HUP0400686A2 - Eljárás és észterszármazékok cefalosporinszármazékok előállítására - Google Patents

Eljárás és észterszármazékok cefalosporinszármazékok előállítására

Info

Publication number
HUP0400686A2
HUP0400686A2 HU0400686A HUP0400686A HUP0400686A2 HU P0400686 A2 HUP0400686 A2 HU P0400686A2 HU 0400686 A HU0400686 A HU 0400686A HU P0400686 A HUP0400686 A HU P0400686A HU P0400686 A2 HUP0400686 A2 HU P0400686A2
Authority
HU
Hungary
Prior art keywords
esters
production
nitrobenzyl
cephalosporin derivatives
cephalosporins
Prior art date
Application number
HU0400686A
Other languages
English (en)
Inventor
Juan Carlos Colberg
Alessandro Donadelli
Giovanni Fogliato
John Lloyd Tucker
Maurizio Zenoni
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0400686A2 publication Critical patent/HUP0400686A2/hu
Publication of HUP0400686A3 publication Critical patent/HUP0400686A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/08—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A találmány tárgya új eljárás para-nitrobenzil-észterek és allil-észterek előállítására, amelyek felhasználhatók a 3-helyzetben gyűrűsétercsoporttal szubsztituált cefalosporinszármazékok előállítására. Atalálmány tárgya továbbá új eljárás az említett para-nitrobenzilészterek és allil-észterek előállítására trimetilfoszfinalkalmazásával. A találmány továbbá a 3-helyzetben gyűrűsétercsoporttal szubsztituált cefalosporinszármazékokra vonatkozik.Ezek a vegyületek előnyös tulajdonságokkal bírnak, így példáulkristályos formájúak és nagy enantiomer fölöslegben állíthatók elő. Acefalosporinszármazékok (I) általános képletében R1 jelentése paca-nitrobenzil- vagy allilcsoport és X jelentése halogénatom. Ó
HU0400686A 2000-12-04 2001-11-19 Process and ester derivatives for preparation of cephalosporins HUP0400686A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25101800P 2000-12-04 2000-12-04
PCT/IB2001/002181 WO2002046199A1 (en) 2000-12-04 2001-11-19 Process and ester derivatives useful for preparation of cephalosporins

Publications (2)

Publication Number Publication Date
HUP0400686A2 true HUP0400686A2 (hu) 2004-06-28
HUP0400686A3 HUP0400686A3 (en) 2010-03-29

Family

ID=22950131

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400686A HUP0400686A3 (en) 2000-12-04 2001-11-19 Process and ester derivatives for preparation of cephalosporins

Country Status (24)

Country Link
US (2) US20020099205A1 (hu)
EP (1) EP1339723B1 (hu)
JP (1) JP2004515503A (hu)
KR (1) KR100526380B1 (hu)
CN (1) CN1243756C (hu)
AR (1) AR035076A1 (hu)
AT (1) ATE319719T1 (hu)
AU (2) AU2392902A (hu)
BR (1) BR0115872A (hu)
CA (1) CA2436863C (hu)
CY (1) CY1104995T1 (hu)
CZ (1) CZ20031526A3 (hu)
DE (1) DE60117876T2 (hu)
DK (1) DK1339723T3 (hu)
ES (1) ES2257471T3 (hu)
HK (1) HK1059265A1 (hu)
HU (1) HUP0400686A3 (hu)
IL (1) IL155701A0 (hu)
MX (1) MXPA03004938A (hu)
PL (1) PL362078A1 (hu)
PT (1) PT1339723E (hu)
RU (1) RU2237671C1 (hu)
WO (1) WO2002046199A1 (hu)
ZA (1) ZA200303498B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03004937A (es) * 2000-12-04 2003-09-10 Pfizer Prod Inc Procedimiento de acoplamiento e intermedios utiles para preparar cefalosporinas.
RU2321590C1 (ru) * 2004-03-09 2008-04-10 Пфайзер Продактс Инк. Способ получения промежуточных соединений цефалоспорина с использованием сложных эфиров альфа-йод-1-азетидинуксусной кислоты и триалкилфосфитов
KR100830754B1 (ko) * 2004-03-09 2008-05-19 화이자 프로덕츠 인코포레이티드 α-요오도-1-아제티딘아세트산 에스테르 및 트라이알킬포스파이트를 이용한 세팔로스포린 중간체의 제조방법
EP1951723B1 (en) 2005-10-20 2017-08-30 Postech Academy-Industry Foundation The application using non-covalent bond between a cucurbituril derivative and a ligand
CN102372738B (zh) * 2010-08-14 2017-11-10 武汉工程大学 Lj反应在制备维蒂希试剂和草铵膦中的应用
CN105254648B (zh) * 2015-11-13 2018-04-03 广东温氏大华农生物科技有限公司 一种头孢维星及其钠盐的合成方法
GB2575261B (en) 2018-07-02 2022-03-09 Norbrook Lab Ltd Intermediates in the synthesis of C3-substituted cephalosporins
CN111892612A (zh) * 2020-07-31 2020-11-06 重庆医药高等专科学校 一种以青霉素钾盐为原料制备头孢维星的中间体异构化物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001997A (en) * 1990-07-24 1999-12-14 Bateson; John Hargreaves Cephalosporins and homologues, preparations and pharmaceutical compositions
US6020329A (en) * 1990-07-24 2000-02-01 Pzifer Inc. Cephaloporins and homologues, preparations and pharmaceutical compositions
MY106399A (en) * 1990-07-24 1995-05-30 Pfizer Cephalosporins and homologeus, preparation and pharmaceutical composition
GB9212609D0 (en) * 1992-06-13 1992-07-29 Smithkline Beecham Plc Novel compounds
GB9424847D0 (en) * 1994-12-09 1995-02-08 Smithkline Beecham Plc Novel process
GB2300856A (en) * 1995-05-16 1996-11-20 Pfizer Ltd Beta-lactam preparation

Also Published As

Publication number Publication date
AU2002223929B2 (en) 2007-08-23
CY1104995T1 (el) 2009-11-04
KR20030070044A (ko) 2003-08-27
ZA200303498B (en) 2004-05-07
AU2392902A (en) 2002-06-18
HK1059265A1 (en) 2004-06-25
US20040267008A1 (en) 2004-12-30
CA2436863A1 (en) 2002-06-13
WO2002046199A1 (en) 2002-06-13
EP1339723B1 (en) 2006-03-08
PL362078A1 (en) 2004-10-18
CN1243756C (zh) 2006-03-01
KR100526380B1 (ko) 2005-11-08
ATE319719T1 (de) 2006-03-15
ES2257471T3 (es) 2006-08-01
WO2002046199A8 (en) 2003-06-12
CN1478094A (zh) 2004-02-25
BR0115872A (pt) 2003-10-28
AR035076A1 (es) 2004-04-14
IL155701A0 (en) 2003-11-23
CZ20031526A3 (en) 2004-04-14
DE60117876T2 (de) 2006-08-31
US20020099205A1 (en) 2002-07-25
JP2004515503A (ja) 2004-05-27
MXPA03004938A (es) 2003-09-10
HUP0400686A3 (en) 2010-03-29
CA2436863C (en) 2007-05-22
RU2237671C1 (ru) 2004-10-10
DK1339723T3 (da) 2006-06-12
PT1339723E (pt) 2006-06-30
DE60117876D1 (de) 2006-05-04
EP1339723A1 (en) 2003-09-03

Similar Documents

Publication Publication Date Title
ATE349451T1 (de) Verfahren zur herstellung von clopidogrel
ATA57097A (de) Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
HUP0203785A2 (hu) Eljárás Casodex enantiomereinek, származékainak és intermediereinek előállítására
ATE218572T1 (de) Verfahren zur herstellung von cefdinir
EG24849A (en) Method for the production of crystalline forms andcrystalline forms of optical enantiomers of modaf inil
HUP0104646A2 (hu) Fuzionált 1,2,4-tiadiazin-származékok, azok előállítása és felhasználása
HUP0001560A2 (hu) Stabil kristályos 5-metil-tetrahidrofolsav-sók
DE69415319D1 (de) Verfahren zur herstellung von piperidinderivaten
HUP0104128A2 (hu) Eljárás citalopram előállítására
HUP0302284A2 (hu) Egy triazolo[4,5-d]pirimidin-vegyület új kristályos és amorf formái
HUP0000728A2 (hu) Naftiridinkarbonsavszármazék sója, eljárás előállítására és a vegyületet tartalmazó gyógyászati készítmény
HUP0400686A2 (hu) Eljárás és észterszármazékok cefalosporinszármazékok előállítására
CA2470726A1 (en) Bicyclic n-arylamides
HUP0402252A2 (hu) Eljárás escitalopram előállítására
CA2479097A1 (en) Amides of acetic and propionic acids
ATE244560T1 (de) Verfahren zur herstellung einer bioverfügbaren oralen darreichungsform von cefuroxim-axetil
CA2281918A1 (en) Oxazolidines as 5-ht2a-antagonists
DE60008830D1 (de) Verfahren zur Herstellung von keramischen Zusammensetzungen
DE50109793D1 (de) Verfahren zur Herstellung von SiO2-TiO2-Gläsern mit geringem thermischen Ausdehnungskoeffizient
HUP0104193A2 (hu) Javított eljárás új antidiabetikus hatású vegyületek előállítására
HUP0401573A2 (hu) Eljárás kinazolinszármazékok előállítására
HUP0302534A2 (hu) Eljárás mandulasavszármazékok előállítására
HRP20090320T1 (en) A process for the preparation of the (s)-enantiomer of omeprazole
EP0247373A3 (en) 7-(phenylacetamido)-4-alkyl coumarins, process for their preparation as well as their application in processes for the fluorometric determination of the activity of hydrolases, especially of penicilline g acylase
HUP0200808A2 (hu) Eljárás a piperazingyűrű kialakítására és új piperazinszármazékok

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished