CY1106658T1 - Αροϋλ πυρρολο ετεροαρυλ και μεθανολες χρησιμες για θεραπεια διαταραχης κεντρικου νευρικου συστηματος - Google Patents

Αροϋλ πυρρολο ετεροαρυλ και μεθανολες χρησιμες για θεραπεια διαταραχης κεντρικου νευρικου συστηματος

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Publication number
CY1106658T1
CY1106658T1 CY20071100793T CY071100793T CY1106658T1 CY 1106658 T1 CY1106658 T1 CY 1106658T1 CY 20071100793 T CY20071100793 T CY 20071100793T CY 071100793 T CY071100793 T CY 071100793T CY 1106658 T1 CY1106658 T1 CY 1106658T1
Authority
CY
Cyprus
Prior art keywords
nervous system
central nervous
system disorder
useful
methanols
Prior art date
Application number
CY20071100793T
Other languages
English (en)
Inventor
John R. Carson
Ellen E. Codd
Philip M. Pitis
Original Assignee
Ortho-Mcneil Pharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.
Publication of CY1106658T1 publication Critical patent/CY1106658T1/el

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12Antihypertensives
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Cardiology (AREA)
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Abstract

Η εφεύρεση αυτή κατευθύνεται σε αροϋλ πυρρολο ετεροαρυλ μεθανόνης και μεθανόλης ενώσεις από τον Τύπο (I) ή τον Τύπο (II) φαρμακευτικώς χρήσιμες σαν παράγοντες για θεραπεία ή ρύθμιση διαταραχής κεντρικού νευρικού συστήματος και μεθόδους θεραπείας ρύθμισης διαταραχής νευρικού κεντρικού συστήματος. (I) (II).
CY20071100793T 2001-12-27 2007-06-14 Αροϋλ πυρρολο ετεροαρυλ και μεθανολες χρησιμες για θεραπεια διαταραχης κεντρικου νευρικου συστηματος CY1106658T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34376801P 2001-12-27 2001-12-27
PCT/US2002/039487 WO2003057219A1 (en) 2001-12-27 2002-12-10 Aroyl pyrrole heteroeryl and methanols useful for treating a central nervous system disorder

Publications (1)

Publication Number Publication Date
CY1106658T1 true CY1106658T1 (el) 2012-01-25

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Family Applications (1)

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CY20071100793T CY1106658T1 (el) 2001-12-27 2007-06-14 Αροϋλ πυρρολο ετεροαρυλ και μεθανολες χρησιμες για θεραπεια διαταραχης κεντρικου νευρικου συστηματος

Country Status (14)

Country Link
US (3) US6897319B2 (el)
EP (1) EP1458386B1 (el)
JP (1) JP2005514412A (el)
AR (1) AR038664A1 (el)
AT (1) ATE359783T1 (el)
AU (2) AU2002364545A1 (el)
CY (1) CY1106658T1 (el)
DE (1) DE60219687T2 (el)
DK (1) DK1458386T3 (el)
ES (1) ES2286328T3 (el)
PT (1) PT1458386E (el)
SI (1) SI1458386T1 (el)
TW (1) TWI282277B (el)
WO (2) WO2003057219A1 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE457724T1 (de) * 2003-08-25 2010-03-15 Newron Pharm Spa Alpha-aminoamid derivate zur verwendung als anti- inflammatorische wirkstoffe
EP1533298A1 (en) 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. 3-aminopyrrolidone derivatives
EP1533295A1 (en) * 2003-11-24 2005-05-25 Newron Pharmaceuticals S.p.A. Cyclopentyl Derivatives
CN100371325C (zh) * 2004-07-23 2008-02-27 中国科学院上海药物研究所 一类茚并吲哚酮类化合物、其制备方法和用途
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. (할로벤질옥시)벤질아미노-프로판아미드를 포함하는 선택적 나트륨 및/또는 칼슘 채널 조절제로서 유용한 약제학적 조성물
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
CA2629065C (en) 2005-12-22 2013-08-06 Newron Pharmaceuticals S.P.A. 2 -phenylethylamino derivatives as calcium and/or sodium channel modulators
MX2009013119A (es) 2007-06-15 2010-03-04 Newron Pharm Spa Derivados de 2-[2-(fenil)etilamino]alcanamida sustituidos y su uso como moduladores del canal de sodio y/o potasio.
GB0804755D0 (en) * 2008-03-14 2008-04-16 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0813873D0 (en) * 2008-07-30 2008-09-03 Univ Dundee Compounds
CA2767112C (en) 2009-07-10 2018-06-19 The General Hospital Corporation Etomidate analogues that do not inhibit adrenocortical steroid synthesis
DK2723710T3 (en) 2011-06-27 2016-11-21 Newron Pharm Spa Flour ready arylalkylaminocarboxamidderivater
ES2617536T3 (es) 2012-01-13 2017-06-19 The General Hospital Corporation Compuestos anestésicos y métodos relacionados de uso
WO2022159980A1 (en) * 2021-01-25 2022-07-28 Athos Therapeutics, Inc. Pharmaceutical compounds and methods of making and using the same

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1912595A (en) 1994-02-03 1995-08-21 Cambridge Neuroscience, Inc. Therapeutic guanidines
GB9509156D0 (en) 1995-05-05 1995-06-28 Sandoz Ltd Organic compounds
US6172085B1 (en) 1996-08-29 2001-01-09 Takeda Chemical Industries, Ltd. Cyclic ether compounds as sodium channel modulators
MA26473A1 (fr) 1997-03-01 2004-12-20 Glaxo Group Ltd Composes pharmacologiquement actifs.
US6110937A (en) 1997-04-03 2000-08-29 Syntex Usa, Inc. Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6256307B1 (en) * 1998-03-27 2001-07-03 Hewlett-Packard Co. Local area network receive filter
AU740813B2 (en) 1998-07-08 2001-11-15 Monash University Pharmaceutical agents
DE19834714A1 (de) 1998-07-31 2000-02-03 Boehringer Ingelheim Pharma Neue 2,3,3a,4,9,9a-Hexahydro-8-hydroxy-1H-ben[f]indole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6169118B1 (en) * 1998-11-12 2001-01-02 Block Drug Company, Inc. Flavor blend for masking unpleasant taste of zinc compounds
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
DK1154996T3 (da) * 1999-02-18 2004-02-16 Ortho Mcneil Pharm Inc Aminoacylaroylpyrroler til behandling af neuropatisk smerte
CA2300698C (en) 1999-02-19 2003-10-07 J. Garfield Purdon Broad spectrum decontamination formulation and method of use
DE19915602A1 (de) 1999-04-07 2000-10-19 Gruenenthal Gmbh 3-Amino-4-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung
GB9907965D0 (en) 1999-04-09 1999-06-02 Glaxo Group Ltd Medical use
JP2003510079A (ja) 1999-09-30 2003-03-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ナトリウムチャンネルβ1Aサブユニットに関連する方法および組成物

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US20050148636A1 (en) 2005-07-07
ES2286328T3 (es) 2007-12-01
US20040058980A1 (en) 2004-03-25
WO2003057147A3 (en) 2003-10-23
WO2003057219A1 (en) 2003-07-17
PT1458386E (pt) 2007-06-04
EP1458386B1 (en) 2007-04-18
SI1458386T1 (sl) 2007-08-31
WO2003057147A2 (en) 2003-07-17
AU2002359856A1 (en) 2003-07-24
AR038664A1 (es) 2005-01-26
ATE359783T1 (de) 2007-05-15
DE60219687D1 (de) 2007-05-31
US6897319B2 (en) 2005-05-24
AU2002364545A1 (en) 2003-07-24
JP2005514412A (ja) 2005-05-19
US20030181481A1 (en) 2003-09-25
EP1458386A1 (en) 2004-09-22
DK1458386T3 (da) 2007-08-13
TW200400030A (en) 2004-01-01
AU2002359856A8 (en) 2003-07-24
TWI282277B (en) 2007-06-11
DE60219687T2 (de) 2007-12-27

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