KR100333149B1 - 담즙산의테트라졸유도체및이를포함하는약제 - Google Patents

담즙산의테트라졸유도체및이를포함하는약제 Download PDF

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Publication number
KR100333149B1
KR100333149B1 KR1019940009971A KR19940009971A KR100333149B1 KR 100333149 B1 KR100333149 B1 KR 100333149B1 KR 1019940009971 A KR1019940009971 A KR 1019940009971A KR 19940009971 A KR19940009971 A KR 19940009971A KR 100333149 B1 KR100333149 B1 KR 100333149B1
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KR
South Korea
Prior art keywords
compound
bile acid
radical
mmol
formula
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019940009971A
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English (en)
Korean (ko)
Inventor
알폰스엔젠
하이너글롬빅
베르너크라머
귄터베스
Original Assignee
훽스트 악티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019940009971A 1993-05-08 1994-05-07 담즙산의테트라졸유도체및이를포함하는약제 Expired - Fee Related KR100333149B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4315368.2 1993-05-08
DE4315368 1993-05-08

Publications (1)

Publication Number Publication Date
KR100333149B1 true KR100333149B1 (ko) 2002-09-19

Family

ID=6487579

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940009971A Expired - Fee Related KR100333149B1 (ko) 1993-05-08 1994-05-07 담즙산의테트라졸유도체및이를포함하는약제

Country Status (19)

Country Link
US (1) US5466815A (enExample)
EP (1) EP0624596B1 (enExample)
JP (1) JP3476157B2 (enExample)
KR (1) KR100333149B1 (enExample)
AT (1) ATE163938T1 (enExample)
AU (1) AU666440B2 (enExample)
CA (1) CA2123048C (enExample)
CY (1) CY2119B1 (enExample)
CZ (1) CZ289515B6 (enExample)
DE (1) DE59405410D1 (enExample)
DK (1) DK0624596T3 (enExample)
ES (1) ES2115096T3 (enExample)
FI (1) FI942075L (enExample)
GR (1) GR3026496T3 (enExample)
HU (1) HU217439B (enExample)
IL (1) IL109581A (enExample)
NO (1) NO304795B1 (enExample)
NZ (1) NZ260469A (enExample)
TW (1) TW289757B (enExample)

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EP0624593A3 (de) * 1993-05-08 1995-06-07 Hoechst Ag Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel.
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US6323190B1 (en) 1998-07-31 2001-11-27 The Univeristy Of Georgia Research Foundation, Inc. Estrogen mimetics lacking reproductive tract effects
KR20020028876A (ko) 1999-04-30 2002-04-17 추후제출 스테로이드 유도체
US7086134B2 (en) * 2000-08-07 2006-08-08 Shipley Company, L.L.C. Alignment apparatus and method for aligning stacked devices
CA2438221A1 (en) * 2001-02-08 2002-08-15 The University Of Chicago Steroidal derivatives
WO2002090375A2 (en) * 2001-05-03 2002-11-14 The University Of Chicago Liver x receptor agonists
US7078396B2 (en) * 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
US20070197484A1 (en) * 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
US6816317B2 (en) * 2002-01-31 2004-11-09 Lightel Technologies Inc. Collimator for ready fitting to an optical device with precise optical alignment without need for adjusting positions or angles to compensate for offsets or deviations during optical device assembly and method of making same
CA2482195A1 (en) * 2002-04-12 2003-10-23 The University Of Chicago Farnesoid x-activated receptor agonists
MXPA06015049A (es) 2004-07-08 2007-02-08 Novo Nordisk As Marcadores prolongadores de polipeptidos que comprenden una porcion tetrazol.
US20070032464A1 (en) * 2004-10-08 2007-02-08 Shutsung Liao Methods of treating cancers
US7960439B1 (en) 2006-06-12 2011-06-14 Iowa State University Research Foundation, Inc. Environmentally sensitive foldable oligomers
US8829213B2 (en) * 2009-07-29 2014-09-09 The University Of Chicago Liver X receptor agonists
KR101890959B1 (ko) 2010-11-04 2018-08-22 알비레오 에이비 간질환 치료를 위한 ｉｂａｔ 억제제
CN103228270B (zh) 2010-11-08 2016-02-10 阿尔比里奥公司 含ibat抑制剂和胆汁酸结合剂的药物组合
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CN106659726A (zh) 2014-06-25 2017-05-10 Ea制药株式会社 固体制剂及其着色防止或着色减少方法
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
CA2966885A1 (en) 2014-11-06 2016-05-12 Enanta Pharmaceuticals, Inc. Bile acid analogs an fxr/tgr5 agonists and methods of use thereof
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
HK1244708A1 (zh) * 2014-11-26 2018-08-17 英安塔制药有限公司 作爲fxr/tgr5激动剂的胆汁酸类似物及其使用方法
RU2017130466A (ru) * 2015-02-11 2019-03-12 Энанта Фармасьютикалс, Инк. Аналоги желчной кислоты в качестве агонистов fxr/tgr5 и способы их применения
NZ735126A (en) 2015-03-31 2022-10-28 Enanta Pharm Inc Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
CN111116699B (zh) * 2015-04-28 2023-02-28 江苏豪森药业集团有限公司 胆酸衍生物及其制备方法和医药用途
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
WO2017138878A1 (en) 2016-02-09 2017-08-17 Albireo Ab Oral cholestyramine formulation and use thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
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US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10323060B2 (en) 2016-02-23 2019-06-18 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof
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US10472386B2 (en) 2017-02-14 2019-11-12 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR agonists and methods of use thereof
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CN112449637B (zh) 2018-06-05 2024-03-19 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
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US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
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US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
CN115418389A (zh) * 2019-03-19 2022-12-02 美国西门子医学诊断股份有限公司 减轻疏水分析物的体外诊断测定中的脂蛋白干扰的组合物、装置和方法
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Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0417725A2 (de) * 1989-09-14 1991-03-20 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung, Verwendung als Arzneimittel
EP0489423A1 (de) * 1990-12-06 1992-06-10 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindung als Arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417725A2 (de) * 1989-09-14 1991-03-20 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung, Verwendung als Arzneimittel
EP0489423A1 (de) * 1990-12-06 1992-06-10 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindung als Arzneimittel

Also Published As

Publication number Publication date
NO941677L (no) 1994-11-09
FI942075A0 (fi) 1994-05-05
CZ289515B6 (cs) 2002-02-13
DK0624596T3 (da) 1998-10-07
ES2115096T3 (es) 1998-06-16
ATE163938T1 (de) 1998-03-15
JPH06329695A (ja) 1994-11-29
AU6194794A (en) 1994-11-10
HU217439B (hu) 2000-01-28
FI942075A7 (fi) 1994-11-09
IL109581A0 (en) 1994-08-26
CA2123048C (en) 2005-11-29
AU666440B2 (en) 1996-02-08
NO304795B1 (no) 1999-02-15
JP3476157B2 (ja) 2003-12-10
HUT67390A (en) 1995-04-28
CY2119B1 (en) 2002-04-26
CZ113594A3 (en) 1994-12-15
TW289757B (enExample) 1996-11-01
EP0624596A3 (de) 1995-06-07
NO941677D0 (no) 1994-05-06
IL109581A (en) 1998-03-10
HU9401443D0 (en) 1994-08-29
GR3026496T3 (en) 1998-07-31
DE59405410D1 (de) 1998-04-16
FI942075L (fi) 1994-11-09
NZ260469A (en) 1995-03-28
EP0624596A2 (de) 1994-11-17
EP0624596B1 (de) 1998-03-11
US5466815A (en) 1995-11-14
CA2123048A1 (en) 1994-11-09

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R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000