ATE441702T1 - Verfahren zur herstellung eines hmg-coa reduktase hemmers - Google Patents
Verfahren zur herstellung eines hmg-coa reduktase hemmersInfo
- Publication number
- ATE441702T1 ATE441702T1 AT00901980T AT00901980T ATE441702T1 AT E441702 T1 ATE441702 T1 AT E441702T1 AT 00901980 T AT00901980 T AT 00901980T AT 00901980 T AT00901980 T AT 00901980T AT E441702 T1 ATE441702 T1 AT E441702T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- hmg
- producing
- coa reductase
- reductase inhibitor
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 108020004414 DNA Proteins 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000000640 hydroxylating effect Effects 0.000 abstract 1
- 125000000686 lactone group Chemical group 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2170799 | 1999-01-29 | ||
| PCT/JP2000/000472 WO2000044886A1 (fr) | 1999-01-29 | 2000-01-28 | TECHNIQUE DE PRODUCTION D'INHIBITEUR DE HMG-CoA REDUCTASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE441702T1 true ATE441702T1 (de) | 2009-09-15 |
Family
ID=12062541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00901980T ATE441702T1 (de) | 1999-01-29 | 2000-01-28 | Verfahren zur herstellung eines hmg-coa reduktase hemmers |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US7049111B1 (de) |
| EP (1) | EP1148122B1 (de) |
| JP (1) | JP4668420B2 (de) |
| KR (1) | KR20010108139A (de) |
| CN (1) | CN1329508C (de) |
| AT (1) | ATE441702T1 (de) |
| AU (1) | AU2321600A (de) |
| CA (1) | CA2360080A1 (de) |
| CZ (1) | CZ20012728A3 (de) |
| DE (1) | DE60042879D1 (de) |
| HK (1) | HK1040530A1 (de) |
| HU (1) | HUP0105145A3 (de) |
| IL (1) | IL144526A0 (de) |
| WO (1) | WO2000044886A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4428866B2 (ja) | 1999-01-20 | 2010-03-10 | 協和発酵バイオ株式会社 | ＨＭＧ−ＣｏＡレダクターゼ阻害剤の製造法 |
| KR20010108139A (ko) | 1999-01-29 | 2001-12-07 | 히라타 다다시 | 히드록시메틸글루타릴 코에이 환원효소 저해제의 제조방법 |
| JP5631534B2 (ja) * | 2005-11-29 | 2014-11-26 | 協和発酵バイオ株式会社 | 新規蛋白質および該蛋白質をコードするｄｎａ |
| JP2010512733A (ja) * | 2006-12-13 | 2010-04-30 | ディーエスエム アイピー アセッツ ビー．ブイ． | プラバスタチンを調製するための方法 |
| US8383381B2 (en) | 2007-09-27 | 2013-02-26 | Shjonogi & Co., Ltd. | Method for producing hydroxylated adaivjantane using cytochrome P450 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| JPS5750894A (en) | 1980-09-08 | 1982-03-25 | Sankyo Co Ltd | Preparation of ml-236b derivative |
| JPS5720894A (en) | 1980-07-15 | 1982-02-03 | Nippon Keibi Hosho Kk | Fault diagnozing method for ultrasonic alarm unit |
| US4356621A (en) | 1980-07-25 | 1982-11-02 | Toyoda Koki Kabushiki Kaisha | Machine tool with automatic tool change |
| JPS5889191A (ja) | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法 |
| JP2672551B2 (ja) * | 1987-03-02 | 1997-11-05 | 三共株式会社 | チトクロームｐ−４５０遺伝子を含有するｄｎａ |
| US6043064A (en) * | 1993-10-22 | 2000-03-28 | Bristol-Myers Squibb Company | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof |
| US5942423A (en) | 1995-06-07 | 1999-08-24 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
| AU8460698A (en) * | 1997-08-07 | 1999-03-01 | Kyowa Hakko Kogyo Co. Ltd. | Process for the preparation of hmg-coa reductase inhibitors |
| EP1015600A1 (de) | 1997-08-22 | 2000-07-05 | Dsm N.V. | Fermentative herstellung von statin |
| SI9800144A (sl) | 1998-05-21 | 1999-12-31 | LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. | Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4' |
| JP4428866B2 (ja) | 1999-01-20 | 2010-03-10 | 協和発酵バイオ株式会社 | ＨＭＧ−ＣｏＡレダクターゼ阻害剤の製造法 |
| KR20010108139A (ko) | 1999-01-29 | 2001-12-07 | 히라타 다다시 | 히드록시메틸글루타릴 코에이 환원효소 저해제의 제조방법 |
-
2000
- 2000-01-28 KR KR1020017009457A patent/KR20010108139A/ko active IP Right Grant
- 2000-01-28 DE DE60042879T patent/DE60042879D1/de not_active Expired - Lifetime
- 2000-01-28 JP JP2000596130A patent/JP4668420B2/ja not_active Expired - Lifetime
- 2000-01-28 WO PCT/JP2000/000472 patent/WO2000044886A1/ja active Search and Examination
- 2000-01-28 HU HU0105145A patent/HUP0105145A3/hu not_active Application Discontinuation
- 2000-01-28 EP EP00901980A patent/EP1148122B1/de not_active Expired - Lifetime
- 2000-01-28 US US09/869,334 patent/US7049111B1/en not_active Expired - Fee Related
- 2000-01-28 CN CNB008056293A patent/CN1329508C/zh not_active Expired - Fee Related
- 2000-01-28 CZ CZ20012728A patent/CZ20012728A3/cs unknown
- 2000-01-28 CA CA002360080A patent/CA2360080A1/en not_active Abandoned
- 2000-01-28 AT AT00901980T patent/ATE441702T1/de not_active IP Right Cessation
- 2000-01-28 IL IL14452600A patent/IL144526A0/xx unknown
- 2000-01-28 AU AU23216/00A patent/AU2321600A/en not_active Abandoned
-
2002
- 2002-03-12 HK HK02101906.9A patent/HK1040530A1/zh unknown
-
2006
- 2006-02-13 US US11/352,308 patent/US7470528B2/en not_active Expired - Fee Related
-
2008
- 2008-05-22 US US12/125,569 patent/US20080261273A1/en not_active Abandoned
- 2008-11-17 US US12/272,448 patent/US7897370B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2321600A (en) | 2000-08-18 |
| KR20010108139A (ko) | 2001-12-07 |
| EP1148122B1 (de) | 2009-09-02 |
| US20090148916A1 (en) | 2009-06-11 |
| US20060154348A1 (en) | 2006-07-13 |
| US7897370B2 (en) | 2011-03-01 |
| CA2360080A1 (en) | 2000-08-03 |
| CN1345371A (zh) | 2002-04-17 |
| US7049111B1 (en) | 2006-05-23 |
| HUP0105145A3 (en) | 2006-02-28 |
| CZ20012728A3 (cs) | 2002-02-13 |
| EP1148122A4 (de) | 2008-02-13 |
| WO2000044886A1 (fr) | 2000-08-03 |
| IL144526A0 (en) | 2002-05-23 |
| EP1148122A1 (de) | 2001-10-24 |
| HK1040530A1 (zh) | 2002-06-14 |
| DE60042879D1 (de) | 2009-10-15 |
| CN1329508C (zh) | 2007-08-01 |
| US7470528B2 (en) | 2008-12-30 |
| US20080261273A1 (en) | 2008-10-23 |
| HUP0105145A2 (hu) | 2002-04-29 |
| JP4668420B2 (ja) | 2011-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |