ATE359783T1 - Aroylpyrrolheteroeryl und methanole zur behandlung von störungen des zentralnervensystems - Google Patents

Aroylpyrrolheteroeryl und methanole zur behandlung von störungen des zentralnervensystems

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Publication number
ATE359783T1
ATE359783T1 AT02799923T AT02799923T ATE359783T1 AT E359783 T1 ATE359783 T1 AT E359783T1 AT 02799923 T AT02799923 T AT 02799923T AT 02799923 T AT02799923 T AT 02799923T AT E359783 T1 ATE359783 T1 AT E359783T1
Authority
AT
Austria
Prior art keywords
aroylpyrrolheteroeryl
methanols
treatment
nervous system
central nervous
Prior art date
Application number
AT02799923T
Other languages
English (en)
Inventor
John R Carson
Ellen E Codd
Philip M Pitis
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of ATE359783T1 publication Critical patent/ATE359783T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
AT02799923T 2001-12-27 2002-12-10 Aroylpyrrolheteroeryl und methanole zur behandlung von störungen des zentralnervensystems ATE359783T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34376801P 2001-12-27 2001-12-27

Publications (1)

Publication Number Publication Date
ATE359783T1 true ATE359783T1 (de) 2007-05-15

Family

ID=23347573

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02799923T ATE359783T1 (de) 2001-12-27 2002-12-10 Aroylpyrrolheteroeryl und methanole zur behandlung von störungen des zentralnervensystems

Country Status (14)

Country Link
US (3) US6897319B2 (de)
EP (1) EP1458386B1 (de)
JP (1) JP2005514412A (de)
AR (1) AR038664A1 (de)
AT (1) ATE359783T1 (de)
AU (2) AU2002364545A1 (de)
CY (1) CY1106658T1 (de)
DE (1) DE60219687T2 (de)
DK (1) DK1458386T3 (de)
ES (1) ES2286328T3 (de)
PT (1) PT1458386E (de)
SI (1) SI1458386T1 (de)
TW (1) TWI282277B (de)
WO (2) WO2003057219A1 (de)

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ATE457724T1 (de) * 2003-08-25 2010-03-15 Newron Pharm Spa Alpha-aminoamid derivate zur verwendung als anti- inflammatorische wirkstoffe
EP1533298A1 (de) 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. 3-aminopyrrolidonederivate
EP1533295A1 (de) * 2003-11-24 2005-05-25 Newron Pharmaceuticals S.p.A. Cyclopentylderivate
CN100371325C (zh) * 2004-07-23 2008-02-27 中国科学院上海药物研究所 一类茚并吲哚酮类化合物、其制备方法和用途
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. （할로벤질옥시）벤질아미노－프로판아미드를 포함하는 선택적 나트륨 및／또는 칼슘 채널 조절제로서 유용한 약제학적 조성물
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
CA2629065C (en) 2005-12-22 2013-08-06 Newron Pharmaceuticals S.P.A. 2 -phenylethylamino derivatives as calcium and/or sodium channel modulators
MX2009013119A (es) 2007-06-15 2010-03-04 Newron Pharm Spa Derivados de 2-[2-(fenil)etilamino]alcanamida sustituidos y su uso como moduladores del canal de sodio y/o potasio.
GB0804755D0 (en) * 2008-03-14 2008-04-16 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0813873D0 (en) * 2008-07-30 2008-09-03 Univ Dundee Compounds
CA2767112C (en) 2009-07-10 2018-06-19 The General Hospital Corporation Etomidate analogues that do not inhibit adrenocortical steroid synthesis
DK2723710T3 (en) 2011-06-27 2016-11-21 Newron Pharm Spa Flour ready arylalkylaminocarboxamidderivater
ES2617536T3 (es) 2012-01-13 2017-06-19 The General Hospital Corporation Compuestos anestésicos y métodos relacionados de uso
WO2022159980A1 (en) * 2021-01-25 2022-07-28 Athos Therapeutics, Inc. Pharmaceutical compounds and methods of making and using the same

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AU1912595A (en) 1994-02-03 1995-08-21 Cambridge Neuroscience, Inc. Therapeutic guanidines
GB9509156D0 (en) 1995-05-05 1995-06-28 Sandoz Ltd Organic compounds
US6172085B1 (en) 1996-08-29 2001-01-09 Takeda Chemical Industries, Ltd. Cyclic ether compounds as sodium channel modulators
MA26473A1 (fr) 1997-03-01 2004-12-20 Glaxo Group Ltd Composes pharmacologiquement actifs.
US6110937A (en) 1997-04-03 2000-08-29 Syntex Usa, Inc. Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6256307B1 (en) * 1998-03-27 2001-07-03 Hewlett-Packard Co. Local area network receive filter
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DE19834714A1 (de) 1998-07-31 2000-02-03 Boehringer Ingelheim Pharma Neue 2,3,3a,4,9,9a-Hexahydro-8-hydroxy-1H-ben[f]indole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6169118B1 (en) * 1998-11-12 2001-01-02 Block Drug Company, Inc. Flavor blend for masking unpleasant taste of zinc compounds
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
DK1154996T3 (da) * 1999-02-18 2004-02-16 Ortho Mcneil Pharm Inc Aminoacylaroylpyrroler til behandling af neuropatisk smerte
CA2300698C (en) 1999-02-19 2003-10-07 J. Garfield Purdon Broad spectrum decontamination formulation and method of use
DE19915602A1 (de) 1999-04-07 2000-10-19 Gruenenthal Gmbh 3-Amino-4-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung
GB9907965D0 (en) 1999-04-09 1999-06-02 Glaxo Group Ltd Medical use
JP2003510079A (ja) 1999-09-30 2003-03-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ナトリウムチャンネルβ１Ａサブユニットに関連する方法および組成物

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US20050148636A1 (en) 2005-07-07
ES2286328T3 (es) 2007-12-01
US20040058980A1 (en) 2004-03-25
WO2003057147A3 (en) 2003-10-23
WO2003057219A1 (en) 2003-07-17
PT1458386E (pt) 2007-06-04
EP1458386B1 (de) 2007-04-18
SI1458386T1 (sl) 2007-08-31
WO2003057147A2 (en) 2003-07-17
AU2002359856A1 (en) 2003-07-24
AR038664A1 (es) 2005-01-26
DE60219687D1 (de) 2007-05-31
US6897319B2 (en) 2005-05-24
AU2002364545A1 (en) 2003-07-24
JP2005514412A (ja) 2005-05-19
US20030181481A1 (en) 2003-09-25
EP1458386A1 (de) 2004-09-22
DK1458386T3 (da) 2007-08-13
TW200400030A (en) 2004-01-01
AU2002359856A8 (en) 2003-07-24
TWI282277B (en) 2007-06-11
CY1106658T1 (el) 2012-01-25
DE60219687T2 (de) 2007-12-27

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