KR100344732B1 - 디아자-스피로[3.5]노난 유도체 - Google Patents

디아자-스피로[3.5]노난 유도체 Download PDF

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Publication number
KR100344732B1
KR100344732B1 KR1019990021485A KR19990021485A KR100344732B1 KR 100344732 B1 KR100344732 B1 KR 100344732B1 KR 1019990021485 A KR1019990021485 A KR 1019990021485A KR 19990021485 A KR19990021485 A KR 19990021485A KR 100344732 B1 KR100344732 B1 KR 100344732B1
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KR
South Korea
Prior art keywords
phenyl
spiro
diaza
nonan
lower alkyl
Prior art date
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Expired - Fee Related
Application number
KR1019990021485A
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English (en)
Korean (ko)
Other versions
KR20000006060A (ko
Inventor
아담지오
세수라안드레아
쟝크프랑소와
콜제비스키사빈
뢰버스테판
위크만쥐르겐
Original Assignee
에프. 호프만-라 로슈 아게
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Publication of KR20000006060A publication Critical patent/KR20000006060A/ko
Application granted granted Critical
Publication of KR100344732B1 publication Critical patent/KR100344732B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
KR1019990021485A 1998-06-12 1999-06-10 디아자-스피로[3.5]노난 유도체 Expired - Fee Related KR100344732B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110804.6 1998-06-12
EP98110804 1998-06-12

Publications (2)

Publication Number Publication Date
KR20000006060A KR20000006060A (ko) 2000-01-25
KR100344732B1 true KR100344732B1 (ko) 2002-07-19

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019990021485A Expired - Fee Related KR100344732B1 (ko) 1998-06-12 1999-06-10 디아자-스피로[3.5]노난 유도체

Country Status (28)

Country Link
US (1) US6113527A (enExample)
EP (1) EP0970957B1 (enExample)
JP (1) JP3286268B2 (enExample)
KR (1) KR100344732B1 (enExample)
CN (1) CN1107066C (enExample)
AR (1) AR019859A1 (enExample)
AT (1) ATE204279T1 (enExample)
AU (1) AU743983B2 (enExample)
BR (1) BR9902651A (enExample)
CA (1) CA2274202A1 (enExample)
DE (1) DE69900220T2 (enExample)
DK (1) DK0970957T3 (enExample)
ES (1) ES2162503T3 (enExample)
HR (1) HRP990188A2 (enExample)
HU (1) HU220894B1 (enExample)
ID (1) ID23304A (enExample)
IL (1) IL130377A0 (enExample)
MA (1) MA26644A1 (enExample)
NO (1) NO312590B1 (enExample)
NZ (1) NZ336189A (enExample)
PE (1) PE20000548A1 (enExample)
PL (1) PL333695A1 (enExample)
PT (1) PT970957E (enExample)
SG (1) SG79259A1 (enExample)
SI (1) SI0970957T1 (enExample)
TR (1) TR199901381A2 (enExample)
YU (1) YU26499A (enExample)
ZA (1) ZA993852B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
JP2005502619A (ja) * 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター１アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
PT1491212E (pt) * 2002-03-29 2012-11-16 Mitsubishi Tanabe Pharma Corp Medicamento para distúrbios de sono
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
EA009789B1 (ru) * 2002-07-05 2008-04-28 Таргасепт, Инк. N-арилдиазаспирациклические соединения и способы их получения и применения
KR20050043935A (ko) * 2002-09-09 2005-05-11 얀센 파마슈티카 엔.브이. Ｏｒｌ-1 수용체 매개 장애의 치료에 유용한 하이드록시 알킬 치환된 1,3,8-트리아자스피로[4.5]데칸-4-온 유도체
GB0323204D0 (en) * 2003-10-03 2003-11-05 Novartis Ag Organic compounds
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
CA2575461A1 (en) * 2004-08-20 2006-03-02 Targacept, Inc. The use of n-aryl diazaspiracyclic compounds in the treatment of addiction
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
KR20090083954A (ko) * 2006-11-28 2009-08-04 얀센 파마슈티카 엔.브이. 3-(3-아미노-2-(ｒ)-하이드록시프로필)-1-(4-플루오로페닐)-8-(8-메틸나프탈렌-1-일메틸)-1,3,8-트리아자-스피로[4.5]데칸-4-온의 염
CA2683598C (en) * 2007-04-09 2015-11-17 Janssen Pharmaceutica Nv 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
TW202340202A (zh) * 2021-12-22 2023-10-16 美國加利福尼亞大學董事會 Gtp酶抑制劑及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Also Published As

Publication number Publication date
CN1107066C (zh) 2003-04-30
ZA993852B (en) 1999-12-13
JP2000053679A (ja) 2000-02-22
MA26644A1 (fr) 2004-12-20
JP3286268B2 (ja) 2002-05-27
EP0970957B1 (en) 2001-08-16
PL333695A1 (en) 1999-12-20
AR019859A1 (es) 2002-03-20
TR199901381A3 (tr) 2000-01-21
BR9902651A (pt) 2000-05-16
IL130377A0 (en) 2000-06-01
EP0970957A1 (en) 2000-01-12
DK0970957T3 (da) 2001-12-03
AU743983B2 (en) 2002-02-14
TR199901381A2 (xx) 2000-01-21
NO312590B1 (no) 2002-06-03
HU9901911D0 (en) 1999-08-30
DE69900220T2 (de) 2002-05-08
DE69900220D1 (de) 2001-09-20
US6113527A (en) 2000-09-05
NO992873L (no) 1999-12-13
CN1242366A (zh) 2000-01-26
AU3498799A (en) 1999-12-23
CA2274202A1 (en) 1999-12-12
KR20000006060A (ko) 2000-01-25
HUP9901911A1 (hu) 2000-05-28
PE20000548A1 (es) 2000-07-15
PT970957E (pt) 2002-02-28
SI0970957T1 (enExample) 2001-12-31
YU26499A (sh) 2002-09-19
HRP990188A2 (en) 2000-02-29
NO992873D0 (no) 1999-06-11
SG79259A1 (en) 2001-03-20
ATE204279T1 (de) 2001-09-15
ES2162503T3 (es) 2001-12-16
NZ336189A (en) 2000-10-27
ID23304A (id) 2000-04-05
HU220894B1 (en) 2002-06-29

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