KR100526379B1 - 세팔로스포린 제조에 유용한 커플링법 및 중간체 - Google Patents

세팔로스포린 제조에 유용한 커플링법 및 중간체 Download PDF

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Publication number
KR100526379B1
KR100526379B1 KR10-2003-7007396A KR20037007396A KR100526379B1 KR 100526379 B1 KR100526379 B1 KR 100526379B1 KR 20037007396 A KR20037007396 A KR 20037007396A KR 100526379 B1 KR100526379 B1 KR 100526379B1
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South Korea
Prior art keywords
formula
alkyl
compound
aryl
solution
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Expired - Fee Related
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KR10-2003-7007396A
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English (en)
Korean (ko)
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KR20030070043A (ko
Inventor
주안 카를로스 콜버그
알레산드로 도나델리
지오바니 포그리아토
모리지오 제노니
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화이자 프로덕츠 인크.
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR10-2003-7007396A 2000-12-04 2001-11-22 세팔로스포린 제조에 유용한 커플링법 및 중간체 Expired - Fee Related KR100526379B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25101400P 2000-12-04 2000-12-04
US60/251,014 2000-12-04
PCT/IB2001/002225 WO2002046198A1 (en) 2000-12-04 2001-11-22 Coupling process and intermediates useful for preparing cephalosphorins

Publications (2)

Publication Number Publication Date
KR20030070043A KR20030070043A (ko) 2003-08-27
KR100526379B1 true KR100526379B1 (ko) 2005-11-08

Family

ID=22950114

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7007396A Expired - Fee Related KR100526379B1 (ko) 2000-12-04 2001-11-22 세팔로스포린 제조에 유용한 커플링법 및 중간체

Country Status (17)

Country Link
US (2) US20020198375A1 (enExample)
EP (1) EP1339722A1 (enExample)
JP (1) JP2004520293A (enExample)
KR (1) KR100526379B1 (enExample)
CN (1) CN1243755C (enExample)
AR (1) AR035511A1 (enExample)
AU (2) AU2394302A (enExample)
BR (1) BR0115870A (enExample)
CA (1) CA2436848C (enExample)
CZ (1) CZ20031525A3 (enExample)
HU (1) HUP0400642A3 (enExample)
IL (1) IL155714A0 (enExample)
MX (1) MXPA03004937A (enExample)
PL (1) PL362144A1 (enExample)
RU (1) RU2237670C1 (enExample)
WO (1) WO2002046198A1 (enExample)
ZA (1) ZA200303670B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030051895A (ko) * 2000-12-04 2003-06-25 후지사와 야꾸힝 고교 가부시키가이샤 아미노티아졸 유도체의 무수물의 제조 방법
US7378408B2 (en) * 2001-11-30 2008-05-27 Pfizer Inc. Methods of treatment and formulations of cephalosporin
RU2321590C1 (ru) * 2004-03-09 2008-04-10 Пфайзер Продактс Инк. Способ получения промежуточных соединений цефалоспорина с использованием сложных эфиров альфа-йод-1-азетидинуксусной кислоты и триалкилфосфитов
SG194779A1 (en) 2011-05-04 2013-12-30 Univ Cornell Multiblock copolymer films, methods of making same, and uses thereof
EP2740730B1 (en) 2011-08-03 2016-11-16 Kyowa Hakko Kirin Co., Ltd. Dibenzooxepin derivative
CN102718779B (zh) * 2012-05-25 2015-07-29 深圳致君制药有限公司 注射用头孢唑肟钠及其制备方法、原料药头孢唑肟钠的合成方法
CN105254648B (zh) * 2015-11-13 2018-04-03 广东温氏大华农生物科技有限公司 一种头孢维星及其钠盐的合成方法
WO2018229580A1 (en) * 2017-06-14 2018-12-20 Aurobindo Pharma Ltd An improved process for the preparation of cefovecin sodium
EP3697524A4 (en) 2017-09-19 2021-09-01 Terapore Technologies, Inc. CHEMICALLY RESISTANT ISOPOROUS CROSS-LINKED BLOCK COPOLYMER STRUCTURE
EP3774003A4 (en) * 2018-04-04 2022-01-05 Terapore Technologies, Inc. ENCAPSULATION PARTICLE FRACTIONATION DEVICES AND SYSTEMS AND THEIR METHODS OF USE
GB2575261B (en) 2018-07-02 2022-03-09 Norbrook Lab Ltd Intermediates in the synthesis of C3-substituted cephalosporins
US11051804B2 (en) * 2018-07-02 2021-07-06 DePuy Synthes Products, Inc. Orthopedic fixation system and method of use thereof
CN110396034A (zh) * 2019-07-31 2019-11-01 上海应用技术大学 一种烯丙基化合物的制备方法
CN111187284A (zh) * 2020-03-10 2020-05-22 赵俊瑶 一种头孢克洛的制备方法
CN111892612A (zh) * 2020-07-31 2020-11-06 重庆医药高等专科学校 一种以青霉素钾盐为原料制备头孢维星的中间体异构化物及其制备方法
CN112321611B (zh) * 2020-10-29 2022-05-06 湖北凌晟药业有限公司 一种头孢沙定母核的制备方法
CN115873021A (zh) * 2022-12-19 2023-03-31 华北制药集团动物保健品有限责任公司 一种头孢维星钠的制备方法
CN116731039B (zh) * 2023-06-12 2025-02-18 重庆汉佩生物科技有限公司 头孢维星衍生物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY106399A (en) * 1990-07-24 1995-05-30 Pfizer Cephalosporins and homologeus, preparation and pharmaceutical composition
US6001997A (en) * 1990-07-24 1999-12-14 Bateson; John Hargreaves Cephalosporins and homologues, preparations and pharmaceutical compositions
GB9212609D0 (en) * 1992-06-13 1992-07-29 Smithkline Beecham Plc Novel compounds
GB9424847D0 (en) * 1994-12-09 1995-02-08 Smithkline Beecham Plc Novel process
GB2300856A (en) * 1995-05-16 1996-11-20 Pfizer Ltd Beta-lactam preparation
GB0019124D0 (en) * 2000-08-03 2000-09-27 Pfizer Novel process
DE60117876T2 (de) * 2000-12-04 2006-08-31 Pfizer Products Inc., Groton Verfahren und esterderivate zur herstellung von cephalosphorinen

Also Published As

Publication number Publication date
HK1059435A1 (en) 2004-07-02
CA2436848C (en) 2008-12-02
BR0115870A (pt) 2004-02-03
MXPA03004937A (es) 2003-09-10
AU2002223943B2 (en) 2006-10-05
JP2004520293A (ja) 2004-07-08
WO2002046198A1 (en) 2002-06-13
ZA200303670B (en) 2004-05-13
HUP0400642A3 (en) 2010-03-29
AU2394302A (en) 2002-06-18
RU2237670C1 (ru) 2004-10-10
CZ20031525A3 (cs) 2004-04-14
US20020198375A1 (en) 2002-12-26
IL155714A0 (en) 2003-11-23
US20040167327A1 (en) 2004-08-26
CN1243755C (zh) 2006-03-01
EP1339722A1 (en) 2003-09-03
CA2436848A1 (en) 2002-06-13
PL362144A1 (en) 2004-10-18
CN1478093A (zh) 2004-02-25
KR20030070043A (ko) 2003-08-27
HUP0400642A2 (hu) 2004-06-28
AR035511A1 (es) 2004-06-02
US7129350B2 (en) 2006-10-31

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