KR100400810B1 - 옥사졸리딘중간체를사용하는탁산의제조방법 - Google Patents

옥사졸리딘중간체를사용하는탁산의제조방법 Download PDF

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Publication number
KR100400810B1
KR100400810B1 KR1019960007702A KR19960007702A KR100400810B1 KR 100400810 B1 KR100400810 B1 KR 100400810B1 KR 1019960007702 A KR1019960007702 A KR 1019960007702A KR 19960007702 A KR19960007702 A KR 19960007702A KR 100400810 B1 KR100400810 B1 KR 100400810B1
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South Korea
Prior art keywords
carbon atoms
ring
rings
compound
formula
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KR1019960007702A
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English (en)
Korean (ko)
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KR960034193A (ko
Inventor
케이. 쏘타틸 죤
디. 트리푸노비치 이반
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브리스톨-마이어스스퀴브컴파니
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Publication of KR960034193A publication Critical patent/KR960034193A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
KR1019960007702A 1995-03-22 1996-03-21 옥사졸리딘중간체를사용하는탁산의제조방법 KR100400810B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40867695A 1995-03-22 1995-03-22
US08/408,676 1995-03-22

Publications (2)

Publication Number Publication Date
KR960034193A KR960034193A (ko) 1996-10-22
KR100400810B1 true KR100400810B1 (ko) 2004-05-31

Family

ID=23617282

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960007702A KR100400810B1 (ko) 1995-03-22 1996-03-21 옥사졸리딘중간체를사용하는탁산의제조방법

Country Status (11)

Country Link
US (2) US6365750B1 (fr)
EP (1) EP0735036A1 (fr)
JP (1) JPH08291119A (fr)
KR (1) KR100400810B1 (fr)
CN (2) CN1161347C (fr)
AU (1) AU718066B2 (fr)
CA (1) CA2170661A1 (fr)
HU (1) HUP9600708A3 (fr)
IL (1) IL117486A (fr)
SG (1) SG43251A1 (fr)
TW (1) TW359671B (fr)

Families Citing this family (14)

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CA2170661A1 (fr) * 1995-03-22 1996-09-23 John K. Thottathil Methodes pour la preparation de taxanes a l'aide d'oxazolidines comme produits intermediaires
KR100225535B1 (ko) * 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
WO2002012216A1 (fr) * 2000-08-08 2002-02-14 Dr. Reddy's Research Foundation Procede ameliore de preparation de docetaxel
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US20050272807A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
EP1647552A1 (fr) * 2004-10-08 2006-04-19 INDENA S.p.A. Semisynthese de preparation de 10-deacetyl-n-debenzoyl-paclitaxel
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
EP1712552A1 (fr) * 2005-04-11 2006-10-18 INDENA S.p.A. Semisynthese de preparation de 10-deacetyl-n-debenzoyl paclitaxel
FR2882362B1 (fr) * 2005-02-23 2007-05-11 Seripharm Procede de preparation du paclitaxel
US7847111B2 (en) * 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN107056767B (zh) * 2015-12-04 2022-07-15 江苏恩华络康药物研发有限公司 用于制备水溶性紫杉烷类衍生物的方法及中间体

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WO1994013654A1 (fr) * 1992-12-09 1994-06-23 Rhone-Poulenc Rorer S.A. Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
KR950704286A (ko) * 1992-11-23 1995-11-17 탁산 유도체의 신규한 제조방법, 이로써 얻은 신규한 유도체 및 이를 함유한 조성물(novel method for preparing taxane derivatives, novel dervatvatives thus obtained and compositions containing them)
EP0735036A1 (fr) * 1995-03-22 1996-10-02 Bristol-Myers Squibb Company Méthodes de préparation de taxanes utilisant des intermédiaires oxazolidine
KR100206457B1 (ko) * 1990-11-23 1999-07-01 쟈끄 삘라드 탁산 유도체의 제조 방법, 이로써 얻어진 신규한 유도체 및 이를 함유하는 제약학적 조성물
KR100301237B1 (ko) * 1992-10-05 2001-11-22 자끄 사비나 탁산유도체의제조방법
KR100297197B1 (ko) * 1992-10-05 2001-11-26 자끄 사비나 탁산유도체의제조방법

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KR100206457B1 (ko) * 1990-11-23 1999-07-01 쟈끄 삘라드 탁산 유도체의 제조 방법, 이로써 얻어진 신규한 유도체 및 이를 함유하는 제약학적 조성물
WO1994007877A1 (fr) * 1992-10-05 1994-04-14 Rhone-Poulenc Rorer S.A. Procede de preparation de derives du taxane
KR100301237B1 (ko) * 1992-10-05 2001-11-22 자끄 사비나 탁산유도체의제조방법
KR100297197B1 (ko) * 1992-10-05 2001-11-26 자끄 사비나 탁산유도체의제조방법
KR950704286A (ko) * 1992-11-23 1995-11-17 탁산 유도체의 신규한 제조방법, 이로써 얻은 신규한 유도체 및 이를 함유한 조성물(novel method for preparing taxane derivatives, novel dervatvatives thus obtained and compositions containing them)
WO1994013654A1 (fr) * 1992-12-09 1994-06-23 Rhone-Poulenc Rorer S.A. Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
EP0735036A1 (fr) * 1995-03-22 1996-10-02 Bristol-Myers Squibb Company Méthodes de préparation de taxanes utilisant des intermédiaires oxazolidine

Also Published As

Publication number Publication date
AU4818696A (en) 1996-10-03
HUP9600708A3 (en) 1998-04-28
EP0735036A1 (fr) 1996-10-02
CN1528752A (zh) 2004-09-15
SG43251A1 (en) 1997-10-17
JPH08291119A (ja) 1996-11-05
CA2170661A1 (fr) 1996-09-23
TW359671B (en) 1999-06-01
CN1143641A (zh) 1997-02-26
IL117486A (en) 2005-03-20
US20020161238A1 (en) 2002-10-31
CN1161347C (zh) 2004-08-11
AU718066B2 (en) 2000-04-06
IL117486A0 (en) 1996-07-23
KR960034193A (ko) 1996-10-22
CN1286823C (zh) 2006-11-29
US6784304B2 (en) 2004-08-31
HU9600708D0 (en) 1996-05-28
HUP9600708A2 (en) 1997-05-28
US6365750B1 (en) 2002-04-02

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