KR100609359B1 - 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체 - Google Patents

위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체 Download PDF

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KR100609359B1
KR100609359B1 KR1020007001703A KR20007001703A KR100609359B1 KR 100609359 B1 KR100609359 B1 KR 100609359B1 KR 1020007001703 A KR1020007001703 A KR 1020007001703A KR 20007001703 A KR20007001703 A KR 20007001703A KR 100609359 B1 KR100609359 B1 KR 100609359B1
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South Korea
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composition
gabapentin
compound
gastrointestinal
treatment
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Expired - Fee Related
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KR1020007001703A
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KR20010023084A (ko
Inventor
안토니오 구글리에타
챨스 프라이스 쥬니어 테일러
지아유안 렌
더블유. 피. 왓슨
마이클 프란시스 래퍼티
라우렌 디오프
마리아 쇼베
리오넬 부에노
힐러리 제이. 리틀
Original Assignee
워너-램버트 캄파니 엘엘씨
더 유니버시티 오브 오클라호마
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Application filed by 워너-램버트 캄파니 엘엘씨, 더 유니버시티 오브 오클라호마 filed Critical 워너-램버트 캄파니 엘엘씨
Publication of KR20010023084A publication Critical patent/KR20010023084A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
KR1020007001703A 1997-08-20 1998-08-18 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체 Expired - Fee Related KR100609359B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5675397P 1997-08-20 1997-08-20
US60/056,753 1997-08-20
US7479498P 1998-02-16 1998-02-16
US60/074,794 1998-02-16
US8293698P 1998-04-24 1998-04-24
US60/082,936 1998-04-24
PCT/US1998/017082 WO1999008671A1 (en) 1997-08-20 1998-08-18 Gaba analogs to prevent and treat gastrointestinal damage

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020057022543A Division KR20050116168A (ko) 1997-08-20 1998-08-18 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체

Publications (2)

Publication Number Publication Date
KR20010023084A KR20010023084A (ko) 2001-03-26
KR100609359B1 true KR100609359B1 (ko) 2006-08-04

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ID=27369092

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020007001703A Expired - Fee Related KR100609359B1 (ko) 1997-08-20 1998-08-18 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체
KR1020057022543A Ceased KR20050116168A (ko) 1997-08-20 1998-08-18 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020057022543A Ceased KR20050116168A (ko) 1997-08-20 1998-08-18 위장 손상의 예방 및 치료를 위한감마-아미노부티르산(ｇａｂａ) 동족체

Country Status (25)

Country Link
US (2) US6242488B1 (https=)
EP (1) EP1009399B1 (https=)
JP (1) JP4681116B2 (https=)
KR (2) KR100609359B1 (https=)
AT (1) ATE461698T1 (https=)
AU (2) AU8668598A (https=)
BR (1) BR9812133A (https=)
CA (1) CA2297163C (https=)
CO (1) CO4960645A1 (https=)
CY (1) CY1109981T1 (https=)
DE (1) DE69841574D1 (https=)
DK (1) DK1009399T3 (https=)
ES (1) ES2341154T3 (https=)
HU (1) HUP0004551A3 (https=)
IL (1) IL134164A (https=)
IS (1) IS2749B (https=)
MY (1) MY155223A (https=)
NO (1) NO327983B1 (https=)
NZ (1) NZ502729A (https=)
PE (1) PE107299A1 (https=)
PL (1) PL194125B1 (https=)
PT (1) PT1009399E (https=)
TW (2) TWI251485B (https=)
UY (1) UY25148A1 (https=)
WO (2) WO1999008670A1 (https=)

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EP1009399A1 (en) 2000-06-21
BR9812133A (pt) 2000-07-18
HUP0004551A2 (hu) 2001-05-28
IL134164A (en) 2005-05-17
DE69841574D1 (de) 2010-05-06
PL338705A1 (en) 2000-11-20
US6426368B2 (en) 2002-07-30
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CA2297163C (en) 2001-11-20
MY155223A (en) 2015-09-30
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US6242488B1 (en) 2001-06-05
AU8668598A (en) 1999-03-08
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IS5361A (is) 2000-01-25
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PL194125B1 (pl) 2007-04-30
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US20010014698A1 (en) 2001-08-16
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