KR100583545B1 - 인돌릴-3-글리옥실산 유도체를 포함하는 약제학적 조성물 - Google Patents

인돌릴-3-글리옥실산 유도체를 포함하는 약제학적 조성물 Download PDF

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KR100583545B1
KR100583545B1 KR1020007010934A KR20007010934A KR100583545B1 KR 100583545 B1 KR100583545 B1 KR 100583545B1 KR 1020007010934 A KR1020007010934 A KR 1020007010934A KR 20007010934 A KR20007010934 A KR 20007010934A KR 100583545 B1 KR100583545 B1 KR 100583545B1
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glyoxylamide
acid
physiologically acceptable
indol
pyridin
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KR20010042368A (ko
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닉켈베른트
슈첼레니이이스트판
슈밋트위르겐
에믹페터
라이헤르트디트마르
귄터엑크하르트
브루네카이
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아스타 메디카 아크티엔게젤샤프트
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
KR1020007010934A 1998-04-02 1999-03-22 인돌릴-3-글리옥실산 유도체를 포함하는 약제학적 조성물 Expired - Fee Related KR100583545B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19814838.0 1998-04-02
DE19814838A DE19814838C2 (de) 1998-04-02 1998-04-02 Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung

Publications (2)

Publication Number Publication Date
KR20010042368A KR20010042368A (ko) 2001-05-25
KR100583545B1 true KR100583545B1 (ko) 2006-05-26

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Country Status (32)

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US (4) US6232327B1 (enExample)
EP (1) EP1071420B1 (enExample)
JP (2) JP5253696B2 (enExample)
KR (1) KR100583545B1 (enExample)
CN (1) CN1148183C (enExample)
AR (1) AR018175A1 (enExample)
AT (1) ATE304352T1 (enExample)
AU (1) AU768510B2 (enExample)
BG (1) BG64838B1 (enExample)
BR (1) BR9909902A (enExample)
CA (1) CA2326833C (enExample)
DE (2) DE19814838C2 (enExample)
DK (1) DK1071420T3 (enExample)
EE (1) EE04354B1 (enExample)
ES (1) ES2249884T3 (enExample)
GE (1) GEP20032967B (enExample)
HR (1) HRP20000643A2 (enExample)
HU (1) HUP0101530A3 (enExample)
ID (1) ID26504A (enExample)
IL (2) IL138737A0 (enExample)
IS (1) IS2307B (enExample)
NO (1) NO327721B1 (enExample)
NZ (1) NZ507084A (enExample)
PL (1) PL192779B1 (enExample)
RS (1) RS49866B (enExample)
RU (1) RU2262339C2 (enExample)
SK (1) SK286393B6 (enExample)
TR (1) TR200002853T2 (enExample)
TW (1) TWI230608B (enExample)
UA (1) UA70942C2 (enExample)
WO (1) WO1999051224A1 (enExample)
ZA (1) ZA200006150B (enExample)

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DK1071420T3 (da) 2006-01-16
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EP1071420A1 (de) 2001-01-31
NO327721B1 (no) 2009-09-14
BR9909902A (pt) 2000-12-26
AU768510B2 (en) 2003-12-18
ES2249884T3 (es) 2006-04-01
BG64838B1 (bg) 2006-06-30
BG104849A (en) 2001-05-31
JP2011148809A (ja) 2011-08-04
NO20004916L (no) 2000-12-01
NO20004916D0 (no) 2000-09-29
US7579365B2 (en) 2009-08-25
RU2262339C2 (ru) 2005-10-20
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CA2326833C (en) 2009-06-23
HRP20000643A2 (en) 2001-04-30
PL192779B1 (pl) 2006-12-29
EE200000581A (et) 2002-02-15
US20030195360A1 (en) 2003-10-16
CN1148183C (zh) 2004-05-05
JP5253696B2 (ja) 2013-07-31
WO1999051224A1 (de) 1999-10-14
RS49866B (sr) 2008-08-07
DE19814838A1 (de) 1999-10-14
IL138737A0 (en) 2001-10-31
IS5635A (is) 2000-09-22
IL138737A (en) 2007-02-11
ID26504A (id) 2001-01-11
TWI230608B (en) 2005-04-11
YU59300A (sh) 2002-11-15
PL343525A1 (en) 2001-08-27
UA70942C2 (uk) 2004-11-15
SK14302000A3 (sk) 2001-11-06
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JP2002510622A (ja) 2002-04-09
ZA200006150B (en) 2001-01-11
HUP0101530A3 (en) 2002-12-28
US6232327B1 (en) 2001-05-15
ATE304352T1 (de) 2005-09-15
AU2934999A (en) 1999-10-25
US20030023093A1 (en) 2003-01-30
SK286393B6 (sk) 2008-09-05
AR018175A1 (es) 2001-10-31
US20080027110A1 (en) 2008-01-31
IS2307B (is) 2007-10-15
EP1071420B1 (de) 2005-09-14
TR200002853T2 (tr) 2001-02-21
DE19814838C2 (de) 2001-01-18
CA2326833A1 (en) 1999-10-14
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