KR100464692B1 - 비환식뉴클레오시드유도체및이를포함하는약제학적조성물 - Google Patents

비환식뉴클레오시드유도체및이를포함하는약제학적조성물 Download PDF

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Publication number
KR100464692B1
KR100464692B1 KR10-1998-0706309A KR19980706309A KR100464692B1 KR 100464692 B1 KR100464692 B1 KR 100464692B1 KR 19980706309 A KR19980706309 A KR 19980706309A KR 100464692 B1 KR100464692 B1 KR 100464692B1
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KR
South Korea
Prior art keywords
butyl
guanine
valyloxy
amino
alkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR10-1998-0706309A
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English (en)
Korean (ko)
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KR19990082571A (ko
Inventor
페르 엥겔하르트
마리타 회그베르크
시아오-샹 쥬
비외른 린드보르그
닐스 군나르 요한슨
Original Assignee
메디비르 아베
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Publication date
Priority claimed from SE9600613A external-priority patent/SE9600613D0/xx
Priority claimed from SE9600614A external-priority patent/SE9600614D0/xx
Application filed by 메디비르 아베 filed Critical 메디비르 아베
Publication of KR19990082571A publication Critical patent/KR19990082571A/ko
Application granted granted Critical
Publication of KR100464692B1 publication Critical patent/KR100464692B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR10-1998-0706309A 1996-02-16 1997-02-14 비환식뉴클레오시드유도체및이를포함하는약제학적조성물 Expired - Fee Related KR100464692B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9600614-3 1996-02-16
SE9600613-5 1996-02-16
SE9600613A SE9600613D0 (sv) 1996-02-16 1996-02-16 Acyclic nucleoside derivatives
SE9600614A SE9600614D0 (sv) 1996-02-16 1996-02-16 Antiviral compounds

Publications (2)

Publication Number Publication Date
KR19990082571A KR19990082571A (ko) 1999-11-25
KR100464692B1 true KR100464692B1 (ko) 2005-06-21

Family

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Application Number Title Priority Date Filing Date
KR10-1998-0706309A Expired - Fee Related KR100464692B1 (ko) 1996-02-16 1997-02-14 비환식뉴클레오시드유도체및이를포함하는약제학적조성물

Country Status (25)

Country Link
US (5) US5869493A (enExample)
EP (2) EP0888348B1 (enExample)
JP (2) JP2000504721A (enExample)
KR (1) KR100464692B1 (enExample)
CN (1) CN1067073C (enExample)
AR (1) AR005827A1 (enExample)
AT (2) ATE231507T1 (enExample)
AU (1) AU715062B2 (enExample)
BG (1) BG64179B1 (enExample)
CA (1) CA2243826C (enExample)
CZ (1) CZ292169B6 (enExample)
DE (2) DE69718619T2 (enExample)
DK (1) DK0888348T3 (enExample)
EA (2) EA001404B1 (enExample)
ES (2) ES2189942T3 (enExample)
HU (1) HU229865B1 (enExample)
IL (1) IL124760A (enExample)
MY (1) MY123083A (enExample)
NO (1) NO322930B1 (enExample)
NZ (1) NZ330472A (enExample)
PL (1) PL184892B1 (enExample)
SK (1) SK284613B6 (enExample)
TR (1) TR199801318T2 (enExample)
TW (1) TW533213B (enExample)
WO (2) WO1997030052A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170000438A (ko) 2015-06-23 2017-01-03 (주)농협아그로 끈끈이 엠보싱 트랩 테이프 및 그 제조방법

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US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
JP2001503767A (ja) * 1996-11-12 2001-03-21 メディヴィル・アクチボラグ ヌクレオシド
US6184376B1 (en) * 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
CA2572577C (en) * 1997-02-10 2011-04-05 Medivir Ab Synthesis of acyclic nucleoside derivatives
DE69829784T2 (de) * 1997-08-15 2006-02-16 Medivir Ab 3'-Fluorierte Guanosinderivate zur Behandlung oder Prophylaxe von HBV- oder retroviralen Infektionen
WO1999032490A1 (en) * 1997-12-19 1999-07-01 Bristol-Myers Squibb Company Prodrugs of lobucavir and methods of use
TW200510415A (en) * 2003-04-30 2005-03-16 Teva Pharma Process for the preparation of famciclovir
EP1835916B1 (en) 2004-12-30 2009-04-01 Medivir Ab Compounds useful in the treatment of hiv
US20080233053A1 (en) * 2005-02-07 2008-09-25 Pharmalight Inc. Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients
CN101033238B (zh) * 2006-03-06 2011-02-16 中国科学院上海药物研究所 嘌呤类化合物双氨基酸酯的制备方法和用途
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
US9296776B2 (en) 2007-07-09 2016-03-29 Eastern Virginia Medical School Substituted nucleoside derivatives with antiviral and antimicrobial properties
MX2010003056A (es) 2007-09-21 2010-04-07 Epiphany Biosciences Inc Polimorfos de valomaciclovir.
WO2011022712A1 (en) * 2009-08-21 2011-02-24 Epiphany Biosciences, Inc. Method of treating infectious mononucleosis with acylic nucleoside derivatives
ES2667425T3 (es) 2011-06-10 2018-05-10 Oregon Health & Science University Glucoproteínas y vectores recombinantes de CMV
US20260191871A1 (en) * 2022-11-28 2026-07-09 Epiphany Biosciences Use of antiviral agents, composition of matter, combination preparations/agents to treat chronic diseases associated with epstein-barr virus and other human herpes viruses

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170000438A (ko) 2015-06-23 2017-01-03 (주)농협아그로 끈끈이 엠보싱 트랩 테이프 및 그 제조방법

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AU1818397A (en) 1997-09-02
MY123083A (en) 2006-05-31
CZ232298A3 (cs) 1998-10-14
CZ292169B6 (cs) 2003-08-13
TW533213B (en) 2003-05-21
EP0880521B1 (en) 2003-01-22
WO1997030051A1 (en) 1997-08-21
US20120123119A1 (en) 2012-05-17
HK1015773A1 (en) 1999-10-22
EA002809B1 (ru) 2002-10-31
BG102647A (en) 1999-04-30
SK284613B6 (sk) 2005-07-01
ATE231508T1 (de) 2003-02-15
US6576763B1 (en) 2003-06-10
NZ330472A (en) 2000-02-28
AU1818297A (en) 1997-09-02
DE69718626D1 (de) 2003-02-27
PL328335A1 (en) 1999-01-18
EA200000787A1 (ru) 2001-04-23
BG64179B1 (bg) 2004-03-31
JP4171069B2 (ja) 2008-10-22
US20090076041A1 (en) 2009-03-19
US5869493A (en) 1999-02-09
EA199800729A1 (ru) 1999-02-25
CA2243826C (en) 2005-12-27
JP2000504720A (ja) 2000-04-18
DE69718619D1 (de) 2003-02-27
NO983216L (no) 1998-10-13
US6255312B1 (en) 2001-07-03
ES2189941T3 (es) 2003-07-16
JP2000504721A (ja) 2000-04-18
TR199801318T2 (xx) 1998-10-21
DE69718626T2 (de) 2003-09-11
AR005827A1 (es) 1999-07-14
HUP9900680A2 (hu) 1999-06-28
KR19990082571A (ko) 1999-11-25
PL184892B1 (pl) 2003-01-31
DK0888348T3 (da) 2003-04-14
CA2243826A1 (en) 1997-08-21
SK98598A3 (en) 1998-12-02
NO322930B1 (no) 2006-12-18
IL124760A0 (en) 1999-01-26
EP0880521A1 (en) 1998-12-02
ES2189942T3 (es) 2003-07-16
NO983216D0 (no) 1998-07-13
EP0888348B1 (en) 2003-01-22
EA001404B1 (ru) 2001-02-26
CN1210537A (zh) 1999-03-10
CN1067073C (zh) 2001-06-13
EP0888348A1 (en) 1999-01-07
AU715062B2 (en) 2000-01-13
US8124609B2 (en) 2012-02-28
HU229865B1 (en) 2014-10-28
IL124760A (en) 2003-09-17
WO1997030052A1 (en) 1997-08-21
AU713916B2 (en) 1999-12-16
ATE231507T1 (de) 2003-02-15
DE69718619T2 (de) 2003-08-21
HUP9900680A3 (en) 2001-02-28

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