CA2448058C - Pyrazole derivatives as hiv reverse transcriptase inhibitors - Google Patents
Pyrazole derivatives as hiv reverse transcriptase inhibitors Download PDFInfo
- Publication number
- CA2448058C CA2448058C CA002448058A CA2448058A CA2448058C CA 2448058 C CA2448058 C CA 2448058C CA 002448058 A CA002448058 A CA 002448058A CA 2448058 A CA2448058 A CA 2448058A CA 2448058 C CA2448058 C CA 2448058C
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- alkyl
- substituted
- isopropyl
- pyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0113524.3A GB0113524D0 (en) | 2001-06-04 | 2001-06-04 | Pyrazole derivatives |
| GB0113524.3 | 2001-06-04 | ||
| PCT/EP2002/005898 WO2002100853A1 (en) | 2001-06-04 | 2002-05-29 | Pyrazole derivatives as hiv reverse transcriptase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2448058A1 CA2448058A1 (en) | 2002-12-19 |
| CA2448058C true CA2448058C (en) | 2008-12-23 |
Family
ID=9915841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002448058A Expired - Fee Related CA2448058C (en) | 2001-06-04 | 2002-05-29 | Pyrazole derivatives as hiv reverse transcriptase inhibitors |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6538015B1 (enExample) |
| EP (1) | EP1401826B1 (enExample) |
| JP (1) | JP4088249B2 (enExample) |
| KR (1) | KR100627532B1 (enExample) |
| CN (1) | CN1249052C (enExample) |
| AT (1) | ATE357439T1 (enExample) |
| AU (1) | AU2002325221B2 (enExample) |
| BR (1) | BR0210158A (enExample) |
| CA (1) | CA2448058C (enExample) |
| DE (1) | DE60219009T2 (enExample) |
| DK (1) | DK1401826T3 (enExample) |
| ES (1) | ES2282446T3 (enExample) |
| GB (1) | GB0113524D0 (enExample) |
| MX (1) | MXPA03011199A (enExample) |
| PT (1) | PT1401826E (enExample) |
| WO (1) | WO2002100853A1 (enExample) |
| ZA (1) | ZA200308781B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200423930A (en) * | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| JP4993407B2 (ja) | 2004-08-04 | 2012-08-08 | 大正製薬株式会社 | トリアゾール誘導体 |
| CA2592909A1 (en) * | 2005-01-06 | 2006-07-13 | Pfizer Limited | Imidazole derivatives as enzyme reverse transcriptase modulators |
| PL1988083T3 (pl) | 2006-02-03 | 2014-08-29 | Taisho Pharmaceutical Co Ltd | Pochodna triazolowa |
| RU2395499C2 (ru) | 2006-02-06 | 2010-07-27 | Тайсо Фармасьютикал Ко., Лтд. | Ингибитор связывания сфингозин-1-фосфата |
| DE602007013573D1 (de) | 2006-08-16 | 2011-05-12 | Hoffmann La Roche | Nicht-nukleosidische reverse-transkriptase-hemmer |
| WO2009000663A1 (en) | 2007-06-22 | 2008-12-31 | F. Hoffmann-La Roche Ag | Urea and carbamate derivatives as non-nucleoside reverse transcriptase inhibitors |
| ATE554070T1 (de) | 2007-08-01 | 2012-05-15 | Taisho Pharmaceutical Co Ltd | Hemmer der s1p1-bindung |
| AU2008340422B2 (en) | 2007-12-21 | 2014-06-19 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| DE102008015033A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
| EP2295038B1 (en) * | 2009-09-11 | 2013-05-29 | AiCuris GmbH & Co. KG | Solid dispersion comprising an anti-HIV agent |
| WO2011144549A1 (en) * | 2010-05-20 | 2011-11-24 | Bayer Cropscience Ag | Method for manufacturing 1 - alkyl - 3 - difluormethyl - 5 - hydroxypyrazoles |
| ES2565193T3 (es) | 2010-07-15 | 2016-04-01 | Sumitomo Dainippon Pharma Co., Ltd. | Compuesto de pirazol |
| US9695127B2 (en) | 2012-11-08 | 2017-07-04 | University of Pittsburgh—of the Commonwealth System of Higher Education | Compounds for treating HIV and methods for using the compounds |
| US9925190B2 (en) | 2015-02-16 | 2018-03-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecules targeting HIV-1 Nef |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993015060A1 (fr) | 1992-01-22 | 1993-08-05 | Nissan Chemical Industries, Ltd. | Derive de pyrazole substitue et bactericide agrohorticole |
| US6005109A (en) | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| BR9509024A (pt) | 1994-09-26 | 1997-09-30 | Shionogi & Co | Derivados de imidazol |
| US5698495A (en) | 1995-11-15 | 1997-12-16 | Zeneca Limited | Herbicidal substituted pyrazole compounds |
| GB0016787D0 (en) | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| GB0024795D0 (en) | 2000-10-10 | 2000-11-22 | Hoffmann La Roche | Pyrazole derivatives for the treatment of viral diseases |
-
2001
- 2001-06-04 GB GBGB0113524.3A patent/GB0113524D0/en not_active Ceased
-
2002
- 2002-05-24 US US10/154,585 patent/US6538015B1/en not_active Expired - Fee Related
- 2002-05-29 CN CNB028111974A patent/CN1249052C/zh not_active Expired - Fee Related
- 2002-05-29 PT PT02758207T patent/PT1401826E/pt unknown
- 2002-05-29 WO PCT/EP2002/005898 patent/WO2002100853A1/en not_active Ceased
- 2002-05-29 JP JP2003503620A patent/JP4088249B2/ja not_active Expired - Fee Related
- 2002-05-29 EP EP02758207A patent/EP1401826B1/en not_active Expired - Lifetime
- 2002-05-29 KR KR1020037015833A patent/KR100627532B1/ko not_active Expired - Fee Related
- 2002-05-29 BR BR0210158-0A patent/BR0210158A/pt not_active IP Right Cessation
- 2002-05-29 ES ES02758207T patent/ES2282446T3/es not_active Expired - Lifetime
- 2002-05-29 MX MXPA03011199A patent/MXPA03011199A/es active IP Right Grant
- 2002-05-29 CA CA002448058A patent/CA2448058C/en not_active Expired - Fee Related
- 2002-05-29 AT AT02758207T patent/ATE357439T1/de not_active IP Right Cessation
- 2002-05-29 AU AU2002325221A patent/AU2002325221B2/en not_active Ceased
- 2002-05-29 DK DK02758207T patent/DK1401826T3/da active
- 2002-05-29 DE DE60219009T patent/DE60219009T2/de not_active Expired - Fee Related
-
2003
- 2003-11-11 ZA ZA200308781A patent/ZA200308781B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03011199A (es) | 2004-02-26 |
| EP1401826B1 (en) | 2007-03-21 |
| DE60219009D1 (de) | 2007-05-03 |
| JP4088249B2 (ja) | 2008-05-21 |
| DK1401826T3 (da) | 2007-07-30 |
| CN1527829A (zh) | 2004-09-08 |
| ATE357439T1 (de) | 2007-04-15 |
| US6538015B1 (en) | 2003-03-25 |
| CN1249052C (zh) | 2006-04-05 |
| KR100627532B1 (ko) | 2006-09-21 |
| CA2448058A1 (en) | 2002-12-19 |
| JP2004532276A (ja) | 2004-10-21 |
| DE60219009T2 (de) | 2007-12-13 |
| AU2002325221B2 (en) | 2008-07-31 |
| BR0210158A (pt) | 2004-06-08 |
| WO2002100853A1 (en) | 2002-12-19 |
| GB0113524D0 (en) | 2001-07-25 |
| KR20040003050A (ko) | 2004-01-07 |
| EP1401826A1 (en) | 2004-03-31 |
| PT1401826E (pt) | 2007-06-19 |
| ES2282446T3 (es) | 2007-10-16 |
| ZA200308781B (en) | 2005-02-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |