ATE471147T1 - Verwendung von (r)-(halogenbenzyloxy)-benzylamino-propanamiden als natrium- und/oder calciumkanal- selektive modulatoren - Google Patents

Verwendung von (r)-(halogenbenzyloxy)-benzylamino-propanamiden als natrium- und/oder calciumkanal- selektive modulatoren

Info

Publication number
ATE471147T1
ATE471147T1 AT05769799T AT05769799T ATE471147T1 AT E471147 T1 ATE471147 T1 AT E471147T1 AT 05769799 T AT05769799 T AT 05769799T AT 05769799 T AT05769799 T AT 05769799T AT E471147 T1 ATE471147 T1 AT E471147T1
Authority
AT
Austria
Prior art keywords
halobenzyloxy
propanamides
benzylamino
sodium
calcium channel
Prior art date
Application number
AT05769799T
Other languages
English (en)
Inventor
Elena Barbanti
Florian Thaler
Carla Caccia
Ruggero Fariello
Patricia Salvati
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Application granted granted Critical
Publication of ATE471147T1 publication Critical patent/ATE471147T1/de

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05769799T 2004-09-10 2005-07-28 Verwendung von (r)-(halogenbenzyloxy)-benzylamino-propanamiden als natrium- und/oder calciumkanal- selektive modulatoren ATE471147T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04021525 2004-09-10
PCT/EP2005/008200 WO2006027052A2 (en) 2004-09-10 2005-07-28 (halobenzyloxy) benzylamino-propanamides as sodium and/or calcium channel selective modulators

Publications (1)

Publication Number Publication Date
ATE471147T1 true ATE471147T1 (de) 2010-07-15

Family

ID=34926488

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05769799T ATE471147T1 (de) 2004-09-10 2005-07-28 Verwendung von (r)-(halogenbenzyloxy)-benzylamino-propanamiden als natrium- und/oder calciumkanal- selektive modulatoren

Country Status (28)

Country Link
US (2) US20080096965A1 (de)
EP (1) EP1809271B9 (de)
JP (1) JP5319920B2 (de)
KR (1) KR101277520B1 (de)
CN (1) CN101018546B (de)
AR (1) AR050638A1 (de)
AT (1) ATE471147T1 (de)
AU (1) AU2005282028B2 (de)
BR (1) BRPI0515154A (de)
CA (1) CA2577408C (de)
CY (1) CY1110770T1 (de)
DE (1) DE602005021907D1 (de)
DK (1) DK1809271T5 (de)
ES (1) ES2347581T3 (de)
HK (1) HK1105359A1 (de)
HR (1) HRP20100400T1 (de)
IL (1) IL181445A (de)
ME (1) ME01801B (de)
MX (1) MX2007002713A (de)
NO (1) NO338713B1 (de)
NZ (1) NZ553970A (de)
PL (1) PL1809271T3 (de)
PT (1) PT1809271E (de)
RS (1) RS51411B (de)
RU (1) RU2391973C2 (de)
SI (1) SI1809271T1 (de)
TW (1) TWI351950B (de)
WO (1) WO2006027052A2 (de)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
DK1423168T3 (da) * 2001-09-03 2006-05-15 Newron Pharm Spa Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse
EP1438956A1 (de) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-Aminoamidderivate die als Antimigränemittel nützlich sind
WO2005018627A1 (en) * 2003-08-25 2005-03-03 Newron Pharmaceuticals, Spa Alpha-aminoamide derivatives useful as anti-inflammatory agents
ES2347581T3 (es) * 2004-09-10 2010-11-02 Newron Pharmaceuticals S.P.A. Uso de (r)-(halobenciloxi)bencilamino-propanamidas como moduladores selectivos del canal de sodio y/o calcio.
BRPI0620239B8 (pt) * 2005-12-22 2021-05-25 Newron Pharm Spa derivados de 2-feniletilamino.
BRPI0712936B8 (pt) 2006-06-19 2021-05-25 Newron Pharm Spa processo para a produção de 2-[4-(3- e 2-fluorbenziloxi)benzila-mino]propanamidas
AU2008261325B2 (en) 2007-06-15 2012-12-06 Newron Pharmaceuticals S.P.A. Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
AU2008334778B2 (en) * 2007-12-11 2013-05-23 Newron Pharmaceuticals S.P.A. Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree
BRPI0821026A2 (pt) * 2007-12-19 2015-06-16 Newron Pharmaceutical S P A Derivados de alfa-minoamidas úteis no tratamento de transtornos psiquiátricos
WO2009109334A1 (en) * 2008-03-07 2009-09-11 Newron Pharmaceuticals S.P.A. (s)-(+)-2-[4-fluorbenzyloxy)benzylamino]propanamide for use in the treatment of mixed or combined pain
WO2010138794A2 (en) 2009-05-29 2010-12-02 The University Of North Carolina At Chapel Hill Regulation of sodium channels by plunc proteins
WO2011134763A1 (en) * 2010-04-27 2011-11-03 Newron Pharmaceuticals S.P.A. Process for the production of ralfinamide methanesulfonate salts or their r-enantiomers
DK2723710T3 (en) 2011-06-27 2016-11-21 Newron Pharm Spa Flour ready arylalkylaminocarboxamidderivater
JP2017536334A (ja) 2014-10-08 2017-12-07 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル ナトリウムチャネルの改善されたペプチド阻害剤
US11154544B2 (en) * 2017-06-20 2021-10-26 Raqualia Pharma Inc. Amide derivatives as Nav1.7 and Nav1.8 blockers

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Also Published As

Publication number Publication date
HK1105359A1 (en) 2008-02-15
CY1110770T1 (el) 2015-06-10
EP1809271A2 (de) 2007-07-25
PL1809271T3 (pl) 2010-10-29
IL181445A0 (en) 2007-07-04
KR101277520B1 (ko) 2013-06-21
HRP20100400T1 (hr) 2010-09-30
NZ553970A (en) 2010-01-29
DE602005021907D1 (de) 2010-07-29
JP5319920B2 (ja) 2013-10-16
WO2006027052A3 (en) 2006-05-26
KR20070061863A (ko) 2007-06-14
RU2391973C2 (ru) 2010-06-20
DK1809271T3 (da) 2010-09-20
PT1809271E (pt) 2010-08-30
NO20071792L (no) 2007-06-11
CA2577408C (en) 2013-07-09
CN101018546A (zh) 2007-08-15
EP1809271B9 (de) 2010-09-22
EP1809271B1 (de) 2010-06-16
WO2006027052A2 (en) 2006-03-16
TW200612894A (en) 2006-05-01
DK1809271T5 (da) 2010-12-06
AR050638A1 (es) 2006-11-08
IL181445A (en) 2014-03-31
RU2007113190A (ru) 2008-10-27
NO338713B1 (no) 2016-10-03
JP2008512405A (ja) 2008-04-24
ES2347581T3 (es) 2010-11-02
AU2005282028A2 (en) 2006-03-16
US20110184068A1 (en) 2011-07-28
AU2005282028B2 (en) 2011-03-24
SI1809271T1 (sl) 2010-10-29
MX2007002713A (es) 2007-05-23
BRPI0515154A (pt) 2008-07-08
TWI351950B (en) 2011-11-11
US20080096965A1 (en) 2008-04-24
RS51411B (en) 2011-02-28
AU2005282028A1 (en) 2006-03-16
CN101018546B (zh) 2013-06-12
CA2577408A1 (en) 2006-03-16
ME01801B (me) 2011-02-28

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