HUP0400642A2 - Kefalosporinok előállítására alkalmas kapcsolási eljárás és köztitermékek - Google Patents
Kefalosporinok előállítására alkalmas kapcsolási eljárás és köztitermékekInfo
- Publication number
- HUP0400642A2 HUP0400642A2 HU0400642A HUP0400642A HUP0400642A2 HU P0400642 A2 HUP0400642 A2 HU P0400642A2 HU 0400642 A HU0400642 A HU 0400642A HU P0400642 A HUP0400642 A HU P0400642A HU P0400642 A2 HUP0400642 A2 HU P0400642A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- aryl
- general formula
- formula
- Prior art date
Links
- 238000010168 coupling process Methods 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- -1 carboxylate salt Chemical group 0.000 abstract 1
- 150000001735 carboxylic acids Chemical group 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Abstract
A találmány (I) általános képletű 3-helyzetben gyűrűs éterrelszubsztituált kefalosporinok új előállítási eljárására vonatkozik,ahol a képletben a CO2R1 jelentése karbonsav vagy karboxilátsó és R2jelentése (a) általános képletű csoport, ahol R2 jelentése (a)általános képletű csoport, ahol Al jelentése 6-10 szénatomos aril-, 1-10 szénatomos heteroaril- vagy 1-10 szénatomos heterociklusos csoport; A2 jelentése hidrogénatom, 1-6 szénatomos alkil-, 3-10 szénatomoscikloalkil-, 6-10 szénatomos arilcsoport, (1-6 szénatomos alkil) (CO)(1-6 szénatomos alkil)-O-képletű csoport, HO (CO) (1-6 szénatomosalkil)-csoport, mono-(6-10 szénatomos aril) (1-6 szénatomos alkil)-csoport, di-(6-10 szénatomos aril) (1-6 szénatomos alkil)csoport vagytri-(6-10 szénatomos aril) (1-6 szénatomos alkil)-csoport; egy (II)képletű ikerionos vegyületből vagy egy (V) általános képletűvegyületből, ahol R2 jelentése a fentiekben megadott és R3 jelentésepara-nitrobenzil- vagy allilcsoport. A találmány továbbá (II) képletűés (V) általános képletű vegyületekre és ezek előállítási eljárásáravonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25101400P | 2000-12-04 | 2000-12-04 | |
| PCT/IB2001/002225 WO2002046198A1 (en) | 2000-12-04 | 2001-11-22 | Coupling process and intermediates useful for preparing cephalosphorins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0400642A2 true HUP0400642A2 (hu) | 2004-06-28 |
| HUP0400642A3 HUP0400642A3 (en) | 2010-03-29 |
Family
ID=22950114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400642A HUP0400642A3 (en) | 2000-12-04 | 2001-11-22 | Coupling process and intermediates useful for preparing cephalosphorins |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20020198375A1 (hu) |
| EP (1) | EP1339722A1 (hu) |
| JP (1) | JP2004520293A (hu) |
| KR (1) | KR100526379B1 (hu) |
| CN (1) | CN1243755C (hu) |
| AR (1) | AR035511A1 (hu) |
| AU (2) | AU2394302A (hu) |
| BR (1) | BR0115870A (hu) |
| CA (1) | CA2436848C (hu) |
| CZ (1) | CZ20031525A3 (hu) |
| HK (1) | HK1059435A1 (hu) |
| HU (1) | HUP0400642A3 (hu) |
| IL (1) | IL155714A0 (hu) |
| MX (1) | MXPA03004937A (hu) |
| PL (1) | PL362144A1 (hu) |
| RU (1) | RU2237670C1 (hu) |
| WO (1) | WO2002046198A1 (hu) |
| ZA (1) | ZA200303670B (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1340751A4 (en) * | 2000-12-04 | 2005-07-27 | Fujisawa Pharmaceutical Co | PROCESS FOR PRODUCING ANHYDRIDE OF AMINOTHIAZOLE DERIVATIVE |
| US7378408B2 (en) * | 2001-11-30 | 2008-05-27 | Pfizer Inc. | Methods of treatment and formulations of cephalosporin |
| BRPI0508595A (pt) * | 2004-03-09 | 2007-08-21 | Pfizer Prod Inc | processo para a preparação de intermediários de cefalosporina usando ésteres do ácido alfa-iodo-1-azetidinaacético e trialquil-fosfitos |
| CN103874697A (zh) | 2011-08-03 | 2014-06-18 | 协和发酵麒麟株式会社 | 二苯并氧杂*衍生物 |
| CN102718779B (zh) * | 2012-05-25 | 2015-07-29 | 深圳致君制药有限公司 | 注射用头孢唑肟钠及其制备方法、原料药头孢唑肟钠的合成方法 |
| CN105254648B (zh) * | 2015-11-13 | 2018-04-03 | 广东温氏大华农生物科技有限公司 | 一种头孢维星及其钠盐的合成方法 |
| WO2018229580A1 (en) * | 2017-06-14 | 2018-12-20 | Aurobindo Pharma Ltd | An improved process for the preparation of cefovecin sodium |
| EP3774003A4 (en) * | 2018-04-04 | 2022-01-05 | Terapore Technologies, Inc. | ENCAPSULATION PARTICLE FRACTION DEVICES AND SYSTEMS AND METHODS OF USE THEREOF |
| US11051804B2 (en) * | 2018-07-02 | 2021-07-06 | DePuy Synthes Products, Inc. | Orthopedic fixation system and method of use thereof |
| GB2575261B (en) | 2018-07-02 | 2022-03-09 | Norbrook Lab Ltd | Intermediates in the synthesis of C3-substituted cephalosporins |
| CN110396034A (zh) * | 2019-07-31 | 2019-11-01 | 上海应用技术大学 | 一种烯丙基化合物的制备方法 |
| CN111187284A (zh) * | 2020-03-10 | 2020-05-22 | 赵俊瑶 | 一种头孢克洛的制备方法 |
| CN111892612A (zh) * | 2020-07-31 | 2020-11-06 | 重庆医药高等专科学校 | 一种以青霉素钾盐为原料制备头孢维星的中间体异构化物及其制备方法 |
| CN112321611B (zh) * | 2020-10-29 | 2022-05-06 | 湖北凌晟药业有限公司 | 一种头孢沙定母核的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001997A (en) * | 1990-07-24 | 1999-12-14 | Bateson; John Hargreaves | Cephalosporins and homologues, preparations and pharmaceutical compositions |
| MY106399A (en) * | 1990-07-24 | 1995-05-30 | Pfizer | Cephalosporins and homologeus, preparation and pharmaceutical composition |
| GB9212609D0 (en) * | 1992-06-13 | 1992-07-29 | Smithkline Beecham Plc | Novel compounds |
| GB9424847D0 (en) * | 1994-12-09 | 1995-02-08 | Smithkline Beecham Plc | Novel process |
| GB2300856A (en) * | 1995-05-16 | 1996-11-20 | Pfizer Ltd | Beta-lactam preparation |
| GB0019124D0 (en) * | 2000-08-03 | 2000-09-27 | Pfizer | Novel process |
| CN1243756C (zh) * | 2000-12-04 | 2006-03-01 | 辉瑞产品公司 | 用于制备头孢菌素的方法和酯衍生物 |
-
2001
- 2001-11-22 PL PL01362144A patent/PL362144A1/xx not_active Application Discontinuation
- 2001-11-22 BR BR0115870-8A patent/BR0115870A/pt not_active IP Right Cessation
- 2001-11-22 HU HU0400642A patent/HUP0400642A3/hu unknown
- 2001-11-22 IL IL15571401A patent/IL155714A0/xx unknown
- 2001-11-22 WO PCT/IB2001/002225 patent/WO2002046198A1/en active IP Right Grant
- 2001-11-22 AU AU2394302A patent/AU2394302A/xx active Pending
- 2001-11-22 CA CA002436848A patent/CA2436848C/en not_active Expired - Fee Related
- 2001-11-22 RU RU2003116519/04A patent/RU2237670C1/ru active
- 2001-11-22 CN CNB018199623A patent/CN1243755C/zh not_active Expired - Fee Related
- 2001-11-22 JP JP2002547935A patent/JP2004520293A/ja active Pending
- 2001-11-22 MX MXPA03004937A patent/MXPA03004937A/es active IP Right Grant
- 2001-11-22 EP EP01999227A patent/EP1339722A1/en not_active Withdrawn
- 2001-11-22 AU AU2002223943A patent/AU2002223943B2/en not_active Ceased
- 2001-11-22 CZ CZ20031525A patent/CZ20031525A3/cs unknown
- 2001-11-22 KR KR10-2003-7007396A patent/KR100526379B1/ko not_active IP Right Cessation
- 2001-12-03 AR ARP010105609A patent/AR035511A1/es not_active Application Discontinuation
- 2001-12-04 US US10/006,279 patent/US20020198375A1/en not_active Abandoned
-
2003
- 2003-05-13 ZA ZA200303670A patent/ZA200303670B/en unknown
-
2004
- 2004-02-11 US US10/776,795 patent/US7129350B2/en not_active Expired - Lifetime
- 2004-03-25 HK HK04102215A patent/HK1059435A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2237670C1 (ru) | 2004-10-10 |
| AU2002223943B2 (en) | 2006-10-05 |
| JP2004520293A (ja) | 2004-07-08 |
| US20020198375A1 (en) | 2002-12-26 |
| CN1478093A (zh) | 2004-02-25 |
| KR100526379B1 (ko) | 2005-11-08 |
| CN1243755C (zh) | 2006-03-01 |
| KR20030070043A (ko) | 2003-08-27 |
| MXPA03004937A (es) | 2003-09-10 |
| CA2436848C (en) | 2008-12-02 |
| US20040167327A1 (en) | 2004-08-26 |
| PL362144A1 (en) | 2004-10-18 |
| CZ20031525A3 (cs) | 2004-04-14 |
| ZA200303670B (en) | 2004-05-13 |
| HUP0400642A3 (en) | 2010-03-29 |
| US7129350B2 (en) | 2006-10-31 |
| EP1339722A1 (en) | 2003-09-03 |
| HK1059435A1 (en) | 2004-07-02 |
| CA2436848A1 (en) | 2002-06-13 |
| WO2002046198A1 (en) | 2002-06-13 |
| BR0115870A (pt) | 2004-02-03 |
| AU2394302A (en) | 2002-06-18 |
| AR035511A1 (es) | 2004-06-02 |
| IL155714A0 (en) | 2003-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |