KR20010012568A - 펩타이드 부갑상선 호르몬 유사체 및 이를 포함하는 약제학적 조성물 - Google Patents
펩타이드 부갑상선 호르몬 유사체 및 이를 포함하는 약제학적 조성물 Download PDFInfo
- Publication number
- KR20010012568A KR20010012568A KR1019997010523A KR19997010523A KR20010012568A KR 20010012568 A KR20010012568 A KR 20010012568A KR 1019997010523 A KR1019997010523 A KR 1019997010523A KR 19997010523 A KR19997010523 A KR 19997010523A KR 20010012568 A KR20010012568 A KR 20010012568A
- Authority
- KR
- South Korea
- Prior art keywords
- parathyroid hormone
- hormone analogs
- peptide parathyroid
- peptide
- analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4647297P | 1997-05-14 | 1997-05-14 | |
| US60/046,472 | 1997-05-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010012568A true KR20010012568A (ko) | 2001-02-15 |
| KR100351213B1 KR100351213B1 (ko) | 2002-09-05 |
Family
ID=21943653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019997010523A KR100351213B1 (ko) | 1997-05-14 | 1998-05-13 | 펩타이드 부갑상선 호르몬 유사체 및 이를 포함하는 약제학적 조성물 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6472505B1 (ko) |
| EP (1) | EP0986395A4 (ko) |
| JP (1) | JP2001517957A (ko) |
| KR (1) | KR100351213B1 (ko) |
| CN (1) | CN1261281A (ko) |
| AP (1) | AP9901686A0 (ko) |
| AU (1) | AU746461B2 (ko) |
| BG (1) | BG103957A (ko) |
| BR (1) | BR9808786A (ko) |
| CA (1) | CA2290443A1 (ko) |
| EA (1) | EA002819B1 (ko) |
| HU (1) | HUP0003349A3 (ko) |
| IL (1) | IL132901A0 (ko) |
| NO (1) | NO995568L (ko) |
| OA (1) | OA11216A (ko) |
| PL (1) | PL336803A1 (ko) |
| SK (1) | SK151599A3 (ko) |
| UA (1) | UA62967C2 (ko) |
| WO (1) | WO1998051324A1 (ko) |
| ZA (1) | ZA984077B (ko) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2325572A1 (en) * | 1998-04-15 | 1999-10-21 | Aventis Pharmaceuticals Products Inc. | Process for the preparation of resin-bound cyclic peptides |
| US6316410B1 (en) * | 1999-09-22 | 2001-11-13 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| WO2003097690A2 (en) * | 2002-05-16 | 2003-11-27 | Theratechnologies Inc. | Pth derivatives resistant to skin proteases |
| WO2004073587A2 (en) * | 2003-02-19 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with parathyroid hormone receptor 1 (pthr1) |
| CN1822853A (zh) * | 2003-07-15 | 2006-08-23 | 加拿大国家研究委员会 | 用于治疗特征在于过度增殖皮肤细胞的疾病的人类甲状旁腺激素环状类似物 |
| US7439226B2 (en) * | 2003-09-30 | 2008-10-21 | The United States Of America As Represented By The Department Of Health And Human Services | Serine protease inhibitors |
| RU2006143544A (ru) * | 2004-05-10 | 2008-06-20 | Нэстек Фармасьютикал Кампани Инк. (Us) | Композиции и способ для облегченной чресслизистой доставки паратиреоидного гормона |
| US20060052306A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | GRAS composition for enhanced mucosal delivery of parathyroid hormone |
| US20060127320A1 (en) * | 2004-05-10 | 2006-06-15 | Nastech Pharmaceutical Company Inc. | Method of delivering parathyroid hormone to a human |
| US20060052305A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | Method of treating osteoporosis using intranasal parathyroid hormone |
| US9051379B2 (en) | 2005-07-07 | 2015-06-09 | Fulcrum Sp Ltd. | Sp1 polypeptides, modified Sp1 polypeptides and uses thereof |
| US20070173447A1 (en) * | 2005-10-25 | 2007-07-26 | Nastech Pharmaceutical Company Inc. | Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent |
| CA2628945A1 (en) * | 2005-11-10 | 2007-05-24 | Board Of Control Of Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| US20080051332A1 (en) * | 2005-11-18 | 2008-02-28 | Nastech Pharmaceutical Company Inc. | Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone |
| EP2084183B1 (en) * | 2006-10-13 | 2010-05-26 | Eli Lilly & Company | Pegylated pth as pth receptor modulators and uses thereof |
| US8691760B2 (en) | 2009-02-02 | 2014-04-08 | Ramot At Tel-Aviv University | Peptides, pharmaceutical compositions comprising same and uses thereof |
| JP2012522762A (ja) | 2009-04-01 | 2012-09-27 | ザ メディカル リサーチ， インフラストラクチャー， アンド ヘルス サーヴィシーズ ファンド オブ ザ テル アヴィヴ メディカル センター | ケラチノサイトの増殖および分化を調節する方法 |
| WO2010116375A1 (en) | 2009-04-08 | 2010-10-14 | Yeda Research And Development Co. Ltd. | Isolated peptides for regulating apoptosis |
| EP2435078A1 (en) | 2009-05-28 | 2012-04-04 | Yeda Research and Development Co. Ltd. | Methods of treating inflammation |
| EP2459208B1 (en) | 2009-07-29 | 2016-09-28 | Kai Pharmaceuticals, Inc. | Therapeutic agents for reducing parathyroid hormone levels |
| WO2011071480A1 (en) | 2009-12-07 | 2011-06-16 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| WO2011138785A2 (en) | 2010-05-05 | 2011-11-10 | Rappaport Family Institute For Research In The Medical Sciences | Use of ccl1 in therapy |
| KR101900078B1 (ko) * | 2010-05-13 | 2018-09-18 | 더 제너럴 하스피탈 코포레이션 | 부갑상선 호르몬 아날로그 및 그의 용도 |
| US8901074B2 (en) | 2010-08-04 | 2014-12-02 | Ramot At Tel-Aviv University | Methods of treating autoimmune diseases of the central nervous system (CNS) and neurodegenerative diseases |
| WO2012131680A2 (en) | 2011-03-28 | 2012-10-04 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating inflammation |
| ES2702487T3 (es) * | 2011-06-17 | 2019-03-01 | Nantenergy Inc | Líquido iónico que contiene iones sulfonato |
| JP6429191B2 (ja) | 2012-03-06 | 2018-11-28 | セレクト バイオセラピューティクス リミテッド | アポトーシスシグナル伝達抵抗性細胞を選択する装置および方法ならびにその使用 |
| EP3046929B1 (en) | 2013-09-17 | 2019-01-16 | Yeda Research and Development Co., Ltd. | Erk-derived peptides and uses thereof |
| US20160340659A1 (en) | 2014-01-30 | 2016-11-24 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. | Actin binding peptides and compositions comprising same for inhibiting angiogenesis and treating medical conditions associated with same |
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| IL243838A (en) | 2016-01-28 | 2017-07-31 | Sp Nano Ltd | The composition containing sp1 protein and carbon nanoparticles and its uses |
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| CA3197108A1 (en) | 2020-11-03 | 2022-05-12 | Ilya Ruderfer | Modified uricase and uses thereof |
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Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4086196A (en) * | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
| US4423037A (en) | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
| US4427827A (en) | 1982-10-20 | 1984-01-24 | Usv Pharmaceutical Corporation | Synthesis of hormone fragments |
| FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
| US4771124A (en) | 1987-05-26 | 1988-09-13 | Merck & Co., Inc. | Parathyroid hormone antagonists with simplified synthetic methodology |
| CA2040264A1 (en) | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
| CA2087087C (en) | 1992-01-22 | 2000-07-18 | Burton H. Sage, Jr. | Molecules for iontophoretic delivery |
| US5434246A (en) | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
| US5814603A (en) | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| CA2098639A1 (en) | 1992-06-19 | 1993-12-20 | K. Anne Kronis | Bone stimulating, non-vasoactive parathyroid hormone variants |
| US5589452A (en) | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU672790B2 (en) | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| EP0679088B1 (en) | 1992-09-29 | 2002-07-10 | Inhale Therapeutic Systems | Pulmonary delivery of active fragments of parathyroid hormone |
| US5556940A (en) | 1994-06-20 | 1996-09-17 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| CO4410206A1 (es) | 1994-07-28 | 1997-01-09 | Sandoz Ag | DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN |
| DE19508672A1 (de) * | 1995-03-10 | 1996-09-12 | Boehringer Mannheim Gmbh | Neue cyclische Parathormonfragmente, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| CA2178392A1 (en) | 1995-06-07 | 1996-12-08 | Robert W. Horst | Fail-fast, fail-functional, fault-tolerant multiprocessor system |
| US5717062A (en) * | 1995-06-07 | 1998-02-10 | Beth Israel Hospital Association | Cyclic analogs of PTH and PTHrP |
| US5723577A (en) * | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
| SK287397B6 (sk) * | 1996-08-02 | 2010-08-09 | National Research Council Of Canada | Analógy paratyroidného hormónu na liečenie osteoporózy |
-
1998
- 1998-05-13 UA UA99126574A patent/UA62967C2/uk unknown
- 1998-05-13 IL IL13290198A patent/IL132901A0/xx unknown
- 1998-05-13 SK SK1515-99A patent/SK151599A3/sk unknown
- 1998-05-13 EP EP98921200A patent/EP0986395A4/en not_active Withdrawn
- 1998-05-13 CA CA002290443A patent/CA2290443A1/en not_active Abandoned
- 1998-05-13 EA EA199901025A patent/EA002819B1/ru not_active IP Right Cessation
- 1998-05-13 CN CN98806651A patent/CN1261281A/zh active Pending
- 1998-05-13 WO PCT/US1998/009843 patent/WO1998051324A1/en not_active Application Discontinuation
- 1998-05-13 BR BR9808786-0A patent/BR9808786A/pt not_active Application Discontinuation
- 1998-05-13 HU HU0003349A patent/HUP0003349A3/hu unknown
- 1998-05-13 JP JP54953698A patent/JP2001517957A/ja not_active Ceased
- 1998-05-13 PL PL98336803A patent/PL336803A1/xx unknown
- 1998-05-13 KR KR1019997010523A patent/KR100351213B1/ko not_active IP Right Cessation
- 1998-05-13 AP APAP/P/1999/001686A patent/AP9901686A0/en unknown
- 1998-05-13 AU AU73867/98A patent/AU746461B2/en not_active Ceased
- 1998-05-14 ZA ZA984077A patent/ZA984077B/xx unknown
-
1999
- 1999-01-12 US US09/228,990 patent/US6472505B1/en not_active Expired - Fee Related
- 1999-11-12 NO NO995568A patent/NO995568L/no not_active Application Discontinuation
- 1999-11-12 OA OA9900247A patent/OA11216A/en unknown
- 1999-12-06 BG BG103957A patent/BG103957A/bg unknown
-
2002
- 2002-03-13 US US10/097,079 patent/US20020132973A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL132901A0 (en) | 2001-03-19 |
| UA62967C2 (en) | 2004-01-15 |
| KR100351213B1 (ko) | 2002-09-05 |
| AU746461B2 (en) | 2002-05-02 |
| NO995568D0 (no) | 1999-11-12 |
| CA2290443A1 (en) | 1998-11-19 |
| AU7386798A (en) | 1998-12-08 |
| HUP0003349A3 (en) | 2001-12-28 |
| HUP0003349A2 (hu) | 2001-01-29 |
| EA199901025A1 (ru) | 2000-06-26 |
| CN1261281A (zh) | 2000-07-26 |
| JP2001517957A (ja) | 2001-10-09 |
| OA11216A (en) | 2003-07-10 |
| EA002819B1 (ru) | 2002-10-31 |
| WO1998051324A1 (en) | 1998-11-19 |
| BR9808786A (pt) | 2000-07-11 |
| NO995568L (no) | 1999-12-29 |
| EP0986395A1 (en) | 2000-03-22 |
| ZA984077B (en) | 1998-11-24 |
| US6472505B1 (en) | 2002-10-29 |
| SK151599A3 (en) | 2000-09-12 |
| AP9901686A0 (en) | 1999-12-31 |
| EP0986395A4 (en) | 2004-12-01 |
| PL336803A1 (en) | 2000-07-17 |
| US20020132973A1 (en) | 2002-09-19 |
| BG103957A (bg) | 2000-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
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