NZ260469A - Tetrazolyl bile acid derivatives (optionally dimeric) with a tetrazole group on the side chain; medicaments - Google Patents
Tetrazolyl bile acid derivatives (optionally dimeric) with a tetrazole group on the side chain; medicamentsInfo
- Publication number
- NZ260469A NZ260469A NZ260469A NZ26046994A NZ260469A NZ 260469 A NZ260469 A NZ 260469A NZ 260469 A NZ260469 A NZ 260469A NZ 26046994 A NZ26046994 A NZ 26046994A NZ 260469 A NZ260469 A NZ 260469A
- Authority
- NZ
- New Zealand
- Prior art keywords
- radical
- bile acid
- formula
- alkyl
- chain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4315368 | 1993-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ260469A true NZ260469A (en) | 1995-03-28 |
Family
ID=6487579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ260469A NZ260469A (en) | 1993-05-08 | 1994-05-06 | Tetrazolyl bile acid derivatives (optionally dimeric) with a tetrazole group on the side chain; medicaments |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5466815A (enExample) |
| EP (1) | EP0624596B1 (enExample) |
| JP (1) | JP3476157B2 (enExample) |
| KR (1) | KR100333149B1 (enExample) |
| AT (1) | ATE163938T1 (enExample) |
| AU (1) | AU666440B2 (enExample) |
| CA (1) | CA2123048C (enExample) |
| CY (1) | CY2119B1 (enExample) |
| CZ (1) | CZ289515B6 (enExample) |
| DE (1) | DE59405410D1 (enExample) |
| DK (1) | DK0624596T3 (enExample) |
| ES (1) | ES2115096T3 (enExample) |
| FI (1) | FI942075L (enExample) |
| GR (1) | GR3026496T3 (enExample) |
| HU (1) | HU217439B (enExample) |
| IL (1) | IL109581A (enExample) |
| NO (1) | NO304795B1 (enExample) |
| NZ (1) | NZ260469A (enExample) |
| TW (1) | TW289757B (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW289020B (enExample) * | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
| EP0624593A3 (de) * | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
| US6323190B1 (en) * | 1998-07-31 | 2001-11-27 | The Univeristy Of Georgia Research Foundation, Inc. | Estrogen mimetics lacking reproductive tract effects |
| IL146223A0 (en) | 1999-04-30 | 2002-07-25 | Arch Dev Corp | Steroid derivatives |
| US7086134B2 (en) * | 2000-08-07 | 2006-08-08 | Shipley Company, L.L.C. | Alignment apparatus and method for aligning stacked devices |
| CN1498222A (zh) * | 2001-02-08 | 2004-05-19 | 芝加哥大学 | 类固醇衍生物 |
| US7078396B2 (en) * | 2001-05-03 | 2006-07-18 | Arch Development Corporation | Method of treating disorder related to high cholesterol concentration |
| DK1392713T3 (da) * | 2001-05-03 | 2008-02-18 | Univ Chicago | Lever-X-receptoragonister |
| US20070197484A1 (en) * | 2001-05-03 | 2007-08-23 | Ching Song | Method of treating disorder related to high cholesterol concentration |
| US6816317B2 (en) * | 2002-01-31 | 2004-11-09 | Lightel Technologies Inc. | Collimator for ready fitting to an optical device with precise optical alignment without need for adjusting positions or angles to compensate for offsets or deviations during optical device assembly and method of making same |
| CA2482195A1 (en) * | 2002-04-12 | 2003-10-23 | The University Of Chicago | Farnesoid x-activated receptor agonists |
| ES2542228T3 (es) * | 2004-07-08 | 2015-08-03 | Novo Nordisk A/S | Marcas de prolongación polipeptídica que comprenden un resto de tetrazol |
| US20070032464A1 (en) * | 2004-10-08 | 2007-02-08 | Shutsung Liao | Methods of treating cancers |
| US7960439B1 (en) | 2006-06-12 | 2011-06-14 | Iowa State University Research Foundation, Inc. | Environmentally sensitive foldable oligomers |
| EP2459581A4 (en) * | 2009-07-29 | 2012-12-26 | Univ Chicago | LIVER X-RECEPTOR AGONISTS |
| PL3400944T3 (pl) | 2010-11-04 | 2020-11-16 | Albireo Ab | Inhibitory ibat w leczeniu chorób wątroby |
| PT2637646T (pt) | 2010-11-08 | 2016-08-17 | Albireo Ab | Uma combinação farmacêutica que compreende um inibidor do ibat e um sequestrador de ácido biliar |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| KR102560954B1 (ko) | 2014-06-25 | 2023-07-31 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| BR112017009657A2 (pt) | 2014-11-06 | 2018-01-23 | Enanta Pharmaceuticals, Inc | análogos de ácidos biliares como agonistas de fxr/tgr5 e métodos de uso dos mesmos |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| CA2968404A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
| RU2017130466A (ru) | 2015-02-11 | 2019-03-12 | Энанта Фармасьютикалс, Инк. | Аналоги желчной кислоты в качестве агонистов fxr/tgr5 и способы их применения |
| SI3277286T1 (sl) | 2015-03-31 | 2021-09-30 | Enanta Pharmaceuticals, Inc. | Derivati žolčne kisline kot antagonisti FXR/TGR5 in metode za njihovo uporabo |
| WO2016173397A1 (zh) * | 2015-04-28 | 2016-11-03 | 上海翰森生物医药科技有限公司 | 胆酸衍生物及其制备方法和医药用途 |
| ES2874669T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| CN108601745B (zh) | 2016-02-09 | 2021-12-07 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
| WO2017147137A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof |
| US10323061B2 (en) | 2016-02-23 | 2019-06-18 | Enanta Pharmaceuticals, Inc. | Heteroaryl containing bile acid analogs as FXR/TGR5 agonists and methods of use thereof |
| US10584145B2 (en) | 2016-11-29 | 2020-03-10 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonylurea bile acid derivatives |
| WO2018152171A1 (en) | 2017-02-14 | 2018-08-23 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr agonists and methods of use thereof |
| ES2971092T3 (es) | 2017-04-07 | 2024-06-03 | Enanta Pharm Inc | Procedimiento para la preparación de derivados de ácidos biliares de carbamato de sulfonilo |
| WO2019032027A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE TABLETS, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| EP3802504B1 (en) | 2018-06-05 | 2023-01-18 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| EP3810084A1 (en) | 2018-06-20 | 2021-04-28 | Albireo AB | Pharmaceutical formulation of odevixibat |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| CA3124703C (en) * | 2019-01-14 | 2023-10-17 | Beijing Xuanyi Pharmasciences Co., Ltd. | Tetrazolone substituted steroids and use thereof |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| DK3921028T3 (da) | 2019-02-06 | 2023-01-23 | Albireo Ab | Benzothiadiazepinforbindelser og anvendelse deraf som galdesyremodulatorer |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| CN118834175A (zh) | 2019-02-06 | 2024-10-25 | 阿尔比里奥公司 | 苯并硫氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 |
| US11358143B2 (en) * | 2019-03-19 | 2022-06-14 | Siemens Healthcare Diagnostics Inc. | Compositions, devices, and methods of mitigating lipoprotein interference in in vitro diagnostic assays for hydrophobic analytes |
| DK4069360T3 (da) | 2019-12-04 | 2024-02-26 | Albireo Ab | Benzothia(di)azepinforbindelser og anvendelse deraf som galdesyremodulatorer |
| TWI877263B (zh) | 2019-12-04 | 2025-03-21 | 瑞典商艾爾比瑞歐公司 | 苯并噻二氮呯化合物及其作為膽酸調節劑之用途 |
| WO2021110886A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2021110884A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| ES2972045T3 (es) | 2019-12-04 | 2024-06-10 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| JP7696897B2 (ja) | 2019-12-04 | 2025-06-23 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| PT4069360T (pt) | 2019-12-04 | 2024-03-06 | Albireo Ab | Compostos de benzotia(di)azepina e a sua utilização como moduladores de ácido biliar |
| CN114761018B (zh) | 2019-12-04 | 2025-12-02 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| AR120674A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiazepina y su uso como ácido biliar |
| WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CN116157389B (zh) | 2020-08-03 | 2026-02-10 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| JP2023549226A (ja) | 2020-11-12 | 2023-11-22 | アルビレオ エービー | 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット |
| WO2022117778A1 (en) | 2020-12-04 | 2022-06-09 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| JP2025516153A (ja) | 2022-04-22 | 2025-05-27 | アルビレオ・アクチボラグ | Ａｓｂｔ阻害剤の皮下投与 |
| AU2023285002A1 (en) | 2022-06-09 | 2024-12-05 | Albireo Ab | Treating hepatitis |
| KR20250022070A (ko) * | 2022-06-09 | 2025-02-14 | 산동 루예 파마슈티칼 컴파니 리미티드 | 19-노르 c3,3-이치환된 c21-아자헤테로고리 치환 스테로이드 및 이의 사용 방법 |
| US20240067617A1 (en) | 2022-07-05 | 2024-02-29 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US20240207286A1 (en) | 2022-12-09 | 2024-06-27 | Albireo Ab | Asbt inhibitors in the treatment of renal diseases |
| WO2025119319A1 (zh) * | 2023-12-08 | 2025-06-12 | 山东绿叶制药有限公司 | 一种gabaa受体调节剂的晶型及其制备方法和应用 |
| WO2025146508A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2025146507A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| US5250524A (en) * | 1990-12-06 | 1993-10-05 | Hoechst Aktiengesellschaft | Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals |
-
1993
- 1993-11-23 TW TW082109825A patent/TW289757B/zh active
-
1994
- 1994-05-02 EP EP94106848A patent/EP0624596B1/de not_active Expired - Lifetime
- 1994-05-02 DK DK94106848T patent/DK0624596T3/da active
- 1994-05-02 DE DE59405410T patent/DE59405410D1/de not_active Expired - Lifetime
- 1994-05-02 AT AT94106848T patent/ATE163938T1/de not_active IP Right Cessation
- 1994-05-02 ES ES94106848T patent/ES2115096T3/es not_active Expired - Lifetime
- 1994-05-05 US US08/238,741 patent/US5466815A/en not_active Expired - Lifetime
- 1994-05-05 FI FI942075A patent/FI942075L/fi unknown
- 1994-05-06 NO NO934800A patent/NO304795B1/no not_active IP Right Cessation
- 1994-05-06 HU HU9401443A patent/HU217439B/hu not_active IP Right Cessation
- 1994-05-06 CZ CZ19941135A patent/CZ289515B6/cs not_active IP Right Cessation
- 1994-05-06 IL IL109581A patent/IL109581A/en not_active IP Right Cessation
- 1994-05-06 AU AU61947/94A patent/AU666440B2/en not_active Ceased
- 1994-05-06 JP JP09442494A patent/JP3476157B2/ja not_active Expired - Fee Related
- 1994-05-06 NZ NZ260469A patent/NZ260469A/en unknown
- 1994-05-06 CA CA002123048A patent/CA2123048C/en not_active Expired - Fee Related
- 1994-05-07 KR KR1019940009971A patent/KR100333149B1/ko not_active Expired - Fee Related
-
1998
- 1998-04-03 GR GR980400679T patent/GR3026496T3/el unknown
- 1998-09-29 CY CY9800037A patent/CY2119B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ113594A3 (en) | 1994-12-15 |
| HU217439B (hu) | 2000-01-28 |
| CY2119B1 (en) | 2002-04-26 |
| CA2123048C (en) | 2005-11-29 |
| IL109581A (en) | 1998-03-10 |
| HUT67390A (en) | 1995-04-28 |
| IL109581A0 (en) | 1994-08-26 |
| US5466815A (en) | 1995-11-14 |
| NO304795B1 (no) | 1999-02-15 |
| ATE163938T1 (de) | 1998-03-15 |
| NO941677D0 (no) | 1994-05-06 |
| AU6194794A (en) | 1994-11-10 |
| EP0624596A2 (de) | 1994-11-17 |
| TW289757B (enExample) | 1996-11-01 |
| DE59405410D1 (de) | 1998-04-16 |
| EP0624596B1 (de) | 1998-03-11 |
| FI942075A0 (fi) | 1994-05-05 |
| CZ289515B6 (cs) | 2002-02-13 |
| NO941677L (no) | 1994-11-09 |
| DK0624596T3 (da) | 1998-10-07 |
| KR100333149B1 (ko) | 2002-09-19 |
| FI942075A7 (fi) | 1994-11-09 |
| ES2115096T3 (es) | 1998-06-16 |
| JPH06329695A (ja) | 1994-11-29 |
| FI942075L (fi) | 1994-11-09 |
| HU9401443D0 (en) | 1994-08-29 |
| JP3476157B2 (ja) | 2003-12-10 |
| CA2123048A1 (en) | 1994-11-09 |
| EP0624596A3 (de) | 1995-06-07 |
| AU666440B2 (en) | 1996-02-08 |
| GR3026496T3 (en) | 1998-07-31 |
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