KR100627532B1 - Ｈｉｖ 역전사효소 억제제로서의 피라졸 유도체 - Google Patents

Ｈｉｖ 역전사효소 억제제로서의 피라졸 유도체 Download PDF

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Publication number
KR100627532B1
KR100627532B1 KR1020037015833A KR20037015833A KR100627532B1 KR 100627532 B1 KR100627532 B1 KR 100627532B1 KR 1020037015833 A KR1020037015833 A KR 1020037015833A KR 20037015833 A KR20037015833 A KR 20037015833A KR 100627532 B1 KR100627532 B1 KR 100627532B1
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KR
South Korea
Prior art keywords
methyl
isopropyl
pyridyl
dichlorophenylthio
alkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020037015833A
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English (en)
Korean (ko)
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KR20040003050A (ko
Inventor
다이모크브라이언윌리엄
길아드리안리암
존스필립스티븐
파케스케빈에드워드버든
파라트마틴존
Original Assignee
에프. 호프만-라 로슈 아게
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Publication of KR20040003050A publication Critical patent/KR20040003050A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020037015833A 2001-06-04 2002-05-29 Ｈｉｖ 역전사효소 억제제로서의 피라졸 유도체 Expired - Fee Related KR100627532B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0113524.3 2001-06-04
GBGB0113524.3A GB0113524D0 (en) 2001-06-04 2001-06-04 Pyrazole derivatives
PCT/EP2002/005898 WO2002100853A1 (en) 2001-06-04 2002-05-29 Pyrazole derivatives as hiv reverse transcriptase inhibitors

Publications (2)

Publication Number Publication Date
KR20040003050A KR20040003050A (ko) 2004-01-07
KR100627532B1 true KR100627532B1 (ko) 2006-09-21

Family

ID=9915841

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037015833A Expired - Fee Related KR100627532B1 (ko) 2001-06-04 2002-05-29 Ｈｉｖ 역전사효소 억제제로서의 피라졸 유도체

Country Status (17)

Country Link
US (1) US6538015B1 (enExample)
EP (1) EP1401826B1 (enExample)
JP (1) JP4088249B2 (enExample)
KR (1) KR100627532B1 (enExample)
CN (1) CN1249052C (enExample)
AT (1) ATE357439T1 (enExample)
AU (1) AU2002325221B2 (enExample)
BR (1) BR0210158A (enExample)
CA (1) CA2448058C (enExample)
DE (1) DE60219009T2 (enExample)
DK (1) DK1401826T3 (enExample)
ES (1) ES2282446T3 (enExample)
GB (1) GB0113524D0 (enExample)
MX (1) MXPA03011199A (enExample)
PT (1) PT1401826E (enExample)
WO (1) WO2002100853A1 (enExample)
ZA (1) ZA200308781B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200423930A (en) * 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
JP4993407B2 (ja) 2004-08-04 2012-08-08 大正製薬株式会社 トリアゾール誘導体
WO2006072833A1 (en) * 2005-01-06 2006-07-13 Pfizer Limited Imidazole derivatives as enzyme reverse transcriptase modulators
EP1988083B1 (en) 2006-02-03 2014-04-02 Taisho Pharmaceutical Co., Ltd. Triazole derivative
RU2395499C2 (ru) * 2006-02-06 2010-07-27 Тайсо Фармасьютикал Ко., Лтд. Ингибитор связывания сфингозин-1-фосфата
PL2057125T3 (pl) 2006-08-16 2011-09-30 Hoffmann La Roche Nienukleozydowe inhibitory odwrotnej transkryptazy
BRPI0813404A2 (pt) 2007-06-22 2014-12-30 Hoffmann La Roche Derivados de uréia e carbamato como inibidores de transcriptase reversa de não-nucleosídeo
SI2177512T1 (sl) 2007-08-01 2012-06-29 Taisho Pharmaceutical Co Ltd Inhibitor vezave S1P1
RU2495878C2 (ru) 2007-12-21 2013-10-20 Ф.Хоффманн-Ля Рош Аг Гетероциклические антивирусные соединения
DE102008015032A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte Pyrazolamide und ihre Verwendung
DE102008015033A1 (de) * 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062878A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung
DE102008062863A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
EP2295038B1 (en) * 2009-09-11 2013-05-29 AiCuris GmbH & Co. KG Solid dispersion comprising an anti-HIV agent
ES2528646T3 (es) * 2010-05-20 2015-02-11 Bayer Intellectual Property Gmbh Procedimiento para la fabricación de 1-alquil-3-difluorometil-5-hidroxipirazoles
JP5722891B2 (ja) 2010-07-15 2015-05-27 大日本住友製薬株式会社 ピラゾール化合物
WO2014074628A1 (en) * 2012-11-08 2014-05-15 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Compounds for treating hiv and methods for using the compounds
US9925190B2 (en) 2015-02-16 2018-03-27 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecules targeting HIV-1 Nef

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627423A4 (en) 1992-01-22 1995-02-15 Nissan Chemical Ind Ltd SUBSTITUTED PYRAZOLE DERIVATIVES AND BACTERICIDES FOR AGRICULTURE AND GARDENING.
US6005109A (en) 1997-10-30 1999-12-21 Pflizer Inc. Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
DK0786455T3 (da) 1994-09-26 2004-03-29 Shionogi & Co Imidazolderivater
US5698495A (en) 1995-11-15 1997-12-16 Zeneca Limited Herbicidal substituted pyrazole compounds
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
GB0024795D0 (en) 2000-10-10 2000-11-22 Hoffmann La Roche Pyrazole derivatives for the treatment of viral diseases

Also Published As

Publication number Publication date
PT1401826E (pt) 2007-06-19
AU2002325221B2 (en) 2008-07-31
JP4088249B2 (ja) 2008-05-21
CN1527829A (zh) 2004-09-08
WO2002100853A1 (en) 2002-12-19
CN1249052C (zh) 2006-04-05
MXPA03011199A (es) 2004-02-26
US6538015B1 (en) 2003-03-25
DE60219009T2 (de) 2007-12-13
EP1401826A1 (en) 2004-03-31
ATE357439T1 (de) 2007-04-15
JP2004532276A (ja) 2004-10-21
ZA200308781B (en) 2005-02-11
CA2448058C (en) 2008-12-23
GB0113524D0 (en) 2001-07-25
CA2448058A1 (en) 2002-12-19
DK1401826T3 (da) 2007-07-30
EP1401826B1 (en) 2007-03-21
BR0210158A (pt) 2004-06-08
DE60219009D1 (de) 2007-05-03
KR20040003050A (ko) 2004-01-07
ES2282446T3 (es) 2007-10-16

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