KR100517832B1 - 평활근 세포 증식 억제제로서의(이미다졸-5-일)메틸-2-퀴놀리논 유도체 - Google Patents

평활근 세포 증식 억제제로서의(이미다졸-5-일)메틸-2-퀴놀리논 유도체 Download PDF

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Publication number
KR100517832B1
KR100517832B1 KR10-1999-7010744A KR19997010744A KR100517832B1 KR 100517832 B1 KR100517832 B1 KR 100517832B1 KR 19997010744 A KR19997010744 A KR 19997010744A KR 100517832 B1 KR100517832 B1 KR 100517832B1
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alkyl
hydrogen
alkyloxy
formula
methyl
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Korean (ko)
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KR20010012782A (ko
Inventor
엔드데이비드윌리암
젤레스코미카엘제이.
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얀센 파마슈티카 엔.브이.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR10-1999-7010744A 1997-06-02 1998-05-25 평활근 세포 증식 억제제로서의(이미다졸-5-일)메틸-2-퀴놀리논 유도체 Expired - Lifetime KR100517832B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4737697P 1997-06-02 1997-06-02
US60/047,376 1997-06-02
PCT/EP1998/003182 WO1998055124A1 (en) 1997-06-02 1998-05-25 (imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation

Publications (2)

Publication Number Publication Date
KR20010012782A KR20010012782A (ko) 2001-02-26
KR100517832B1 true KR100517832B1 (ko) 2005-09-30

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KR10-1999-7010744A Expired - Lifetime KR100517832B1 (ko) 1997-06-02 1998-05-25 평활근 세포 증식 억제제로서의(이미다졸-5-일)메틸-2-퀴놀리논 유도체

Country Status (21)

Country Link
US (4) US6365600B1 (https=)
EP (1) EP0988038B1 (https=)
JP (1) JP4209472B2 (https=)
KR (1) KR100517832B1 (https=)
CN (2) CN100525766C (https=)
AT (1) ATE222104T1 (https=)
AU (1) AU740603B2 (https=)
BR (1) BR9810423A (https=)
CA (1) CA2290992C (https=)
DE (1) DE69807222T2 (https=)
DK (1) DK0988038T3 (https=)
ES (1) ES2182327T3 (https=)
ID (1) ID24675A (https=)
IL (1) IL133212A (https=)
NO (1) NO318834B1 (https=)
NZ (1) NZ501401A (https=)
PT (1) PT988038E (https=)
RU (1) RU2209066C2 (https=)
TR (1) TR199902923T2 (https=)
WO (1) WO1998055124A1 (https=)
ZA (1) ZA984700B (https=)

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US20020091138A1 (en) 2002-07-11
TR199902923T2 (xx) 2000-11-21
HK1025046A1 (en) 2000-11-03
KR20010012782A (ko) 2001-02-26
CN1762355A (zh) 2006-04-26
US6734194B2 (en) 2004-05-11
NO995883L (no) 2000-02-02
ID24675A (id) 2000-07-27
US6365600B1 (en) 2002-04-02
IL133212A (en) 2005-12-18
NO318834B1 (no) 2005-05-09
CN1231215C (zh) 2005-12-14
WO1998055124A1 (en) 1998-12-10
US6743805B2 (en) 2004-06-01
US20030229118A1 (en) 2003-12-11
BR9810423A (pt) 2000-10-03
ES2182327T3 (es) 2003-03-01
ZA984700B (en) 1999-12-01
DE69807222T2 (de) 2003-04-17
PT988038E (pt) 2002-12-31
RU2209066C2 (ru) 2003-07-27
NZ501401A (en) 2002-03-28
US7253183B2 (en) 2007-08-07
DK0988038T3 (da) 2002-12-02
IL133212A0 (en) 2001-03-19
HK1088820A1 (zh) 2006-11-17
JP2002503235A (ja) 2002-01-29
DE69807222D1 (de) 2002-09-19
AU740603B2 (en) 2001-11-08
CA2290992C (en) 2008-02-12
ATE222104T1 (de) 2002-08-15
CN1265585A (zh) 2000-09-06
JP4209472B2 (ja) 2009-01-14
CN100525766C (zh) 2009-08-12
NO995883D0 (no) 1999-12-01
EP0988038A1 (en) 2000-03-29
US20040198771A1 (en) 2004-10-07
CA2290992A1 (en) 1998-12-10
EP0988038B1 (en) 2002-08-14
AU8020798A (en) 1998-12-21

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