·安德森
P·E·弗里德里希
M·-C·康
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trimeris Inc
Original Assignee
Trimeris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trimeris Inc filed Critical Trimeris Inc
Publication of CN1450906A publication Critical patent/CN1450906A/zh
Application granted granted Critical
Publication of CN1267449C publication Critical patent/CN1267449C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB008125309A 1999-07-07 2000-07-05 用于肽合成的方法和组合物 Expired - Fee Related CN1267449C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/349,205 1999-07-07
US09/349,205 US6469136B1 (en) 1999-07-07 1999-07-07 Methods and composition for peptide synthesis

Publications (2)

Publication Number Publication Date
CN1450906A CN1450906A (zh) 2003-10-22
CN1267449C true CN1267449C (zh) 2006-08-02

Family

ID=23371340

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008125309A Expired - Fee Related CN1267449C (zh) 1999-07-07 2000-07-05 用于肽合成的方法和组合物

Country Status (17)

Country Link
US (2) US6469136B1 (https=)
EP (1) EP1372686B1 (https=)
JP (1) JP2003530311A (https=)
KR (1) KR100631874B1 (https=)
CN (1) CN1267449C (https=)
AR (1) AR024686A1 (https=)
AT (1) ATE288278T1 (https=)
AU (1) AU4133701A (https=)
BR (1) BR0012249A (https=)
CA (1) CA2378086A1 (https=)
DE (1) DE60017955T2 (https=)
DK (1) DK1372686T3 (https=)
ES (1) ES2236043T3 (https=)
MX (1) MXPA02000021A (https=)
PT (1) PT1372686E (https=)
TW (1) TWI237640B (https=)
WO (1) WO2001034635A2 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6656906B1 (en) * 1998-05-20 2003-12-02 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
SK782002A3 (en) * 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
IL166037A0 (en) * 2002-07-24 2006-01-15 Hoffmann La Roche Pegylated t1249 polypeptide
US20040158037A1 (en) * 2003-02-12 2004-08-12 Bohling James Charles Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith
AU2004200485A1 (en) * 2003-02-25 2004-09-09 Rohm And Haas Company Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto
PT1624891E (pt) 2003-05-06 2010-01-05 Syntonix Pharmaceuticals Inc Proteínas quiméricas de factor de coagulação-fc destinadas ao tratamento da hemofilia
US7348004B2 (en) 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
EP1701971A2 (en) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptide synthesis using decanting filter
ATE410437T1 (de) * 2003-12-31 2008-10-15 Hoffmann La Roche Verfahren und systeme zur rückgewinnung von peptiden
EP1701976A2 (en) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptide synthesis and deprotection with co-solvent
EP1701970A2 (en) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Methods for recovering cleaved peptide from a support
ES2295961T3 (es) * 2003-12-31 2008-04-16 F. Hoffmann-La Roche Ag Proceso para la sintesis peptidica utilizacndo una cantidad reducida de agente de desproteccion.
JP4805911B2 (ja) * 2004-03-15 2011-11-02 ネクター セラピューティクス Ｈｉｖ侵入阻害剤のポリマー系組成物及び複合体
JP4886702B2 (ja) * 2004-12-30 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー ペプチド中間体断片を使用するペプチドｔ−２０の合成
WO2006069697A1 (en) * 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Colorimetrically assessing peptide characteristics
WO2006069779A1 (en) * 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Preparing of peptides with excellent solubility
ES2329270T3 (es) * 2004-12-30 2009-11-24 F. Hoffmann-La Roche Ag Sintesis del peptido t-1249 utilizando fragmentos intermediarios del ipeptido.
WO2006105199A2 (en) * 2005-03-30 2006-10-05 Trimeris, Inc. Compositions and methods for synthesis of peptide and related conjugate
TW200745163A (en) * 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
US8022181B2 (en) 2006-05-03 2011-09-20 Mallinckrodt Llc Composition and method for the release of protected peptides from a resin
CN101195653B (zh) * 2006-12-08 2010-05-12 吉尔生化（上海）有限公司 亮丙瑞林的固液合成法
MX2010001363A (es) * 2007-08-09 2010-03-09 Syntonix Pharmaceuticals Inc Peptidos inmunomoduladores.
KR20100080812A (ko) * 2007-09-25 2010-07-12 트라이머리스, 인코퍼레이티드 치료용 항-ｈｉｖ 펩티드의 합성 방법
JP5473925B2 (ja) * 2007-10-27 2014-04-16 コーデン ファーマ コロラド インコーポレイテッド 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成
BRPI0820765A2 (pt) * 2007-12-11 2015-06-16 Hoffmann La Roche Métodos para a produção de um peptídeo insulinotrópico e peptídeos
WO2010014909A1 (en) * 2008-08-01 2010-02-04 Syntonix Pharmaceuticals, Inc. Immunomodulatory peptides
SG10201505217WA (en) 2010-07-09 2015-08-28 Biogen Hemophilia Inc Chimeric clotting factors
CN102268065A (zh) * 2011-06-23 2011-12-07 成都圣诺科技发展有限公司 氨基保护丝氨酸寡肽及其制备方法和用途
CN102603869B (zh) * 2012-03-27 2013-03-27 西安华澳丽康生物工程有限公司 六胜肽的合成方法
AR095527A1 (es) 2013-03-15 2015-10-21 Biogen Idec Inc Formulaciones de polipéptido fc-factor ix
WO2014147129A1 (en) 2013-03-21 2014-09-25 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
CN105189465B (zh) 2013-03-21 2019-02-26 赛诺菲-安万特德国有限公司 合成含有乙内酰脲的肽产物
CN108572171A (zh) * 2017-03-10 2018-09-25 江苏金斯瑞生物科技有限公司 一种检测哌啶残留的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4010560B2 (ja) * 1992-07-20 2007-11-21 ドューク ユニバーシティー Ｈｉｖ複製を阻害する化合物
JP3401005B2 (ja) 1992-12-11 2003-04-28 ユニバーシティ オブ フロリダ 有害生物の防除のための材料および方法
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
EP0708659A4 (en) 1993-06-07 2000-08-23 Genentech Inc HIV ENVELOPE POLYPEPTIDES
US6479055B1 (en) 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
CA2324348C (en) * 1998-03-23 2006-03-14 Trimeris, Inc. Methods and compositions for peptide synthesis
US6258782B1 (en) * 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
US6217666B1 (en) 1998-08-31 2001-04-17 Danieli Technology, Inc. Countercurrent reduction of oxides on moving metal

Also Published As

Publication number Publication date
WO2001034635A9 (en) 2002-08-01
CN1450906A (zh) 2003-10-22
EP1372686A2 (en) 2004-01-02
TWI237640B (en) 2005-08-11
JP2003530311A (ja) 2003-10-14
EP1372686A4 (en) 2004-01-02
ES2236043T3 (es) 2005-07-16
US6469136B1 (en) 2002-10-22
PT1372686E (pt) 2005-05-31
DE60017955D1 (de) 2005-03-10
AU4133701A (en) 2001-06-06
CA2378086A1 (en) 2001-05-17
EP1372686B1 (en) 2005-02-02
ATE288278T1 (de) 2005-02-15
WO2001034635A3 (en) 2003-10-16
US20030125516A1 (en) 2003-07-03
DE60017955T2 (de) 2006-01-12
MXPA02000021A (es) 2002-07-02
US6767993B2 (en) 2004-07-27
KR100631874B1 (ko) 2006-10-09
AR024686A1 (es) 2002-10-23
DK1372686T3 (da) 2005-05-30
KR20020038676A (ko) 2002-05-23
BR0012249A (pt) 2003-11-11
WO2001034635A2 (en) 2001-05-17

Similar Documents

Publication Publication Date Title
CN1267449C (zh) 用于肽合成的方法和组合物
CN1132845C (zh) 获得具有正确键合的胱氨酸键的胰岛素前体的改进的方法
CN1205220C (zh) 新颖的环孢菌素
CN1254542C (zh) 用于重组生产抗融合肽的方法
CN1303299A (zh) 关于肽合成的方法以及组合物
CN101044188A (zh) 制备格拉太咪尔的方法
CN1057535C (zh) 生产疏水多肽、蛋白质或肽的方法
CN1795202A (zh) 肽制备用固定于固相载体上的金属螯合物
CN1367789A (zh) 模板固定的β－发夹环模拟物的合成
CN1186355C (zh) 血管活性肠肽类似物的合成
CN1910280A (zh) 模板固定的β发夹环模拟物及其在噬菌体展示中的用途
CN1894211A (zh) 借助费歇尔－芬克型合成和随后的酰化制备4,5－二烷基－3－酰基－吡咯－2－羧酸衍生物
CN1968961A (zh) 制备肽的方法
CN1865283A (zh) 固相多肽合成鲑鱼降钙素的制备方法
CN1745091A (zh) 非靶位点胺基被保护的肽,其制备方法以及使用该肽制备特异性地结合的peg肽的方法
CN1854154A (zh) 一种稻瘟病抗性相关蛋白及其编码基因与应用
CN1184325C (zh) Lh－rh衍生物的制备方法
CN1317296C (zh) 抗hiv融合肽及其制备方法
CN1256695A (zh) 可用于检测o组hiv－1病毒感染的生物试验的合成肽
CN1231587C (zh) 甜菜黑色焦枯病毒作为外源基因的表达载体
CN1356968A (zh) 用于α－氧代醛合成的官能化固相支持物
CN1524873A (zh) 以商业规模制造t-20和t-1249肽的方法，和与其相关的t-20和t-1249组合物
CN101035804A (zh) 经修饰的hiv－1肽及其在检测抗－hiv抗体中的用途
CN1164237A (zh) 具有免疫调节作用的新肽
CN101033248A (zh) 一种制备小牛胸腺alpha 1的新工艺

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060802

Termination date: 20110705