BR0115870A - Processos de acoplamento e intermediários úteis para preparação de cefalosporinas - Google Patents
Processos de acoplamento e intermediários úteis para preparação de cefalosporinasInfo
- Publication number
- BR0115870A BR0115870A BR0115870-8A BR0115870A BR0115870A BR 0115870 A BR0115870 A BR 0115870A BR 0115870 A BR0115870 A BR 0115870A BR 0115870 A BR0115870 A BR 0115870A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- aryl
- preparation
- formula
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"PROCESSOS DE ACOPLAMENTO E INTERMEDIáRIOS úTEIS PARA PREPARAçãO DE CEFALOSPORINAS". A presente invenção refere-se a um novo processo para a preparação de cefalosporinas 3-cíclico-éter-substituída de fórmula I em que o grupo CO~ 2~R^ 1^ é um ácido carboxílico ou um sal carboxilato; e R^ 2^ tem a fórmula: em que A^ 1^ é selecionado do grupo consistindo por C~ 6-10~arila, C~ 1-10~heteroarila ou C~ 1-10~heterociclila; A^ 2^ é selecionado do grupo consistindo em hidrogênio, C~ 1-6~alquila, C~ 3-10~cicloalquila, C~ 6-10~arila, C~ 1-6~alquil(CO)(C~ 1-6~)alquil-O-, HO(CO) (C~ 1-6~)alquila, mono-(C~ 6-10~aril)(C~ 1-6~alquila), di-(C~ 6-10~aril)(C~ 1-6~alquila) ou tri-(C~ 6-10~aril)(C~ 1-6~alquila); a partir de um composto zwiteriónico de fórmula II; ou a partir de um composto de fórmula V: em que R^ 2^ é como definido acima, e R^ 3^ é para-nitrobenzila ou alila. A invenção refere-se também à preparação dos compostos acima de fórmulas II e V.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25101400P | 2000-12-04 | 2000-12-04 | |
| PCT/IB2001/002225 WO2002046198A1 (en) | 2000-12-04 | 2001-11-22 | Coupling process and intermediates useful for preparing cephalosphorins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0115870A true BR0115870A (pt) | 2004-02-03 |
Family
ID=22950114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0115870-8A BR0115870A (pt) | 2000-12-04 | 2001-11-22 | Processos de acoplamento e intermediários úteis para preparação de cefalosporinas |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20020198375A1 (pt) |
| EP (1) | EP1339722A1 (pt) |
| JP (1) | JP2004520293A (pt) |
| KR (1) | KR100526379B1 (pt) |
| CN (1) | CN1243755C (pt) |
| AR (1) | AR035511A1 (pt) |
| AU (2) | AU2394302A (pt) |
| BR (1) | BR0115870A (pt) |
| CA (1) | CA2436848C (pt) |
| CZ (1) | CZ20031525A3 (pt) |
| HK (1) | HK1059435A1 (pt) |
| HU (1) | HUP0400642A3 (pt) |
| IL (1) | IL155714A0 (pt) |
| MX (1) | MXPA03004937A (pt) |
| PL (1) | PL362144A1 (pt) |
| RU (1) | RU2237670C1 (pt) |
| WO (1) | WO2002046198A1 (pt) |
| ZA (1) | ZA200303670B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002222553A1 (en) * | 2000-12-04 | 2002-06-18 | Fujisawa Pharmaceutical Co. Ltd. | Process for producing anhydride of aminothiazole derivative |
| US7378408B2 (en) * | 2001-11-30 | 2008-05-27 | Pfizer Inc. | Methods of treatment and formulations of cephalosporin |
| EP1725568A1 (en) * | 2004-03-09 | 2006-11-29 | Pfizer Products Inc. | Process for preparing cephalosporin intermediates using alpha-iod o-1-azetidineacetic acid esters and trialkylphosphites |
| EP2740730B1 (en) | 2011-08-03 | 2016-11-16 | Kyowa Hakko Kirin Co., Ltd. | Dibenzooxepin derivative |
| CN102718779B (zh) * | 2012-05-25 | 2015-07-29 | 深圳致君制药有限公司 | 注射用头孢唑肟钠及其制备方法、原料药头孢唑肟钠的合成方法 |
| CN105254648B (zh) * | 2015-11-13 | 2018-04-03 | 广东温氏大华农生物科技有限公司 | 一种头孢维星及其钠盐的合成方法 |
| WO2018229580A1 (en) * | 2017-06-14 | 2018-12-20 | Aurobindo Pharma Ltd | An improved process for the preparation of cefovecin sodium |
| KR20200140330A (ko) * | 2018-04-04 | 2020-12-15 | 테라포어 테크놀로지스, 인코포레이티드 | 캡슐화 입자 분획 장치 및 시스템과 이의 사용 방법 |
| US11051804B2 (en) * | 2018-07-02 | 2021-07-06 | DePuy Synthes Products, Inc. | Orthopedic fixation system and method of use thereof |
| GB2575261B (en) | 2018-07-02 | 2022-03-09 | Norbrook Lab Ltd | Intermediates in the synthesis of C3-substituted cephalosporins |
| CN110396034A (zh) * | 2019-07-31 | 2019-11-01 | 上海应用技术大学 | 一种烯丙基化合物的制备方法 |
| CN111187284A (zh) * | 2020-03-10 | 2020-05-22 | 赵俊瑶 | 一种头孢克洛的制备方法 |
| CN111892612A (zh) * | 2020-07-31 | 2020-11-06 | 重庆医药高等专科学校 | 一种以青霉素钾盐为原料制备头孢维星的中间体异构化物及其制备方法 |
| CN112321611B (zh) * | 2020-10-29 | 2022-05-06 | 湖北凌晟药业有限公司 | 一种头孢沙定母核的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY106399A (en) * | 1990-07-24 | 1995-05-30 | Pfizer | Cephalosporins and homologeus, preparation and pharmaceutical composition |
| US6001997A (en) * | 1990-07-24 | 1999-12-14 | Bateson; John Hargreaves | Cephalosporins and homologues, preparations and pharmaceutical compositions |
| GB9212609D0 (en) * | 1992-06-13 | 1992-07-29 | Smithkline Beecham Plc | Novel compounds |
| GB9424847D0 (en) * | 1994-12-09 | 1995-02-08 | Smithkline Beecham Plc | Novel process |
| GB2300856A (en) * | 1995-05-16 | 1996-11-20 | Pfizer Ltd | Beta-lactam preparation |
| GB0019124D0 (en) * | 2000-08-03 | 2000-09-27 | Pfizer | Novel process |
| IL155701A0 (en) * | 2000-12-04 | 2003-11-23 | Pfizer Prod Inc | Process and ester derivatives useful for preparation of cephalosporins |
-
2001
- 2001-11-22 RU RU2003116519/04A patent/RU2237670C1/ru active
- 2001-11-22 CA CA002436848A patent/CA2436848C/en not_active Expired - Fee Related
- 2001-11-22 BR BR0115870-8A patent/BR0115870A/pt not_active IP Right Cessation
- 2001-11-22 JP JP2002547935A patent/JP2004520293A/ja active Pending
- 2001-11-22 IL IL15571401A patent/IL155714A0/xx unknown
- 2001-11-22 KR KR10-2003-7007396A patent/KR100526379B1/ko not_active IP Right Cessation
- 2001-11-22 HU HU0400642A patent/HUP0400642A3/hu unknown
- 2001-11-22 AU AU2394302A patent/AU2394302A/xx active Pending
- 2001-11-22 CZ CZ20031525A patent/CZ20031525A3/cs unknown
- 2001-11-22 CN CNB018199623A patent/CN1243755C/zh not_active Expired - Fee Related
- 2001-11-22 MX MXPA03004937A patent/MXPA03004937A/es active IP Right Grant
- 2001-11-22 EP EP01999227A patent/EP1339722A1/en not_active Withdrawn
- 2001-11-22 PL PL01362144A patent/PL362144A1/xx not_active Application Discontinuation
- 2001-11-22 WO PCT/IB2001/002225 patent/WO2002046198A1/en active IP Right Grant
- 2001-11-22 AU AU2002223943A patent/AU2002223943B2/en not_active Ceased
- 2001-12-03 AR ARP010105609A patent/AR035511A1/es not_active Application Discontinuation
- 2001-12-04 US US10/006,279 patent/US20020198375A1/en not_active Abandoned
-
2003
- 2003-05-13 ZA ZA200303670A patent/ZA200303670B/en unknown
-
2004
- 2004-02-11 US US10/776,795 patent/US7129350B2/en not_active Expired - Lifetime
- 2004-03-25 HK HK04102215A patent/HK1059435A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2436848A1 (en) | 2002-06-13 |
| AR035511A1 (es) | 2004-06-02 |
| US20020198375A1 (en) | 2002-12-26 |
| RU2237670C1 (ru) | 2004-10-10 |
| HUP0400642A2 (hu) | 2004-06-28 |
| CZ20031525A3 (cs) | 2004-04-14 |
| KR100526379B1 (ko) | 2005-11-08 |
| MXPA03004937A (es) | 2003-09-10 |
| US20040167327A1 (en) | 2004-08-26 |
| CN1478093A (zh) | 2004-02-25 |
| HUP0400642A3 (en) | 2010-03-29 |
| CA2436848C (en) | 2008-12-02 |
| CN1243755C (zh) | 2006-03-01 |
| JP2004520293A (ja) | 2004-07-08 |
| WO2002046198A1 (en) | 2002-06-13 |
| AU2394302A (en) | 2002-06-18 |
| US7129350B2 (en) | 2006-10-31 |
| KR20030070043A (ko) | 2003-08-27 |
| EP1339722A1 (en) | 2003-09-03 |
| HK1059435A1 (en) | 2004-07-02 |
| PL362144A1 (en) | 2004-10-18 |
| IL155714A0 (en) | 2003-11-23 |
| ZA200303670B (en) | 2004-05-13 |
| AU2002223943B2 (en) | 2006-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |