BR9909902A - Derivados de ácido indolil-3-glioxìlico com efeito antitumor - Google Patents

Derivados de ácido indolil-3-glioxìlico com efeito antitumor

Info

Publication number
BR9909902A
BR9909902A BR9909902-0A BR9909902A BR9909902A BR 9909902 A BR9909902 A BR 9909902A BR 9909902 A BR9909902 A BR 9909902A BR 9909902 A BR9909902 A BR 9909902A
Authority
BR
Brazil
Prior art keywords
general formula
indolyl
acid derivatives
antitumor effect
oxides
Prior art date
Application number
BR9909902-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Bernd Nickel
Istvan Szelenyi
Juergen Schmidt
Peter Emig
Dietmar Reichert
Eckhard Guenther
Kay Brune
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of BR9909902A publication Critical patent/BR9909902A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
BR9909902-0A 1998-04-02 1999-03-22 Derivados de ácido indolil-3-glioxìlico com efeito antitumor BR9909902A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19814838A DE19814838C2 (de) 1998-04-02 1998-04-02 Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
PCT/EP1999/001918 WO1999051224A1 (de) 1998-04-02 1999-03-22 Indolyl-3-glyoxylsäure-derivate mit antitumorwirkung

Publications (1)

Publication Number Publication Date
BR9909902A true BR9909902A (pt) 2000-12-26

Family

ID=7863398

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909902-0A BR9909902A (pt) 1998-04-02 1999-03-22 Derivados de ácido indolil-3-glioxìlico com efeito antitumor

Country Status (32)

Country Link
US (4) US6232327B1 (enExample)
EP (1) EP1071420B1 (enExample)
JP (2) JP5253696B2 (enExample)
KR (1) KR100583545B1 (enExample)
CN (1) CN1148183C (enExample)
AR (1) AR018175A1 (enExample)
AT (1) ATE304352T1 (enExample)
AU (1) AU768510B2 (enExample)
BG (1) BG64838B1 (enExample)
BR (1) BR9909902A (enExample)
CA (1) CA2326833C (enExample)
DE (2) DE19814838C2 (enExample)
DK (1) DK1071420T3 (enExample)
EE (1) EE04354B1 (enExample)
ES (1) ES2249884T3 (enExample)
GE (1) GEP20032967B (enExample)
HR (1) HRP20000643A2 (enExample)
HU (1) HUP0101530A3 (enExample)
ID (1) ID26504A (enExample)
IL (2) IL138737A0 (enExample)
IS (1) IS2307B (enExample)
NO (1) NO327721B1 (enExample)
NZ (1) NZ507084A (enExample)
PL (1) PL192779B1 (enExample)
RS (1) RS49866B (enExample)
RU (1) RU2262339C2 (enExample)
SK (1) SK286393B6 (enExample)
TR (1) TR200002853T2 (enExample)
TW (1) TWI230608B (enExample)
UA (1) UA70942C2 (enExample)
WO (1) WO1999051224A1 (enExample)
ZA (1) ZA200006150B (enExample)

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US20060280787A1 (en) 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof

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US20080027110A1 (en) 2008-01-31
HK1036408A1 (en) 2002-01-04
TWI230608B (en) 2005-04-11
HUP0101530A3 (en) 2002-12-28
CN1148183C (zh) 2004-05-05
HRP20000643A2 (en) 2001-04-30
US20030023093A1 (en) 2003-01-30
US7579365B2 (en) 2009-08-25
ATE304352T1 (de) 2005-09-15
WO1999051224A1 (de) 1999-10-14
SK14302000A3 (sk) 2001-11-06
NO20004916L (no) 2000-12-01
AR018175A1 (es) 2001-10-31
CN1299280A (zh) 2001-06-13
JP2002510622A (ja) 2002-04-09
SK286393B6 (sk) 2008-09-05
BG104849A (en) 2001-05-31
ES2249884T3 (es) 2006-04-01
UA70942C2 (uk) 2004-11-15
AU2934999A (en) 1999-10-25
NZ507084A (en) 2003-10-31
AU768510B2 (en) 2003-12-18
DK1071420T3 (da) 2006-01-16
JP2011148809A (ja) 2011-08-04
PL192779B1 (pl) 2006-12-29
IL138737A (en) 2007-02-11
NO327721B1 (no) 2009-09-14
EE04354B1 (et) 2004-10-15
DE19814838C2 (de) 2001-01-18
BG64838B1 (bg) 2006-06-30
TR200002853T2 (tr) 2001-02-21
EP1071420B1 (de) 2005-09-14
IL138737A0 (en) 2001-10-31
EE200000581A (et) 2002-02-15
YU59300A (sh) 2002-11-15
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KR20010042368A (ko) 2001-05-25
ID26504A (id) 2001-01-11
GEP20032967B (en) 2003-05-27
US20030195360A1 (en) 2003-10-16
CA2326833A1 (en) 1999-10-14
DE59912562D1 (en) 2005-10-20
EP1071420A1 (de) 2001-01-31
IS2307B (is) 2007-10-15
RU2262339C2 (ru) 2005-10-20
DE19814838A1 (de) 1999-10-14
CA2326833C (en) 2009-06-23
NO20004916D0 (no) 2000-09-29
US6232327B1 (en) 2001-05-15
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JP5253696B2 (ja) 2013-07-31

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