AR019859A1 - Derivados diaza-espiro[3,5]nonano, un procedimiento para su preparacion, composiciones farmaceuticas que los comprenden y el uso de los mismos para la preparacion de un medicamento - Google Patents
Derivados diaza-espiro[3,5]nonano, un procedimiento para su preparacion, composiciones farmaceuticas que los comprenden y el uso de los mismos para la preparacion de un medicamentoInfo
- Publication number
- AR019859A1 AR019859A1 ARP990102763A ARP990102763A AR019859A1 AR 019859 A1 AR019859 A1 AR 019859A1 AR P990102763 A ARP990102763 A AR P990102763A AR P990102763 A ARP990102763 A AR P990102763A AR 019859 A1 AR019859 A1 AR 019859A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- lower alkyl
- naphthalen
- hydrogen
- diaza
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 bicyclo [3.3.1] non-9-yl Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical compound CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004129 indan-1-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])* 0.000 abstract 1
- 125000004130 indan-2-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])(*)C2([H])[H] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98110804 | 1998-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR019859A1 true AR019859A1 (es) | 2002-03-20 |
Family
ID=8232114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102763A AR019859A1 (es) | 1998-06-12 | 1999-06-10 | Derivados diaza-espiro[3,5]nonano, un procedimiento para su preparacion, composiciones farmaceuticas que los comprenden y el uso de los mismos para la preparacion de un medicamento |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6113527A (enExample) |
| EP (1) | EP0970957B1 (enExample) |
| JP (1) | JP3286268B2 (enExample) |
| KR (1) | KR100344732B1 (enExample) |
| CN (1) | CN1107066C (enExample) |
| AR (1) | AR019859A1 (enExample) |
| AT (1) | ATE204279T1 (enExample) |
| AU (1) | AU743983B2 (enExample) |
| BR (1) | BR9902651A (enExample) |
| CA (1) | CA2274202A1 (enExample) |
| DE (1) | DE69900220T2 (enExample) |
| DK (1) | DK0970957T3 (enExample) |
| ES (1) | ES2162503T3 (enExample) |
| HR (1) | HRP990188A2 (enExample) |
| HU (1) | HU220894B1 (enExample) |
| ID (1) | ID23304A (enExample) |
| IL (1) | IL130377A0 (enExample) |
| MA (1) | MA26644A1 (enExample) |
| NO (1) | NO312590B1 (enExample) |
| NZ (1) | NZ336189A (enExample) |
| PE (1) | PE20000548A1 (enExample) |
| PL (1) | PL333695A1 (enExample) |
| PT (1) | PT970957E (enExample) |
| SG (1) | SG79259A1 (enExample) |
| SI (1) | SI0970957T1 (enExample) |
| TR (1) | TR199901381A2 (enExample) |
| YU (1) | YU26499A (enExample) |
| ZA (1) | ZA993852B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030040479A1 (en) * | 2001-07-02 | 2003-02-27 | Omeros Corporation | Rotational intrathecal analgesia method and device |
| WO2003004034A1 (en) * | 2001-07-02 | 2003-01-16 | Omeros Corporation | Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump |
| US7566728B2 (en) * | 2002-03-29 | 2009-07-28 | Mitsubishi Tanabe Pharma Corporation | Remedy for sleep disturbance |
| JP2005289816A (ja) | 2002-05-14 | 2005-10-20 | Banyu Pharmaceut Co Ltd | ベンズイミダゾール誘導体 |
| ATE451373T1 (de) | 2002-07-05 | 2009-12-15 | Targacept Inc | N-aryl diazaspirozyklische verbindungen, deren verwendung und das verfahren zu ihren herstellung |
| NZ538307A (en) * | 2002-09-09 | 2008-04-30 | Janssen Pharmaceutica Nv | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
| GB0323204D0 (en) * | 2003-10-03 | 2003-11-05 | Novartis Ag | Organic compounds |
| US20050228023A1 (en) * | 2003-12-19 | 2005-10-13 | Sri International | Agonist and antagonist ligands of the nociceptin receptor |
| US20060178390A1 (en) * | 2004-08-02 | 2006-08-10 | Alfonzo Jordan | 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
| JP2008510711A (ja) * | 2004-08-20 | 2008-04-10 | ターガセプト，インコーポレイテッド | 嗜癖治療におけるｎ−アリールジアザスピラ環状化合物の使用 |
| US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
| CN101622254B (zh) * | 2006-11-28 | 2013-05-29 | 詹森药业有限公司 | 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐 |
| CA2683598C (en) * | 2007-04-09 | 2015-11-17 | Janssen Pharmaceutica Nv | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
| KR101704226B1 (ko) | 2015-06-30 | 2017-02-07 | 현대자동차주식회사 | 자동차의 쿼터글라스 어셈블리 |
| AU2022421224A1 (en) * | 2021-12-22 | 2024-06-20 | The Regents Of The University Of California | Covalently binding inhibitors of g12s, g12d and/or g12e mutants of k-ras gtpase |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756743A (en) * | 1996-04-10 | 1998-05-26 | Hoechst Marion Roussel Inc. | Spiro cyclopent b!indole-piperidines! |
-
1999
- 1999-06-07 PT PT99110943T patent/PT970957E/pt unknown
- 1999-06-07 DK DK99110943T patent/DK0970957T3/da active
- 1999-06-07 ES ES99110943T patent/ES2162503T3/es not_active Expired - Lifetime
- 1999-06-07 AT AT99110943T patent/ATE204279T1/de not_active IP Right Cessation
- 1999-06-07 SI SI9930008T patent/SI0970957T1/xx unknown
- 1999-06-07 DE DE69900220T patent/DE69900220T2/de not_active Expired - Lifetime
- 1999-06-07 EP EP99110943A patent/EP0970957B1/en not_active Expired - Lifetime
- 1999-06-08 ID IDP990543D patent/ID23304A/id unknown
- 1999-06-08 ZA ZA9903852A patent/ZA993852B/xx unknown
- 1999-06-08 PE PE1999000487A patent/PE20000548A1/es not_active Application Discontinuation
- 1999-06-09 SG SG9903066A patent/SG79259A1/en unknown
- 1999-06-09 IL IL13037799A patent/IL130377A0/xx unknown
- 1999-06-09 CA CA002274202A patent/CA2274202A1/en not_active Abandoned
- 1999-06-09 NZ NZ336189A patent/NZ336189A/xx unknown
- 1999-06-09 HU HU9901911A patent/HU220894B1/hu not_active IP Right Cessation
- 1999-06-10 KR KR1019990021485A patent/KR100344732B1/ko not_active Expired - Fee Related
- 1999-06-10 AR ARP990102763A patent/AR019859A1/es active IP Right Grant
- 1999-06-10 YU YU26499A patent/YU26499A/sh unknown
- 1999-06-10 AU AU34987/99A patent/AU743983B2/en not_active Ceased
- 1999-06-10 JP JP16357099A patent/JP3286268B2/ja not_active Expired - Fee Related
- 1999-06-10 MA MA25616A patent/MA26644A1/fr unknown
- 1999-06-11 US US09/330,851 patent/US6113527A/en not_active Expired - Fee Related
- 1999-06-11 HR HR98110804.6A patent/HRP990188A2/hr not_active Application Discontinuation
- 1999-06-11 PL PL99333695A patent/PL333695A1/xx unknown
- 1999-06-11 CN CN99108373A patent/CN1107066C/zh not_active Expired - Fee Related
- 1999-06-11 NO NO19992873A patent/NO312590B1/no unknown
- 1999-06-11 BR BR9902651-1A patent/BR9902651A/pt not_active Application Discontinuation
- 1999-06-11 TR TR1999/01381A patent/TR199901381A2/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR019859A1 (es) | Derivados diaza-espiro[3,5]nonano, un procedimiento para su preparacion, composiciones farmaceuticas que los comprenden y el uso de los mismos para la preparacion de un medicamento | |
| SE0104334D0 (sv) | Therapeutic agents | |
| HUP0402336A2 (hu) | Tieno[2,3-d]pirimidin-2,4-dion-származékok, eljárás előállításukra, alkalmazásuk autoimmun betegségek modulálására és a vegyületeket tartalmazó gyógyszerkészítmények | |
| PA8472301A1 (es) | Derivados de isotiazol utiles como agentes anticancerosos | |
| MY118163A (en) | Aryl fused azapolycyclic compounds | |
| GR3018212T3 (en) | Naphtylalkylamines, process for their preparation and pharmaceutical compositions containing them. | |
| KR950701323A (ko) | 1-피페라지노-1,2-디히드로인덴 유도체(1-Piperazino-1,2-dihydroindene Derivatives) | |
| AR006360A1 (es) | Derivados de 1,2,3,4-tetrahidronaftaleno substituidos, uso de los mismos para la preparacion de medicamentos y procedimiento para su preparacion. | |
| MX21088A (es) | N-heteroanil-purin-6-aminas, y un proceso para su preparacion y su uso como medicamentos. | |
| AR019860A1 (es) | Derivados di o triaza-espiro (4,5) decano, un procedimiento para su preparacion, un medicamento que los comprende y empleo de dichos derivados para la manufactura de un medicamento. | |
| GEP20063759B (en) | Novel Benzothiazine and Benzothiadiazine Derivatives, Method for Preparing Same and Pharmaceutical Compositions Containing Same | |
| GB2291592B (en) | Pharmaceutical compositions comprising a bicycloheptane derivative | |
| AR020294A1 (es) | COMPUESTOS DERIVADOS DE 1-TRIFLUOROMETIL-4-HIDROXI-7-PIPERIDINIL-AMINOMETILCROMANO, COMPOSICION FARMACEUTICA Y USO EN LA PREPARACIoN DE MEDICAMENTOS. | |
| HU895648D0 (en) | Process for the preparation of n,n-disubstituted diaryl-alkancarboxylic acid amide derivatives and pharmaceutical compositions containing such compounds | |
| AR013538A1 (es) | Nuevos mitogenos especificos de osteoblastos, metodos para prepararlos y drogas que contienen tales compuestos | |
| CA2246482A1 (fr) | Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht [1,2-b]-1,4-oxazines disubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| ES2076054T3 (es) | Nuevas amino-alquil-cromonas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen. | |
| IT1313583B1 (it) | Derivati 2-amminotetralinici per la terapia del glaucoma. | |
| GEP20063757B (en) | Novel Benzothiazine and Benzothiadiazine Derivatives, Method for Preparing Same and Pharmaceutical Compositions Containing Same | |
| ECSP993008A (es) | Derivados de diaza- espiro [3,5] nonano | |
| HU9302081D0 (en) | Procedure for producing preparations for preventing and/or curing ulceral diseases | |
| ES2123038T3 (es) | Nuevos derivados pirrolo-tieno-pirazinicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. | |
| UY28142A1 (es) | Agentes terapéuticos | |
| CA2238710A1 (en) | New amino alcohol derivatives, processes for their production and pharmaceutical agents containing these compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |