DE60028990D1 - Verfahren zur herstellung von aliphatischen carboxylatenmit piperazinsubstituenten - Google Patents

Verfahren zur herstellung von aliphatischen carboxylatenmit piperazinsubstituenten

Info

Publication number
DE60028990D1
DE60028990D1 DE60028990T DE60028990T DE60028990D1 DE 60028990 D1 DE60028990 D1 DE 60028990D1 DE 60028990 T DE60028990 T DE 60028990T DE 60028990 T DE60028990 T DE 60028990T DE 60028990 D1 DE60028990 D1 DE 60028990D1
Authority
DE
Germany
Prior art keywords
piperazine
preparation
alkyl
carboxylate
substituted aliphatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60028990T
Other languages
English (en)
Other versions
DE60028990T2 (de
Inventor
E Hernandaz
E Fairfax
T Michalson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambrex Charles City Inc
Original Assignee
Cambrex Charles City Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambrex Charles City Inc filed Critical Cambrex Charles City Inc
Application granted granted Critical
Publication of DE60028990D1 publication Critical patent/DE60028990D1/de
Publication of DE60028990T2 publication Critical patent/DE60028990T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60028990T 1999-10-20 2000-07-19 Verfahren zur herstellung von aliphatischen carboxylatenmit piperazinsubstituenten Expired - Fee Related DE60028990T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US421514 1999-10-20
US09/421,514 US6239277B1 (en) 1999-10-20 1999-10-20 Process for preparing piperazine-substituted aliphatic carboxylates
PCT/US2000/019625 WO2001029016A1 (en) 1999-10-20 2000-07-19 Process for preparing piperazine-substituted aliphatic carboxylates

Publications (2)

Publication Number Publication Date
DE60028990D1 true DE60028990D1 (de) 2006-08-03
DE60028990T2 DE60028990T2 (de) 2007-02-01

Family

ID=23670848

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60028990T Expired - Fee Related DE60028990T2 (de) 1999-10-20 2000-07-19 Verfahren zur herstellung von aliphatischen carboxylatenmit piperazinsubstituenten

Country Status (5)

Country Link
US (1) US6239277B1 (de)
EP (1) EP1222179B1 (de)
AT (1) ATE330945T1 (de)
DE (1) DE60028990T2 (de)
WO (1) WO2001029016A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL375439A1 (en) * 2002-03-27 2005-11-28 Sun Pharmaceutical Industries Limited 4-(diarylmethyl)-1-piperazinyl derivatives
WO2003104212A1 (en) * 2002-06-05 2003-12-18 Dr.Reddy's Laboratories Ltd. A novel amorphous form of [2-[4-[(4-chlorophenyl)-phenyl methyl]-1- piperazinyl] ethoxy] acetic acid dihydrochloride (cetirizine dihydrochloride)
SI22489A (sl) * 2007-03-12 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek za pripravo levocetirizina in njegovih intermediatov
EP2121643B1 (de) 2007-03-12 2013-10-23 Krka, tovarna zdravil, d.d., Novo mesto Neues verfahren zur herstellung von levocetirizin und zwischenprodukte davon
WO2009150147A1 (en) * 2008-06-11 2009-12-17 Krka, Tovarna Zdravil, D.D., Novo Mesto New process for the preparation of levocetirizine and intermediates thereof
US20110172425A1 (en) * 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
CN113861131B (zh) * 2021-11-08 2024-04-19 深圳菲斯生物科技有限公司 一种西替利嗪杂质c的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO155805C (no) * 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid

Also Published As

Publication number Publication date
US6239277B1 (en) 2001-05-29
EP1222179B1 (de) 2006-06-21
EP1222179A1 (de) 2002-07-17
WO2001029016A1 (en) 2001-04-26
DE60028990T2 (de) 2007-02-01
ATE330945T1 (de) 2006-07-15
EP1222179A4 (de) 2003-01-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee