AU2002325221B2 - Pyrazole Derivatives as HIV Reverse Transcriptase Inhibitors - Google Patents

Pyrazole Derivatives as HIV Reverse Transcriptase Inhibitors Download PDF

Info

Publication number
AU2002325221B2
AU2002325221B2 AU2002325221A AU2002325221A AU2002325221B2 AU 2002325221 B2 AU2002325221 B2 AU 2002325221B2 AU 2002325221 A AU2002325221 A AU 2002325221A AU 2002325221 A AU2002325221 A AU 2002325221A AU 2002325221 B2 AU2002325221 B2 AU 2002325221B2
Authority
AU
Australia
Prior art keywords
methyl
alkyl
substituted
isopropyl
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002325221A
Other languages
English (en)
Other versions
AU2002325221A1 (en
Inventor
Brian William Dymock
Adrian Liam Gill
Philip Stephen Jones
Kevin Edward Burdon Parkes
Martin John Parratt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2002325221A1 publication Critical patent/AU2002325221A1/en
Application granted granted Critical
Publication of AU2002325221B2 publication Critical patent/AU2002325221B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2002325221A 2001-06-04 2002-05-29 Pyrazole Derivatives as HIV Reverse Transcriptase Inhibitors Ceased AU2002325221B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0113524.3A GB0113524D0 (en) 2001-06-04 2001-06-04 Pyrazole derivatives
GB0113524.3 2001-06-04
PCT/EP2002/005898 WO2002100853A1 (en) 2001-06-04 2002-05-29 Pyrazole derivatives as hiv reverse transcriptase inhibitors

Publications (2)

Publication Number Publication Date
AU2002325221A1 AU2002325221A1 (en) 2003-05-15
AU2002325221B2 true AU2002325221B2 (en) 2008-07-31

Family

ID=9915841

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002325221A Ceased AU2002325221B2 (en) 2001-06-04 2002-05-29 Pyrazole Derivatives as HIV Reverse Transcriptase Inhibitors

Country Status (17)

Country Link
US (1) US6538015B1 (enExample)
EP (1) EP1401826B1 (enExample)
JP (1) JP4088249B2 (enExample)
KR (1) KR100627532B1 (enExample)
CN (1) CN1249052C (enExample)
AT (1) ATE357439T1 (enExample)
AU (1) AU2002325221B2 (enExample)
BR (1) BR0210158A (enExample)
CA (1) CA2448058C (enExample)
DE (1) DE60219009T2 (enExample)
DK (1) DK1401826T3 (enExample)
ES (1) ES2282446T3 (enExample)
GB (1) GB0113524D0 (enExample)
MX (1) MXPA03011199A (enExample)
PT (1) PT1401826E (enExample)
WO (1) WO2002100853A1 (enExample)
ZA (1) ZA200308781B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200423930A (en) * 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
JP4993407B2 (ja) 2004-08-04 2012-08-08 大正製薬株式会社 トリアゾール誘導体
CA2592909A1 (en) * 2005-01-06 2006-07-13 Pfizer Limited Imidazole derivatives as enzyme reverse transcriptase modulators
PL1988083T3 (pl) 2006-02-03 2014-08-29 Taisho Pharmaceutical Co Ltd Pochodna triazolowa
RU2395499C2 (ru) 2006-02-06 2010-07-27 Тайсо Фармасьютикал Ко., Лтд. Ингибитор связывания сфингозин-1-фосфата
DE602007013573D1 (de) 2006-08-16 2011-05-12 Hoffmann La Roche Nicht-nukleosidische reverse-transkriptase-hemmer
WO2009000663A1 (en) 2007-06-22 2008-12-31 F. Hoffmann-La Roche Ag Urea and carbamate derivatives as non-nucleoside reverse transcriptase inhibitors
ATE554070T1 (de) 2007-08-01 2012-05-15 Taisho Pharmaceutical Co Ltd Hemmer der s1p1-bindung
AU2008340422B2 (en) 2007-12-21 2014-06-19 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
DE102008015033A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008015032A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte Pyrazolamide und ihre Verwendung
DE102008062863A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062878A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung
EP2295038B1 (en) * 2009-09-11 2013-05-29 AiCuris GmbH & Co. KG Solid dispersion comprising an anti-HIV agent
WO2011144549A1 (en) * 2010-05-20 2011-11-24 Bayer Cropscience Ag Method for manufacturing 1 - alkyl - 3 - difluormethyl - 5 - hydroxypyrazoles
ES2565193T3 (es) 2010-07-15 2016-04-01 Sumitomo Dainippon Pharma Co., Ltd. Compuesto de pirazol
US9695127B2 (en) 2012-11-08 2017-07-04 University of Pittsburgh—of the Commonwealth System of Higher Education Compounds for treating HIV and methods for using the compounds
US9925190B2 (en) 2015-02-16 2018-03-27 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecules targeting HIV-1 Nef

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002221651B2 (en) * 2000-10-10 2006-10-19 F. Hoffmann-La Roche Ag Pyrazole derivatives for the treatment of viral diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993015060A1 (fr) 1992-01-22 1993-08-05 Nissan Chemical Industries, Ltd. Derive de pyrazole substitue et bactericide agrohorticole
US6005109A (en) 1997-10-30 1999-12-21 Pflizer Inc. Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
BR9509024A (pt) 1994-09-26 1997-09-30 Shionogi & Co Derivados de imidazol
US5698495A (en) 1995-11-15 1997-12-16 Zeneca Limited Herbicidal substituted pyrazole compounds
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002221651B2 (en) * 2000-10-10 2006-10-19 F. Hoffmann-La Roche Ag Pyrazole derivatives for the treatment of viral diseases

Also Published As

Publication number Publication date
MXPA03011199A (es) 2004-02-26
EP1401826B1 (en) 2007-03-21
DE60219009D1 (de) 2007-05-03
JP4088249B2 (ja) 2008-05-21
DK1401826T3 (da) 2007-07-30
CN1527829A (zh) 2004-09-08
ATE357439T1 (de) 2007-04-15
US6538015B1 (en) 2003-03-25
CN1249052C (zh) 2006-04-05
KR100627532B1 (ko) 2006-09-21
CA2448058A1 (en) 2002-12-19
JP2004532276A (ja) 2004-10-21
DE60219009T2 (de) 2007-12-13
CA2448058C (en) 2008-12-23
BR0210158A (pt) 2004-06-08
WO2002100853A1 (en) 2002-12-19
GB0113524D0 (en) 2001-07-25
KR20040003050A (ko) 2004-01-07
EP1401826A1 (en) 2004-03-31
PT1401826E (pt) 2007-06-19
ES2282446T3 (es) 2007-10-16
ZA200308781B (en) 2005-02-11

Similar Documents

Publication Publication Date Title
EP1401826B1 (en) Pyrazole derivatives as hiv reverse transcriptase inhibitors
AU2002325221A1 (en) Pyrazole Derivatives as HIV Reverse Transcriptase Inhibitors
CA2441313C (en) New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
KR100390612B1 (ko) 타입 5 시클릭 구아노신 3',5'-모노포스페이트포스포디에스테라제를 억제하는 성기능 장애 치료용피라졸로피리미디논 제조용 중간체의 제조 방법
AU742442B2 (en) Substituted pyridine compounds as anti-inflammatory agents
AU2001234128B2 (en) Novel imidazoline compounds
TWI445707B (zh) 葡萄糖激酶活化劑
AU725652B2 (en) Arylalkanoylpyridazines
IL199019A (en) History of acylaminopyrazole, processes for their preparation, and their use in drug production
JPH0625227A (ja) 環状イミノ誘導体、これらの化合物を含む製薬組成物及びそれらの調製法
SK10192001A3 (sk) Aromatické heterocyklické zlúčeniny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie
JP2005500312A (ja) グルコキナーゼ（ｇｌｋ）モジュレーターとしてのアミノニコチネート誘導体
NO314504B1 (no) Benzimidazolforbindelser, farmasöytiske sammensetninger som inneholder forbindelsene og deres anvendelser
CA2816769A1 (en) Substituted heteroaromatic carboxamide and urea derivatives as vanilloid receptor ligands
NO321120B1 (no) Forbindelser nyttige som anti-inflammatoriske midler, og anvendelse derav, samt farmasoytisk sammensetning.
KR20090108726A (ko) 11-β-ＨＳＤ1 억제제로서 피라졸 유도체
AU2001263874B2 (en) Pyrrole derivatives for treating aids
AU2012291041A1 (en) Uracil derivative and use thereof for medical purposes
IE83508B1 (en) Quinoxalines, processes for their preparation, and their use
US6262103B1 (en) Thienycyclohexanone derivatives as ligands of the GABAA α5 receptor subtype
CA2093797C (en) Substituted imidazobenzazepines and imidazopyridoazepines
AU2001263874A1 (en) Pyrrole derivatives for treating aids
JP2006504674A (ja) 新規のチオフェン誘導体、該誘導体の製造方法、及び該誘導体を含む医薬組成物
DE60319254T2 (de) Pyrazolamide zur behandlung von hiv-infektionen
JP2003048875A (ja) １，２−エタンジアミン誘導体の製造法

Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ ANTI-HIV PYRAZOLE DERIVATIVES

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired