KR100351213B1 - 펩타이드 부갑상선 호르몬 유사체 및 이를 포함하는 약제학적 조성물 - Google Patents
펩타이드 부갑상선 호르몬 유사체 및 이를 포함하는 약제학적 조성물 Download PDFInfo
- Publication number
- KR100351213B1 KR100351213B1 KR1019997010523A KR19997010523A KR100351213B1 KR 100351213 B1 KR100351213 B1 KR 100351213B1 KR 1019997010523 A KR1019997010523 A KR 1019997010523A KR 19997010523 A KR19997010523 A KR 19997010523A KR 100351213 B1 KR100351213 B1 KR 100351213B1
- Authority
- KR
- South Korea
- Prior art keywords
- nle
- seq
- hpth
- cyclo
- fmoc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4647297P | 1997-05-14 | 1997-05-14 | |
| US60/046,472 | 1997-05-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010012568A KR20010012568A (ko) | 2001-02-15 |
| KR100351213B1 true KR100351213B1 (ko) | 2002-09-05 |
Family
ID=21943653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019997010523A Expired - Fee Related KR100351213B1 (ko) | 1997-05-14 | 1998-05-13 | 펩타이드 부갑상선 호르몬 유사체 및 이를 포함하는 약제학적 조성물 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6472505B1 (https=) |
| EP (1) | EP0986395A4 (https=) |
| JP (1) | JP2001517957A (https=) |
| KR (1) | KR100351213B1 (https=) |
| CN (1) | CN1261281A (https=) |
| AP (1) | AP9901686A0 (https=) |
| AU (1) | AU746461B2 (https=) |
| BG (1) | BG103957A (https=) |
| BR (1) | BR9808786A (https=) |
| CA (1) | CA2290443A1 (https=) |
| EA (1) | EA002819B1 (https=) |
| HU (1) | HUP0003349A3 (https=) |
| IL (1) | IL132901A0 (https=) |
| NO (1) | NO995568L (https=) |
| OA (1) | OA11216A (https=) |
| PL (1) | PL336803A1 (https=) |
| SK (1) | SK151599A3 (https=) |
| UA (1) | UA62967C2 (https=) |
| WO (1) | WO1998051324A1 (https=) |
| ZA (1) | ZA984077B (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0101629A2 (en) | 1998-04-15 | 2003-03-28 | Aventis Pharma Inc | Process for the preparation of resin-bound cyclic peptides |
| US6316410B1 (en) * | 1999-09-22 | 2001-11-13 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| WO2003097690A2 (en) * | 2002-05-16 | 2003-11-27 | Theratechnologies Inc. | Pth derivatives resistant to skin proteases |
| WO2004073587A2 (en) * | 2003-02-19 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with parathyroid hormone receptor 1 (pthr1) |
| CA2529777A1 (en) * | 2003-07-15 | 2005-01-27 | National Research Council Of Canada | Cyclic analogs of human parathyroid hormone for the treatment of conditions characterized by hyperproliferative skin cells |
| US7439226B2 (en) * | 2003-09-30 | 2008-10-21 | The United States Of America As Represented By The Department Of Health And Human Services | Serine protease inhibitors |
| MXPA06012980A (es) * | 2004-05-10 | 2007-06-12 | Nastech Pharm Co | Composiciones y metodos para el suministro mucosal mejorado de la hormona paratiroidea. |
| US20060052305A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | Method of treating osteoporosis using intranasal parathyroid hormone |
| US20060127320A1 (en) * | 2004-05-10 | 2006-06-15 | Nastech Pharmaceutical Company Inc. | Method of delivering parathyroid hormone to a human |
| US20060052306A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | GRAS composition for enhanced mucosal delivery of parathyroid hormone |
| WO2007007325A2 (en) | 2005-07-07 | 2007-01-18 | Fulcrum Sp Ltd. | Sp1 polypeptides, modified sp1 polypeptides and uses thereof |
| US20070173447A1 (en) * | 2005-10-25 | 2007-07-26 | Nastech Pharmaceutical Company Inc. | Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent |
| CN101355959B (zh) * | 2005-11-10 | 2013-02-27 | 密歇根理工大学管理委员会 | 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法 |
| US20080051332A1 (en) * | 2005-11-18 | 2008-02-28 | Nastech Pharmaceutical Company Inc. | Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone |
| AU2007313001B2 (en) * | 2006-10-13 | 2012-03-22 | Eli Lilly And Company | Pegylated PTH as PTH receptor modulators and uses thereof |
| US8691760B2 (en) | 2009-02-02 | 2014-04-08 | Ramot At Tel-Aviv University | Peptides, pharmaceutical compositions comprising same and uses thereof |
| US8912142B2 (en) | 2009-04-01 | 2014-12-16 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Method of regulating proliferation and differentiation of keratinocyes |
| WO2010116375A1 (en) | 2009-04-08 | 2010-10-14 | Yeda Research And Development Co. Ltd. | Isolated peptides for regulating apoptosis |
| US20120070449A1 (en) | 2009-05-28 | 2012-03-22 | Yeda Research And Development Co. Ltd. | Methods of treating inflammation |
| ES2729051T3 (es) * | 2009-07-29 | 2019-10-30 | Kai Pharmaceuticals Inc | Agentes terapéuticos para reducir los niveles de hormona paratiroidea |
| EP2509996A1 (en) | 2009-12-07 | 2012-10-17 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| US9352000B2 (en) | 2010-05-05 | 2016-05-31 | Rappaport Family Institute For Research In The Medical Sciences | Use of CCL1 in therapy |
| WO2011143406A2 (en) * | 2010-05-13 | 2011-11-17 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
| WO2012017439A2 (en) | 2010-08-04 | 2012-02-09 | Ramot At Tel-Aviv University Ltd. | Methods of treating autoimmune diseases of the central nervous system (cns) and neurodegenerative diseases |
| WO2012131680A2 (en) | 2011-03-28 | 2012-10-04 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating inflammation |
| ES2702487T3 (es) * | 2011-06-17 | 2019-03-01 | Nantenergy Inc | Líquido iónico que contiene iones sulfonato |
| JP6429191B2 (ja) | 2012-03-06 | 2018-11-28 | セレクト バイオセラピューティクス リミテッド | アポトーシスシグナル伝達抵抗性細胞を選択する装置および方法ならびにその使用 |
| US9695402B2 (en) | 2013-09-17 | 2017-07-04 | Yeda Research And Development Co. Ltd. | ERK-derived peptides and uses thereof |
| WO2015114633A1 (en) | 2014-01-30 | 2015-08-06 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. | Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same |
| US20170174764A1 (en) | 2014-03-27 | 2017-06-22 | Yeda Research And Development Co. Ltd. | T-cell receptor cdr3 peptides and antibodies |
| CN113713090B (zh) | 2015-02-09 | 2023-06-02 | 安特拉贝欧有限公司 | 骨质疏松症的治疗 |
| EP3261582B1 (en) | 2015-02-26 | 2021-01-06 | Remodeless CV Ltd. | Methods and compositions relating to leptin antagonists |
| IL274572B2 (en) | 2015-07-16 | 2024-01-01 | Biolinerx Ltd | Compositions and methods for treating cancer |
| WO2017122209A2 (en) | 2016-01-12 | 2017-07-20 | Yeda Research And Development Co. Ltd. | NF-kappaB INHIBITORS |
| IL243839B (en) | 2016-01-28 | 2018-01-31 | Sp Nano Ltd | Conductive wires |
| IL243838A (en) | 2016-01-28 | 2017-07-31 | Sp Nano Ltd | The composition containing sp1 protein and carbon nanoparticles and its uses |
| EP3464322B1 (en) | 2016-06-05 | 2023-04-05 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Novel molecules for the treatment of inflammation |
| WO2018037416A1 (en) | 2016-08-25 | 2018-03-01 | Yeda Research And Development Co. Ltd. | Methods and compositions for treating autoimmune diseases |
| SG11201810936VA (en) | 2016-12-01 | 2019-01-30 | Univ Ramot | Combined treatment for nerve injuries |
| EP3606615B1 (en) | 2017-04-07 | 2026-01-07 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Method of straightening hair, method for maintenance of straightened hair and kit for straightening hair |
| US20200172604A1 (en) | 2017-05-23 | 2020-06-04 | Technion Research & Development Foundation Limited | Agents which inhibit gads dimerization and methods of use thereof |
| US11660270B2 (en) | 2017-07-20 | 2023-05-30 | Indiana University Research And Technology Corporation | Nanoparticle compositions |
| IL253642A0 (en) | 2017-07-24 | 2017-09-28 | Seger Rony | Combined treatment for cancer |
| IL253984A0 (en) | 2017-08-14 | 2017-09-28 | Yeda Res & Dev | Immunotherapy against aranviruses that bind through transferrin receptor 1 (tfr1 |
| IL274979B2 (en) | 2017-11-29 | 2024-07-01 | Univ Ramot | Methods for the prevention and treatment of neurogenic seizures |
| EP3785279A4 (en) | 2018-05-31 | 2022-07-27 | Immunity Pharma Ltd. | COMPOSITIONS AND METHODS OF USE THEREOF IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| US12134638B2 (en) | 2018-07-11 | 2024-11-05 | Kahr Medical Ltd. | SIRPalpha-4-1BBL variant fusion protein and methods of use thereof |
| IL265486A (en) | 2019-03-19 | 2020-09-30 | Yeda Res & Dev | Bistable type ii opsins and uses thereof |
| IL266728B (en) | 2019-05-19 | 2020-11-30 | Yeda Res & Dev | Identification of recurrent mutant neopeptides |
| US20220267409A1 (en) | 2019-07-11 | 2022-08-25 | Kahr Medical Ltd. | Heterodimers and methods of use thereof |
| IL268111A (en) | 2019-07-16 | 2021-01-31 | Fainzilber Michael | Methods of treating pain |
| IL270800A (en) | 2019-11-20 | 2021-05-31 | Yeda Res & Dev | A method for treating Alzheimer's disease |
| CN115335532A (zh) | 2020-02-09 | 2022-11-11 | Nlc制药有限公司 | Sars-cov-2快速检测测试 |
| WO2021176457A1 (en) | 2020-03-05 | 2021-09-10 | Ariel Scientific Innovations Ltd. | Anti-hemorrhaging compositions |
| US20230127559A1 (en) | 2020-03-16 | 2023-04-27 | Yeda Research And Development Co. Ltd. | Peptide analogs and use of same in treating diseases, disorders or conditions associated with mutant p53 protein |
| IL276599A (en) | 2020-08-09 | 2022-03-01 | Yeda Res & Dev | T cell receptor unique to mage-a1 and its uses |
| IL276627A (en) | 2020-08-10 | 2022-03-01 | Yeda Res & Dev | Compositions for diagnosis and treatment of coronavirus infections |
| WO2022064494A2 (en) | 2020-09-23 | 2022-03-31 | Yeda Research And Development Co. Ltd. | Methods and compositions for treating coronaviral infections |
| CN116635056A (zh) | 2020-10-07 | 2023-08-22 | 波塔力克斯有限公司 | 长效脱氧核糖核酸酶 |
| EP4240423A1 (en) | 2020-11-03 | 2023-09-13 | Protalix Ltd. | Modified uricase and uses thereof |
| EP4294428A1 (en) | 2021-02-18 | 2023-12-27 | Yeda Research and Development Co. Ltd | Method of generating vaccines |
| IL283563A (en) | 2021-05-30 | 2022-12-01 | Yeda Res & Dev | Profiling of amps for the diagnosis, monitoring and treatment of microbiome-related diseases |
| WO2023031934A1 (en) | 2021-09-02 | 2023-03-09 | Yeda Research And Development Co. Ltd. | Agents that target the glycine arginine-rich domain of nucleolin and uses thereof |
| WO2024038462A1 (en) | 2022-08-17 | 2024-02-22 | Yeda Research And Development Co. Ltd. | Novel bacteria-based delivery system for tace (adam17) selective biological inhibitor |
| WO2024241314A1 (en) | 2023-05-22 | 2024-11-28 | Neomanna Ltd | Black soldier fly protein extracts |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4086196A (en) * | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
| US4423037A (en) | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
| US4427827A (en) | 1982-10-20 | 1984-01-24 | Usv Pharmaceutical Corporation | Synthesis of hormone fragments |
| FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
| US4771124A (en) | 1987-05-26 | 1988-09-13 | Merck & Co., Inc. | Parathyroid hormone antagonists with simplified synthetic methodology |
| CA2040264A1 (en) | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
| CA2087087C (en) | 1992-01-22 | 2000-07-18 | Burton H. Sage, Jr. | Molecules for iontophoretic delivery |
| US5434246A (en) | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
| US5814603A (en) | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| CA2098639A1 (en) | 1992-06-19 | 1993-12-20 | K. Anne Kronis | Bone stimulating, non-vasoactive parathyroid hormone variants |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU672790B2 (en) | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| ES2179831T3 (es) | 1992-09-29 | 2003-02-01 | Inhale Therapeutic Syst | Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana. |
| CA2126299C (en) | 1994-06-20 | 2000-12-12 | Gordon E. Willick | Parathyroid hormone analogues for the treatment of osteoporosis |
| CO4410206A1 (es) | 1994-07-28 | 1997-01-09 | Sandoz Ag | DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN |
| DE19508672A1 (de) * | 1995-03-10 | 1996-09-12 | Boehringer Mannheim Gmbh | Neue cyclische Parathormonfragmente, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| DE69629758T2 (de) | 1995-06-07 | 2004-06-03 | Compaq Computer Corp., Houston | Verfahren und Vorrichtung für die Überwachung des Datenflusses in einem fehlertoleranten Multiprozessorsystem |
| US5717062A (en) * | 1995-06-07 | 1998-02-10 | Beth Israel Hospital Association | Cyclic analogs of PTH and PTHrP |
| US5723577A (en) | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
| DK0915911T3 (da) * | 1996-08-02 | 2004-03-08 | Ca Nat Research Council | Analoger til parathyreoideahormon til behandling af osteoporose |
-
1998
- 1998-05-13 SK SK1515-99A patent/SK151599A3/sk unknown
- 1998-05-13 EP EP98921200A patent/EP0986395A4/en not_active Withdrawn
- 1998-05-13 CA CA002290443A patent/CA2290443A1/en not_active Abandoned
- 1998-05-13 WO PCT/US1998/009843 patent/WO1998051324A1/en not_active Ceased
- 1998-05-13 AP APAP/P/1999/001686A patent/AP9901686A0/en unknown
- 1998-05-13 HU HU0003349A patent/HUP0003349A3/hu unknown
- 1998-05-13 JP JP54953698A patent/JP2001517957A/ja not_active Ceased
- 1998-05-13 BR BR9808786-0A patent/BR9808786A/pt not_active Application Discontinuation
- 1998-05-13 AU AU73867/98A patent/AU746461B2/en not_active Ceased
- 1998-05-13 IL IL13290198A patent/IL132901A0/xx unknown
- 1998-05-13 UA UA99126574A patent/UA62967C2/uk unknown
- 1998-05-13 KR KR1019997010523A patent/KR100351213B1/ko not_active Expired - Fee Related
- 1998-05-13 EA EA199901025A patent/EA002819B1/ru not_active IP Right Cessation
- 1998-05-13 CN CN98806651A patent/CN1261281A/zh active Pending
- 1998-05-13 PL PL98336803A patent/PL336803A1/xx unknown
- 1998-05-14 ZA ZA984077A patent/ZA984077B/xx unknown
-
1999
- 1999-01-12 US US09/228,990 patent/US6472505B1/en not_active Expired - Fee Related
- 1999-11-12 OA OA9900247A patent/OA11216A/en unknown
- 1999-11-12 NO NO995568A patent/NO995568L/no not_active Application Discontinuation
- 1999-12-06 BG BG103957A patent/BG103957A/bg unknown
-
2002
- 2002-03-13 US US10/097,079 patent/US20020132973A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU746461B2 (en) | 2002-05-02 |
| EP0986395A4 (en) | 2004-12-01 |
| AP9901686A0 (en) | 1999-12-31 |
| OA11216A (en) | 2003-07-10 |
| ZA984077B (en) | 1998-11-24 |
| UA62967C2 (en) | 2004-01-15 |
| HUP0003349A3 (en) | 2001-12-28 |
| CA2290443A1 (en) | 1998-11-19 |
| NO995568L (no) | 1999-12-29 |
| EA002819B1 (ru) | 2002-10-31 |
| AU7386798A (en) | 1998-12-08 |
| BG103957A (bg) | 2000-04-28 |
| HUP0003349A2 (hu) | 2001-01-29 |
| US6472505B1 (en) | 2002-10-29 |
| WO1998051324A1 (en) | 1998-11-19 |
| JP2001517957A (ja) | 2001-10-09 |
| EP0986395A1 (en) | 2000-03-22 |
| NO995568D0 (no) | 1999-11-12 |
| EA199901025A1 (ru) | 2000-06-26 |
| BR9808786A (pt) | 2000-07-11 |
| CN1261281A (zh) | 2000-07-26 |
| PL336803A1 (en) | 2000-07-17 |
| US20020132973A1 (en) | 2002-09-19 |
| KR20010012568A (ko) | 2001-02-15 |
| SK151599A3 (en) | 2000-09-12 |
| IL132901A0 (en) | 2001-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100351213B1 (ko) | 펩타이드 부갑상선 호르몬 유사체 및 이를 포함하는 약제학적 조성물 | |
| FI92326C (fi) | LHRH:n nonapeptidi- ja dekapeptidianalogeja, jotka ovat käyttökelpoisia LHRH:n antagonisteina | |
| KR0161972B1 (ko) | 크기가 감소된 lhrh 동족체 | |
| US5110904A (en) | Lhrh analogs | |
| KR910002550B1 (ko) | Lhrh의 노나펩타이드 및 데카펩타이드 동족체 및 이의 제조방법 | |
| AU636301B2 (en) | Cyclic grf-analogs ii | |
| BRPI0717441B1 (pt) | Composto, medicamento, e, uso do derivado de metastina | |
| US5300492A (en) | LHRH analogs | |
| JP2542362B2 (ja) | 新規ハロ低級アルキルグアニジノ置換アミノ酸化合物およびその製法 | |
| CN101983068B (zh) | N末端和c末端取代的人gh-rh拮抗类似物 | |
| RS52007B (sr) | Derivati metastina i njihova upotreba | |
| KR100629013B1 (ko) | Igf-ⅰ 및 -ⅱ를 억제하는 gh-rh의 길항 유사체 | |
| JPH07507330A (ja) | ポリペプチドのボンベシン拮抗物質 | |
| EP2161037A2 (en) | Camptothecin-Somatostatin conjugates | |
| JP2002502381A (ja) | 環状crfアンタゴニストペプチド | |
| HU186877B (en) | Process for preparing new hormone antagonists releasing luteinizing hormone and acid addition salts thereof | |
| EP0328090A2 (en) | LHRH analogs | |
| JPS61210099A (ja) | 新規な成長ホルモン放出性ペプチド | |
| JP2012500284A (ja) | ペプチド性pth受容体アゴニスト | |
| JPH08505611A (ja) | 5位及び6位に修飾アミノアシル残基を有するlhrh拮抗薬 | |
| NZ251969A (en) | Cyclic hexapeptide derivatives and analogs and compositions thereof | |
| MXPA99010562A (en) | Peptide parathyroid hormone analogs | |
| MXPA99010560A (en) | Detergent compositions | |
| CZ9904022A3 (cs) | Peptidové analogy parathyroidálního hormonu | |
| PT94923B (pt) | Processo de preparacao de analogos "pseudo" hexapeptidos, heptapeptidos, octapeptidos e nonapeptidos da lhrh e de composicoes farmaceuticas que os contem |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| A201 | Request for examination | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| FPAY | Annual fee payment |
Payment date: 20060816 Year of fee payment: 5 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 5 |
|
| LAPS | Lapse due to unpaid annual fee | ||
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20070822 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20070822 |