KR100585548B1 - 다중분석물을동시검출하기위한장치 - Google Patents

다중분석물을동시검출하기위한장치 Download PDF

Info

Publication number
KR100585548B1
KR100585548B1 KR1019980014131A KR19980014131A KR100585548B1 KR 100585548 B1 KR100585548 B1 KR 100585548B1 KR 1019980014131 A KR1019980014131 A KR 1019980014131A KR 19980014131 A KR19980014131 A KR 19980014131A KR 100585548 B1 KR100585548 B1 KR 100585548B1
Authority
KR
South Korea
Prior art keywords
substrate
analyte
ligand
ligands
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019980014131A
Other languages
English (en)
Korean (ko)
Other versions
KR19980081571A (ko
Inventor
스테펜 페터 피쯔제럴드
존 빅터 라몬트
로버트 이반 맥코넬
엘 오우아르드 벤치크
Original Assignee
란독스 래브러토리스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 란독스 래브러토리스 리미티드 filed Critical 란독스 래브러토리스 리미티드
Publication of KR19980081571A publication Critical patent/KR19980081571A/ko
Application granted granted Critical
Publication of KR100585548B1 publication Critical patent/KR100585548B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
KR1019980014131A 1997-04-21 1998-04-21 다중분석물을동시검출하기위한장치 Expired - Fee Related KR100585548B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97302707 1997-04-21
EP97302707.1 1997-04-21

Publications (2)

Publication Number Publication Date
KR19980081571A KR19980081571A (ko) 1998-11-25
KR100585548B1 true KR100585548B1 (ko) 2007-07-06

Family

ID=8229307

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980014131A Expired - Fee Related KR100585548B1 (ko) 1997-04-21 1998-04-21 다중분석물을동시검출하기위한장치

Country Status (31)

Country Link
US (1) US6498010B1 (enExample)
JP (1) JP4209494B2 (enExample)
KR (1) KR100585548B1 (enExample)
CN (1) CN1178063C (enExample)
AR (1) AR015110A1 (enExample)
AT (1) ATE289684T1 (enExample)
AU (1) AU713388B2 (enExample)
BR (1) BR9800655A (enExample)
CA (1) CA2235183C (enExample)
CZ (1) CZ297165B6 (enExample)
DE (1) DE69829089T3 (enExample)
EG (1) EG22471A (enExample)
ES (1) ES2238750T5 (enExample)
GB (1) GB2324866B (enExample)
GE (1) GEP20022846B (enExample)
HR (1) HRP980215A2 (enExample)
HU (1) HU220777B1 (enExample)
ID (1) ID20179A (enExample)
MY (1) MY114814A (enExample)
NO (1) NO981766L (enExample)
NZ (1) NZ330227A (enExample)
PL (1) PL325914A1 (enExample)
PT (1) PT874242E (enExample)
RU (1) RU2168174C2 (enExample)
SG (1) SG87765A1 (enExample)
SK (1) SK283340B6 (enExample)
TR (1) TR199800737A1 (enExample)
TW (1) TWI225928B (enExample)
UA (1) UA54400C2 (enExample)
YU (1) YU49328B (enExample)
ZA (1) ZA983345B (enExample)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ297165B6 (cs) * 1997-04-21 2006-09-13 Randox Laboratories Ltd. A British Company Of Ardmore Zpusob výroby zarízení s pevnou fází k provádení multianalytních rozboru
US20060029926A1 (en) * 1998-05-06 2006-02-09 Metrika, Inc. Blocking compositions for immunoassays
JP4261661B2 (ja) * 1999-01-28 2009-04-30 キヤノン株式会社 プローブ結合基板、プローブ結合基板の製造方法、プローブアレイ、標的物質の検出方法、サンプル中の一本鎖核酸の塩基配列を特定する方法、及びサンプル中の標的物質の定量方法
US6326083B1 (en) * 1999-03-08 2001-12-04 Calipher Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
DE60041363D1 (de) * 1999-07-14 2009-02-26 Spectral Diagnostics Inc Präparierung von sphären für diagnostische tests
CA2397091A1 (en) * 2000-01-11 2001-07-19 Markus Schweitzer Biomolecules having multiple attachment moieties for binding to a substrate surface
AUPR005600A0 (en) * 2000-09-12 2000-10-05 University Of Sydney, The Diagnostic assay
GB0027064D0 (en) * 2000-11-06 2000-12-20 Randox Lab Ltd Multi-analyte immunoassay
US6649078B2 (en) * 2000-12-06 2003-11-18 The Regents Of The University Of California Thin film capillary process and apparatus
GB0102357D0 (en) 2001-01-30 2001-03-14 Randox Lab Ltd Imaging method
WO2003006676A2 (en) 2001-07-13 2003-01-23 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
GB0120202D0 (en) 2001-08-18 2001-10-10 Psimedica Body fluid collection and analysis
US7097882B2 (en) * 2001-08-21 2006-08-29 Samsung Sdi Co., Ltd. Substrate for immobilizing physiological material, and method of fabricating same
GB0124338D0 (en) * 2001-10-10 2001-11-28 Randox Lab Ltd Biochips
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
KR100450191B1 (ko) * 2001-12-28 2004-10-02 삼성에스디아이 주식회사 생체물질 고정용 기판 및 이의 제조방법
US20050158848A1 (en) * 2002-04-12 2005-07-21 Ulrich Sieben Method for immobolizing molecules on surfaces
US20030208936A1 (en) * 2002-05-09 2003-11-13 Lee Charles Hee Method for manufacturing embroidery decorated cards and envelopes
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
US7070922B2 (en) 2002-12-04 2006-07-04 International Business Machines Corporation Surface treatment
US20040129676A1 (en) * 2003-01-07 2004-07-08 Tan Roy H. Apparatus for transfer of an array of liquids and methods for manufacturing same
US6972148B2 (en) 2003-06-23 2005-12-06 Kimberly-Clark Worldwide, Inc. Glove having improved donning characteristics
RU2326172C2 (ru) * 2003-09-18 2008-06-10 Поско Макромолекула регулируемого размера
US7695688B2 (en) * 2003-09-19 2010-04-13 Applied Biosystems, Llc High density plate filler
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US7998435B2 (en) 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
US9492820B2 (en) 2003-09-19 2016-11-15 Applied Biosystems, Llc High density plate filler
US7407630B2 (en) 2003-09-19 2008-08-05 Applera Corporation High density plate filler
US8105845B2 (en) * 2003-11-12 2012-01-31 Bio-Rad Haifa Ltd. System and method for carrying out multiple binding reactions in an array format
EP1700117B1 (en) * 2003-12-31 2008-05-21 Council of Scientific and Industrial Research Method and kit for pesticide analysis
US8592219B2 (en) 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent
US20090010819A1 (en) * 2004-01-17 2009-01-08 Gyros Patent Ab Versatile flow path
ES2332523T3 (es) * 2004-02-09 2010-02-08 Rapid Pathogen Screening Inc. Metodo para el diagnostico rapido de blancos en fluidos corporales humanos.
US20140031249A1 (en) * 2004-07-20 2014-01-30 Sqi Diagnostics Systems Inc. Multiplex measure of isotype antigen response
US7229782B1 (en) 2004-08-03 2007-06-12 Labone, Inc. Antibodies specific to multiple beta blockers and methods for their use
EP1657235B1 (en) 2004-11-10 2011-09-21 Randox Laboratories Ltd. Phenethanolamine-derived haptens, immunogens and conjugates comprising them and antibodies recognising said immunogenes and conjugates
FR2879483B1 (fr) * 2004-12-20 2007-04-27 Commissariat Energie Atomique Procede pour augmenter l'hydrophobicite d'un revetement externe d'un dispositif d'analyse, tel qu'une biopuce, un tel dispositif et procedes pour sa fabrication
US7396689B2 (en) * 2005-02-04 2008-07-08 Decision Biomarkers Incorporated Method of adjusting the working range of a multi-analyte assay
US8445293B2 (en) 2005-02-09 2013-05-21 Rapid Pathogen Screening, Inc. Method to increase specificity and/or accuracy of lateral flow immunoassays
EP1712914A1 (fr) * 2005-04-14 2006-10-18 Unisensor S.A. Procédé in vitro pour la detection et l'identification simultanées d'antibiotiques de classes differentes et trousse de diagnostic correspondante
EP1787699A1 (en) * 2005-11-17 2007-05-23 Vicam, L.P. Multi-analyte affinity column
KR100722321B1 (ko) 2005-12-28 2007-05-28 성균관대학교산학협력단 모세관력 리소그래피와 자기조립단분자막을 이용한 단백질패턴 형성 방법 및 이를 이용하여 제조된 단백질칩
US8084765B2 (en) * 2007-05-07 2011-12-27 Xerox Corporation Electronic device having a dielectric layer
EP3543357A1 (en) 2007-05-08 2019-09-25 Trustees of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
JP5255247B2 (ja) * 2007-09-04 2013-08-07 富士フイルム株式会社 基質の結合と反応生成物を同時に検出できるバイオセンサー
US20110058984A1 (en) 2008-05-08 2011-03-10 Hitachi High-Technologies Corporation Automatic analyzer
DK3404093T3 (da) 2008-07-16 2020-03-16 Childrens Medical Center Anordning og fremgangsmåde til overvågning af celleadfærd
EP2460012B1 (en) 2009-07-29 2016-04-20 Randox Laboratories Ltd. Method for detection of, or the risk of, bladder cancer
EP2483680A4 (en) 2009-09-30 2014-01-01 Quantapore Inc ULTRASOUND SEQUENCING OF BIOLOGICAL POLYMERS WITH THE HELP OF A MARKED NANOPORE
WO2012154729A1 (en) * 2011-05-09 2012-11-15 President And Fellows Of Harvard College A microfluidic module and uses thereof
US9566560B2 (en) * 2011-10-06 2017-02-14 Illumina, Inc. Array domains having rotated patterns
US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
GB201214440D0 (en) 2012-08-13 2012-09-26 Randox Lab Ltd Kidney disease biomarker
US20140072959A1 (en) 2012-09-12 2014-03-13 Force Diagnostics, Inc. Rapid tests for insurance underwriting
GB201218570D0 (en) 2012-10-16 2012-11-28 Randox Lab Ltd Method
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
EP3004385B1 (en) 2013-05-24 2018-11-28 Quantapore Inc. Nanopore-based nucleic acid analysis with mixed fret detection
BE1022360B1 (fr) * 2013-11-19 2016-03-24 Tekinvest Sprl Puits de microplaque, support de maintien et procede pour la detection d'analytes
US10288618B2 (en) * 2014-04-09 2019-05-14 Randox Laboratories Ltd. Diagnosis of cancer by detecting dimeric IL-18
WO2015161219A1 (en) * 2014-04-17 2015-10-22 SFC Fluidics, Inc. Microdialysis platform
EP2963124B1 (en) 2014-07-01 2018-06-20 Randox Laboratories Ltd. Biomarker combinations for use in pancreatic cancer screening
ES2789000T3 (es) 2014-10-10 2020-10-23 Quantapore Inc Análisis de polinucleótidos basado en nanoporos con marcadores fluorescentes que se inactivan mutuamente
CA2964790C (en) 2014-10-24 2023-02-21 Quantapore, Inc. Efficient optical analysis of polymers using arrays of nanostructures
WO2017011560A1 (en) 2015-07-15 2017-01-19 Hycor Biomedical, Llc. Customizable instrument
GB201519142D0 (en) 2015-10-29 2015-12-16 Randox Lab Ltd Method
GB201520341D0 (en) * 2015-11-18 2015-12-30 Randox Lab Ltd And Randox Teoranta Improvements relating to substrates for the attachment of molecules
WO2018002362A1 (en) 2016-06-30 2018-01-04 Randox Laboratories Ltd Measurement of fabp for diagnosis
US10823721B2 (en) 2016-07-05 2020-11-03 Quantapore, Inc. Optically based nanopore sequencing
GB201818744D0 (en) 2018-11-16 2019-01-02 Randox Laboratories Ltd Detection of bladder cancer
HU231258B1 (hu) 2019-01-28 2022-07-28 Ioi Auranae Kft. Berendezés és eljárás anion- és kationszint automatikus meghatározására vizeletből
GB201910730D0 (en) 2019-07-26 2019-09-11 Randox Teoranta Bovine Pathogen Array
GB201916186D0 (en) 2019-11-07 2019-12-25 Randox Laboratories Ltd Biomarkers for aiding in the diagnosis of mental disorders
GB202014755D0 (en) 2020-09-18 2020-11-04 Randox Laboratories Ltd Methods to determine coronavirus infectivty status
GB202019663D0 (en) 2020-12-14 2021-01-27 Randox Laboratories Predictive biomarkers for risk of bladder cancer in diabetes patients
US20240061001A1 (en) * 2020-12-30 2024-02-22 Beckman Coulter, Inc. Clinical laboratory automation system with single calibrator
GB202104287D0 (en) 2021-03-26 2021-05-12 Randox Laboratories Method for determining prognosis of chronic kidney disease
GB202111635D0 (en) 2021-08-13 2021-09-29 Randox Laboratories Risk prediction model for prostate cancer
GB202114088D0 (en) 2021-10-01 2021-11-17 Randox Laboratories Detection of bladder cancer in males
GB202203639D0 (en) 2022-03-16 2022-04-27 Randox Laboratories Ltd Standardisation method for glycosylation arrays
GB202204413D0 (en) 2022-03-29 2022-05-11 Randox Laboratories Ltd Markers for progression of inflammatory liver disease
GB202405974D0 (en) 2024-04-29 2024-06-12 Randox Laboratories Ltd Method of stratifying haematuria patients

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127438A1 (en) * 1983-05-25 1984-12-05 National Research Development Corporation Diagnostic device incorporating a biochemical ligand
US4960714A (en) * 1984-09-06 1990-10-02 Burroughs Wellcome Co. Diagnostic test methods
JPH06148188A (ja) * 1992-11-13 1994-05-27 Olympus Optical Co Ltd 免疫学的再検査方法
EP0874242A1 (en) * 1997-04-21 1998-10-28 Randox Laboratories Ltd. Device and apparatus for the simultaneous detection of multiple analytes
JPH10319011A (ja) * 1997-04-21 1998-12-04 Randox Lab Ltd 複数の分析物の同時検出デバイス及び装置

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063810B1 (en) * 1981-04-29 1986-03-05 Ciba-Geigy Ag New devices and kits for immunological analysis
SE431620B (sv) 1982-07-07 1984-02-20 Stojan Popovic Suganordning, speciellt avsedd att anvendas som tennsug vid lodningsarbeten
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US4829010A (en) * 1987-03-13 1989-05-09 Tanox Biosystems, Inc. Immunoassay device enclosing matrixes of antibody spots for cell determinations
JPH0743338B2 (ja) * 1987-07-03 1995-05-15 テルモ株式会社 マルチセンサ
GB8803000D0 (en) * 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
SU1696399A1 (ru) 1988-07-01 1991-12-07 Государственный научно-исследовательский и проектный институт по обогащению руд цветных металлов "Казмеханобр" Способ очистки сточных вод от ионов т желых металлов
WO1990001564A1 (en) * 1988-08-09 1990-02-22 Microprobe Corporation Methods for multiple target analyses through nucleic acid hybridization
US5077210A (en) * 1989-01-13 1991-12-31 Eigler Frances S Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent
US5120662A (en) * 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
RU2000572C1 (ru) * 1991-08-02 1993-09-07 Институт геохимии и аналитической химии им.В.М.Вернадского РАН Светоадресуемое потенциометрическое устройство дл биохимического анализа
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
FR2693740B1 (fr) 1992-07-17 1994-10-14 Univ Joseph Fourier Procédé de détection tissulaire ou cellulaire mettant en Óoeuvre des réactifs chimiluminescents.
WO1994003807A1 (en) 1992-08-03 1994-02-17 Gec-Marconi Limited Separation method
EP0692096A1 (en) * 1993-03-30 1996-01-17 Terrapin Technologies, Inc. Determination of concentration by affinity titration and competitive displacement in drug delivery
WO1994027137A2 (en) * 1993-05-18 1994-11-24 University Of Utah Research Foundation Apparatus and methods for multianalyte homogeneous fluoroimmunoassays
GB9325100D0 (en) * 1993-12-07 1994-02-02 Univ Court Of The University O Device
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
EP0768530A1 (en) * 1995-10-16 1997-04-16 Nippon Paint Co., Ltd. Process for assaying biological substance

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127438A1 (en) * 1983-05-25 1984-12-05 National Research Development Corporation Diagnostic device incorporating a biochemical ligand
US4960714A (en) * 1984-09-06 1990-10-02 Burroughs Wellcome Co. Diagnostic test methods
JPH06148188A (ja) * 1992-11-13 1994-05-27 Olympus Optical Co Ltd 免疫学的再検査方法
EP0874242A1 (en) * 1997-04-21 1998-10-28 Randox Laboratories Ltd. Device and apparatus for the simultaneous detection of multiple analytes
JPH10319011A (ja) * 1997-04-21 1998-12-04 Randox Lab Ltd 複数の分析物の同時検出デバイス及び装置
US6498010B1 (en) * 1997-04-21 2002-12-24 Randox Laboratories, Ltd Method for making a device for the simultaneous detection of multiple analytes

Also Published As

Publication number Publication date
PT874242E (pt) 2005-06-30
KR19980081571A (ko) 1998-11-25
HRP980215A2 (en) 1999-02-28
AR015110A1 (es) 2001-04-18
ES2238750T3 (es) 2005-09-01
CA2235183A1 (en) 1998-10-21
MX9803102A (es) 1998-12-31
ID20179A (id) 1998-10-22
AU6198898A (en) 1998-10-22
HU9800920D0 (en) 1998-06-29
DE69829089D1 (de) 2005-03-31
NZ330227A (en) 1999-10-28
YU49328B (sh) 2005-07-19
JP4209494B2 (ja) 2009-01-14
BR9800655A (pt) 1999-08-10
ZA983345B (en) 1999-04-21
TWI225928B (en) 2005-01-01
GB2324866A (en) 1998-11-04
RU2168174C2 (ru) 2001-05-27
GB9808309D0 (en) 1998-06-17
CN1215167A (zh) 1999-04-28
PL325914A1 (en) 1998-10-26
SK51098A3 (en) 1998-11-04
DE69829089T3 (de) 2009-11-26
NO981766L (no) 1998-10-22
HUP9800920A1 (hu) 1998-10-28
AU713388B2 (en) 1999-12-02
SG87765A1 (en) 2002-04-16
CZ116998A3 (cs) 1998-11-11
NO981766D0 (no) 1998-04-20
HK1012202A1 (en) 1999-07-30
EG22471A (en) 2003-02-26
JPH10319011A (ja) 1998-12-04
TR199800737A1 (xx) 1998-11-23
ATE289684T1 (de) 2005-03-15
DE69829089T2 (de) 2005-12-29
ES2238750T5 (es) 2009-11-03
US6498010B1 (en) 2002-12-24
CZ297165B6 (cs) 2006-09-13
CN1178063C (zh) 2004-12-01
HU220777B1 (hu) 2002-05-28
YU17498A (en) 1999-11-22
MY114814A (en) 2003-01-31
SK283340B6 (sk) 2003-06-03
GEP20022846B (en) 2002-11-25
UA54400C2 (uk) 2003-03-17
CA2235183C (en) 2009-08-11
GB2324866B (en) 2001-11-14

Similar Documents

Publication Publication Date Title
US6498010B1 (en) Method for making a device for the simultaneous detection of multiple analytes
EP0874242B1 (en) Device and apparatus for the simultaneous detection of multiple analytes
JP4209978B2 (ja) ポリエチレングリコール誘導化生体分子及び不均質検出法におけるその使用
US4689310A (en) Methods for attaching ligands or anti-ligands to a solid phase
WO2011109372A1 (en) Ultra-sensitive detection of molecules using dual detection methods
JPH0731206B2 (ja) 固定化したビオチン化受容体を用いるリガンド測定のための試験装置，キットおよび方法
JP3214795B2 (ja) ビオチンシラン化合物及びこれらの化合物を含む結合マトリックス
CN1720096A (zh) 表面处理
US4791069A (en) Methods for attaching ligands or anti-ligands to a solid phase
JP5089511B2 (ja) 吸光物質含有コロイドシリカ粒子を用いた生体分子の検出ないしは定量方法
US7011955B1 (en) Quantitative determination of analytes in a heterogeneous system
JP3715348B2 (ja) 修飾アポペルオキシダーゼを用いる分析要素、組成物および方法
JP3808527B2 (ja) 特異的結合方法および試験キット
MXPA98003102A (es) Dispositivo y aparato para la deteccion simultanea de analitos multiples
EP0184701A2 (en) A method for determining a ligand
US20030224459A1 (en) Protein detection method
JPH01317389A (ja) 生化学反応用担体およびその製造方法

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

AMND Amendment
J201 Request for trial against refusal decision
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PJ0201 Trial against decision of rejection

St.27 status event code: A-3-3-V10-V11-apl-PJ0201

PB0901 Examination by re-examination before a trial

St.27 status event code: A-6-3-E10-E12-rex-PB0901

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

B701 Decision to grant
PB0701 Decision of registration after re-examination before a trial

St.27 status event code: A-3-4-F10-F13-rex-PB0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20130524

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

FPAY Annual fee payment

Payment date: 20140530

Year of fee payment: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

FPAY Annual fee payment

Payment date: 20150619

Year of fee payment: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

FPAY Annual fee payment

Payment date: 20160512

Year of fee payment: 11

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20170525

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20170525

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000